Tao Wang

Summary

Country: China

Publications

  1. Yang S, Sun F, Ruan J, Yan J, Huang P, Wang J, et al. Anti-inflammatory constituents from Cortex Dictamni. Fitoterapia. 2019;134:465-473 pubmed publisher
    ..7 macrophages, which suggested alkaloids and phenolic acids might be anti-inflammation therapeutic substance in Cortex Dictamni. ..
  2. Zhang Y, Huang P, He W, Sakah K, Ruan J, Li Z, et al. Bioactive constituents obtained from the fruits of Citrus aurantium. J Nat Med. 2019;73:146-153 pubmed publisher
    ..Moreover, inhibitory effects of all compounds on motility of mouse isolated intestine tissue were determined. As a result, 1, 4-8, and 11 displayed significant inhibitory effects on contraction tension. ..
  3. He W, Li Y, Liu M, Yu H, Chen Q, Chen Y, et al. Citrus aurantium L. and Its Flavonoids Regulate TNBS-Induced Inflammatory Bowel Disease through Anti-Inflammation and Suppressing Isolated Jejunum Contraction. Int J Mol Sci. 2018;19: pubmed publisher
  4. Qu L, Ruan J, Wu S, Huang P, Yan J, Yu H, et al. Separation and Bioactive Assay of 25R/S-Spirostanol Saponin Diastereomers from Yucca schidigera Roezl (Mojave) Stems. Molecules. 2018;23: pubmed publisher
    ..Moreover, 3a, 5a, 6a, 3b6b showed strong inhibitory activities on the growth of SW620 cell lines with the IC50 values of 12.02⁻69.17 μM. ..
  5. Ruan J, Li Z, Yan J, Huang P, Yu H, Han L, et al. Bioactive Constituents from the Aerial Parts of Pluchea indica Less. Molecules. 2018;23: pubmed publisher
    ..7 macrophages, while compounds 3, 4, 2629 possessed moderate inhibitory effects. ..
  6. Li X, Qu L, Dong Y, Han L, Liu E, Fang S, et al. A review of recent research progress on the astragalus genus. Molecules. 2014;19:18850-80 pubmed publisher
    ..The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. ..
  7. Qu J, Wu Z, Gao J, Wen H, Wang T, Yuan D. Excretion of tectoridin metabolites in rat urine and bile orally administrated at different dosages and their inhibitory activity against aldose reductase. Fitoterapia. 2014;99:99-108 pubmed publisher
    ..4-15.5 μM), whereas irisolidone-7-O-glucuronide (Ir-7G) and irisolidone showed little activity. ..
  8. Zhang Y, Jin L, Chen Q, Wu Z, Dong Y, Han L, et al. Hypoglycemic activity evaluation and chemical study on hollyhock flowers. Fitoterapia. 2015;102:7-14 pubmed publisher
    ..At the dosage of 20μg/mL for 1-5, the glucose uptake increasing level was nearly 30%-40% in HepG2 cells. We partly revealed the glucose metabolism regulation effect may relate to dihydroflavonols in hollyhock flower. ..
  9. Shi P, Chao L, Wang T, Liu E, Han L, Zong Q, et al. New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd. Fitoterapia. 2015;103:197-205 pubmed publisher
    ..Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety. ..

More Information

Publications31

  1. Hao J, Li J, Li X, Liu Y, Ruan J, Dong Y, et al. Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao. Molecules. 2016;21:354 pubmed publisher
    ..Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport. ..
  2. Wang S, Ni Y, Liu J, Yu H, Guo B, Liu E, et al. Protective effects of Weilikang decoction on gastric ulcers and possible mechanisms. J Nat Med. 2016;70:391-403 pubmed publisher
    ..The anti-ulcer potential of WLK can be primarily attributed to its regulatory effects on nitric oxide, sulfhydryl compounds, and reduction effect on mucosal expression of proinflammatory cytokines. ..
  3. Ruan J, Zheng C, Qu L, Liu Y, Han L, Yu H, et al. Plant Resources, (13)C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids. Molecules. 2016;21: pubmed publisher
  4. Zhang Y, Chen Y, Wang S, Dong Y, Wang T, Qu L, et al. Bioactive Constituents from the Aerial Parts of Lippia triphylla. Molecules. 2015;20:21946-59 pubmed publisher
    ..The structures of them were elucidated by chemical and spectroscopic methods. The antioxidant and triglyceride accumulation inhibition effects of the 31 compounds were examined in L6 cells and HepG2 cells, respectively. ..
  5. Chen Q, Liu M, Yu H, Li J, Wang S, Zhang Y, et al. Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway. J Nat Med. 2018;72:655-666 pubmed publisher
    ..Taken together, S. baicalensis conferred preventive effects against FFA-induced lipotoxicity through the AMPK-mediated SREBP signaling pathway. ..
  6. Zhang Y, Li X, Ruan J, Wang T, Dong Y, Hao J, et al. Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Fitoterapia. 2016;109:99-105 pubmed publisher
    ..Compounds 1-5, 7, 8, 11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells. ..
  7. Han L, Shi P, Dong Y, Wang T, Li X, Hao J, et al. New Rare Sinapoyl Acylated Flavonoid Glycosides Obtained from the Seeds of Lepidium apetalum Willd. Molecules. 2015;20:13982-96 pubmed publisher
    ..Their structures were elucidated by chemical and spectroscopic methods. ..
  8. Yang S, Li Z, Wang J, Ruan J, Zheng C, Huang P, et al. Eudesmane-Type Sesquiterpene Glycosides from Dictamnus dasycarpus Turcz. Molecules. 2018;23: pubmed publisher
    ..Meanwhile, compounds 3-5, 7, and 9-13 displayed TG accumulation inhibitory effects on HepG2 cells. ..
  9. Qu L, Wang J, Ruan J, Yao X, Huang P, Wang Y, et al. Spirostane-Type Saponins Obtained from Yucca schidigera. Molecules. 2018;23: pubmed publisher
    ..Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and MS spectra, and comparing with published data. ..
  10. Zhang Y, Chao L, Ruan J, Zheng C, Yu H, Qu L, et al. Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb. Fitoterapia. 2016;115:165-172 pubmed publisher
    ..Moreover, all the isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages, and compounds 7, 11, 15, and 16 were found to display significant inhibition of nitrite production. ..
  11. Wang S, Shi P, Qu L, Ruan J, Yang S, Yu H, et al. Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd. Molecules. 2017;22: pubmed publisher
    ..As a result, two new compounds (1 and 2), together with known isolates 7-11, 13, 14, 16-18, 20, 21, and 25 possessed significant inhibitory effects in the cells. ..
  12. Zhang Y, Yang Y, Ruan J, Chen Q, Li J, Guo Y, et al. Isobenzofuranones from the aerial parts of Leontopodium leontopodioides (Wild.) Beauv. Fitoterapia. 2018;124:66-72 pubmed publisher
    ..Moreover, compounds 1, 2, 5, and 7-9 displayed TG accumulation inhibitory effects on HepG2 cells. ..
  13. Shi W, Liu L, Li J, Qu L, Pang X, Yu H, et al. Bioactive flavonoids from Flos Sophorae. J Nat Med. 2017;71:513-522 pubmed publisher
    ..In addition, a high dose (30 ?mol/l) of kaempferol was found to inhibit HepG2 cell growth, while a low dose (10 ?mol/l) was observed to decrease TG accumulation. ..
  14. Ding Z, Liu Y, Ruan J, Yang S, Yu H, Chen M, et al. Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten. Molecules. 2017;22: pubmed publisher
  15. Chen Q, Wang T, Li J, Wang S, Qiu F, Yu H, et al. Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). Nutrients. 2017;9: pubmed publisher
    ..Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD. ..
  16. Li J, Adelakun T, Wang S, Ruan J, Yang S, Li X, et al. Inhibitory Effects of Constituents from the Aerial Parts of Rosmarinus officinalis L. on Triglyceride Accumulation. Molecules. 2017;22: pubmed publisher
    ..Among them, the activities of compounds 1 and 20 were comparable to that of orlistat, which suggested that these compounds in this plant might be involved in lipid metabolism. ..
  17. Zhang Y, Ruan J, Li J, Chao L, Shi W, Yu H, et al. Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb. Fitoterapia. 2017;117:28-33 pubmed publisher
  18. Ruan J, Zheng C, Liu Y, Qu L, Yu H, Han L, et al. Chemical and Biological Research on Herbal Medicines Rich in Xanthones. Molecules. 2017;22: pubmed publisher
  19. Chen Q, Li J, Ruan J, Qu L, Wei H, Ma X, et al. Bioactive constituents from the whole plants of Leontopodium leontopodioides (Wild.) Beauv. J Nat Med. 2018;72:202-210 pubmed publisher
    ..Beauv. Their structures were elucidated by chemical and spectroscopic methods. Moreover, compounds 4 and 5 showed significant effects on stimulating the hepatic glucose uptake in HepG2 cells. ..
  20. Liu Y, Ni Y, Ruan J, Qu L, Yu H, Han L, et al. Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten. Fitoterapia. 2016;113:164-9 pubmed publisher
    ..As results, xanthones 1, 2, 6, 7, 9, 10 and 14 were found to have significant reduce effect on intestine contraction tension, and structure-activity relationship was discussed. ..
  21. Zhang Y, Yu H, Chao L, Qu L, Ruan J, Liu Y, et al. Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb. Steroids. 2016;112:95-102 pubmed publisher
    ..7 murine macrophages. Among them, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure-activity relationship was summarized. ..
  22. Wang T, Ruan J, Li X, Chao L, Shi P, Han L, et al. Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. J Nat Med. 2016;70:198-206 pubmed publisher
    ..Meanwhile, compounds 1-3, 5-9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells. ..