Research Topics
Species | Tak Ming WongSummaryAffiliation: University of Hong Kong Country: China Publications
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Publications
Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgeryTak Ming Wong
Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Card Surg 17:462-4. 2002..The finding indicates that opioids such as morphine may be used in the treatment of ischemic heart diseases and in open heart surgery...- Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course studyJian Ming Pei
Dept of Physiology, Faculty of Medicine, Univ of Hong Kong, 21 Sassoon Rd, Hong Kong, China
Am J Physiol Cell Physiol 285:C1420-8. 2003..The results indicate impaired Ca2+ handling, which may be responsible for the attenuated Ca2+ responses to beta-adrenoceptor stimulation in CH... - Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanismsTak Ming Wong
Department of Physiology, The University of Hong Kong, 4 F, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, PR China
Sheng Li Xue Bao 55:115-20. 2003.... - Cardioprotection by the female sex hormone -- interaction with the beta(1)-adrenoceptor and its signaling pathwaysKathie A Wong
Department of Physiology, The University of Hong Kong, Hong Kong, China E mail
Sheng Li Xue Bao 59:571-7. 2007..Estrogen plays an important role not only in reproduction but also in other regulatory functions such as cardioprotection... - Modulation of sympathetic actions on the heart by opioid receptor stimulationT M Wong
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
J Biomed Sci 8:299-306. 2001..Other than opioid peptides, female sex hormone and adenosine also inhibit the sympathetic actions on the heart. In addition, sympathetic action is also inhibited presynaptically by kappa-opioid peptides via their receptor... - Cardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrineT M Wong
Department of Physiology, University of Hong Kong, Li Shu Fan Building, Sassoon Road, Hong Kong, China
Acta Pharmacol Sin 21:1083-8. 2000..So the RST extract may be a therapeutically better agent in the treatment of ischemic heart diseases and hypertension than Ca2+ channel antagonists because of the absence of the inhibitory effect on heart rate during myocardial ischemia... 
Testosterone-augmented contractile responses to alpha1- and beta1-adrenoceptor stimulation are associated with increased activities of RyR, SERCA, and NCX in the heartSharon Tsang
Dept of Physiology, The University of Hong Kong, Hong Kong, China
Am J Physiol Cell Physiol 296:C766-82. 2009..The increased contractility and speedier relaxation were associated with increased Ca(2+) release via the RyR and faster Ca(2+) removal out of the cytosol via SERCA and NCX...- Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusionHang Mee Yeung
Dept of Physiology, University of Hong Kong, Pokfulam, Hong Kong
Am J Physiol Cell Physiol 292:C2046-56. 2007..Thus, CIH confers cardioprotection against I/R injury in rat cardiomyocytes by altered Ca(2+) handling with augmented RyR and NCX activities via protein kinase activation... - Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase AGennadi M Kravtsov
Department of Physiology, 4 F Laboratory Block, Faculty of Medicine Bldgs, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
Am J Physiol Cell Physiol 292:C1625-35. 2007..The increased release of Ca(2+) through RyR and removal of Ca(2+) by NCX are believed to be responsible for the greater contractility and faster relaxation after Ovx... - Role of reverse mode Na+/Ca2+ exchanger in the cardioprotection of metabolic inhibition preconditioning in rat ventricular myocytesShu Zhuang Li
Department of Physiology, Fourth Military Medical University, Xi an, 710032, China
Eur J Pharmacol 561:14-22. 2007..The results indicate that increased reverse mode NCX activity during preconditioning triggered cardioprotection, and reduced reverse mode NCX activity during reperfusion after index ischaemia conferred cardioprotection... 
Role of protein kinase C-epsilon in the development of kappa-opioid receptor tolerance to U50,488H in rat ventricular myocytesJing Jun Zhou
Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
Br J Pharmacol 135:1675-84. 2002..These results indicate that activation of PKC-epsilon is a critical step in the development of tolerance in the kappa-OR...- Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteinsWai Ho Tang
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
J Mol Cell Cardiol 49:58-69. 2010..Thus, in I/R heart, inhibition of polyol pathway improved the function of SERCA and RyR by protecting them from irreversible oxidation... - Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa, and mu opioid receptors in ratsRui Li
Department of Anesthesiology, University of Hong Kong, Hong Kong
Anesth Analg 108:23-9. 2009..In this study, we compared the extent of cardioprotection conferred by IT-MPC with IPC and investigated the role of opioid receptors in this effect... - Testosterone and cardioprotection against myocardial ischemiaSharon Tsang
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam, HKSAR, China
Cardiovasc Hematol Disord Drug Targets 7:119-25. 2007..Further studies are warranted to further delineate the integration of signaling mechanisms and to explore the possibility of using testosterone in the aging male population with ischemic heart diseases... - Effects of heat shock protein 70 activation by metabolic inhibition preconditioning or kappa-opioid receptor stimulation on Ca2+ homeostasis in rat ventricular myocytes subjected to ischemic insultsJing Liu
Department of Physiology, Institute of Cardiovascular Sciences and Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
J Pharmacol Exp Ther 310:606-13. 2004..This study provides first evidence that activation of HSP70 induced by preconditioning, which conferred delayed cardioprotection, restored partially the [Ca(2+)](i) homeostasis altered by ischemic insults... - Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptorsYe Zhang
Department of Anaesthesiology, University of Hong Kong, China
Anesthesiology 102:371-8. 2005..CONCLUSION: Cardiac delta- and kappa- but not mu-ORs mediate the cardioprotection produced by RPC. Both protein kinase C and the mitochondrial KATP channel were involved in this effect... - Forskolin fails to activate L-type calcium current in hypertrophied cardiomyocytes of chronically hypoxic ratsMan Lung Fung
Department of Physiology, Institute of Cardiovascular Science and Medicine, University of Hong Kong, Pokfulam, People s Republic of China
Life Sci 70:1801-9. 2002..The failure of activation of the Ca2+ current is consistent with the idea that adenylyl cyclase function is down-regulated in CH hypertrophied myocytes... - Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized ratsKenneth W L Kam
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Br J Pharmacol 144:972-81. 2005.... - Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heartX C Yu
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
Life Sci 68:2863-72. 2001.... - Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioningJing Liu
Department of Physiology, Faculty of Medicine, The University of Hong Kong, 4/F Laboratory Block, Faculty of Medicine Buildings, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
Endocrinology 147:4569-77. 2006..In conclusion, preconditioning requires testosterone to increase heat shock protein 70 synthesis, which mediates delayed cardioprotection in the male. These effects of testosterone are mediated by the androgen receptor... - Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethaneYuan Zhou
Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Toxicology 290:295-304. 2011..L), I(to), I(Na), HCN2, and hERG channels... - Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the ratX C Yu
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Pharm Pharmacol 56:115-22. 2004..Since only 7% of the extract was tetrandrine, the observation indicates that tetrandrine was not the only component that was responsible for the actions of the extract... - Estrogen reduces cardiac injury and expression of beta1-adrenoceptor upon ischemic insult in the rat heartKenneth W L Kam
Department of Physiology, Faculty of Medicine, The University of Hong Kong Special Administrative Region, China
J Pharmacol Exp Ther 309:8-15. 2004..Therefore, suppression of the enhanced expression of cardiac beta(1)-AR in Ovx rats represents a novel cardioprotective mechanism of estrogen replacement therapy... - Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heartWai Ho Tang
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
Free Radic Biol Med 45:602-10. 2008..This was confirmed by the fact that administration of the iron chelator deferoxamine attenuated the I/R-induced myocardial infarction... - A new view of K+ -induced contraction in rat aorta: the role of Ca2+ bindingGennadi M Kravtsov
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, ROC
Pflugers Arch 446:529-40. 2003..This Ca2+ binding may then activate actin-myosin interaction... - Cardiac effects of the extract and active components of Radix stephaniae tetrandrae. I. Electrically-induced intracellular calcium transient and protein release during the calcium paradoxS Wu
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
Life Sci 68:2853-61. 2001..The observations suggest that the RST extract, which contains a mixture of components, may have more potent effects in the heart than its main active component... - Remifentanil preconditioning protects against ischemic injury in the intact rat heartYe Zhang
Department of Anaesthesiology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
Anesthesiology 101:918-23. 2004..This differs from ischemic preconditioning, which confers cardioprotection via kappa- and Delta-, but not mu-opioid receptors. Part of the protective effect of remifentanil may be produced by mu-agonist activity outside the heart... - Calcium antagonistic and antiarrhythmic actions of CPU-23, a substituted tetrahydroisoquinolineH Dong
Department of Physiology, Faculty of Medicine, University of Hong Kong
Br J Pharmacol 109:113-9. 1993.... - Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migrationWilliam Ka Kei Wu
Department of Pharmacology, Basic Medical Sciences Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Mol Cell Biochem 308:219-26. 2008..In conclusion, the present study demonstrates for the first time that voltage-gated K(+) and Na(+) channels are involved in the modulation of gastric epithelial cell migration... - Melatonin potentiates phenylephrine-stimulated intracellular Ca2+ transient in smooth muscle cell of large arteries of chick embryoXiao Fei Wang
Department of Physiology, University of Hong Kong, SAR, China
J Cardiovasc Pharmacol 40:356-62. 2002..Melatonin potentiates the effects of alpha1-adrenergic stimulation... - Reduced inhibitory actions of adenosine A1 and kappa 1-opioid receptor agonists on beta-adrenoceptors in spontaneously hypertensive rat heartX C Yu
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong
Clin Exp Pharmacol Physiol 24:976-7. 1997.... - Remifentanil preconditioning confers delayed cardioprotection in the ratC K Yu
Department of Anaesthesiology, The University of Hong Kong, Queen Mary Hospital, Room 424, Block K, Pokfulam Road, Hong Kong
Br J Anaesth 99:632-8. 2007..Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors... - Role of opioid receptors in cardioprotection of cold-restraint stress and morphineS Wu
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
J Biomed Sci 11:726-31. 2004..The effects were also attenuated by blockade of protein kinase C or the mitochondrial K(ATP) channel. The finding is first evidence that all three OR subtypes mediate cardioprotection of cold-restraint stress in the rat... - Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytesJ J Zhou
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
Am J Physiol Heart Circ Physiol 281:H40-7. 2001..These observations provide evidence that stress-inducible HSP70 mediates delayed cardioprotection of prior kappa-OR stimulation... - Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulationS Tsang
Department of Physiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Br J Pharmacol 153:693-709. 2008..Androgen receptors are present in the heart, and testosterone upregulates gene expression of cardiac beta(1)-adrenoceptors. We hypothesize that testosterone may confer cardioprotection by interacting with adrenoceptors... - Failure to confer cardioprotection and to increase the expression of heat-shock protein 70 by preconditioning with a kappa-opioid receptor agonist during ischaemia and reperfusion in streptozotocin-induced diabetic ratsJ S Qi
Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 4/F Laboratory Block, Hong Kong SAR, China
Diabetologia 47:214-20. 2004.... - kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the ratDan Shan
Key Lab of Molecular Biology and Drug Research, Jinzhou Medical College, Jinzhou, China
Eur J Pharmacol 555:100-5. 2007..In conclusion the results show that kappa-opioid receptor stimulation abolished both the cardiac hypertrophy and enhanced amplitude and frequency of the spontaneous intracellular Ca2+ transient induced by beta1-adrenoceptor stimulation... - kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B)Guoqiang Wu
Key Laboratory of Molecular Biology and Drug Research, Liaoning Medical College, Liaoning, PR China
Eur J Pharmacol 595:52-7. 2008..These results suggest that the inhibitory effect of kappa-opioid receptor stimulation on beta(1)-adrenoceptor stimulation may also involve CaMKIIdelta... - Further study on the role of HSP70 on Ca2+ homeostasis in rat ventricular myocytes subjected to simulated ischemiaJing Liu
Muscular and Neurodegenerative Disease Unit, University of Genoa and G. Gaslini Pediatric Institute, Genoa, Italy
Am J Physiol Cell Physiol 290:C583-91. 2006.... - delta-Opioid receptor stimulation enhances the growth of neonatal rat ventricular myocytes via the extracellular signal-regulated kinase pathwayMin Zhao
Key Laboratory of Molecular Biology and Drug Research, Liaoning Medical College, Liaoning, China
Clin Exp Pharmacol Physiol 35:97-102. 2008..5. In conclusion, delta-opioid receptor stimulation enhances the proliferation and development of the ventricular myocytes of neonatal rats. The ERK pathway and related signalling mechanisms, namely PKC and PKA, are involved... - Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytesGuijun Wang
Department of Pharmacology, Jinzhou Medical College, Jinzhou, China
Eur J Pharmacol 498:53-8. 2004..The stimulatory effects of sympathetic activity on growth occurs via both alpha- and beta-adrenoceptors... - 2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent mannerGudrun H Borchert
University of the Balearic Islands, Palma de Mallorca, Spain
Am J Physiol Heart Circ Physiol 294:H1948-55. 2008..The present results indicate that 2-OHOA selectively increases myocyte inotropic responsiveness, which could underlie its beneficial cardiovascular effects...