Zhong Wang

Summary

Country: China

Publications

  1. ncbi request reprint Significant overlapping modules and biological processes between stroke and coronary heart disease
    Yingying Zhang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    CNS Neurol Disord Drug Targets 13:652-60. 2014
  2. ncbi request reprint Hierarchical profiles of signaling pathways and networks reveal two complementary pharmacological mechanisms
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    CNS Neurol Disord Drug Targets 12:882-93. 2013
  3. doi request reprint Navigating personalized medicine dependent on modular flexibility
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Trends Mol Med 19:393-5. 2013
  4. doi request reprint Modular pharmacology: deciphering the interacting structural organization of the targeted networks
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Drug Discov Today 18:560-6. 2013
  5. doi request reprint Fangjiomics: in search of effective and safe combination therapies
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    J Clin Pharmacol 51:1132-51. 2011
  6. doi request reprint Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Eur J Pharmacol 667:278-86. 2011
  7. doi request reprint Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    CNS Neurosci Ther 18:674-82. 2012
  8. ncbi request reprint Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Vascul Pharmacol 47:319-27. 2007
  9. doi request reprint Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    Naunyn Schmiedebergs Arch Pharmacol 385:797-806. 2012
  10. doi request reprint Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study
    Liying Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie, Beijing 100700, China
    Brain Res 1372:13-21. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Significant overlapping modules and biological processes between stroke and coronary heart disease
    Yingying Zhang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    CNS Neurol Disord Drug Targets 13:652-60. 2014
    ....
  2. ncbi request reprint Hierarchical profiles of signaling pathways and networks reveal two complementary pharmacological mechanisms
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    CNS Neurol Disord Drug Targets 12:882-93. 2013
    ..Analysis of network functions and known pathways may be two complementary paradigms for revealing potential pharmacological mechanisms based on the same phenotype variation. ..
  3. doi request reprint Navigating personalized medicine dependent on modular flexibility
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Trends Mol Med 19:393-5. 2013
    ..Deconstructing networks and rewiring alterable modules in a rational way is critical to optimize drug discovery and develop personalized medicine. ..
  4. doi request reprint Modular pharmacology: deciphering the interacting structural organization of the targeted networks
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Drug Discov Today 18:560-6. 2013
    ..We develop a framework of Modular Pharmacology (MP) that deciphers a given-ordered modular design of diseases and optimizes modules in a pharmacological network to reverse the complex diseases...
  5. doi request reprint Fangjiomics: in search of effective and safe combination therapies
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    J Clin Pharmacol 51:1132-51. 2011
    ..This approach may lead to the discovery of controllable array-designed therapies to combine less potent elements that are more effective collectively but have fewer adverse side effects than does any element singly...
  6. doi request reprint Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Eur J Pharmacol 667:278-86. 2011
    ..Rather than selecting compounds only based on experience in the past, this study would give a new insight into the systematic strategies for designing synergistic combination therapies...
  7. doi request reprint Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    CNS Neurosci Ther 18:674-82. 2012
    ..The aim of this study was to reveal the pharmacogenomic mechanism of this synergistic effect of jasminoidin and ursodeoxycholic acid...
  8. ncbi request reprint Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Vascul Pharmacol 47:319-27. 2007
    ..Brain plasticity originates from a balance of up and downregulated genes (Yin and Yang), and reversal of gene expression in multiple pathways indicates that a complex signaling network may be constructed and investigated further...
  9. doi request reprint Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing 100700, China
    Naunyn Schmiedebergs Arch Pharmacol 385:797-806. 2012
    ..Therefore, these different compounds may function through both overlapping and distinct pharmacological mechanisms to exert their therapeutic action...
  10. doi request reprint Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study
    Liying Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie, Beijing 100700, China
    Brain Res 1372:13-21. 2011
    ....
  11. ncbi request reprint A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury
    Zhan Jun Zhang
    Beijing Normal University, The Key Laboratory of Traditional Chinese Medicine Protection and Utilization, 19 Xinjiekouwai Street, Haidian District, Beijing, PA 100875, China
    Brain Res 1123:188-95. 2006
    ..However, the combination of baicalin and jasminoidin can significantly improve their effectiveness. This may be related to its better regulation on the BDNF and caspase-3...
  12. ncbi request reprint Outcome-dependent global similarity analysis of imbalanced core signaling pathways in ischemic mouse hippocampus
    Jun Liu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    CNS Neurol Disord Drug Targets 11:1070-82. 2012
    ..0% as assessed by leave-one-out cross-validation...
  13. ncbi request reprint Comparison of the network structural characteristics of calcium signaling pathway in cerebral ischemia after intervention by different components of Chinese medicine
    Zhi Wei Jing
    Institute of Clinical Fundamental Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    J Tradit Chin Med 31:251-5. 2011
    ..To explore the network control mechanism of the calcium signaling pathway in cerebral ischemic injury after intervention by the main components of Qingkailing (see text), i.e. Baicalin, Jasminoidin and their combination...
  14. ncbi request reprint [The effect of Baicalin on gene expression profile in rat brain of focal cerebral ischemia]
    Zhong Wang
    Xi Yuan Hospital of China Academy of Traditional Chinese Medicine, Beijing, 100091, China
    Zhongguo Zhong Yao Za Zhi 29:83-6. 2004
    ..To explore the difference of genes expression profiles between focal cerebral ischemia tissue and that treated with Baicalin using cDNA microarray...
  15. ncbi request reprint [Microarray and research of Chinese medications: pharmcogenomics of Chinese medications]
    Zhi Wei Jing
    Institute of Clinical Fundational Chinese Medicine, China Academy of Chinese Medicine Science, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 32:289-92. 2007
    ..We suggest the concept of Pharmacogenomics of Chinese medications with the guidance of the theory of Chinese medications for further development of Chinese medications...
  16. doi request reprint Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury
    Ying ying Zhang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
    CNS Neurosci Ther 20:253-63. 2014
    ..Disappointedly, most of the previous studies were limited to a single gene or a single pathway. The extent to which all involved pathways are translated into fusing mechanisms of a combination therapy is of fundamental importance...
  17. ncbi request reprint [Similarity and diversity analysis of qingkailing effective components in regulating hippocampus ischemia-related genes of mice]
    Caixiu Zhou
    Institute of Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 35:2475-9. 2010
    ..To compare the different gene expression profiles among Qingkailing components of BA (baicalin), JA (jasminoidin), CA (cholic acid) and CM (concha margaritiferausta) in regulating hippocampus ischemia related genes of mice...
  18. doi request reprint Modular pharmacology: the next paradigm in drug discovery
    Zhong Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 18 Baixincang, Dongzhimennei, Beijing 100700, China
    Expert Opin Drug Discov 7:667-77. 2012
    ..In order to disturb the complex direct and indirect target hubs, new approaches in adaptive pharmacology should be developed to regulate target loops using module-based designs...
  19. doi request reprint Association between Glu298Asp/677C-T single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke
    Lihui Xiong
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Gene 511:475-9. 2012
    ..The results confirmed that the TT genotype of Glu298Asp in the eNOS gene may be one of the risk factors associated with BSS-IS, while the genotype of 677C-T (Ala‚ÜíVal) in the MTHRF gene may not be relevant to BSS-IS...
  20. ncbi request reprint Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice
    Zhong Wang
    The Key Laboratory of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing, China
    J Neurochem 88:1406-15. 2004
    ..These results suggest that microarray analysis of gene expression might be useful for elucidating the mechanisms of pharmacological function of recipes...
  21. ncbi request reprint Modeling phenotypic plasticity in growth trajectories: a statistical framework
    Zhong Wang
    Center for Computational Biology, Beijing Forestry University, Beijing, 100083, China
    Evolution 68:81-91. 2014
    ..Under this framework, development, genetics, and evolution can be synthesized through statistical bridges to better address how evolution results from phenotypic variation in the process of development via genetic alterations. ..
  22. ncbi request reprint Spatiotemporal positioning of multipotent modules in diverse biological networks
    Yinying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimen, Beijing, 100700, China
    Cell Mol Life Sci 71:2605-24. 2014
    ....
  23. doi request reprint Statistical resolution of missing longitudinal data in clinical pharmacogenomics
    Zhong Wang
    Center for Computational Biology, Beijing Forestry University, Beijing, China
    Adv Drug Deliv Rev 65:980-6. 2013
    ..Simulation studies were performed to investigate the statistical properties of the model and validate its practical usefulness. The model will find its implications for clinical pharmacogenomics toward personalized medicine. ..
  24. pmc To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial
    Hongli Wu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No 16 Nanxiaojie, Dongzhimen Nei, Beijing, 100700, China
    BMC Gastroenterol 11:81. 2011
    ..IFCA) and the other contains that of Citrus sinensis Osbeck (IFCS). The trial's objective was to compare the efficacy of two kinds of Zhizhu pills on symptom changes in patients with FD of spleen-deficiency and qi-stagnation syndrome...
  25. ncbi request reprint [Application of network analysis in diseases and drug studies]
    Yin ying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 38:773-6. 2013
    ....
  26. doi request reprint A multivalent three-point linkage analysis model of autotetraploids
    Yafei Lu
    Center for Computational Biology, Beijing Forestry University, Beijing, China
    Brief Bioinform 14:460-8. 2013
    ..The model was applied to reanalyze a published data in tetraploid switchgrass, validating its practical usefulness and utilization. ..
  27. ncbi request reprint [Advance in study on pharmacological mechanisms of Qingkailing injection in intervention of ischemic cerebral injury]
    Yin ying Chen
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 37:3198-202. 2012
    ....
  28. ncbi request reprint [Clinical study on naoxintong capsule for stroke recovery of Qi-deficiency and blood-stasis syndrome]
    Liya Su
    China Academy of Chinese Medial Sciences, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 36:1530-3. 2011
    ..To study the efficacy and safety of Naoxintong capsule treatment of stroke recovery with Qi-deficiency and blood-stasis syndrome (cerebral infarction), and to compared the non-inferiority analysis with the positive drug Tongxinluo capsule...