Wutian Wu

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts
    Zelda H Cheung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, China
    J Neurotrauma 19:369-78. 2002
  2. pmc Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease
    Qiuju Yuan
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e53480. 2013
  3. pmc Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the Notch pathway
    Xin Li
    Department of Emergency, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan II, Guangzhou, 510080 Guangdong, China
    Neurochem Res 36:2363-72. 2011
  4. ncbi request reprint Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats
    Wutian Wu
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Neurotrauma 21:1050-8. 2004
  5. ncbi request reprint GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
    Wutian Wu
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Neurotrauma 20:603-12. 2003
  6. doi request reprint Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats
    Huanxing Su
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurotrauma 26:67-80. 2009
  7. doi request reprint Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury
    Qiuju Yuan
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Brain Res 1320:7-15. 2010
  8. doi request reprint LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension
    Qing Ling Fu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, and State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Eur J Neurosci 31:1091-7. 2010
  9. doi request reprint Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor
    Huanxing Su
    Department of Anatomy, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 108:1385-98. 2009
  10. ncbi request reprint The response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult rats
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
    Brain Res 1113:45-53. 2006

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts
    Zelda H Cheung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, China
    J Neurotrauma 19:369-78. 2002
    ..This study demonstrates that herbs can act as a potential neuroprotective agent for damaged RGCs. It also suggests that the therapeutic value of herbal remedies can be maximized by the use of mixtures of appropriate herbs...
  2. pmc Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease
    Qiuju Yuan
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e53480. 2013
    ..These findings are indicative that plaque load per se may not be used as a significant criterion for evaluating the effect of stress on AD patients...
  3. pmc Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the Notch pathway
    Xin Li
    Department of Emergency, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan II, Guangzhou, 510080 Guangdong, China
    Neurochem Res 36:2363-72. 2011
    ..Our results suggest that sNgR-Fc may modulate Nogo activity to induce NPC proliferation via the Notch pathway...
  4. ncbi request reprint Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats
    Wutian Wu
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Neurotrauma 21:1050-8. 2004
    ..Therefore, the delayed implantation of a PN graft after root avulsion may provide a continued conducive environment to support regeneration...
  5. ncbi request reprint GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
    Wutian Wu
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Neurotrauma 20:603-12. 2003
    ....
  6. doi request reprint Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats
    Huanxing Su
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurotrauma 26:67-80. 2009
    ..Such beneficial effects are possibly due to their inherent ability to secrete various trophic factors after transplantation in vivo...
  7. doi request reprint Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury
    Qiuju Yuan
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Brain Res 1320:7-15. 2010
    ....
  8. doi request reprint LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension
    Qing Ling Fu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, and State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Eur J Neurosci 31:1091-7. 2010
    ..This neuronal protective effect was blocked by anti-BDNF antibody. LINGO-1 antagonism therefore promotes RGC survival by regulating the BDNF and TrkB signaling pathway after ocular hypertension...
  9. doi request reprint Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor
    Huanxing Su
    Department of Anatomy, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 108:1385-98. 2009
    ....
  10. ncbi request reprint The response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult rats
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
    Brain Res 1113:45-53. 2006
    ..Relationships between NOS induction and magnocellular neuronal survival and regeneration were discussed...
  11. doi request reprint Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush
    Qiuju Yuan
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Exp Gerontol 47:329-36. 2012
    ..These data provide a neurobiological explanation for the poor outcome associated with nerve repair in the aged...
  12. ncbi request reprint A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells
    Zelda H Cheung
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 1 F, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Cell Mol Neurobiol 28:137-55. 2008
    ....
  13. doi request reprint Implantation of neurotrophic factor-treated sensory nerve graft enhances survival and axonal regeneration of motoneurons after spinal root avulsion
    Tak Ho Chu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neuropathol Exp Neurol 68:94-101. 2009
    ..Our results suggest that infusion of trophic factors into sensory nerve grafts promote motoneuron survival and axonal regeneration. The technique is technically easy and is, therefore, potentially clinically applicable...
  14. ncbi request reprint Neurotrophic factor treatment after spinal root avulsion injury
    Tak Ho Chu
    Department of Anatomy, The University of Hong Kong, Pokfulam, SAR, China
    Cent Nerv Syst Agents Med Chem 9:40-55. 2009
    ..We will include recent studies on trophic factors for motoneuron survival and regeneration in peripheral nerve and avulsion injuries. We will also discuss the potential use of trophic factors in the context of avulsion injuries...
  15. doi request reprint Bone morphogenetic proteins mediate cellular response and, together with Noggin, regulate astrocyte differentiation after spinal cord injury
    Qi Xiao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Exp Neurol 221:353-66. 2010
    ....
  16. doi request reprint Assessment of the rate of spinal motor axon regeneration by choline acetyltransferase immunohistochemistry following sciatic nerve crush injury in mice
    Qiuju Yuan
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    J Neurosurg 120:502-8. 2014
    ..The purpose of this study was to examine whether choline acetyltransferase (ChAT) staining can be used for assessing the rate of motor neuron regeneration at an early phase of axon outgrowth...
  17. doi request reprint Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection
    Qing Ling Fu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Invest Ophthalmol Vis Sci 49:975-85. 2008
    ..The authors sought to examine whether blocking LINGO-1 function with LINGO-1 antagonists promotes retinal ganglion cell (RGC) survival after ocular hypertension and optic nerve transection...
  18. ncbi request reprint Potential roles of Alzheimer precursor protein A4 and beta-amyloid in survival and function of aged spinal motor neurons after axonal injury
    Yuanyun Xie
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, People s Republic of China
    J Neurosci Res 73:557-64. 2003
    ..Our data indicate that APP and A/beta might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury...
  19. doi request reprint The potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
    Qiuju Yuan
    Department of Anatomy, The University of Hong Kong, Pokfulam, China
    Neurochem Res 34:1907-13. 2009
    ..These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular neurons of the HNS following hypophysectomy...
  20. ncbi request reprint Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats
    Yuen Man Chan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, China
    Exp Neurol 181:190-203. 2003
    ..Collectively, these data provide evidence that injured neonatal motoneurons can survive and reinnervate peripheral muscle targets following inhibition of caspases...
  21. doi request reprint Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion
    Huanxing Su
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cell Transplant 20:167-76. 2011
    ..Our study suggests that the cervical ventral horn at 2 weeks postavulsion both supports neuronal differentiation and induces region-specific neuronal generation possibly because of its higher expression of BDNF and GDNF...
  22. ncbi request reprint Development of the regenerative capacity of postnatal axotomized rat spinal motoneurons
    Yuen Man Chan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Neuroreport 13:1071-4. 2002
    ..The percentage of regenerated motoneurons increased from P21 to P28 and was similar to that of adult animals. Therefore, the regenerative capacity of rat spinal motoneurons first begins at about P14, which seems to be critical...
  23. ncbi request reprint Differential activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats
    Qiuju Yuan
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Anat Rec (Hoboken) 290:1050-6. 2007
    ..This study demonstrates that c-fos expression after hypophysectomy is regulated differently during development...
  24. doi request reprint Neural progenitor cells generate motoneuron-like cells to form functional connections with target muscles after transplantation into the musculocutaneous nerve
    Huanxing Su
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cell Transplant 21:2651-63. 2012
    ....
  25. ncbi request reprint Expression and role of low-affinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury
    Yuanyun Xie
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Dev Neurosci 25:65-71. 2003
    ..Following axonal injury in aged rats, up-regulation of p75 seems to coincide with the survival of injured motor neurons. Potential roles of re-expression of p75 in aged motor neurons are discussed...
  26. doi request reprint Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
    Qiuju Yuan
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Nitric Oxide 23:258-63. 2010
    ..In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not...
  27. ncbi request reprint Age-related reexpression of p75 in axotomized motoneurons
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, China
    Neuroreport 17:711-5. 2006
    ..The potential role of such reexpression in motoneuron protection is discussed...
  28. doi request reprint Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway
    Qiuju Yuan
    Faculty of Science, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    J Alzheimers Dis 35:675-85. 2013
    ..The characteristics of Aβ distribution in TgCRND8 mice suggest that there are other ways related to the formation of Aβ plaques in addition to the terminal and synaptic release of Aβ...
  29. doi request reprint Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats
    Tak Ho Chu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Exp Neurol 212:562-5. 2008
    ..Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve...
  30. doi request reprint Minocycline inhibited the pro-apoptotic effect of microglia on neural progenitor cells and protected their neuronal differentiation in vitro
    Xuqing Liu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region
    Neurosci Lett 542:30-6. 2013
    ..This suggested that minocycline might inhibit the negative effects of microglia on NPCs, and have the potential to support the survival and neuronal differentiation of transplanted NPCs for SCI...
  31. ncbi request reprint Regulation of caspase activation in axotomized retinal ganglion cells
    Zelda H Cheung
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Mol Cell Neurosci 25:383-93. 2004
    ..Our findings thus indicate that the PI3K/Akt pathway may serve as an endogenous regulator of caspase activation in axotomized RGCs, thereby, contributing to the late onset of RGC death following axotomy...
  32. doi request reprint Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats
    Qiuju Yuan
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neurosci Bull 29:509-16. 2013
    ..The difference in secondary degeneration between neonatal and adult rats remains to be explored. ..
  33. ncbi request reprint Inflammatory response associated with axonal injury to spinal motoneurons in newborn rats
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Dev Neurosci 25:72-8. 2003
    ..In contrast, after distal axotomy only microglia but not BMOs were observed in the lesioned area. These microglial cells were small in size with long and fine-branched processes. They were ED1-negative but OX-42-positive...
  34. ncbi request reprint A subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats
    Qiuju Yuan
    Department of Anatomy, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Brain Res 1159:18-27. 2007
    ....
  35. ncbi request reprint Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat
    Lihua Zhou
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Exp Neurol 197:84-92. 2006
    ....
  36. ncbi request reprint Microarray analysis of gene expression patterns in adult spinal motoneurons after different types of axonal injuries
    Yi Yang
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Brain Res 1075:1-12. 2006
    ..This study presents an approach for selecting specific genes and their products that may be involved in motoneuron degeneration following axonal injuries...
  37. doi request reprint Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain
    Jiasong Guo
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Nanomedicine 5:345-51. 2009
    ..Thus, SAPNS may help to reconstruct the acutely injured brain and reduce the glial reaction and inflammation in the surrounding brain tissue...
  38. ncbi request reprint Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle
    Huanxing Su
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Stem Cell Res 11:529-39. 2013
    ..Our study provides evidence for the first time that human iPSC-derived motoneurons are truly functional not only in vitro but also in vivo, and they have potential for stem cell-based therapies for motoneuron diseases...
  39. ncbi request reprint Existence of different types of senile plaques between brain and spinal cord of TgCRND8 mice
    Qiuju Yuan
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Neurochem Int 62:211-20. 2013
    ..Our findings strongly indicate that diffuse and dense-core plaques may form via independent processes in AD and Aβ42 is more prone to form dense-core plaques than is Aβ40...
  40. ncbi request reprint Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC
    Leung Wah Yick
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Exp Neurol 182:160-8. 2003
    ..This result further suggests that CSPG is inhibitory to the regeneration of neurons in the spinal cord after traumatic injury...
  41. ncbi request reprint Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold
    Jiasong Guo
    Department of Anatomy, The University of Hong Kong Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong SAR, China
    Nanomedicine 3:311-21. 2007
    ....
  42. ncbi request reprint Survival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion
    Li Hua Zhou
    Department of Anatomy, Zhong Shan Medical College, Sun Yat Sen University, Guangzhou, Guangzhou, China
    J Neurotrauma 23:920-7. 2006
    ..These findings provide useful information for choosing the best time frame for the potential clinical treatment of brachial plexus avulsion...
  43. ncbi request reprint Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord
    Huanxing Su
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Exp Neurol 206:296-307. 2007
    ....
  44. doi request reprint Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions
    Zai Wang
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Development 140:617-26. 2013
    ..Functional mapping of Kif5b revealed a 64-amino acid α-helix domain in the tail region, which directly interacted with desmin and might be responsible for the transportation of these proteins in a complex...
  45. ncbi request reprint Axotomy induces cytochrome c release in retinal ganglion cells
    Zelda H Cheung
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 1 F, Laboratory Block, 21 Sassoon Road, Hong Kong, China
    Neuroreport 14:279-82. 2003
    ..Our data indicate that cytochrome c release potentially contributes to the death of axotomized RGCs...
  46. ncbi request reprint Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension
    Qing Ling Fu
    Department of Anatomy, The University of Hong Kong Li Ka Shing Faculty of Medicine, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Cell Mol Neurobiol 28:317-29. 2008
    ..In this study, we investigate the role of the EPO/EPO receptor (EPOR) system in the rat retina after ocular hypertension injury that mimics glaucoma...
  47. pmc Induction of phosphorylated c-Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration
    Qiuju Yuan
    Faculty of Medicine, School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China Department of Anatomy, University of Hong Kong, Hong Kong, China
    J Anat 224:575-82. 2014
    ..Our findings therefore support the hypothesis that active c-Jun is involved in both neuronal degeneration and regeneration...
  48. doi request reprint Neural progenitor cell apoptosis and differentiation were affected by activated microglia in spinal cord slice culture
    Xuqing Liu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neurol Sci 35:415-9. 2014
    ..In NPC transplantation strategy for SCI, microglia would be manipulated to improve the survival and neuronal differentiation of NPCs...
  49. ncbi request reprint Systemic progesterone for modulating electrocautery-induced secondary brain injury
    Ka Chun Un
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Clin Neurosci 20:1329-30. 2013
    ..Future studies may focus on different dosing regimens, neuronal survival, functional outcome, and to compare progesterone with other agents such as dexamethasone...
  50. pmc Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 8:e60862. 2013
    ..To our knowledge, we identified for the first time the critical role of NK cells in the mechanism of IgG-induced induction of Treg cells in treatment of autoimmunity...
  51. ncbi request reprint Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress
    Tak Ho Chu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neuropathol Appl Neurobiol 40:435-51. 2014
    ..Accumulation of damaged bases causes genome instability and jeopardizes cell survival. Our study is to examine APE1 regulation under oxidative stress in spinal motor neurones which are vulnerable to oxidative insult...
  52. doi request reprint Cyp26b1 mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells
    Carly Leung
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Stem Cells Dev 21:2252-61. 2012
    ....
  53. doi request reprint Peptide nanofiber scaffold for brain tissue reconstruction
    Gilberto Ka Kit Leung
    Li Ka Shing Faculty of Medicine, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Methods Enzymol 508:177-90. 2012
    ..New experimental models and research methods are required to fully explore its potential in minimizing secondary brain injuries and to promote neuronal regeneration...
  54. ncbi request reprint Developmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system
    Qiuju Yuan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Anat Rec A Discov Mol Cell Evol Biol 288:36-45. 2006
    ....
  55. ncbi request reprint CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury
    Cheng Wu Zhang
    Laboratory for Neural Repair, Shantou University Medical College, Shantou, People s Republic of China
    Invest Ophthalmol Vis Sci 46:1497-503. 2005
    ....
  56. ncbi request reprint Morphine acts via mu-opioid receptors to enhance spinal regeneration and synaptic reconstruction of primary afferent fibers injured by sciatic nerve crush
    Yuan shan Zeng
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, China
    Brain Res 1130:108-13. 2007
    ....