Tak Ming Wong

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery
    Tak Ming Wong
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Card Surg 17:462-4. 2002
  2. ncbi request reprint Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study
    Jian Ming Pei
    Dept of Physiology, Faculty of Medicine, Univ of Hong Kong, 21 Sassoon Rd, Hong Kong, China
    Am J Physiol Cell Physiol 285:C1420-8. 2003
  3. ncbi request reprint Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms
    Tak Ming Wong
    Department of Physiology, The University of Hong Kong, 4 F, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, PR China
    Sheng Li Xue Bao 55:115-20. 2003
  4. ncbi request reprint Cardioprotection by the female sex hormone -- interaction with the beta(1)-adrenoceptor and its signaling pathways
    Kathie A Wong
    Department of Physiology, The University of Hong Kong, Hong Kong, China E mail
    Sheng Li Xue Bao 59:571-7. 2007
  5. ncbi request reprint Cardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrine
    T M Wong
    Department of Physiology, University of Hong Kong, Li Shu Fan Building, Sassoon Road, Hong Kong, China
    Acta Pharmacol Sin 21:1083-8. 2000
  6. ncbi request reprint Modulation of sympathetic actions on the heart by opioid receptor stimulation
    T M Wong
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Biomed Sci 8:299-306. 2001
  7. doi request reprint Testosterone-augmented contractile responses to alpha1- and beta1-adrenoceptor stimulation are associated with increased activities of RyR, SERCA, and NCX in the heart
    Sharon Tsang
    Dept of Physiology, The University of Hong Kong, Hong Kong, China
    Am J Physiol Cell Physiol 296:C766-82. 2009
  8. pmc The K(Ca) channel as a trigger for the cardioprotection induced by kappa-opioid receptor stimulation -- its relationship with protein kinase C
    Chun mei Cao
    Department of Physiology, The University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 145:984-91. 2005
  9. pmc Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H
    Mai Chen
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 140:750-8. 2003
  10. ncbi request reprint Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion
    Hang Mee Yeung
    Dept of Physiology, University of Hong Kong, Pokfulam, Hong Kong
    Am J Physiol Cell Physiol 292:C2046-56. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery
    Tak Ming Wong
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Card Surg 17:462-4. 2002
    ..The finding indicates that opioids such as morphine may be used in the treatment of ischemic heart diseases and in open heart surgery...
  2. ncbi request reprint Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study
    Jian Ming Pei
    Dept of Physiology, Faculty of Medicine, Univ of Hong Kong, 21 Sassoon Rd, Hong Kong, China
    Am J Physiol Cell Physiol 285:C1420-8. 2003
    ..The results indicate impaired Ca2+ handling, which may be responsible for the attenuated Ca2+ responses to beta-adrenoceptor stimulation in CH...
  3. ncbi request reprint Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms
    Tak Ming Wong
    Department of Physiology, The University of Hong Kong, 4 F, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, PR China
    Sheng Li Xue Bao 55:115-20. 2003
    ....
  4. ncbi request reprint Cardioprotection by the female sex hormone -- interaction with the beta(1)-adrenoceptor and its signaling pathways
    Kathie A Wong
    Department of Physiology, The University of Hong Kong, Hong Kong, China E mail
    Sheng Li Xue Bao 59:571-7. 2007
    ..Estrogen plays an important role not only in reproduction but also in other regulatory functions such as cardioprotection...
  5. ncbi request reprint Cardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrine
    T M Wong
    Department of Physiology, University of Hong Kong, Li Shu Fan Building, Sassoon Road, Hong Kong, China
    Acta Pharmacol Sin 21:1083-8. 2000
    ..So the RST extract may be a therapeutically better agent in the treatment of ischemic heart diseases and hypertension than Ca2+ channel antagonists because of the absence of the inhibitory effect on heart rate during myocardial ischemia...
  6. ncbi request reprint Modulation of sympathetic actions on the heart by opioid receptor stimulation
    T M Wong
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Biomed Sci 8:299-306. 2001
    ..Other than opioid peptides, female sex hormone and adenosine also inhibit the sympathetic actions on the heart. In addition, sympathetic action is also inhibited presynaptically by kappa-opioid peptides via their receptor...
  7. doi request reprint Testosterone-augmented contractile responses to alpha1- and beta1-adrenoceptor stimulation are associated with increased activities of RyR, SERCA, and NCX in the heart
    Sharon Tsang
    Dept of Physiology, The University of Hong Kong, Hong Kong, China
    Am J Physiol Cell Physiol 296:C766-82. 2009
    ..The increased contractility and speedier relaxation were associated with increased Ca(2+) release via the RyR and faster Ca(2+) removal out of the cytosol via SERCA and NCX...
  8. pmc The K(Ca) channel as a trigger for the cardioprotection induced by kappa-opioid receptor stimulation -- its relationship with protein kinase C
    Chun mei Cao
    Department of Physiology, The University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 145:984-91. 2005
    ..In conclusion, the high-conductance K(Ca) channel triggers cardioprotection induced by kappa-OR stimulation that involves inhibition of MPTP opening. The K(Ca) channel is located downstream of PKC...
  9. pmc Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H
    Mai Chen
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 140:750-8. 2003
    ..The effects of these channels may result from prevention/attenuation of [Ca2+]i overload induced by ischaemic insults...
  10. ncbi request reprint Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion
    Hang Mee Yeung
    Dept of Physiology, University of Hong Kong, Pokfulam, Hong Kong
    Am J Physiol Cell Physiol 292:C2046-56. 2007
    ..Thus, CIH confers cardioprotection against I/R injury in rat cardiomyocytes by altered Ca(2+) handling with augmented RyR and NCX activities via protein kinase activation...
  11. ncbi request reprint Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A
    Gennadi M Kravtsov
    Department of Physiology, 4 F Laboratory Block, Faculty of Medicine Bldgs, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
    Am J Physiol Cell Physiol 292:C1625-35. 2007
    ..The increased release of Ca(2+) through RyR and removal of Ca(2+) by NCX are believed to be responsible for the greater contractility and faster relaxation after Ovx...
  12. ncbi request reprint Role of reverse mode Na+/Ca2+ exchanger in the cardioprotection of metabolic inhibition preconditioning in rat ventricular myocytes
    Shu Zhuang Li
    Department of Physiology, Fourth Military Medical University, Xi an, 710032, China
    Eur J Pharmacol 561:14-22. 2007
    ..The results indicate that increased reverse mode NCX activity during preconditioning triggered cardioprotection, and reduced reverse mode NCX activity during reperfusion after index ischaemia conferred cardioprotection...
  13. ncbi request reprint Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning
    Chun mei Cao
    Department of Physiology, 4 F, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
    J Pharmacol Exp Ther 312:644-50. 2005
    ..In conclusion, the study provides evidence that the K(Ca) channel triggers cardioprotection of IPC, which involves mPTP...
  14. ncbi request reprint Attenuated "cross talk" between kappa-opioid receptors and beta-adrenoceptors in the heart of chronically hypoxic rats
    Jian Shan
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, SAR, China
    Pflugers Arch 444:126-32. 2002
    ..The attenuation may be due to decreased responses of Gs-protein and adenylyl cyclase to kappa-opioid receptor activation in addition to desensitization of the receptor itself...
  15. ncbi request reprint Cardioprotection of interleukin-2 is mediated via kappa-opioid receptors
    Chun mei Cao
    Department of Physiology, The University of Hong Kong, Hong Kong Special Administrative Region, SAR, China
    J Pharmacol Exp Ther 309:560-7. 2004
    ....
  16. ncbi request reprint In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes
    Guo Sheng Xiao
    Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Anesthesiology 103:280-6. 2005
    ..L), delayed rectifier K+ current (IK), and inward rectifier K+ current (IK1) in isolated rabbit ventricular myocytes...
  17. ncbi request reprint Aprikalim reduces the Na+-Ca2+ exchange outward current enhanced by hyperkalemia in rat ventricular myocytes
    Hong yu Li
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Ann Thorac Surg 73:1253-9; discussion 1259-60. 2002
    ..There is evidence that cardioplegia increases the Na+-Ca2+ exchange activity without affecting Ca2+ influx through L-type Ca2+ channels or Ca2+ content in the sarcoplasmic reticulum, the intracellular Ca2+ store...
  18. pmc Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins
    Wai Ho Tang
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Mol Cell Cardiol 49:58-69. 2010
    ..Thus, in I/R heart, inhibition of polyol pathway improved the function of SERCA and RyR by protecting them from irreversible oxidation...
  19. pmc Role of protein kinase C-epsilon in the development of kappa-opioid receptor tolerance to U50,488H in rat ventricular myocytes
    Jing Jun Zhou
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 135:1675-84. 2002
    ..These results indicate that activation of PKC-epsilon is a critical step in the development of tolerance in the kappa-OR...
  20. doi request reprint Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa, and mu opioid receptors in rats
    Rui Li
    Department of Anesthesiology, University of Hong Kong, Hong Kong
    Anesth Analg 108:23-9. 2009
    ..In this study, we compared the extent of cardioprotection conferred by IT-MPC with IPC and investigated the role of opioid receptors in this effect...
  21. ncbi request reprint Testosterone and cardioprotection against myocardial ischemia
    Sharon Tsang
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam, HKSAR, China
    Cardiovasc Hematol Disord Drug Targets 7:119-25. 2007
    ..Further studies are warranted to further delineate the integration of signaling mechanisms and to explore the possibility of using testosterone in the aging male population with ischemic heart diseases...
  22. ncbi request reprint Involvement of anion channel(s) in the modulation of the transient outward K(+) channel in rat ventricular myocytes
    Xiao Gang Lai
    Department of Physiology, The Fourth Military Medical University, Xi an 710032, China
    Am J Physiol Cell Physiol 287:C163-70. 2004
    ..These results suggest that the I(to) channel is modulated by anion channel(s), in which the actin cytoskeleton may be implicated...
  23. ncbi request reprint Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes
    Guo Sheng Xiao
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China
    Eur J Pharmacol 473:97-103. 2003
    ..These results indicate that U50,488H affects both Ito1 and IKur in young human atrial myocytes in an opioid receptor-independent manner...
  24. ncbi request reprint Effects of heat shock protein 70 activation by metabolic inhibition preconditioning or kappa-opioid receptor stimulation on Ca2+ homeostasis in rat ventricular myocytes subjected to ischemic insults
    Jing Liu
    Department of Physiology, Institute of Cardiovascular Sciences and Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Pharmacol Exp Ther 310:606-13. 2004
    ..This study provides first evidence that activation of HSP70 induced by preconditioning, which conferred delayed cardioprotection, restored partially the [Ca(2+)](i) homeostasis altered by ischemic insults...
  25. ncbi request reprint Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors
    Ye Zhang
    Department of Anaesthesiology, University of Hong Kong, China
    Anesthesiology 102:371-8. 2005
    ..The authors also investigated the involvement of signaling mechanisms, namely protein kinase C and mitochondrial adenosine triphosphate-sensitive potassium (KATP) channels...
  26. pmc Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats
    Kenneth W L Kam
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Br J Pharmacol 144:972-81. 2005
    ....
  27. ncbi request reprint Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart
    X C Yu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Life Sci 68:2863-72. 2001
    ....
  28. ncbi request reprint Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes
    Zhan Gao
    Institute of Cardiovascular Science and Medicine, University of Hong Kong, SAR Hong Kong, China
    Cell Signal 16:333-41. 2004
    ..These results indicate that activation of I(to), I(ss), and I(K1) channels is modulated by genistein-sensitive PTKs in rat ventricular myocytes...
  29. ncbi request reprint Forskolin fails to activate L-type calcium current in hypertrophied cardiomyocytes of chronically hypoxic rats
    Man Lung Fung
    Department of Physiology, Institute of Cardiovascular Science and Medicine, University of Hong Kong, Pokfulam, People s Republic of China
    Life Sci 70:1801-9. 2002
    ..The failure of activation of the Ca2+ current is consistent with the idea that adenylyl cyclase function is down-regulated in CH hypertrophied myocytes...
  30. ncbi request reprint Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioning
    Jing Liu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, 4 F Laboratory Block, Faculty of Medicine Buildings, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Endocrinology 147:4569-77. 2006
    ..In conclusion, preconditioning requires testosterone to increase heat shock protein 70 synthesis, which mediates delayed cardioprotection in the male. These effects of testosterone are mediated by the androgen receptor...
  31. doi request reprint Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane
    Yuan Zhou
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Toxicology 290:295-304. 2011
    ..L), I(to), I(Na), HCN2, and hERG channels...
  32. ncbi request reprint Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat
    X C Yu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Pharm Pharmacol 56:115-22. 2004
    ..Since only 7% of the extract was tetrandrine, the observation indicates that tetrandrine was not the only component that was responsible for the actions of the extract...
  33. ncbi request reprint Estrogen reduces cardiac injury and expression of beta1-adrenoceptor upon ischemic insult in the rat heart
    Kenneth W L Kam
    Department of Physiology, Faculty of Medicine, The University of Hong Kong Special Administrative Region, China
    J Pharmacol Exp Ther 309:8-15. 2004
    ..Therefore, suppression of the enhanced expression of cardiac beta(1)-AR in Ovx rats represents a novel cardioprotective mechanism of estrogen replacement therapy...
  34. ncbi request reprint A new view of K+ -induced contraction in rat aorta: the role of Ca2+ binding
    Gennadi M Kravtsov
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, ROC
    Pflugers Arch 446:529-40. 2003
    ..This Ca2+ binding may then activate actin-myosin interaction...
  35. doi request reprint Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart
    Wai Ho Tang
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Free Radic Biol Med 45:602-10. 2008
    ..This was confirmed by the fact that administration of the iron chelator deferoxamine attenuated the I/R-induced myocardial infarction...
  36. ncbi request reprint Cardiac effects of the extract and active components of Radix stephaniae tetrandrae. I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox
    S Wu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Life Sci 68:2853-61. 2001
    ..The observations suggest that the RST extract, which contains a mixture of components, may have more potent effects in the heart than its main active component...
  37. ncbi request reprint Remifentanil preconditioning protects against ischemic injury in the intact rat heart
    Ye Zhang
    Department of Anaesthesiology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Anesthesiology 101:918-23. 2004
    ..Remifentanil is a new, potent ultra-short-acting phenylpiperidine opioid used in high doses for anesthesia. The authors hypothesize that pretreatment with this drug confers cardioprotection...
  38. pmc Calcium antagonistic and antiarrhythmic actions of CPU-23, a substituted tetrahydroisoquinoline
    H Dong
    Department of Physiology, Faculty of Medicine, University of Hong Kong
    Br J Pharmacol 109:113-9. 1993
    ....
  39. ncbi request reprint Melatonin potentiates phenylephrine-stimulated intracellular Ca2+ transient in smooth muscle cell of large arteries of chick embryo
    Xiao Fei Wang
    Department of Physiology, University of Hong Kong, SAR, China
    J Cardiovasc Pharmacol 40:356-62. 2002
    ..Melatonin potentiates the effects of alpha1-adrenergic stimulation...
  40. ncbi request reprint Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration
    William Ka Kei Wu
    Department of Pharmacology, Basic Medical Sciences Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Mol Cell Biochem 308:219-26. 2008
    ..In conclusion, the present study demonstrates for the first time that voltage-gated K(+) and Na(+) channels are involved in the modulation of gastric epithelial cell migration...
  41. ncbi request reprint Reduced inhibitory actions of adenosine A1 and kappa 1-opioid receptor agonists on beta-adrenoceptors in spontaneously hypertensive rat heart
    X C Yu
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong
    Clin Exp Pharmacol Physiol 24:976-7. 1997
    ....
  42. ncbi request reprint Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes
    J J Zhou
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Am J Physiol Heart Circ Physiol 281:H40-7. 2001
    ..These observations provide evidence that stress-inducible HSP70 mediates delayed cardioprotection of prior kappa-OR stimulation...
  43. pmc Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulation
    S Tsang
    Department of Physiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Br J Pharmacol 153:693-709. 2008
    ..Androgen receptors are present in the heart, and testosterone upregulates gene expression of cardiac beta(1)-adrenoceptors. We hypothesize that testosterone may confer cardioprotection by interacting with adrenoceptors...
  44. ncbi request reprint Role of opioid receptors in cardioprotection of cold-restraint stress and morphine
    S Wu
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    J Biomed Sci 11:726-31. 2004
    ..The effects were also attenuated by blockade of protein kinase C or the mitochondrial K(ATP) channel. The finding is first evidence that all three OR subtypes mediate cardioprotection of cold-restraint stress in the rat...
  45. ncbi request reprint Remifentanil preconditioning confers delayed cardioprotection in the rat
    C K Yu
    Department of Anaesthesiology, The University of Hong Kong, Queen Mary Hospital, Room 424, Block K, Pokfulam Road, Hong Kong
    Br J Anaesth 99:632-8. 2007
    ..Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors...
  46. ncbi request reprint Failure to confer cardioprotection and to increase the expression of heat-shock protein 70 by preconditioning with a kappa-opioid receptor agonist during ischaemia and reperfusion in streptozotocin-induced diabetic rats
    J S Qi
    Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 4 F Laboratory Block, Hong Kong SAR, China
    Diabetologia 47:214-20. 2004
    ..The aim of this study was to determine the effects of preconditioning on injury and expression of heat shock proteins 70 in diabetic rat hearts...
  47. doi request reprint kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B)
    Guoqiang Wu
    Key Laboratory of Molecular Biology and Drug Research, Liaoning Medical College, Liaoning, PR China
    Eur J Pharmacol 595:52-7. 2008
    ..These results suggest that the inhibitory effect of kappa-opioid receptor stimulation on beta(1)-adrenoceptor stimulation may also involve CaMKIIdelta...
  48. ncbi request reprint kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the rat
    Dan Shan
    Key Lab of Molecular Biology and Drug Research, Jinzhou Medical College, Jinzhou, China
    Eur J Pharmacol 555:100-5. 2007
    ..In conclusion the results show that kappa-opioid receptor stimulation abolished both the cardiac hypertrophy and enhanced amplitude and frequency of the spontaneous intracellular Ca2+ transient induced by beta1-adrenoceptor stimulation...
  49. ncbi request reprint Further study on the role of HSP70 on Ca2+ homeostasis in rat ventricular myocytes subjected to simulated ischemia
    Jing Liu
    Muscular and Neurodegenerative Disease Unit, University of Genoa and G Gaslini Pediatric Institute, Genoa, Italy
    Am J Physiol Cell Physiol 290:C583-91. 2006
    ....
  50. ncbi request reprint delta-Opioid receptor stimulation enhances the growth of neonatal rat ventricular myocytes via the extracellular signal-regulated kinase pathway
    Min Zhao
    Key Laboratory of Molecular Biology and Drug Research, Liaoning Medical College, Liaoning, China
    Clin Exp Pharmacol Physiol 35:97-102. 2008
    ..5. In conclusion, delta-opioid receptor stimulation enhances the proliferation and development of the ventricular myocytes of neonatal rats. The ERK pathway and related signalling mechanisms, namely PKC and PKA, are involved...
  51. ncbi request reprint Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes
    Guijun Wang
    Department of Pharmacology, Jinzhou Medical College, Jinzhou, China
    Eur J Pharmacol 498:53-8. 2004
    ..The stimulatory effects of sympathetic activity on growth occurs via both alpha- and beta-adrenoceptors...
  52. doi request reprint 2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner
    Gudrun H Borchert
    University of the Balearic Islands, Palma de Mallorca, Spain
    Am J Physiol Heart Circ Physiol 294:H1948-55. 2008
    ..The present results indicate that 2-OHOA selectively increases myocyte inotropic responsiveness, which could underlie its beneficial cardiovascular effects...