Research Topics
Genomes and GenesSpecies
| Kwok Yung YuenSummaryAffiliation: University of Hong Kong Country: China Publications
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Detail Information
Publications
Wild animal surveillance for coronavirus HKU1 and potential variants of other coronavirusesK Y Yuen
Department of Microbiology, The University of Hong Kong Queen Mary Hospital, Hong Kong SAR, China
Hong Kong Med J 18:25-6. 2012..5. This study also revealed a previously unknown diversity of coronaviruses in bats, which are important natural reservoir for coronaviruses including SARS-CoV-like viruses...
Laribacter hongkongensis gen. nov., sp. nov., a novel gram-negative bacterium isolated from a cirrhotic patient with bacteremia and empyemaK Y Yuen
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
J Clin Microbiol 39:4227-32. 2001..nov., sp. nov., is proposed, for which HKU1 is the type strain. Further studies should be performed to ascertain the potential of this bacterium to become an emerging pathogen...- Human infection by avian influenza A H5N1K Y Yuen
Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
Hong Kong Med J 11:189-99. 2005.... - Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assaySusanna K P Lau
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 42:2884-9. 2004..Further studies on serial clinical specimens should reveal the duration of nucleocapsid protein shedding and may reveal a higher detection rate in SARS patients... - False-positive results in a recombinant severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid enzyme-linked immunosorbent assay due to HCoV-OC43 and HCoV-229E rectified by Western blotting with recombinant SARS-CoV spike polypepPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 42:5885-8. 2004..None of these samples were found to contain a specific antibody in the recombinant SARS-CoV spike polypeptide-based Western blot assay... - Life-threatening invasive Helcococcus kunzii infections in intravenous-drug users and ermA-mediated erythromycin resistancePatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 43:6205-8. 2005..Gram smears of both H. kunzii isolates showed a mixture of gram-positive and gram-negative cocci. The isolate from the first patient, resistant to erythromycin and clindamycin, possessed an ermA gene... - An oral mucosal DNA vaccine for SARS coronavirus infectionsK Y Yuen
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR, China
Hong Kong Med J 15:41-2. 2009..3. This study indicates that the type of vaccine used for priming is crucial for determining the type of immune response developed.Subsequent doses will boost the immune response generated by the first dose of vaccine... 
Lichtheimia hongkongensis sp. nov., a novel Lichtheimia spp. associated with rhinocerebral, gastrointestinal, and cutaneous mucormycosisPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
Diagn Microbiol Infect Dis 66:274-84. 2010..to describe this fungus, which caused rhinocerebral, gastrointestinal, and cutaneous mucormycosis, respectively, in 3 patients. A significant proportion of L. corymbifera associated with mucormycosis reported may be L. hongkongensis...- Typhoid fever associated with acute appendicitis caused by an H1-j strain of Salmonella enterica serotype TyphiSusanna K P Lau
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 43:1470-2. 2005..She recovered with appendectomy and antibiotic treatment. Further studies should be performed to determine the prevalence of this unusual S. enterica serotype Typhi strain in our locality... - Natural selection retains overrepresented out-of-frame stop codons against frameshift peptides in prokaryotesHerman Tse
Carol Yu Centre for Infection, Department of Microbiology, The University of Hong Kong, Hong Kong, China
BMC Genomics 11:491. 2010..Given such a functional significance, we expect statistically overrepresented OSCs in coding sequences as a result of a widespread selection. Accordingly, we examined available prokaryotic genomes to look for evidence of this selection... - Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong KongSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
J Infect Dis 196:986-93. 2007..We conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (NPAs) and fecal samples... - Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombinationSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Virol 85:11325-37. 2011.... - Anaerospora hongkongensis gen. nov. sp. nov., a novel genus and species with ribosomal DNA operon heterogeneity isolated from an intravenous drug abuser with pseudobacteremiaPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Hong Kong
Microbiol Immunol 49:31-9. 2005..hippei and P. vibrioides. The G+C content of the bacterium (mean +/- SD) was 46.8 +/- 3.2%. For these reasons, a new genus and species, Anaerospora hongkongensis gen. nov. sp. nov., is proposed, for which HKU15T is the type strain... - Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensisPatrick C Y Woo
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
New Microbiol 30:139-47. 2007.... - Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control studyPatrick C Y Woo
Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong, People s Republic of China
Lancet 363:1941-7. 2004..We undertook a multicentre case-control study to investigate the association of L hongkongensis with gastroenteritis... - Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronaviPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, Hong Kong, and Guangzhou Center for Disease Control and Prevention, Guangzhou, China
J Virol 86:3995-4008. 2012.... - Seronegative bacteremic melioidosis caused by Burkholderia pseudomallei with ambiguous biochemical profile: clinical importance of accurate identification by 16S rRNA gene and groEL gene sequencingPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 41:3973-7. 2003..Sequencing of the groEL gene showed that the isolate was B. pseudomallei. Proper identification of the bacterium in this study is crucial, since there would be a radical difference in the duration of antimicrobial therapy... - Use of cefoperazone MacConkey agar for selective isolation of Laribacter hongkongensisSusanna K P Lau
Department of Microbiology, The University of Hong Kong, Hong Kong
J Clin Microbiol 41:4839-41. 2003..In addition, with CMA, Arcobacter butzleri was unexpectedly isolated from the stools of six patients... - Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from ChinaSusanna K P Lau
Department of Microbiology, The University of Hong Kong, Hong Kong, China
Virology 404:106-16. 2010..Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes... - Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-Lanying Du
Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
J Immunol 180:948-56. 2008..n. vaccination may be the preferred route of administration due to its ability to induce SARS-CoV-specific systemic and mucosal immune responses and its better safety profile... - Seasonal and tissue distribution of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, in retail freshwater fish in Hong KongSusanna K P Lau
Department of Microbiology, The University of Hong Kong, Hong Kong
Int J Food Microbiol 113:62-6. 2007..Proper handling of freshwater fish for cooking, especially the gills and gut, is recommended to prevent acquisition of L. hongkongensis, and other freshwater fish related infections... - Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup featuresPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Virol 81:1574-85. 2007..Further molecular epidemiological studies on coronaviruses in the bats of other countries, as well as in other animals, and complete genome sequencing will shed more light on coronavirus diversity and their evolutionary histories... - Laribacter hongkongensis: a potential cause of infectious diarrheaPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, China
Diagn Microbiol Infect Dis 47:551-6. 2003..More extensive epidemiologic studies should be carried out to ascertain the causative association between L. hongkongensis and diarrhea and to define the reservoir and modes of transmission of L. hongkongensis... - Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detectionChe Man Chan
Department of Microbiology, The University of Hong Kong, Hong Kong Special Administration Region, Hong Kong
Exp Biol Med (Maywood) 233:1527-36. 2008..The data suggest that the native form of HCoV-HKU1 spike expressed in our system can be used in developing serological diagnostic assay and in understanding the role of S in the viral life cycle... - Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and β-tubulin gene sequencingKelvin K W To
Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
Diagn Microbiol Infect Dis 74:190-7. 2012..parasiticum. Cases of P. parasiticum infections should be confirmed by a polyphasic approach using morphologic characterization and ITS and β-tubulin gene sequencing... - Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different subordersSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
J Virol 86:11906-18. 2012..This study provided the first evidence for interspecies transmission of coronavirus between bats of different suborders... - Identification and characterization of bocaviruses in cats and dogs reveals a novel feline bocavirus and a novel genetic group of canine bocavirusSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Hong Kong
J Gen Virol 93:1573-82. 2012..Although the pathogenicity of FBoV and CBoV remains to be determined, their presence in different host tissues suggested wide tissue tropism... - Detection of human rhinovirus C in fecal samples of children with gastroenteritisSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Hong Kong
J Clin Virol 53:290-6. 2012..Despite recent discovery of the novel human rhinovirus species, HRV-C, little is known about the association of HRV-C in diseases other than respiratory tract infections... - Characterization of a novel insertion sequence, IS Bp1, in Burkholderia pseudomalleiPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
Arch Microbiol 177:267-73. 2002..Using several insertion sequences and a combination of insertion-sequence-based and non-insertion-sequence-based methods such as ribotyping will probably increase the discriminatory power of molecular typing in B. pseudomallei... - Comparative analysis of six genome sequences of three novel picornaviruses, turdiviruses 1, 2 and 3, in dead wild birds, and proposal of two novel genera, Orthoturdivirus and Paraturdivirus, in the family PicornaviridaePatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, Hong Kong Special Administration Region, Hong Kong SAR
J Gen Virol 91:2433-48. 2010..Based on our results we propose two novel genera, Orthoturdivirus for TV1, and Paraturdivirus for TV2 and TV3, in the family Picornaviridae. The type of internal ribosomal entry site for TV1, TV2 and TV3 remains to be determined... - Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroupSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong, China
J Virol 84:11385-94. 2010..Such unique phenomena, and the unusual instability of ORF7a, are likely due to recombination which may have been facilitated by the dense roosting behavior and long foraging range of Leschenault's rousette... - Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and CanadaSusanna K P Lau
Department of Microbiology, The University of Hong Kong, Hong Kong
J Clin Microbiol 45:395-401. 2007..hongkongensis. Further studies should be performed to ascertain the epidemiology and other disease associations of this bacterium... - Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumoniaPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Virol 79:884-95. 2005..13 x 10(6) copies per ml, from a 35-year-old woman with pneumonia. Our data support the existence of a novel group 2 coronavirus associated with pneumonia in humans... - Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe batsSusanna K P Lau
Department of Microbiology, Research Centre of Infection and Immunology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China
Proc Natl Acad Sci U S A 102:14040-5. 2005..Neutralizing antibody to human SARS-CoV also was detected in bats with lower viral loads. Precautions should be exercised in the handling of these animals... - Human parainfluenza virus 4 outbreak and the role of diagnostic testsSusanna K P Lau
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital
J Clin Microbiol 43:4515-21. 2005..To better define the epidemiology and clinical spectrum of disease of HPIV-4 infections, HPIV-4 should be included in the routine panels of respiratory virus detection on respiratory specimens... - Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical geneticsRichard Y Kao
Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Chem Biol 11:1293-9. 2004.... - Ecoepidemiology of Laribacter hongkongensis, a novel bacterium associated with gastroenteritisJade L L Teng
Department of Microbiology, University of Hong Kong, Hong Kong
J Clin Microbiol 43:919-22. 2005..Comparing the pulsed-field gel electrophoresis patterns of fish and patient isolates revealed that most patient isolates were clustered together, suggesting that some clones could be more virulent... - Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination eventsSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
J Virol 84:2808-19. 2010..Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS... - Leptin mediates the pathogenesis of severe 2009 pandemic influenza A(H1N1) infection associated with cytokine dysregulation in mice with diet-induced obesityAnna J X Zhang
Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Pokfulam, Hong Kong SAR, China
J Infect Dis 207:1270-80. 2013..The mechanism for severe lung injury in obese patients and the specific treatment strategy remain elusive... - Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbitsSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
J Virol 86:5481-96. 2012..Antibody against RbCoV was detected in 20 (67%) of 30 rabbit sera tested by an N-protein-based Western blot assay, whereas neutralizing antibody was detected in 1 of these 20 rabbits... - Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genomeSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Hong Kong
Virology 367:428-39. 2007..These suggest a common evolutionary origin in the spike protein of bat-CoV HKU2, bat-SARS-CoV, and SARS-CoV... - Natural occurrence and characterization of two internal ribosome entry site elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamilyPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
J Virol 86:2797-808. 2012..Based on our results, we have proposed a novel species, canine picodicistrovirus (CPDV), to describe this novel member of the picornavirus-like superfamily, which could represent a novel family of viruses... - D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in miceBojian Zheng
Department of Microbiology, The University of Hong Kong, Pokfulam, China
Exp Biol Med (Maywood) 235:981-8. 2010..The only consistent mutation in the genomes of viral clones obtained from dying mice was D225G substitution... - Clinical and molecular epidemiology of human parainfluenza virus 4 infections in hong kong: subtype 4B as common as subtype 4ASusanna K P Lau
Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong
J Clin Microbiol 47:1549-52. 2009..Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B... - High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffeiPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, Hong Kong, China
FEBS J 277:3750-8. 2010..marneffei and 6 min for the alb1 knockdown mutant of P. marneffei, implying that the melanin-biosynthesis gene cluster contributed to virulence through decreased susceptibility to killing by hydrogen peroxide... - Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirusHerman Tse
Department of Microbiology, The University of Hong Kong, Hong Kong, China
PLoS ONE 6:e25619. 2011..Results from the present study provide further support to the classification of partetraviruses as a separate genus in Parvovirinae... - Complete genome analysis of three novel picornaviruses from diverse bat speciesSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Virol 85:8819-28. 2011..This report describes the discovery and complete genome analysis of three picornaviruses in bats, and their presence in diverse bat genera/species suggests the ability to cross the species barrier... - Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229EBone S F Tang
Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Center of Infection and Immunology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
J Virol 79:6180-93. 2005..These transcriptomal changes are compatible with the histological changes of pulmonary vasculitis and microvascular thrombosis in addition to the diffuse alveolar damage involving the pneumocytes... - Development of a multi-locus sequence typing scheme for Laribacter hongkongensis, a novel bacterium associated with freshwater fish-borne gastroenteritis and traveler's diarrheaPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China
BMC Microbiol 9:21. 2009..hongkongensis. In this study, a multilocus sequence typing (MLST) system was developed for L. hongkongensis. The system was used to characterize 146 L. hongkongensis isolates, including 39 from humans and 107 from fish... - Analysis of a viridans group strain reveals a case of bacteremia due to lancefield group G alpha-hemolytic Streptococcus dysgalactiae subsp equisimilis in a patient with pyomyositis and reactive arthritisPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, Hong Kong
J Clin Microbiol 41:613-8. 2003..dysgalactiae subsp. equisimilis or a novel type of S. dysgalactiae. The present case showed that group G alpha-hemolytic S. dysgalactiae subsp. equisimilis can be associated with serious invasive infection and poststreptococcal sequelae... - Internal transcribed spacer region sequence heterogeneity in Rhizopus microsporus: implications for molecular diagnosis in clinical microbiology laboratoriesPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
J Clin Microbiol 48:208-14. 2010..When thick bands and double peaks are observed during PCR sequencing of a gene target, such a strain should be sent to reference laboratories proficient in molecular technologies for further identification and/or genotyping... - Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar TyphiChi Chun Ho
Department of Microbiology, The University of Hong Kong, Hong Kong, China
J Clin Microbiol 50:1905-11. 2012..Typhi. These and other validated targets should be applicable to the identification and direct PCR detection of bacterial pathogens from uncultured, mixed, and environmental samples... - Identification of a novel feline picornavirus from the domestic catSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Hong Kong
J Virol 86:395-405. 2012..Further studies are important to understand the pathogenicity, epidemiology, and genetic evolution of FePV in these common pet animals... - Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in childrenSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
J Clin Microbiol 45:3655-64. 2007..A newly identified HRV species, HRV-C, is circulating worldwide and is an important cause of febrile wheeze and asthmatic exacerbations in children requiring hospitalization... - A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infectionJie Zhou
Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong, Hong Kong SAR, China
Immunogenetics 61:423-30. 2009..We conclude that a functional -56C/T SNP in IFNGR1 promoter is associated with the clinical outcome of HBV infection in this Chinese population... - Identification of influenza A nucleoprotein as an antiviral targetRichard Y Kao
Department of Microbiology, The University of Hong Kong, Hong Kong
Nat Biotechnol 28:600-5. 2010..Our results demonstrate that viral NP is a valid target for the development of small-molecule therapies... - Construction of an inducible expression shuttle vector for Laribacter hongkongensis, a novel bacterium associated with gastroenteritisPatrick C Y Woo
Department of Microbiology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong
FEMS Microbiol Lett 252:57-65. 2005..This inducible expression system was able to express two commonly used reporter genes, the green fluorescent protein gene and the glutathione S-transferase gene, efficiently in E. coli and L. hongkongensis... - Identification of a novel bat papillomavirus by metagenomicsHerman Tse
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong Island, Hong Kong
PLoS ONE 7:e43986. 2012..We propose MscPV1 as the first member of the novel Dyolambda-papillomavirus genus... - MBEToolbox: a MATLAB toolbox for sequence data analysis in molecular biology and evolutionJames J Cai
Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
BMC Bioinformatics 6:64. 2005..However, few functions are freely available in MATLAB to perform the sequence data analyses specifically required for molecular biology and evolution... - Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscessPatrick C Y Woo
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong
Syst Appl Microbiol 28:316-22. 2005.... - First report of Gordonibacter pamelaeae bacteremiaPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
J Clin Microbiol 48:319-22. 2010..The bacterium was a nonsporulating, anaerobic, gram-positive, nonmotile, coccobacillus that was catalase, arginine dihydrolase, and arginine acrylamidase positive. The gastrointestinal tract is probably its reservoir... - Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c miceKwok Hung Chan
Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China
PLoS ONE 5:e13757. 2010..Pregnant women infected by the pandemic influenza A (H1N1) 2009 virus had more severe disease and higher mortality but its pathogenesis is still unclear... - Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong KongPak Leung Ho
Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong SAR, PR China
Diagn Microbiol Infect Dis 57:145-51. 2007..In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds... - Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infectionKelvin K W To
Carol Yu Centre for Infection, The University of Hong Kong, China
Postgrad Med J 86:515-21. 2010..The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection... - Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009Ivan F N Hung
Department of Microbiology, The University of Hong Kong, Hong Kong
Clin Infect Dis 51:274-9. 2010..The relative lack of background neutralizing antibody against this novel virus provides a unique opportunity for understanding this issue... - Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infectionLanying Du
Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Vaccine 26:1644-51. 2008.... - Viral load in patients infected with pandemic H1N1 2009 influenza A virusKelvin K W To
Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
J Med Virol 82:1-7. 2010..Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures... - Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus Strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA geneKelvin K W To
Carol Yu Centre for Infection, Research Centre of Infection and Immunology, State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong
J Clin Microbiol 49:3398-402. 2011.... - Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosisGilman Kit Hang Siu
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, China
J Antimicrob Chemother 66:730-3. 2011..Our study aims to identify the mutations outside the RRDR that are associated with rifampicin resistance in M. tuberculosis... - Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae, and evidence for inter- and intra-host genetic diversity and recombinationSusanna K P Lau
State Key Laboratory of Emerging Infectious Diseases, Hong Kong SAR
J Gen Virol 92:2047-59. 2011..This is the first report describing marked sequence diversity and the co-existence of two viruses of the family Parvoviridae within the same host, which may have originated from and, in turn, facilitated recombination... - Cytokine profiles induced by the novel swine-origin influenza A/H1N1 virus: implications for treatment strategiesPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
J Infect Dis 201:346-53. 2010..For individual S-OIV-infected patients with severe primary viral pneumonia, severe sepsis, and multiorgan failure, immunomodulators may be considered as an adjunctive therapy in clinical trials... - Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assayRichard Y Kao
Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong, China
FEBS Lett 576:325-30. 2004..The identified inhibitors have Ki values at low microM range with comparable anti-SARS-CoV activity in cell-based assays... - A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitorsLeo L M Poon
Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
J Clin Virol 30:214-7. 2004.... - Plasmid profile and construction of a small shuttle vector in Laribacter hongkongensisPatrick C Y Woo
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Room 423, University Pathology Building, Queen Mary Hospital Compound, Pokfulam, Hong Kong
Biotechnol Lett 29:1575-82. 2007..This shuttle vector can propagate in E. coli and L. hongkongensis with good transformation efficiencies...