Yan-Jiang Wang

Summary

Affiliation: Third Military Medical University Daping Hospital
Location: Chongqing, China
URL: http://neurologist.haodf.com/
Summary:
1. Immunotherapy for Alzheimers disease
2. Neurotrophin and Alzheimers disease
3. Vascular risk and Alzheimers disease
4. Polyphenols and Abeta clearance
Grants:
Roles of p75NTR in regulation Abeta neurotoxicity, metabolism and clearance in Alzheimers disease, 2010-2013, NSFC (China)
A novel therapy for Alzheimers disease, 2008-2010, NHMRC(Australia)

Publications

  1. doi Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease
    Jing Li
    Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China
    Life Sci 89:86-92. 2011
  2. doi p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide 5001, South Australia, Australia
    J Neurosci 31:2292-304. 2011
  3. doi Association between bone mineral density and the risk of Alzheimer's disease
    Rui Zhou
    State Key Laboratory of Trauma Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Alzheimers Dis 24:101-8. 2011
  4. doi Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease
    Yan Jiang Wang
    Department of Human Physiology, Center for Neuroscience, Flinders University, Adelaide 5042, Australia
    Brain Behav Immun 24:1281-93. 2010
  5. ncbi Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats
    Juan Deng
    Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China
    Eur J Pharmacol 637:83-8. 2010
  6. doi ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury
    Ira Wong
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Brain Behav Immun 24:585-97. 2010
  7. doi Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism
    Yan Jiang Wang
    Department of Human Physiology, Flinders University, Adelaide, SA, Australia
    Neurotox Res 17:257-67. 2010
  8. doi Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA, Australia
    Neurotox Res 15:3-14. 2009
  9. doi Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease
    Philip Thomas
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, SA 5000, Australia
    Mutat Res 661:25-34. 2009
  10. doi Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats
    Yong Jun Fan
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Eur J Neurosci 27:2380-90. 2008

Collaborators

Detail Information

Publications16

  1. doi Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease
    Jing Li
    Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China
    Life Sci 89:86-92. 2011
    ....
  2. doi p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide 5001, South Australia, Australia
    J Neurosci 31:2292-304. 2011
    ....
  3. doi Association between bone mineral density and the risk of Alzheimer's disease
    Rui Zhou
    State Key Laboratory of Trauma Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Alzheimers Dis 24:101-8. 2011
    ..Uncovering the relation linking osteoporosis and AD is important for understanding the pathogenesis and developing therapeutic strategies for these two common disorders afflicting elderly people...
  4. doi Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease
    Yan Jiang Wang
    Department of Human Physiology, Center for Neuroscience, Flinders University, Adelaide 5042, Australia
    Brain Behav Immun 24:1281-93. 2010
    ....
  5. ncbi Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats
    Juan Deng
    Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China
    Eur J Pharmacol 637:83-8. 2010
    ..The use of nicotine for treatment of Alzheimer's disease should be reassessed...
  6. doi ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury
    Ira Wong
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Brain Behav Immun 24:585-97. 2010
    ..Our data suggest that proBDNF is a suppressing factor for macrophage migration and infiltration and may play a detrimental role after SCI...
  7. doi Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism
    Yan Jiang Wang
    Department of Human Physiology, Flinders University, Adelaide, SA, Australia
    Neurotox Res 17:257-67. 2010
    ..proNGF is localized to the Abeta plaques in AD mice brain, however, it had no significant effect on Abeta production in vitro and in vivo. Our findings suggest that proNGF is an important factor involving AD pathogenesis...
  8. doi Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA, Australia
    Neurotox Res 15:3-14. 2009
    ..Conclusively, polyphenol-rich GSE prevents the Abeta deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD...
  9. doi Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease
    Philip Thomas
    CSIRO Human Nutrition, PO Box 10041, Adelaide BC, Adelaide, SA 5000, Australia
    Mutat Res 661:25-34. 2009
    ..These results suggest potential protective effects of polyphenols against genomic instability events in different somatic tissues of a transgenic mouse model for AD...
  10. doi Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats
    Yong Jun Fan
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Eur J Neurosci 27:2380-90. 2008
    ..We conclude that proBDNF may induce the death of axotomized sensory neurons and suppress neuronal addition in the intact DRG in neonatal rats, and the suppression of endogenous proBDNF may protect neurons after neurotrauma...
  11. ncbi Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, SA, Australia
    Neurobiol Aging 30:364-76. 2009
    ....
  12. ncbi Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives
    Yan Jiang Wang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide 5042, Australia
    Drug Discov Today 11:931-8. 2006
    ..In this review, we discuss recent progress and problems with respect to Abeta clearance mechanisms and propose strategies for the development of therapeutics targeting Abeta clearance...
  13. pmc The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-β
    Xin Fu Zhou
    Department of Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia
    Prion 5:161-3. 2011
    ..Understanding the roles of p75NTR in the solubility and clearance of Aβ may allow targetting p75NTR as a unique opportunity to develop therapeutic drugs for the prevention and treatment of AD...
  14. ncbi Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance
    Yan Jiang Wang
    Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China yanjiang
    J Alzheimers Dis 21:1065-75. 2010
    ..These ultimately represent future directions of therapeutic approaches toward safer and effective Aβ clearance...