M-F Yuen

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
  2. pmc Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials
    Fan Cheung
    School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Chin Med 7:5. 2012
  3. pmc Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Chin Med 5:33. 2010
  4. doi request reprint Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    J Hepatol 50:80-8. 2009
  5. doi request reprint HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gastroenterology 135:1192-9. 2008
  6. ncbi request reprint Response to combined interferon and ribavirin is better in patients infected with hepatitis C virus genotype 6 than genotype 1 in Hong Kong
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Intervirology 49:96-8. 2006
  7. ncbi request reprint Recommendations and potential future options in the treatment of hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Expert Opin Pharmacother 7:2225-31. 2006
  8. ncbi request reprint A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:977-83. 2006
  9. ncbi request reprint Significance of viral load, core promoter/precore mutations and specific sequences of polymerase gene in HBV-infected patients on 3-year lamivudine treatment
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:779-86. 2006
  10. ncbi request reprint Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 14:269-75. 2007

Collaborators

Detail Information

Publications97

  1. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
    ....
  2. pmc Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials
    Fan Cheung
    School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Chin Med 7:5. 2012
    ..abstract:..
  3. pmc Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Chin Med 5:33. 2010
    ..The present study aims to determine the hepatoprotective effects of berberine on serum and tissue superoxide dismutase (SOD) levels, the histology in tetrachloride (CCl4)-induced liver injury...
  4. doi request reprint Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    J Hepatol 50:80-8. 2009
    ....
  5. doi request reprint HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gastroenterology 135:1192-9. 2008
    ..Our aims were to study the virologic, histologic, and clinical outcome in chronic hepatitis B (CHB) patients with hepatitis B surface antigen (HBsAg) seroclearance...
  6. ncbi request reprint Response to combined interferon and ribavirin is better in patients infected with hepatitis C virus genotype 6 than genotype 1 in Hong Kong
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Intervirology 49:96-8. 2006
    ..In conclusion, patients with HCV genotype 6 gain a better response to combined treatment with IFN-alpha and ribavirin than those with HCV genotype 1 and achieve a significantly higher rate of sustained virological response...
  7. ncbi request reprint Recommendations and potential future options in the treatment of hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Expert Opin Pharmacother 7:2225-31. 2006
    ..Nucleotide/nucleoside analogues will become the mainstay of treatment. Future treatment strategic plans should target maximising antiviral potency and minimising the chance of drug resistance...
  8. ncbi request reprint A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:977-83. 2006
    ..It is effective against both wild-type and YMDD mutant HBV. LB80380 is converted to its parent drug, LB80331, after oral absorption, and further metabolized to its active form, LB80317...
  9. ncbi request reprint Significance of viral load, core promoter/precore mutations and specific sequences of polymerase gene in HBV-infected patients on 3-year lamivudine treatment
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:779-86. 2006
    ..Comprehensive study on viral factors predicting treatment responsiveness to lamivudine is lacking...
  10. ncbi request reprint Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 14:269-75. 2007
    ..038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B...
  11. ncbi request reprint Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Gut 57:98-102. 2008
    ..To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis...
  12. doi request reprint Hepatitis B virus genotypes: natural history and implications for treatment
    Man Fung Yuen
    The University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Expert Rev Gastroenterol Hepatol 1:321-8. 2007
    ..However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy...
  13. ncbi request reprint Revisiting the natural history of chronic hepatitis B: impact of new concepts on clinical management
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 22:973-6. 2007
    ..5 times the upper limit of the normal range. Therefore, prolonged, adequate suppression of viral replication should be the practical goal for the treatment of CHB disease in the Asian population...
  14. ncbi request reprint Telbivudine: an upcoming agent for chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Expert Rev Anti Infect Ther 3:489-94. 2005
    ..2%, with only 4.5% showing alanine aminotransferase flares. Telbivudine is probably one of the most potent antiviral agents for hepatitis B virus that will become available in the near future...
  15. doi request reprint Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Infect Dis 52:624-32. 2011
    ..We aimed to determine the transmissibility of HBV in blood donors with OHB through transfusion in animal and human studies...
  16. doi request reprint Treatment of chronic hepatitis B: Evolution over two decades
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    J Gastroenterol Hepatol 26:138-43. 2011
    ..In addition, long-term treatment with these antiviral agents is associated with a reduced risk of development of hepatocellular carcinoma...
  17. doi request reprint Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B
    J Fung
    Department of Medicine, The University of Hong Kong, Pokfulam Road Queen Mary Hospital, Hong Kong SAR
    J Viral Hepat 18:738-44. 2011
    ..In HBeAg-negative CHB patients, a liver stiffness measurement of ≥ 10 kPa was associated with a significantly increased risk of subsequent HCC development and mortality...
  18. ncbi request reprint Combination of baseline parameters and on-treatment hepatitis B virus DNA levels to start and continue patients with lamivudine therapy
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 14:679-85. 2009
    ..This study aimed to identify the baseline hepatitis B virus (HBV) DNA, alanine aminotransferase (ALT) levels and on-treatment HBV DNA levels for favourable outcome in patients receiving 5-year lamivudine...
  19. pmc Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Antimicrob Agents Chemother 53:1779-85. 2009
    ..LB80317 has a long half-life at steady-state, supporting the use of a once-daily dosing regimen. The ingestion of a high-fat diet delays the rate of absorption of LB80380 without affecting the extent of absorption...
  20. doi request reprint Hepatocellular carcinoma in the Asia pacific region
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 24:346-53. 2009
    ..However, transmission of HCV by injection drug use, and rising prevalence of obesity and diabetes, both independent risk factors for HCC, may partly offset this decline...
  21. ncbi request reprint Impact of precore and core promoter mutations on hepatic histology in patients with chronic hepatitis B
    H J Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital
    Aliment Pharmacol Ther 22:301-7. 2005
    ..The details of liver histology of patients with precore and core promoter mutations are still not clear...
  22. ncbi request reprint Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 21:841-9. 2005
    ..Long-term effect of YMDD mutations on liver histology in Chinese hepatitis B patients is unknown...
  23. pmc Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    Gut 54:1610-4. 2005
    ..Identifying risk factors for the development of complications of chronic hepatitis B (CHB) is important for setting up treatment criteria...
  24. ncbi request reprint Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study
    J Fung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 26:377-82. 2007
    ..To investigate the level of hepatitis B virus (HBV) DNA in Chinese chronic hepatitis B (CHB) patients below which hepatocellular carcinoma (HCC) is unlikely to occur...
  25. ncbi request reprint Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 12:513-8. 2005
    ..034), but not with HAI-F score (P = 0.3). CP mutations were associated with more severe necroinflammation. The association between genotype C and poor histology was probably because of the association between genotype C and CP mutations...
  26. ncbi request reprint The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B
    H J Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR
    J Viral Hepat 12:373-9. 2005
    ..The major factor for the development of cirrhotic complications was viral loads but cirrhotic complications continued to develop in patients with HBVDNA levels below 10(4) copies/mL...
  27. pmc A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gut 52:416-9. 2003
    ..In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients...
  28. ncbi request reprint Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 12:41-6. 2007
    ....
  29. ncbi request reprint Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Aliment Pharmacol Ther 24:1179-86. 2006
    ..Safety of traditional Chinese medicine in patients with chronic hepatitis B is unknown...
  30. ncbi request reprint Retained common bile duct stones: a comparison between biliary stenting and complete clearance of stones by electrohydraulic lithotripsy
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 17:289-96. 2003
    ....
  31. ncbi request reprint Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong
    T K Cheung
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 24:573-83. 2006
    ..Clinical features of hepatocellular carcinoma patients are changing because of screening...
  32. ncbi request reprint One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Antivir Ther 11:909-16. 2006
    ..CccDNA becomes the dominant form of HBV DNA during viral suppression and is possibly responsible for viral rebound after short-term antiviral therapy...
  33. ncbi request reprint Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Hepatol 41:119-25. 2004
    ..We conducted a population study to document the prevalence of hepatitis B virus (HBV) genotypes in Hong Kong...
  34. ncbi request reprint The natural history of chronic hepatitis B
    C L Lai
    Department of Medicine, The University of Hong Kong, Hong Kong
    J Viral Hepat 14:6-10. 2007
    ..However, continuing viral replication, even at a relatively low level of <10(4) copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications...
  35. ncbi request reprint Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older
    C K Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 19:1153-8. 2004
    ..However, there is limited data on the outcome of therapeutic endoscopic retrograde cholangiopancreatography in patients above 90 years of age with severe acute cholangitis...
  36. pmc Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong
    J Clin Microbiol 42:5036-40. 2004
    ....
  37. ncbi request reprint Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 37:562-7. 2003
    ..Genotypes B and C are associated with high prevalence of precore and core promoter mutations, respectively...
  38. ncbi request reprint Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Hepatol 45:553-9. 2006
    ..This study aimed to measure the intrahepatic total hepatitis B virus (HBV) DNA and covalently closed circular DNA (cccDNA) levels in tumor and non-tumor tissues in hepatocellular carcinoma (HCC) patients...
  39. ncbi request reprint Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 12:1295-303. 2007
    ..Our aim was to investigate the effects of long-term lamivudine treatment and lamivudine-resistant virus (YMDD) on the development of cirrhosis and hepatocellular carcinoma (HCC) in asymptomatic patients without advanced disease...
  40. pmc Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    J Clin Microbiol 45:3942-7. 2007
    ..In conclusion, serum HBcrAg levels correlated with HBV virological markers and reflected the chronic hepatitis B disease activity in the liver...
  41. ncbi request reprint HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 39:1694-701. 2004
    ..Intrahepatic HBV DNA level was low and predominantly in the form of cccDNA. However, HCC could still develop, particularly in patients with cirrhosis who had HBsAg seroclearance at an older age...
  42. pmc A randomised controlled trial of endoscopic sphincterotomy in acute cholangitis without common bile duct stones
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gut 51:245-7. 2002
    ..However, it is not known whether EPT with decompression of the bile duct is beneficial in patients with acute cholangitis and gall bladder stones but without evidence of CBD stones...
  43. ncbi request reprint Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Ann Oncol 14:1463-7. 2003
    ..The prognosis for patients with hepatocellular carcinoma (HCC) is poor by the time they present with symptoms. This review examines the usefulness of screening programs from the perspectives of survival benefit and of cost-effectiveness...
  44. ncbi request reprint Specific considerations in the design of hepatitis B virus clinical studies in the far East
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Hong Kong
    Methods Mol Med 96:457-64. 2004
  45. pmc Determinants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearance
    He Jun Yuan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong, China
    J Clin Microbiol 43:1594-9. 2005
    ..Patients with delayed HBeAg seroclearance had a higher frequency of HBeAg seroreversion...
  46. ncbi request reprint Hepatitis B genotypes in chronic hepatitis B and lamivudine therapy
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR
    Intervirology 46:373-6. 2003
    ..5 months). In conclusion, there is no influence of HBV genotypes on the development of long-term complications and lamivudine therapy in Hong Kong...
  47. ncbi request reprint Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR, China
    J Hepatol 39:850-5. 2003
    ..To study the outcome and the virologic profiles of severe hepatitis exacerbations due to YMDD mutants in lamivudine-treated patients...
  48. ncbi request reprint Adefovir dipivoxil in chronic hepatitis B infection
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Expert Opin Pharmacother 5:2361-7. 2004
    ..Adefovir dipivoxil can be recommended as a first-line treatment but can also be used in patients with chronic hepatitis B infection who are failing lamivudine therapy...
  49. ncbi request reprint Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B
    He Jun Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    J Infect 54:497-503. 2007
    ..To determine the prevalence of precore and core promoter (CP) mutations before, at and after HBeAg seroclearance in Chinese patients...
  50. doi request reprint Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection
    Ivan F N Hung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 103:1663-73. 2008
    ..To identify the risk factors for recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after resection...
  51. ncbi request reprint Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 46:1695-703. 2007
    ..The treatment can be continued for those with HBV DNA levels of less than 4 log copies/mL (2000 IU/mL). The addition of or switch to alternative antiviral agents should be considered for patients who fail to achieve this early target...
  52. ncbi request reprint Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 100:1099-103. 2005
    ..To determine the effect of 1-yr lamivudine treatment on serum covalently closed-circular DNA (cccDNA) level...
  53. ncbi request reprint Hepatitis B virus genotypes B and C do not affect the antiviral response to lamivudine
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 8:531-4. 2003
    ..Determination of HBV genotypes before lamivudine therapy was probably not an important pretreatment investigation to predict antiviral responses in Chinese patients...
  54. pmc Detection of intrahepatic hepatitis B virus DNA and correlation with hepatic necroinflammation and fibrosis
    Danny Ka Ho Wong
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    J Clin Microbiol 42:3920-4. 2004
    ..842; P < 0.001) and with the degree of fibrosis (P = 0.014). We conclude that the method that we describe is reliable and convenient for the measurement of intrahepatic HBV DNA levels and has potential clinical significance...
  55. pmc Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, Peoples Republic of China
    J Clin Microbiol 42:3932-6. 2004
    ..Biochemical flares were common, with 16% being severe in nature. High pretreatment ALT levels were associated with a higher chance of biochemical flares...
  56. ncbi request reprint Significance of HBV DNA levels in liver histology of HBeAg and Anti-HBe positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Am J Gastroenterol 99:2032-7. 2004
    ..To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores...
  57. ncbi request reprint Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Carcinogenesis 25:1593-8. 2004
    ..The association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of CP mutations in patients with genotype C...
  58. pmc Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer
    A O O Chan
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Gut 52:502-6. 2003
    ..Silencing of E-cadherin by promoter CpG methylation has been shown in both familial and sporadic gastric cancers. Helicobacter pylori is a class I carcinogen in gastric cancer...
  59. ncbi request reprint Comparison of the efficacy of lamivudine and famciclovir in Asian patients with chronic hepatitis B: results of 24 weeks of therapy
    Ching Lung Lai
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Med Virol 67:334-8. 2002
    ..It was concluded that in Chinese patients with chronic hepatitis B infection, lamivudine achieved effective suppression of HBV DNA levels within 4 weeks of therapy whereas famciclovir had a significantly weaker action...
  60. ncbi request reprint The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Ann Intern Med 147:58-61. 2007
    ..5 times the upper limit of normal...
  61. ncbi request reprint A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Hepatology 40:719-26. 2004
    ..In conclusion, these results support expanded clinical studies of this new agent for the treatment of hepatitis B...
  62. ncbi request reprint Viral hepatitis B
    Ching Lung Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Lancet 362:2089-94. 2003
    ..Lamivudine, and presumably other nucleoside analogues, can reverse cirrhosis of the liver...
  63. pmc Natural history of hepatitis-related hepatocellular carcinoma
    David Yiu Kuen But
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    World J Gastroenterol 14:1652-6. 2008
    ..Combined with markers of liver reserve and performance status, accurate scoring systems and models have been developed to predict patients' survival and match best treatment option...
  64. doi request reprint Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Gastroenterol 103:1421-6. 2008
    ..To document the prevalence and factors associated with severe fibrosis and cirrhosis in a large population of Asian chronic hepatitis B (CHB) patients...
  65. ncbi request reprint Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin
    Wing Y Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Int J Hematol 82:259-61. 2005
    ..A sustained response occurred in 50% of the patients completing treatment and occurred only in patients with genotypes 1, 3, and 6 but not with quasi species...
  66. doi request reprint Chronic hepatitis C virus genotype 6 infection: response to pegylated interferon and ribavirin
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Infect Dis 198:808-12. 2008
    ..We aimed to determine the efficacy of pegylated interferon plus ribavirin for treating infection with genotype 6 versus genotype 1...
  67. ncbi request reprint Prognostic factors in severe exacerbation of chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Infect Dis 36:979-84. 2003
    ..3%; P=.004). Patients with severe exacerbation of hepatitis B with poor prognostic factors should be considered for early liver transplantation...
  68. pmc HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection
    Man Fung Yuen
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People s Republic of China
    J Clin Microbiol 42:4882-4. 2004
    ..In conclusion, lamivudine therapy can result in HBsAg seroclearance at an early age even though the phenomenon is rare...
  69. ncbi request reprint Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: a comparison with genotype 1
    Chee Kin Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    J Infect Dis 187:1071-4. 2003
    ..05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P=.04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR...
  70. ncbi request reprint Current and future antiviral agents for chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Antimicrob Chemother 51:481-5. 2003
  71. ncbi request reprint Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Infect Dis 37:593-7. 2003
    ..Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P=.05)...
  72. ncbi request reprint Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Infect Dis 186:1335-8. 2002
    ..The development of complications was not related to precore mutations but was probably due to the persistence of significant viremia after HBeAg seroconversion...
  73. ncbi request reprint Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients
    Danny Ka Ho Wong
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 40:727-37. 2004
    ..Serum and intrahepatic total HBV DNA and cccDNA levels become lower as the disease progresses from HBeAg-positive to anti-HBe-positive phase, with cccDNA becoming the predominant form of intrahepatic HBV DNA...
  74. ncbi request reprint 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children
    Man Fung Yuen
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Clin Gastroenterol Hepatol 2:941-5. 2004
    ..The long-term immunogenicity and efficacy of hepatitis B virus (HBV) vaccination remain to be defined. We aimed to examine the long-term immunogenicity and efficacy of HBV vaccination with 3 different regimens over 18 years of follow-up...
  75. pmc Clinical evaluation of the digene hybrid capture II test and the COBAS AMPLICOR monitor test for determination of hepatitis B virus DNA levels
    He Jun Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, People s Republic of China
    J Clin Microbiol 42:3513-7. 2004
    ..The cost for assaying each serum sample by using different strategies was calculated. The COBAS-AM assay was more sensitive than the Digene HC II assay and more suitable for monitoring low levels of HBV viremia...
  76. ncbi request reprint Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 16:929-36. 2002
    ..Complications of endoscopic sphincterotomy are closely related to the endoscopic technique. To date, there have been no studies to indicate that aspirin increases the risk of bleeding after endoscopic sphincterotomy...
  77. ncbi request reprint Comparison of the COBAS TaqMan HBV test with the COBAS Amplicor monitor test for measurement of hepatitis B virus DNA in serum
    Simon Siu Man Sum
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Med Virol 77:486-90. 2005
    ..300 copies/ml), shorter assay time (6 vs. 10 hr), and wider dynamic range (8 vs. 3 logs), and was more cost-effective in a clinical setting. These data indicate that the TaqMan test is an excellent tool for HBV DNA quantitation...
  78. ncbi request reprint A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma
    Annie O Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cancer 94:1747-52. 2002
    ..Transcatheter intraarterial lipiodol chemoembolization (TACE) has been reported to be one of the most effective palliative measures for HCC. However, its severe side effects continue to make its use controversial...
  79. ncbi request reprint Prevalence and significance of hepatitis GB virus-c/hepatitis G virus viremia in a large cohort of patients with chronic hepatitis B infection, with chronic hepatitis C infection, and on renal replacement therapy in Hong Kong
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Dig Dis Sci 47:432-7. 2002
    ..1%) probably because of a higher susceptibility as a result of immunosuppression. However, hepatitis GB virus-C viraemia did not cause liver biochemistry derangement in renal transplanted patients...
  80. ncbi request reprint Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion
    Annie Pang
    University Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China
    J Hepatol 40:1008-17. 2004
    ..We tested the hypothesis that the quantity of A(1762)T-G(1764)A and G(1896)A mutants might have clinical impact, by quantifying these mutants before and after HBe antigen (HBeAg) seroconversion in 58 patients...
  81. ncbi request reprint Serological markers of liver cancer
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Best Pract Res Clin Gastroenterol 19:91-9. 2005
    ..Some novel markers including glypican-3 are being extensively studied...
  82. ncbi request reprint Recombinant interferon alfa 2b therapy in a patient with metastatic hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Clin Gastroenterol 35:272-5. 2002
    ..The time for its administration can also serve as an observation period, which is vital in deciding whether definitive surgical treatment of any residual lesions is indicated...
  83. ncbi request reprint A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, Center for the Study of Liver Disease, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hepatology 36:687-91. 2002
    ..Further studies should be performed in patients with less advanced disease and/or different etiology to evaluate its benefit...
  84. ncbi request reprint Cholangiocarcinoma in liver cirrhosis
    Chee Kin Hui
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 18:337-41. 2003
    ..The purpose of the present study was to evaluate CC in liver cirrhosis...
  85. pmc Real-time PCR assay using molecular beacon for quantitation of hepatitis B virus DNA
    Simon Siu Man Sum
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    J Clin Microbiol 42:3438-40. 2004
    ....
  86. ncbi request reprint Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection
    Jie Zhou
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Hepatol 46:198-205. 2007
    ..We aimed to study polymorphisms of type I interferon receptor 1 (IFNAR1) promoter and their potential effects on chronic HBV infection...
  87. ncbi request reprint A pilot study of transcatheter arterial interferon embolization for patients with hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, USA
    Cancer 97:2776-82. 2003
    ..The objective of the current study was to determine the efficacy and safety of transcatheter arterial interferon embolization for the treatment of patients with inoperable HCC...
  88. ncbi request reprint Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance
    Wai Man Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Infect Dis 37:882-9. 2003
    ..MtxR and ClaR significantly affected the success of eradication therapy. Posttreatment rates of resistance were high and were related to the presence of pretreatment antibiotic resistance...
  89. ncbi request reprint Mirtazapine-induced hepatotoxicity
    Chee Kin Hui
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Gastroenterol 35:270-1. 2002
    ..The cause of mirtazapine-induced liver toxicity was unknown, and to our knowledge, these are the first reported cases of mirtazapine-induced prolonged jaundice...
  90. pmc Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 78:13591-9. 2004
    ....
  91. ncbi request reprint T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection
    Kiyoaki Ito
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Infect Dis 42:1-7. 2006
    ....
  92. ncbi request reprint Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastroenterology 130:703-14. 2006
    ..This approach was combined with analyses of the hepatitis C virus (HCV) epidemiologic-historical background and HCV-related hepatocellular carcinoma (HCC) in different countries...
  93. ncbi request reprint Combination therapy for chronic hepatitis B: simultaneous or sequential?
    Man Fung Yuen
    Am J Gastroenterol 102:105-6. 2007
    ..Sequential therapy with lamivudine followed by IFN-alpha seems to have better sustained virologic response. However, the long-term beneficial effect of using this approach remains to be defined...
  94. pmc Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay
    Evelien Libbrecht
    Innogenetics NV, Industriepark Zwijnaarde 7 4, B 9052, Ghent, Belgium
    J Clin Microbiol 45:3935-41. 2007
    ....
  95. ncbi request reprint Viral hepatitis C
    Thierry Poynard
    Service d Hepato gastro enterologie, Groupe Hospitalier Pitie Salpetriere, Universite, Paris, France
    Lancet 362:2095-100. 2003
    ..These antiviral treatments reduce liver fibrosis progression and can reverse cirrhosis. Unfortunately, even in developed countries, death due to hepatitis C is increasing because of inadequate detection and treatment...
  96. ncbi request reprint Hepatitis B virus genotype A and D and clinical outcomes of liver transplantation for HBV-related disease
    Raffaele Girlanda
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London
    Liver Transpl 10:58-64. 2004
    ..In conclusion, HBV genotype A and D did not have a significant impact on clinical outcomes of LT for HBV-related liver disease in patients of European origin. These data do not support routine HBV genotyping in liver transplantation...
  97. ncbi request reprint Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Hepatol 45:646-53. 2006
    ..Hepatitis B virus genotype C (HBV/C) has been classified into two geographically distinct subgenotypes; HBV/C1/Cs (Southeast Asia) and HBV/C2/Ce (East Asia)...