Jingyun Wang

Summary

Country: China

Publications

  1. doi request reprint Lipase entrapment in protamine-induced bio-zirconia particles: characterization and application to the resolution of (R,S)-1-phenylethanol
    Jing Yun Wang
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Enzyme Microb Technol 51:40-6. 2012
  2. doi request reprint Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced by single-walled carbon nanotubes
    Jingyun Wang
    School of Life Science and Biotechnology, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, PR China
    Toxicol In Vitro 26:32-41. 2012
  3. doi request reprint Cytotoxicity of single-walled carbon nanotubes on PC12 cells
    Jingyun Wang
    School of Biological Science and Technology, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Ganjingzi District, Dalian, PR China
    Toxicol In Vitro 25:242-50. 2011
  4. ncbi request reprint A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria
    Na Jiang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Chem Commun (Camb) 49:10620-2. 2013
  5. doi request reprint A ratiometric near-infrared fluorescent probe for hydrazine and its in vivo applications
    Chong Hu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, PR China
    Org Lett 15:4022-5. 2013
  6. ncbi request reprint Fluorescence discrimination of cancer from inflammation by molecular response to COX-2 enzymes
    Hua Zhang
    State Key Laboratory of Fine Chemicals, School of Life Science and Biotechnology, and School of Pharmaceutical Science and Technology, Dalian University of Technology, 2 Linggong Road, Hi Tech Zone, Dalian 116024, People s Republic of China
    J Am Chem Soc 135:17469-75. 2013
  7. doi request reprint Construction of long-wavelength fluorescein analogues and their application as fluorescent probes
    Xiaoqing Xiong
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116025, PR China
    Chemistry 19:6538-45. 2013
  8. doi request reprint The use of a near-infrared RNA fluorescent probe with a large Stokes shift for imaging living cells assisted by the macrocyclic molecule CB7
    Zhiyong Li
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, Hi Tech Zone, Dalian 116024, PR China
    Biomaterials 34:6473-81. 2013
  9. doi request reprint A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability
    Si Zhang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, PR China
    Org Biomol Chem 11:555-8. 2013
  10. doi request reprint A fluorescent ratiometric chemodosimeter for Cu2+ based on TBET and its application in living cells
    Jiangli Fan
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Org Lett 15:492-5. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Lipase entrapment in protamine-induced bio-zirconia particles: characterization and application to the resolution of (R,S)-1-phenylethanol
    Jing Yun Wang
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Enzyme Microb Technol 51:40-6. 2012
    ..9% under the following optimal conditions: octane as solvent, 0.1M (R,S)-1-phenylethanol, 70 mg immobilized lipase, 180 rpm, 50 °C for 48 h. After 6 cycles (288 h), the conversion and ee(s) were still 43% and 85%, respectively...
  2. doi request reprint Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced by single-walled carbon nanotubes
    Jingyun Wang
    School of Life Science and Biotechnology, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, PR China
    Toxicol In Vitro 26:32-41. 2012
    ..In summary, VE might protect PC12 cells from the injury induced by SWCNTs through the down-regulation of oxidative stress and prevention of mitochondrial-mediated apoptosis...
  3. doi request reprint Cytotoxicity of single-walled carbon nanotubes on PC12 cells
    Jingyun Wang
    School of Biological Science and Technology, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Ganjingzi District, Dalian, PR China
    Toxicol In Vitro 25:242-50. 2011
    ....
  4. ncbi request reprint A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria
    Na Jiang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Chem Commun (Camb) 49:10620-2. 2013
    ..Thus, this probe is a highly suitable imaging agent for targeting mitochondria and tracking morphology changes...
  5. doi request reprint A ratiometric near-infrared fluorescent probe for hydrazine and its in vivo applications
    Chong Hu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, PR China
    Org Lett 15:4022-5. 2013
    ....
  6. ncbi request reprint Fluorescence discrimination of cancer from inflammation by molecular response to COX-2 enzymes
    Hua Zhang
    State Key Laboratory of Fine Chemicals, School of Life Science and Biotechnology, and School of Pharmaceutical Science and Technology, Dalian University of Technology, 2 Linggong Road, Hi Tech Zone, Dalian 116024, People s Republic of China
    J Am Chem Soc 135:17469-75. 2013
    ..So the probe may have potential application varying from cancer inflammation diagnosis to guiding tumor resection during surgery. ..
  7. doi request reprint Construction of long-wavelength fluorescein analogues and their application as fluorescent probes
    Xiaoqing Xiong
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116025, PR China
    Chemistry 19:6538-45. 2013
    ..Three derivatives were found to specifically stain mitochondria and one dye responds to thiols with a strong turn-on NIR fluorescence signal and colorimetric change, in vitro and in vivo...
  8. doi request reprint The use of a near-infrared RNA fluorescent probe with a large Stokes shift for imaging living cells assisted by the macrocyclic molecule CB7
    Zhiyong Li
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, Hi Tech Zone, Dalian 116024, PR China
    Biomaterials 34:6473-81. 2013
    ..The introducing of CB7 provides a platform to amplify the application of some cell-impermeant fluorescent stains through the supramolecular chemistry methods...
  9. doi request reprint A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability
    Si Zhang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, PR China
    Org Biomol Chem 11:555-8. 2013
    ..OBEP can label swollen mitochondria resulting from different degrees of cell damage in light and resist fading even after 12 h of incubation...
  10. doi request reprint A fluorescent ratiometric chemodosimeter for Cu2+ based on TBET and its application in living cells
    Jiangli Fan
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Org Lett 15:492-5. 2013
    ....
  11. doi request reprint Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease
    Xiaoqiang Chen
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China
    Bioorg Med Chem Lett 19:4139-42. 2009
    ..Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage...
  12. doi request reprint A new fluorescent chemodosimeter for Hg2+: selectivity, sensitivity, and resistance to Cys and GSH
    Jianjun Du
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, Dalian 116012, P R China
    Org Lett 12:476-9. 2010
    ..Moreover, the fluorescence response of Rho-Hg1 to Hg(2+) has little interference from sulfur compounds such as cysteine and glutathione and could be used in the Hg(2+) imaging in living cells...
  13. doi request reprint Highly selective and anions controlled fluorescent sensor for Hg(2+) in aqueous environment
    Jianjun Du
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, Dalian, 116012, People s Republic of China
    J Fluoresc 18:919-24. 2008
    ..Furthermore, BHg1 also displays response to some anions such as Cl(-)(Br(-)), CO(2)(3)(-), SCN(-) and CH(3)COO(-), which is attributed to the significant coordinating ability of these anions to Hg(2+)...
  14. doi request reprint A novel fluorescent sensor for detection of highly reactive oxygen species, and for imaging such endogenous hROS in the mitochondria of living cells
    Fei Liu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, China
    Analyst 138:775-8. 2013
    ..Moreover PTZ-Cy2 shows selectivity for hROS over other oxidants, and gives a highly sensitive response to such endogenous species within the mitochondria of living cells...
  15. doi request reprint A two-photon fluorescent probe with near-infrared emission for hydrogen sulfide imaging in biosystems
    Wen Sun
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, PR China
    Chem Commun (Camb) 49:3890-2. 2013
    ..Here we report a novel two-photon fluorescent probe with NIR emission for H2S detection. It was successfully used to realize H2S imaging in bovine serum, living cells, tissues as well as in living mice...
  16. doi request reprint Ratiometric detection of viscosity using a two-photon fluorescent sensor
    Fei Liu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024 P R China, Fax 86 411 84986306
    Chemistry 19:1548-53. 2013
    ..Its success is based on the fast- and low-barrier rotation around its methine bond and the huge increase of the fluorescence quantum yield (QY) from the loss of mobility in viscous media...
  17. doi request reprint FRET spectral unmixing: a ratiometric fluorescent nanoprobe for hypochlorite
    Gengwen Chen
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, P R China
    Chem Commun (Camb) 48:2949-51. 2012
    ..The separation of FRET pairs' emissions reaches 175 nm, which ensures that the FRET probing is more accurate. This new nanoprobe shows high selectivity and potential in biological systems...
  18. ncbi request reprint A selective fluorescent sensor for imaging Cd2+ in living cells
    Xiaojun Peng
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, Dalian 116012, P R China
    J Am Chem Soc 129:1500-1. 2007
  19. doi request reprint A highly specific BODIPY-based probe localized in mitochondria for HClO imaging
    Guanghui Cheng
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, P R China
    Analyst 138:6091-6. 2013
    ..Confocal fluorescence microscopy demonstrated that the probe could permeate the mitochondria and made possible the fast fluorescent imaging of endogenous HClO. ..
  20. ncbi request reprint Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa
    Xiuli Zhang
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
    Phytomedicine 15:484-90. 2008
    ..Catalpol may be a potential anti-aging agent and worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's and Parkinson's diseases...
  21. doi request reprint A highly selective, fluorescent chemosensor for bioimaging of Fe³⁺
    Lizhu Zhang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Rd, Hi Tech Zone, Dalian 116024, PR China
    Bioorg Med Chem Lett 21:5413-6. 2011
    ..The pK(a) of the sensor is as low as of 3.2. It can be used in the range of pH 5-9...
  22. ncbi request reprint Thermally activated delayed fluorescence of fluorescein derivative for time-resolved and confocal fluorescence imaging
    Xiaoqing Xiong
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, People s Republic of China
    J Am Chem Soc 136:9590-7. 2014
    ..The straightforward synthesis of DCF-MPYM and wide availability of its starting materials contribute to the excellent potential of the compound to replace luminescent lanthanide complexes in future time-resolved imaging technologies. ..
  23. doi request reprint Fluorescence imaging lysosomal changes during cell division and apoptosis observed using Nile Blue based near-infrared emission
    Jiangli Fan
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Chem Commun (Camb) 50:882-4. 2014
    ..It was first successfully used to observe the disappearance and reproduction of lysosomes during cell division. ..
  24. doi request reprint Characterization of thermo-stable endoinulinase from a new strain Bacillus smithii T7
    Wei Gao
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, People s Republic of China
    Appl Biochem Biotechnol 157:498-506. 2009
    ..17 mM) and higher maximum reaction velocity (833 IU/mg protein) demonstrate the endoinulinase's greater affinity for inulin substrate. These findings are significant for its potential industrial application...
  25. doi request reprint An off-on COX-2-specific fluorescent probe: targeting the Golgi apparatus of cancer cells
    Hua Zhang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi Tech Zone, Dalian 116024, PR China
    J Am Chem Soc 135:11663-9. 2013
    ..Furthermore, ANQ-IMC-6 may be able to visualize dynamic changes of the Golgi apparatus during cancer cell apoptosis, with possible application to early diagnosis. ..
  26. doi request reprint A near-infrared and ratiometric fluorescent chemosensor for palladium
    Junyu Wang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian, 116024, China
    Analyst 138:3667-72. 2013
    ..PEG400 was employed as the reducing agent and palladium ligand instead of water-insoluble triphenylphosphine. The chemosensor's bioimaging potential was demonstrated by in vitro and in vivo experiments...
  27. ncbi request reprint Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex
    Xiaoqiang Chen
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China
    Bioorg Med Chem Lett 18:109-13. 2008
    ..DNA binding experiments indicated that introduction of positively charged guanidinium groups can obtain more than one order of magnitude enhancement in the affinity of complex with DNA...
  28. doi request reprint Fluorescence ratiometry and fluorescence lifetime imaging: using a single molecular sensor for dual mode imaging of cellular viscosity
    Xiaojun Peng
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi Tech Zone, Dalian 116024, PR China
    J Am Chem Soc 133:6626-35. 2011
    ..Although living cells are complex the correlation observed between the two imaging procedures offers the possibility of previously unavailable reliability and accuracy when determining intracellular viscosity...
  29. ncbi request reprint A "distorted-BODIPY"-based fluorescent probe for imaging of cellular viscosity in live cells
    Hao Zhu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024 China, Fax 86 411 84986306
    Chemistry 20:4691-6. 2014
    ..62) together with stringent selectivity to viscosity, thus enabling viscosity mapping in live cells. Significantly, the increase of cytoplasmic viscosity during apoptosis was observed by BV-1 in real time. ..
  30. doi request reprint Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group
    Hao Zhu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, No 2 Linggong Road, High Tech District, Dalian 116024, China
    Chem Commun (Camb) 48:11766-8. 2012
    ..Rlyso was successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the "alkalizing effect" on lysosomes of current lysosomal probes with nitrogen-containing sidechains...
  31. doi request reprint Apoptosis of BGC823 cell line induced by p-hydroxymethoxybenzobijuglone, a novel compound from Juglans mandshurica
    Zhibo Li
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, China
    Phytother Res 23:551-7. 2009
    ..These findings suggest that HMBBJ could significantly induce apoptosis in BGC823 cells and should be considered as a potential candidate for a chemotherapeutic drug against cancer...
  32. doi request reprint Efficient targeted pDNA/siRNA delivery with folate-low-molecular-weight polyethyleneimine-modified pullulan as non-viral carrier
    Jingyun Wang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, PR China School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, PR China Electronic address
    Mater Sci Eng C Mater Biol Appl 34:98-109. 2014
    ..These results indicate that P-PEI-FA is a potential candidate for safe and targeted gene delivery applications. ..
  33. ncbi request reprint Purification and characterization of Ulva pertusa Kjellm alkaline phosphatase
    Dong Yang
    Department of Bioengineering, Dalian University of Technology, Dalian, P R China
    Prep Biochem Biotechnol 33:113-23. 2003
    ..8, and was completely inhibited by DTT and partly by NBS. The Michaelis-Menten constant Km and the maximum reaction velocity Vmax, at pH 9.8 and 37 degrees C were 0.950 mM and 5.00 microM/min, respectively...
  34. ncbi request reprint Identification of a novel thrombin-like phospholipase A2 from Gloydius ussuriensis snake venom
    Qiuyan Zhang
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, PR China
    Blood Coagul Fibrinolysis 18:723-9. 2007
    ..This finding demonstrates that Gln49-PLA2 is consistent with thrombin-like properties, and therefore should be a new thrombin-like serine protease...
  35. ncbi request reprint Boron dipyrromethene fluorophore based fluorescence sensor for the selective imaging of Zn(II) in living cells
    Yunkou Wu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
    Org Biomol Chem 3:1387-92. 2005
    ..The apparent dissociation constant (Kd) is 1.0 +/- 0.1 nM. Using fluorescence microscopy, the sensor is shown to be capable of imaging intracellular Zn2+ changes...