Zhen Fan Yang

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Hong Kong, China
    J Immunol 173:2507-15. 2004
  2. doi request reprint Significance of CD90+ cancer stem cells in human liver cancer
    Zhen Fan Yang
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Cell 13:153-66. 2008
  3. ncbi request reprint Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10
    Zhen Fan Yang
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 13:571-8. 2007
  4. ncbi request reprint Antiinflammatory properties of IL-10 rescue small-for-size liver grafts
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Transpl 13:558-65. 2007
  5. ncbi request reprint Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma
    Zhen Fan Yang
    Centre for the Study of Lvier Disease and Department of Surgery, The University of Hong Kong, Hong Kong, P R China
    Oncol Rep 16:1237-43. 2006
  6. ncbi request reprint Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop
    Zhen Fan Yang
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Biochem Biophys Res Commun 346:981-5. 2006
  7. ncbi request reprint Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, L9 41 Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Int Immunol 17:1391-7. 2005
  8. doi request reprint An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells
    Chi Keung Lau
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 15:3462-71. 2009
  9. ncbi request reprint Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma
    Chi Keung Lau
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Biol Ther 6:1900-7. 2007
  10. doi request reprint Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinoma
    Ka Ho Tam
    Center for Cancer Research, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Cancer Lett 273:201-9. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Hong Kong, China
    J Immunol 173:2507-15. 2004
    ..In conclusion, the present study showed that the up-regulated expression of VEGF and its interaction with Flk-1 in small-for-size liver grafts might facilitate the activities of macrophages...
  2. doi request reprint Significance of CD90+ cancer stem cells in human liver cancer
    Zhen Fan Yang
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Cell 13:153-66. 2008
    ..Differential gene expression profiles were identified in the CD45(-)CD90+ and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls...
  3. ncbi request reprint Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10
    Zhen Fan Yang
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 13:571-8. 2007
    ..Supplementary exogenous IL-10 administration combined with low-dose immunosuppressive drug may be a useful strategy to induce long-term liver allograft survival...
  4. ncbi request reprint Antiinflammatory properties of IL-10 rescue small-for-size liver grafts
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Transpl 13:558-65. 2007
    ....
  5. ncbi request reprint Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma
    Zhen Fan Yang
    Centre for the Study of Lvier Disease and Department of Surgery, The University of Hong Kong, Hong Kong, P R China
    Oncol Rep 16:1237-43. 2006
    ..A higher serum BDNF level was associated with a more advanced tumor status in the HCC patients. The interaction between serum BDNF and platelets might play an important role in HCC tumor progression...
  6. ncbi request reprint Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop
    Zhen Fan Yang
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Biochem Biophys Res Commun 346:981-5. 2006
    ..In conclusion, this study suggested the presence of BDNF-TrkB autocrine loop in platelets and its importance in regulating platelet activation during tumor development...
  7. ncbi request reprint Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, L9 41 Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Int Immunol 17:1391-7. 2005
    ..In conclusion, AIF-1 played an important role in the survival and pro-inflammatory activity of macrophages, and ADAM3 might be an upstream molecule that regulated AIF-1 expression...
  8. doi request reprint An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells
    Chi Keung Lau
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 15:3462-71. 2009
    ....
  9. ncbi request reprint Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma
    Chi Keung Lau
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Biol Ther 6:1900-7. 2007
    ..This finding provides insight into design of a new therapeutic strategy to improve efficacy of chemotherapy in HCC patients...
  10. doi request reprint Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinoma
    Ka Ho Tam
    Center for Cancer Research, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Cancer Lett 273:201-9. 2009
    ..This study demonstrates that inhibition of mTOR suppresses tumor growth and sensitizes tumor cells to chemocytotoxic agents...
  11. ncbi request reprint Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 65:219-25. 2005
    ..BDNF could stimulate tumor cell proliferation in a Hsp90-dependent manner...
  12. doi request reprint Identification of local and circulating cancer stem cells in human liver cancer
    Zhen Fan Yang
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatology 47:919-28. 2008
    ..Treatment of CD90(+) CSCs with anti-human CD44 antibody induced cell apoptosis in a dose-dependent manner...
  13. doi request reprint Cardiotrophin-1 enhances regeneration of cirrhotic liver remnant after hepatectomy through promotion of angiogenesis and cell proliferation
    Zhen Fan Yang
    Department of Surgery, Centre for Cancer Research, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam, Hong Kong, China
    Liver Int 28:622-31. 2008
    ..The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on improving the function of CCl(4)-induced cirrhotic liver remnant after major hepatectomy...
  14. ncbi request reprint Linking inflammation to acute rejection in small-for-size liver allografts: the potential role of early macrophage activation
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Am J Transplant 4:196-209. 2004
    ..In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process in small-for-size allografts...
  15. ncbi request reprint High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Mol Cancer Ther 5:2261-70. 2006
    ..In conclusion, PTK787 combined with hypoxia achieved a better therapeutic efficacy than hypoxia alone through enhancing hypoxia-induced antitumor cell effect and preventing the activation of angiogenic process...
  16. ncbi request reprint Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma
    Ching Tung Lum
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong, People s Republic of China
    Int J Cancer 118:1527-38. 2006
    ..Results from our study demonstrated that gold-1a might be a novel promising chemocytotoxic agent for treating HCC...
  17. ncbi request reprint Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2)
    Chi Keung Lau
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Biochem Biophys Res Commun 348:1443-8. 2006
    ..In conclusion, YC-1 suppressed both protein synthesis and stability of HIF-1alpha in HCC cells, and its inhibitory effects on HIF-1alpha were dependent on Mdm2...
  18. doi request reprint The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinoma
    Zan Shen
    Institute of Molecular Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Cancer Res 68:404-14. 2008
    ..These results suggest for the first time that HGFK1 exerts both antiangiogenic and antitumor cell activities mainly through EGF/EGFR signaling, and may thus be considered as a novel therapeutic strategy for the treatment of HCC...
  19. ncbi request reprint Therapeutic potential of cardiotrophin 1 in fulminant hepatic failure: dual roles in antiapoptosis and cell repair
    David W Ho
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong
    Arch Surg 141:1077-84; discussion 1084. 2006
    ..Administration of cardiotrophin 1 (CT-1) can treat experimental fulminant hepatic failure (FHF)...
  20. ncbi request reprint Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation?
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    Liver Transpl 9:411-20. 2003
    ..Anti-hCTLA4Ig antibodies could be detected in long-term surviving animals, but the extent of humoral response was not severe. This study shows that rAAV can be an effective and safe vector for gene delivery in liver transplantation...
  21. doi request reprint Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study
    Sheung Tat Fan
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 254:569-76. 2011
    ..To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy...
  22. doi request reprint Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver
    Xiao Qi Wang
    Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong, China
    Hepatology 56:1557-66. 2012
    ..In LT patients, there are two types of chimerisms: transient chimerism, resulting from mature leucocytes, and long-term chimerism, derived from putative HSPCs in the liver graft...
  23. pmc Gene expression profiling of liver cancer stem cells by RNA-sequencing
    David W Y Ho
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 7:e37159. 2012
    ....
  24. doi request reprint Vascular changes in hepatocellular carcinoma
    Zhen Fan Yang
    Centre for Cancer Research, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Anat Rec (Hoboken) 291:721-34. 2008
    ....
  25. ncbi request reprint Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression
    Terence K Lee
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 12:5082-9. 2006
    ....
  26. ncbi request reprint Heme oxygenase-1 potentiates the survival of small-for-size liver graft
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Hong Kong, China
    Liver Transpl 10:784-93. 2004
    ..These findings support the beneficial effects of HO-1 on allograft survival. In conclusion, the ability of small-for-size grafts in the induction of HO-1 expression might facilitate their own survival in liver transplantation...
  27. ncbi request reprint The potential role of hypoxia inducible factor 1alpha in tumor progression after hypoxia and chemotherapy in hepatocellular carcinoma
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Cancer Res 64:5496-503. 2004
    ....
  28. doi request reprint Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization: implication in hepatocellular carcinoma
    Chi Tat Lam
    Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 17:3123-33. 2011
    ..Brain-derived neurotrophic factor (BDNF) has emerged as a novel angiogenic factor, and yet its impact on tumorigenesis is unclear. This study aimed at investigating the roles of BDNF in angiogenesis and tumor development...
  29. ncbi request reprint Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study
    Ronnie Tung Ping Poon
    Department of Surgery and Pathology, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    J Clin Oncol 20:1775-85. 2002
    ..This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients undergoing resection of hepatocellular carcinoma (HCC)...
  30. ncbi request reprint Role of stem cells in normal liver and cancer
    Chi Keung Lau
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Anticancer Agents Med Chem 11:522-8. 2011
    ..Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed...
  31. doi request reprint Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway
    Xiao Qi Wang
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Hepatology 52:528-39. 2010
    ..Conclusion: Oct4, a transcriptional factor of pluripotent cells, can mediate chemoresistance through a potential Oct4-AKT-ABCG2 pathway...
  32. ncbi request reprint Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transfer
    Siu Tim Cheung
    Department of Surgery and Center for the Study of Liver Disease, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1008-14. 2002
    ..In this study, we investigated the efficacy of hepatocyte transduction via introduction of the exogenous CTLA4Ig gene to the rat liver graft by retrovirus vector, and examined the presence of target serum protein after gene transfers...
  33. ncbi request reprint Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma
    David Wing Yuen Ho
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer 107:99-107. 2006
    ..The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer...