Jianwei Wang


Country: China


  1. Xiang Z, Li L, Lei X, Zhou H, Zhou Z, He B, et al. Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3. J Virol. 2014;88:6650-9 pubmed publisher
    ..Further investigations revealed that TRIF is cleaved by 3C(pro). These results suggest that control of TRIF by 3C(pro) may be a mechanism by which EV68 impairs type I IFN production in response to TLR3 activation. ..
  2. Xiao X, Lei X, Zhang Z, Ma Y, Qi J, Wu C, et al. Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ-ACBD3 Interaction. J Virol. 2017;91: pubmed publisher
    ..Notably, PI4KB-ACBD3 interaction also differentially mediates the replication of enterovirus 68 and rhinovirus 16. These results provide new insight into the molecular network of enterovirus replication. ..
  3. Wu Z, Lu L, Du J, Yang L, Ren X, Liu B, et al. Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases. Microbiome. 2018;6:178 pubmed publisher
    ..These findings, combined with our previous bat virome data, greatly increase our knowledge of the viral community in wildlife in a densely populated country in an emerging disease hotspot. ..
  4. Zhang Y, Li J, Xiao Y, Zhang J, Wang Y, Chen L, et al. Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination. J Infect. 2015;70:641-50 pubmed publisher
    ..Our results suggest that HCoV-OC43 genotypes are evolving. Such genotype shift may be an adapting mechanism for HCoV-OC43 maintaining its epidemic. ..
  5. Wang H, Lei X, Xiao X, Yang C, Lu W, Huang Z, et al. Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. Cell Rep. 2015;12:42-48 pubmed publisher
    ..Moreover, EV71 3C interacts with NLRP3 and inhibits IL-1β secretion when expressed in mammalian cells. These results thus reveal a set of reciprocal regulations between enterovirus 71 and the NLRP3 inflammasome. ..
  6. Liu C, Xiao Y, Zhang J, Ren L, Li J, Xie Z, et al. Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. BMC Infect Dis. 2015;15:408 pubmed publisher
    ..HAdV-B7 infection tends to have more severe clinical consequences. The presence of newly emerging types or variants and co-infection with different types of HAdV highlights the need for constant and close surveillance of HAdV infection. ..
  7. Picot V, Bénet T, Messaoudi M, Telles J, Chou M, Eap T, et al. Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network). BMC Infect Dis. 2014;14:635 pubmed publisher
    ..The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. ..
  8. Lei X, Xiao X, Wang J. Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction. Viruses. 2016;8: pubmed publisher
  9. Yu J, Xie Z, Zhang T, Lu Y, Fan H, Yang D, et al. Comparison of the prevalence of respiratory viruses in patients with acute respiratory infections at different hospital settings in North China, 2012-2015. BMC Infect Dis. 2018;18:72 pubmed publisher
    ..RSV, adenoviruses, and co-infection of RSV and IFVs were more frequent in hospitalized children (or adenoviruses in adults), which might predict the severity of ARIs. Attending clinicians should be more vigilant of these infections. ..

More Information


  1. Wang C, Zhang Y, Han L, Guo L, Zhong H, Wang J. Hemin ameliorates influenza pneumonia by attenuating lung injury and regulating the immune response. Int J Antimicrob Agents. 2017;49:45-52 pubmed publisher
    ..This study shows that hemin has the potential for the treatment of IAV infection and its effect may be due to attenuation of lung injury and regulation of the immune response. ..