Research Topics
Genomes and Genes | Zhen Fan YangSummaryAffiliation: University of Hong Kong Country: China Publications
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Publications
Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathwayZhen Fan Yang
Center for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Hong Kong, China
J Immunol 173:2507-15. 2004..In conclusion, the present study showed that the up-regulated expression of VEGF and its interaction with Flk-1 in small-for-size liver grafts might facilitate the activities of macrophages...- Antiinflammatory properties of IL-10 rescue small-for-size liver graftsZhen Fan Yang
Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
Liver Transpl 13:558-65. 2007.... - Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10Zhen Fan Yang
Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
Liver Transpl 13:571-8. 2007..Supplementary exogenous IL-10 administration combined with low-dose immunosuppressive drug may be a useful strategy to induce long-term liver allograft survival... - Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinomaZhen Fan Yang
Centre for the Study of Lvier Disease and Department of Surgery, The University of Hong Kong, Hong Kong, P R China
Oncol Rep 16:1237-43. 2006..A higher serum BDNF level was associated with a more advanced tumor status in the HCC patients. The interaction between serum BDNF and platelets might play an important role in HCC tumor progression... 
Significance of CD90+ cancer stem cells in human liver cancerZhen Fan Yang
Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Cell 13:153-66. 2008..Differential gene expression profiles were identified in the CD45(-)CD90+ and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls...- Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loopZhen Fan Yang
Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Biochem Biophys Res Commun 346:981-5. 2006..In conclusion, this study suggested the presence of BDNF-TrkB autocrine loop in platelets and its importance in regulating platelet activation during tumor development... - Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophagesZhen Fan Yang
Centre for the Study of Liver Disease and Department of Surgery, L9 41 Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
Int Immunol 17:1391-7. 2005..In conclusion, AIF-1 played an important role in the survival and pro-inflammatory activity of macrophages, and ADAM3 might be an upstream molecule that regulated AIF-1 expression... - An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cellsChi Keung Lau
Center for Cancer Research and Department of Surgery, The University of Hong Kong, Hong Kong, China
Clin Cancer Res 15:3462-71. 2009.... - Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinomaChi Keung Lau
Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Biol Ther 6:1900-7. 2007..This finding provides insight into design of a new therapeutic strategy to improve efficacy of chemotherapy in HCC patients... - Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinomaKa Ho Tam
Center for Cancer Research, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
Cancer Lett 273:201-9. 2009..This study demonstrates that inhibition of mTOR suppresses tumor growth and sensitizes tumor cells to chemocytotoxic agents... - Identification of local and circulating cancer stem cells in human liver cancerZhen Fan Yang
Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Hepatology 47:919-28. 2008..CONCLUSION: Identification of CD45(-)CD90(+) CSCs in both tumor tissues and circulation suggests that CD45(-)CD90(+) could be used as a marker for human liver cancer and as a target for the diagnosis and therapy of this malignancy... - Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinomaZhen Fan Yang
Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Res 65:219-25. 2005..BDNF could stimulate tumor cell proliferation in a Hsp90-dependent manner... - Cardiotrophin-1 enhances regeneration of cirrhotic liver remnant after hepatectomy through promotion of angiogenesis and cell proliferationZhen Fan Yang
Department of Surgery, Centre for Cancer Research, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam, Hong Kong, China
Liver Int 28:622-31. 2008..The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on improving the function of CCl(4)-induced cirrhotic liver remnant after major hepatectomy... - High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesisZhen Fan Yang
Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Mol Cancer Ther 5:2261-70. 2006..In conclusion, PTK787 combined with hypoxia achieved a better therapeutic efficacy than hypoxia alone through enhancing hypoxia-induced antitumor cell effect and preventing the activation of angiogenic process... - Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinomaChing Tung Lum
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong, People's Republic of China
Int J Cancer 118:1527-38. 2006..Results from our study demonstrated that gold-1a might be a novel promising chemocytotoxic agent for treating HCC... - Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation?Zhen Fan Yang
Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
Liver Transpl 9:411-20. 2003..Anti-hCTLA4Ig antibodies could be detected in long-term surviving animals, but the extent of humoral response was not severe. This study shows that rAAV can be an effective and safe vector for gene delivery in liver transplantation... - Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2)Chi Keung Lau
Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Biochem Biophys Res Commun 348:1443-8. 2006..In conclusion, YC-1 suppressed both protein synthesis and stability of HIF-1alpha in HCC cells, and its inhibitory effects on HIF-1alpha were dependent on Mdm2... - Therapeutic potential of cardiotrophin 1 in fulminant hepatic failure: dual roles in antiapoptosis and cell repairDavid W Ho
Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong
Arch Surg 141:1077-84; discussion 1084. 2006..CONCLUSION: Cardiotrophin 1 may improve the outcome of D-gal-induced FHF through its effects on antiapoptosis and cell repair... - The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinomaZan Shen
Institute of Molecular Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Cancer Res 68:404-14. 2008..These results suggest for the first time that HGFK1 exerts both antiangiogenic and antitumor cell activities mainly through EGF/EGFR signaling, and may thus be considered as a novel therapeutic strategy for the treatment of HCC... 
Gene expression profiling of liver cancer stem cells by RNA-sequencingDavid W Y Ho
Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
PLoS ONE 7:e37159. 2012....- Vascular changes in hepatocellular carcinomaZhen Fan Yang
Centre for Cancer Research, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
Anat Rec (Hoboken) 291:721-34. 2008.... - Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liverXiao Qi Wang
Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong, China
Hepatology 56:1557-66. 2012..In LT patients, there are two types of chimerisms: transient chimerism, resulting from mature leucocytes, and long-term chimerism, derived from putative HSPCs in the liver graft... - Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective studySheung Tat Fan
State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
Ann Surg 254:569-76. 2011..To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy... - Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization: implication in hepatocellular carcinomaChi Tat Lam
Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
Clin Cancer Res 17:3123-33. 2011..Brain-derived neurotrophic factor (BDNF) has emerged as a novel angiogenic factor, and yet its impact on tumorigenesis is unclear. This study aimed at investigating the roles of BDNF in angiogenesis and tumor development... - Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective studyRonnie Tung Ping Poon
Department of Surgery and Pathology, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
J Clin Oncol 20:1775-85. 2002..This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients undergoing resection of hepatocellular carcinoma (HCC)... - Heme oxygenase-1 potentiates the survival of small-for-size liver graftZhen Fan Yang
Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Hong Kong, China
Liver Transpl 10:784-93. 2004..These findings support the beneficial effects of HO-1 on allograft survival. In conclusion, the ability of small-for-size grafts in the induction of HO-1 expression might facilitate their own survival in liver transplantation... - The potential role of hypoxia inducible factor 1alpha in tumor progression after hypoxia and chemotherapy in hepatocellular carcinomaZhen Fan Yang
Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
Cancer Res 64:5496-503. 2004.... - Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expressionTerence K Lee
Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Clin Cancer Res 12:5082-9. 2006.... - Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathwayXiao Qi Wang
Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
Hepatology 52:528-39. 2010..Conclusion: Oct4, a transcriptional factor of pluripotent cells, can mediate chemoresistance through a potential Oct4-AKT-ABCG2 pathway... - Role of stem cells in normal liver and cancerChi Keung Lau
State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
Anticancer Agents Med Chem 11:522-8. 2011..Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed... - Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transferSiu Tim Cheung
Department of Surgery and Center for the Study of Liver Disease, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
J Gastroenterol Hepatol 17:1008-14. 2002..In this study, we investigated the efficacy of hepatocyte transduction via introduction of the exogenous CTLA4Ig gene to the rat liver graft by retrovirus vector, and examined the presence of target serum protein after gene transfers... - Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinomaDavid Wing Yuen Ho
Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
Cancer 107:99-107. 2006..The combination of serum protein profiles with an EBV antibody serology test could further improve the accuracy of NPC screening...