Zhong Wang

Summary

Country: China

Publications

  1. ncbi Outcome-dependent global similarity analysis of imbalanced core signaling pathways in ischemic mouse hippocampus
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    CNS Neurol Disord Drug Targets 11:1070-82. 2012
  2. ncbi Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Eur J Pharmacol 667:278-86. 2011
  3. ncbi Fangjiomics: in search of effective and safe combination therapies
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    J Clin Pharmacol 51:1132-51. 2011
  4. ncbi Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    CNS Neurosci Ther 18:674-82. 2012
  5. ncbi Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Vascul Pharmacol 47:319-27. 2007
  6. ncbi Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study
    Liying Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie, Beijing 100700, China
    Brain Res 1372:13-21. 2011
  7. ncbi Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    Naunyn Schmiedebergs Arch Pharmacol 385:797-806. 2012
  8. ncbi A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury
    Zhan Jun Zhang
    Beijing Normal University, The Key Laboratory of Traditional Chinese Medicine Protection and Utilization, 19 Xinjiekouwai Street, Haidian District, Beijing, PA 100875, China
    Brain Res 1123:188-95. 2006
  9. ncbi Comparison of the network structural characteristics of calcium signaling pathway in cerebral ischemia after intervention by different components of Chinese medicine
    Zhi Wei Jing
    Institute of Clinical Fundamental Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    J Tradit Chin Med 31:251-5. 2011
  10. ncbi [Microarray and research of Chinese medications: pharmcogenomics of Chinese medications]
    Zhi Wei Jing
    Institute of Clinical Fundational Chinese Medicine, China Academy of Chinese Medicine Science, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 32:289-92. 2007

Collaborators

  • Jun Liu
  • Caixiu Zhou
  • Liang Zhang
  • Yi Yu Cheng
  • Li Xu
  • Jing Cheng
  • Tao Li
  • Aiping Lv
  • Hong Ding
  • Peng Li
  • Cun Shuan Xu
  • Xudong Tang
  • Zhiwei Jing
  • Zhi Wei Jing
  • Yanan Yu
  • Yongyan Wang
  • Zhan Jun Zhang
  • Lihui Xiong
  • Fanyun Meng
  • Yinying Chen
  • Hongli Wu
  • Liying Wang
  • Liya Su
  • Yong yan Wang
  • Yong-Yan Wang
  • Xiaoyan Zhang
  • Guoxin Li
  • Mulin Hu
  • Zhanjun Zhang
  • Luqi Huang
  • Youhua Yu
  • Hongxin Cao
  • Zhen Lei Yan
  • Xinyue Wang
  • Jie Zhou
  • Li Ying Wang
  • Suqin Fang
  • Bin Lv
  • Man Li
  • Hong Li Wu
  • Lingxiang Hu
  • Xiaoju Cao
  • Haiwang Ji
  • Shengsheng Zhang
  • Hui Liang
  • Yingkun Li
  • Si Hua Gao
  • Zhi-Wei Jing
  • Si-Hua Gao
  • Xue Jun Zhang
  • Xue-Jun Zhang
  • Zhi-hua Sun
  • Wen Sheng Zhang
  • Wen-sheng Zhang
  • Zhi Hua Sun
  • Zhan-jun Zhang

Detail Information

Publications17

  1. ncbi Outcome-dependent global similarity analysis of imbalanced core signaling pathways in ischemic mouse hippocampus
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    CNS Neurol Disord Drug Targets 11:1070-82. 2012
    ..0% as assessed by leave-one-out cross-validation...
  2. ncbi Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Eur J Pharmacol 667:278-86. 2011
    ..Rather than selecting compounds only based on experience in the past, this study would give a new insight into the systematic strategies for designing synergistic combination therapies...
  3. ncbi Fangjiomics: in search of effective and safe combination therapies
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    J Clin Pharmacol 51:1132-51. 2011
    ..This approach may lead to the discovery of controllable array-designed therapies to combine less potent elements that are more effective collectively but have fewer adverse side effects than does any element singly...
  4. ncbi Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    CNS Neurosci Ther 18:674-82. 2012
    ..The aim of this study was to reveal the pharmacogenomic mechanism of this synergistic effect of jasminoidin and ursodeoxycholic acid...
  5. ncbi Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Vascul Pharmacol 47:319-27. 2007
    ..Brain plasticity originates from a balance of up and downregulated genes (Yin and Yang), and reversal of gene expression in multiple pathways indicates that a complex signaling network may be constructed and investigated further...
  6. ncbi Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study
    Liying Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie, Beijing 100700, China
    Brain Res 1372:13-21. 2011
    ....
  7. ncbi Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    Naunyn Schmiedebergs Arch Pharmacol 385:797-806. 2012
    ..Therefore, these different compounds may function through both overlapping and distinct pharmacological mechanisms to exert their therapeutic action...
  8. ncbi A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury
    Zhan Jun Zhang
    Beijing Normal University, The Key Laboratory of Traditional Chinese Medicine Protection and Utilization, 19 Xinjiekouwai Street, Haidian District, Beijing, PA 100875, China
    Brain Res 1123:188-95. 2006
    ..However, the combination of baicalin and jasminoidin can significantly improve their effectiveness. This may be related to its better regulation on the BDNF and caspase-3...
  9. ncbi Comparison of the network structural characteristics of calcium signaling pathway in cerebral ischemia after intervention by different components of Chinese medicine
    Zhi Wei Jing
    Institute of Clinical Fundamental Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    J Tradit Chin Med 31:251-5. 2011
    ..To explore the network control mechanism of the calcium signaling pathway in cerebral ischemic injury after intervention by the main components of Qingkailing (see text), i.e. Baicalin, Jasminoidin and their combination...
  10. ncbi [Microarray and research of Chinese medications: pharmcogenomics of Chinese medications]
    Zhi Wei Jing
    Institute of Clinical Fundational Chinese Medicine, China Academy of Chinese Medicine Science, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 32:289-92. 2007
    ..We suggest the concept of Pharmacogenomics of Chinese medications with the guidance of the theory of Chinese medications for further development of Chinese medications...
  11. ncbi Association between Glu298Asp/677C-T single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke
    Lihui Xiong
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Gene 511:475-9. 2012
    ..The results confirmed that the TT genotype of Glu298Asp in the eNOS gene may be one of the risk factors associated with BSS-IS, while the genotype of 677C-T (Ala→Val) in the MTHRF gene may not be relevant to BSS-IS...
  12. ncbi [The effect of Baicalin on gene expression profile in rat brain of focal cerebral ischemia]
    Zhong Wang
    Xi Yuan Hospital of China Academy of Traditional Chinese Medicine, Beijing, 100091, China
    Zhongguo Zhong Yao Za Zhi 29:83-6. 2004
    ..To explore the difference of genes expression profiles between focal cerebral ischemia tissue and that treated with Baicalin using cDNA microarray...
  13. ncbi Modular pharmacology: the next paradigm in drug discovery
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Expert Opin Drug Discov 7:667-77. 2012
    ..Further research of pharmacological mechanisms underlying diversity interactions between multiple modules is necessary for a better understanding of the basic therapeutic processes...
  14. ncbi [Similarity and diversity analysis of qingkailing effective components in regulating hippocampus ischemia-related genes of mice]
    Caixiu Zhou
    Institute of Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 35:2475-9. 2010
    ..To compare the different gene expression profiles among Qingkailing components of BA (baicalin), JA (jasminoidin), CA (cholic acid) and CM (concha margaritiferausta) in regulating hippocampus ischemia related genes of mice...
  15. ncbi Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice
    Zhong Wang
    The Key Laboratory of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing, China
    J Neurochem 88:1406-15. 2004
    ..These results suggest that microarray analysis of gene expression might be useful for elucidating the mechanisms of pharmacological function of recipes...
  16. ncbi [Clinical study on naoxintong capsule for stroke recovery of Qi-deficiency and blood-stasis syndrome]
    Liya Su
    China Academy of Chinese Medial Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 36:1530-3. 2011
    ..To study the efficacy and safety of Naoxintong capsule treatment of stroke recovery with Qi-deficiency and blood-stasis syndrome (cerebral infarction), and to compared the non-inferiority analysis with the positive drug Tongxinluo capsule...
  17. ncbi To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial
    Hongli Wu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No 16 Nanxiaojie, Dongzhimen Nei, Beijing, 100700, China
    BMC Gastroenterol 11:81. 2011
    ..IFCA) and the other contains that of Citrus sinensis Osbeck (IFCS). The trial's objective was to compare the efficacy of two kinds of Zhizhu pills on symptom changes in patients with FD of spleen-deficiency and qi-stagnation syndrome...