William Ignace Wei

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Nasopharyngeal cancer: current status of management: a New York Head and Neck Society lecture
    W I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Arch Otolaryngol Head Neck Surg 127:766-9. 2001
  2. ncbi request reprint Quantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: a prospective study
    William I Wei
    Division of Head Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Head Neck 26:878-83. 2004
  3. ncbi request reprint Complications of resection of malignant tumours of the skull base: outcome and solution
    William I Wei
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Eur Arch Otorhinolaryngol 264:733-9. 2007
  4. ncbi request reprint The management of neck metastases in nasopharyngeal cancer
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Curr Opin Otolaryngol Head Neck Surg 15:99-102. 2007
  5. ncbi request reprint Safe tracheostomy for patients with severe acute respiratory syndrome
    William I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, Republic of China
    Laryngoscope 113:1777-9. 2003
  6. ncbi request reprint Cancer of the nasopharynx: functional surgical salvage
    William Ignace Wei
    Department of Surgery, Room 206, Professorial Block, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    World J Surg 27:844-8. 2003
  7. ncbi request reprint Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
  8. ncbi request reprint Commentary: Head and neck carcinomas in the developing world
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    BMJ 325:827. 2002
  9. doi request reprint Surgical salvage of persistent or recurrent nasopharyngeal carcinoma with maxillary swing approach - Critical appraisal after 2 decades
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Head Neck 33:969-75. 2011
  10. ncbi request reprint Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: a clinicopathological study
    W I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Arch Otolaryngol Head Neck Surg 127:1457-62. 2001

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Nasopharyngeal cancer: current status of management: a New York Head and Neck Society lecture
    W I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Arch Otolaryngol Head Neck Surg 127:766-9. 2001
    ..We have achieved a better tumor control rate with conformal radiotherapy and chemotherapy. Surgical salvage treatment has also contributed to helping patients with localized disease in the neck or in the nasopharynx...
  2. ncbi request reprint Quantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: a prospective study
    William I Wei
    Division of Head Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Head Neck 26:878-83. 2004
    ..We measured the copy number of EBV DNA in patients with early recurrent NPC before and after salvage nasopharyngectomy...
  3. ncbi request reprint Complications of resection of malignant tumours of the skull base: outcome and solution
    William I Wei
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Eur Arch Otorhinolaryngol 264:733-9. 2007
    ..Conservative treatment is applicable for small leakage while for large leakage; the exact location of the leak must be identified before the defect can be closed successfully...
  4. ncbi request reprint The management of neck metastases in nasopharyngeal cancer
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Curr Opin Otolaryngol Head Neck Surg 15:99-102. 2007
    ..The strategy of diagnosis and treatment for the lymph nodes on presentation and those that have recurred after initial therapy are different. This review presents the current concept...
  5. ncbi request reprint Safe tracheostomy for patients with severe acute respiratory syndrome
    William I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, Republic of China
    Laryngoscope 113:1777-9. 2003
    ..Some of these patients may require tracheostomy subsequently. This procedure, when performed without protection, may lead to infection of the medical and nursing staff taking care of the patient...
  6. ncbi request reprint Cancer of the nasopharynx: functional surgical salvage
    William Ignace Wei
    Department of Surgery, Room 206, Professorial Block, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    World J Surg 27:844-8. 2003
    ..After a median follow up of 3 years, the 82 patients who underwent this operation demonstrate that with adequate exposure and surgical salvage, satisfactory tumor control rate with good functional outcome is possible...
  7. ncbi request reprint Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
    ..Screening of high-risk individuals in endemic regions together with developments in gene therapy and immunotherapy might further improve outcome...
  8. ncbi request reprint Commentary: Head and neck carcinomas in the developing world
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    BMJ 325:827. 2002
  9. doi request reprint Surgical salvage of persistent or recurrent nasopharyngeal carcinoma with maxillary swing approach - Critical appraisal after 2 decades
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Head Neck 33:969-75. 2011
    ..The purpose of this study was to report on our experience on salvage nasopharyngectomy using the maxillary swing approach for persistent or recurrent nasopharyngeal carcinoma after primary treatment...
  10. ncbi request reprint Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: a clinicopathological study
    W I Wei
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Arch Otolaryngol Head Neck Surg 127:1457-62. 2001
    ....
  11. doi request reprint Recurrent nasopharyngeal carcinoma: surgical salvage vs. additional chemoradiation
    William I Wei
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Curr Opin Otolaryngol Head Neck Surg 19:82-6. 2011
    ..It is timely to review the applicability and efficacy of the various therapeutic options...
  12. ncbi request reprint The dilemma of treating hypopharyngeal carcinoma: more or less: Hayes Martin Lecture
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    Arch Otolaryngol Head Neck Surg 128:229-32. 2002
    ..Adequate tumor extirpation with less extensive and invasive procedures preserving unaffected normal tissue contribute to more tumor control and less morbidity...
  13. ncbi request reprint Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 10:2401-6. 2004
    ..This study aims at evaluation of the potential use of methylated gene promoter DNA as a serological tumor marker of primary and potentially salvageable local or nodal recurrent NPC...
  14. doi request reprint Extracapsular lymph node spread in recurrent nasopharyngeal carcinoma
    Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 121:2576-80. 2011
    ..To study the efficacy of combined neck dissection and brachytherapy for nodal metastasis with extracapsular spread (ECS) in recurrent nasopharyngeal carcinoma (NPC)...
  15. doi request reprint Efficacy of neck dissection for locoregional failures versus isolated nodal failures in nasopharyngeal carcinoma
    Raymond King Yin Tsang
    Department of Surgery, Division of Otorhinolaryngology Head and Neck Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Head Neck 34:638-42. 2012
    ..Neck dissection has been shown to be effective in controlling nodal failures in nasopharyngeal carcinoma. Its efficacy in controlling the disease in patients with synchronous locoregional failure is, however, not documented...
  16. ncbi request reprint Evaluation of hypermethylated tumor suppressor genes as tumor markers in mouth and throat rinsing fluid, nasopharyngeal swab and peripheral blood of nasopharygeal carcinoma patient
    Hsiao Wen Chang
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR, China
    Int J Cancer 105:851-5. 2003
    ..Epigenetic change is found frequently in NPC and the high detection rate in body fluids suggest its potential application in non-invasive screening of NPC or detection of residual carcinoma after treatment...
  17. doi request reprint Early prediction of anastomotic leakage after free jejunal flap reconstruction of circumferential pharyngeal defects
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Plast Reconstr Aesthet Surg 66:376-81. 2013
    ..Anastomotic leakage from the free jejunal flap, if diagnosed late, can result in catastrophes. Our study aims to look for clinical parameters that allow early identification of leakage so that appropriate interventions can be taken...
  18. doi request reprint Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma
    Anthony Po Wing Yuen
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Head Neck 31:765-72. 2009
    ..There are controversies on the benefits of elective neck dissection (END) for oral tongue carcinoma...
  19. ncbi request reprint Differential gene methylation in undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, P R China
    Int J Oncol 22:869-74. 2003
    ..The results show high frequency of methylation in NPC and the potential of using methylation as peripheral blood tumor marker in screening NPC...
  20. ncbi request reprint Promoter hypermethylation of high-in-normal 1 gene in primary nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR China
    Clin Cancer Res 9:3042-6. 2003
    ..The relationship between HIN-1 promoter methylation and transcription in NPC cell lines was evaluated by reverse transcription-PCR and demethylation agent treatment (5-aza-2-deoxycytidine)...
  21. doi request reprint Current management strategy of hypopharyngeal carcinoma
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region
    Auris Nasus Larynx 40:2-6. 2013
    ..In this article, several aspects of surgical and non-surgical approaches in the management of hypopharyngeal cancer are discussed...
  22. doi request reprint Prediction of surgical outcome using plasma Epstein-Barr virus dna and (18)F-FDG PET-CT scan in recurrent nasopharyngeal carcinoma
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Head Neck 34:541-5. 2012
    ....
  23. ncbi request reprint Live donor liver transplantation for fulminant hepatic failure in children
    Chi Leung Liu
    Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Liver Transpl 9:1185-90. 2003
    ..051; patient survival, 89%; P =.281). Although survival outcomes are inferior to those in elective situations, LDLT is a timely and lifesaving procedure for children with FHF...
  24. doi request reprint Efficacy of salvage neck dissection for isolated nodal recurrences in early carcinoma of oral tongue with watchful waiting management of initial N0 neck
    Raymond King Yin Tsang
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Head Neck 33:1482-5. 2011
    ..Recent studies have shown that salvage treatment may be effective for early tongue carcinoma with nodal failures after watchful waiting policy. We wanted to assess the efficacy of salvage neck dissection...
  25. pmc Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center
    Chi Leung Liu
    Centre for the Study of Liver, University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 243:404-10. 2006
    ..To evaluate and compare the operative and survival outcomes of patients who underwent right lobe live donor liver transplantation (RLDLT) and cadaveric whole-graft liver transplant (CWLT) recipients in a single institution...
  26. ncbi request reprint Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma
    Hsiao Wen Chang
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Cancer 101:125-32. 2004
    ..In this study, the authors evaluated the effects of tobacco and alcohol on p15 gene methylation of cells in cells from the mouth and throat of physically healthy individuals and patients with HNSCC...
  27. ncbi request reprint Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
    Thian Sze Wong
    Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, China
    Anticancer Res 30:2851-6. 2010
    ..We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells...
  28. ncbi request reprint Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade
    William Ignace Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, People s Republic of China
    Arch Surg 139:304-7. 2004
    ..Hepatic arterial anastomosis by means of a microvascular technique can be performed with a high success rate in live donor liver transplantation in adult recipients...
  29. ncbi request reprint Long-term performance of indwelling tracheoesophageal speaking valves in Chinese patients undergoing laryngectomy
    Paul Kin Yip Lam
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Otolaryngol Head Neck Surg 131:954-8. 2005
    ..To assess the use of indwelling tracheoesophageal speaking valves in Chinese patients undergoing laryngectomy, to identify the clinicopathologic factors for favorable outcome, and to evaluate the factors that determine prosthesis lifetime...
  30. doi request reprint Quality of dying in head and neck cancer patients: the role of surgical palliation
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, People s Republic of China
    Eur Arch Otorhinolaryngol 270:681-8. 2013
    ..4 days. In selected patients, surgery is effective in palliating symptoms which are otherwise difficult to manage. Detailed planning and good communication is the key to success in improving the quality of dying...
  31. doi request reprint Efficacy of fine-needle aspiration in diagnosing cervical nodal metastasis from nasopharyngeal carcinoma after radiotherapy
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 123:134-9. 2013
    ..Our purpose was to study the effect of previous radiotherapy (RT) on the efficacy of fine-needle aspiration (FNA) in diagnosing cervical nodal metastasis in nasopharyngeal carcinoma (NPC)...
  32. doi request reprint Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10
    Raymond King Yin Tsang
    Department of Surgery, The University of Hong Kong, SAR China
    Cancer Invest 30:503-12. 2012
    ..Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion...
  33. ncbi request reprint Overexpression of Epstein-Barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma
    Jimmy Yu Wai Chan
    Department of Surgery, The University of Hong Kong, China
    Anticancer Res 32:3201-10. 2012
    ..To validate Epstein-Barr virus BamHI-A rightward transcript 7 microRNA (ebv-miR-BART7) expression in plasma from patients with nasopharyngeal carcinoma (NPC) and explore the oncogenic role of ebv-miR-BART7 in NPC cells...
  34. pmc MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Cancer Res Clin Oncol 137:415-22. 2011
    ..This study aimed at evaluating the potential anti-proliferative effects of the microRNA let-7 family in nasopharyngeal carcinoma (NPC) cells. In addition, the association between let-7 suppression and DNA hypermethylation is examined...
  35. doi request reprint Mature miR-184 and squamous cell carcinoma of the tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong
    ScientificWorldJournal 9:130-2. 2009
    ..The data suggested that miR-184 is linked to the pathogenesis of tongue SCC. Further studies are warranted to evaluate the use of microRNA-based serological markers in monitoring tongue SCC...
  36. ncbi request reprint Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery
    Ling Yuen Wong
    Division of Otorhinolaryngology, Department of Surgery, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Head Neck 25:953-9. 2003
    ..The efficacy of salvage treatment of recurrent head and neck squamous cell carcinomas (HNSCC) after primary curative surgery was evaluated...
  37. ncbi request reprint Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance
    Hsiao Wen Chang
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, SAR China
    Cancer 94:386-92. 2002
    ..This study evaluated the role of promoter dense methylation in the downregulation of E-cadherin expression in oral tongue carcinoma...
  38. doi request reprint Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
    ..The aim of this study was to evaluate the microRNA expression patterns in squamous cell carcinoma (SCC) of the tongue...
  39. doi request reprint The role of myringotomy and ventilation tube insertion in maxillary swing approach nasopharyngectomy: review of our 10-year experience
    Ambrose Chung Wai Ho
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Laryngoscope 123:376-80. 2013
    ..The outcome of this otologic procedure has never been reviewed and discussed. The purpose of this study is to examine the role of myringotomy with ventilation tube insertion in this group of patients...
  40. doi request reprint Reconstruction of circumferential pharyngeal defects after tumour resection: reference or preference
    Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Plast Reconstr Aesthet Surg 64:1022-8. 2011
    ..Reconstruction of circumferential hypopharyngeal defects is often challenging. The aim of the study is to examine the result of our experience and to formulate improved management guidelines...
  41. doi request reprint Early resection and reconstruction of head and neck masses in infants with upper airway obstruction
    Birgitta Yee Hang Wong
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Int J Pediatr Otorhinolaryngol 74:287-91. 2010
    ....
  42. ncbi request reprint Prognostic factors of clinically stage I and II oral tongue carcinoma-A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features
    Anthony Po Wing Yuen
    Department of Otorhinolaryngology, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Head Neck 24:513-20. 2002
    ..The results will have important implication for the management of patients...
  43. ncbi request reprint Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinsing fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patient
    Hsiao Wen Chang
    Department of Surgery, The University of Hong Kong, Hong Kong, People s Republic of China
    Clin Cancer Res 9:1033-8. 2003
    ....
  44. ncbi request reprint Short electrode insertion in cochlear implantation: speech perception performance of Cantonese-speaking subjects
    Katie Mee Yee Chu
    Division of Otorhinolaryngology, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, People s Republic of China
    Acta Otolaryngol 125:718-24. 2005
    ..It is thus recommended that the insertion of short electrode arrays should be considered an alternative choice for patients with cochlear ossification...
  45. ncbi request reprint Thyroid dysfunction in laryngectomees-10 years after treatment
    Ambrose Chung Wai Ho
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Head Neck 30:336-40. 2008
    ....
  46. doi request reprint Secondary head and neck cancer in patients with history of hematological malignancy
    Joseph Chun Kit Chung
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Regions, People s Republic of China
    Head Neck 35:729-32. 2013
    ..Head and neck cancer is a common second cancer in patients with a history of hematological malignancies. The purpose of this study was present the clinical characteristics and treatment outcomes of this group of patients...
  47. ncbi request reprint Management of head and neck tumours during pregnancy: case report and literature review
    Velda Ling Yu Chow
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR
    Asian J Surg 31:199-203. 2008
    ..Pregnancy was terminated at 16 weeks. She received a course of neoadjuvant chemoirradiation...
  48. doi request reprint Anatomical study and clinical applications of free posterior tibial flap in the head and neck region
    Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong SAR, China
    Plast Reconstr Surg 128:131e-139e. 2011
    ..The purpose of this study was to examine the anatomical features, clinical applications, and donor-site morbidities of the free posterior tibial flap...
  49. ncbi request reprint Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma
    David Wing Yuen Ho
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer 107:99-107. 2006
    ..The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer...
  50. doi request reprint Mucosal melanoma of the head and neck: 32-year experience in a tertiary referral hospital
    Richie Chiu Lung Chan
    Division of Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, Hong Kong
    Laryngoscope 122:2749-53. 2012
    ..Primary mucosal melanomas of the head and neck (HNMM), albeit being rare, are rapidly lethal. Here we report the experience of patients with HNMM treated in our institution over a 32-year period...
  51. doi request reprint Quality of life of patients after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma
    Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong SAR, China
    Cancer 118:3710-8. 2012
    ..The objective of this study was to examine the quality of life (QOL) of patients who underwent salvage nasopharyngectomy for residual or recurrent nasopharyngeal carcinoma and to justify the value of the procedure...
  52. doi request reprint The changing role of pectoralis major flap in head and neck reconstruction
    Hin Lun Liu
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Eur Arch Otorhinolaryngol 267:1759-63. 2010
    ..In the era of free tissue transfer, the role of PM flap in head and neck surgery has shifted from immediate reconstruction to salvage operation. However, PM flap still has an unique role in the repair of certain head and neck defects...
  53. pmc Extracranial head and neck Schwannomas: a study of the nerve of origin
    Hin Lun Liu
    Division of Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam, Hong Kong, SAR, China
    Eur Arch Otorhinolaryngol 268:1343-7. 2011
    ..Sympathetic trunk and vagus nerve are the two common NOOs. MRI is the investigation of choice in the diagnosis of schwannoma and the identification of NOO...
  54. doi request reprint Second primary squamous cell carcinoma arising in the skin of a pectoralis major myocutaneous flap 12 years after floor of mouth reconstruction
    Ambrose Chung Wai Ho
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Eur Arch Otorhinolaryngol 268:147-50. 2011
    ..Long-term follow up and awareness of this complication are needed for head and neck cancer patients after resection and reconstruction...
  55. ncbi request reprint Management of the N0 neck--reference or preference
    William I Wei
    Division of Head and Neck Surgery, Otorhinolaryngology, Plastic and Reconstructive Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, Peoples Republic of China
    Oral Oncol 42:115-22. 2006
    ....
  56. doi request reprint Stenting of the eustachian tube to prevent otitis media with effusion after maxillary swing approach nasopharyngectomy
    Ambrose Chung Wai Ho
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Laryngoscope 124:139-44. 2014
    ..The purpose of this study was to examine the feasibility of intraoperative ET stenting and the efficacy of preventing ipsilateral OME formation...
  57. doi request reprint Postradiation sarcoma after radiotherapy for nasopharyngeal carcinoma
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 122:2695-9. 2012
    ..The prognosis is poor, and the role of surgery is not well defined. The aim of our study was to review our experience in the management of PRS after RT for nasopharyngeal carcinoma (NPC)...
  58. doi request reprint Recurrent nasopharyngeal carcinoma after salvage nasopharyngectomy
    Jimmy Yu Wai Chan
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong
    Arch Otolaryngol Head Neck Surg 138:572-6. 2012
    ..To study the safety and oncological outcome of salvage surgery for local tumor recurrence after previous maxillary swing nasopharyngectomy...
  59. doi request reprint Critical appraisal of maxillary swing approach for nasopharyngeal carcinoma
    Jimmy Yu Wai Chan
    University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Division of Head and Neck Surgery, Department of Surgery, 102 Pokfulam Road, Hong Kong SAR, China
    Expert Opin Ther Targets 16:S111-7. 2012
    ..The aim of the current study was to report results of salvage nasopharyngectomy using the maxillary swing approach for persistent or recurrent nasopharyngeal carcinoma after primary treatment...
  60. ncbi request reprint Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis
    Paul Lam
    Department of Surgery, Division of Otorhinolaryngology Head and Neck Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, Hong Kong
    Am J Otolaryngol 27:186-9. 2006
    ..To date, however, there is no study to evaluate the prevalence of pH-documented LPR in the Chinese ethnicity...
  61. doi request reprint Natural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patients
    Ambrose Chung Wai Ho
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, Hong Kong
    Oral Oncol 47:742-6. 2011
    ..The current study showed that NPC has a propensity to grow superiorly to involve the skull base rather than laterally or anteriorly. Although the tumor growth rate was very variable, the median natural NPC growth rate was 1.63mm(3)/day...
  62. ncbi request reprint Correlating MRI and histologic tumor thickness in the assessment of oral tongue cancer
    Paul Lam
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong ROC
    AJR Am J Roentgenol 182:803-8. 2004
    ..These included stage I (tumor < or = 3 mm), stage II (> 3 mm but < or = 9 mm) and stage III (> 9 mm)...
  63. ncbi request reprint Control of regional metastasis after induction chemotherapy and radiotherapy for nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, PB 115, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong
    Head Neck 24:350-60. 2002
    ..To study the impact of adding induction chemotherapy to radiotherapy on the long-term control of regional metastasis and survival in patients with nasopharyngeal carcinoma (NPC)...
  64. ncbi request reprint Radial clearance in resection of hypopharyngeal cancer: an independent prognostic factor
    Chiu M Ho
    Department of Surgery, Kwong Wah Hospital, Hong Kong
    Head Neck 24:181-90. 2002
    ..The depth of infiltration of tumor is of particular relevance in hypopharyngeal cancers, because most of them are seen late, and extensive infiltration into the muscle wall and the cartilage are not uncommon...
  65. ncbi request reprint A prospective controlled double-blind trial of great auricular nerve preservation at parotidectomy
    Yau Hui
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, PR China
    Am J Surg 185:574-9. 2003
    ..Earlier reports of the advantages of preservating the posterior branches of the great auricular nerve (GAN) at parotidectomy were conflicting. This prospective study was aimed at clarifying the controversy...
  66. doi request reprint Capecitabine monotherapy for recurrent and metastatic nasopharyngeal cancer
    Daniel Chua
    Department of Clinical Oncology, PB 115, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Jpn J Clin Oncol 38:244-9. 2008
    ..We conducted a retrospective review of patients who received capecitabine for recurrent and metastatic NPC to further evaluate its clinical benefits...
  67. ncbi request reprint Elimination of palatal fistula after the maxillary swing procedure
    Raymond W M Ng
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Head Neck 27:608-12. 2005
    ..We describe a modified palatal incision to reduce the incidence of palatal fistula associated with the maxillary swing procedure...
  68. pmc Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 42:2884-9. 2004
    ..Further studies on serial clinical specimens should reveal the duration of nucleocapsid protein shedding and may reveal a higher detection rate in SARS patients...
  69. ncbi request reprint Quality of life of patients with recurrent nasopharyngeal carcinoma treated with nasopharyngectomy using the maxillary swing approach
    Raymond W M Ng
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Arch Otolaryngol Head Neck Surg 132:309-16. 2006
    ..To investigate factors affecting the quality of life (QOL) of patients with recurrent nasopharyngeal carcinoma who underwent a nasopharyngectomy using the maxillary swing approach...
  70. ncbi request reprint ENT management of a child with CHARGE association
    Dennis K K Au
    Division of Otorhinolaryngology, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Block S3, 102 Pokfulam Road, Hong Kong SAR, China
    Asian J Surg 27:141-3. 2004
    ..The benefits of cochlear implantation in children with multiple congenital defects are discussed...
  71. ncbi request reprint Time course in the relief of nasal blockage after septal and turbinate surgery: a prospective study
    Wai Kuen Ho
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, Queen Mary Hospital, University of Hong Kong Medical Centre, Hong Kong
    Arch Otolaryngol Head Neck Surg 130:324-8. 2004
    ..To evaluate prospectively the time course of the change in efficacy of septal and turbinate surgery in relieving nasal obstruction...
  72. ncbi request reprint Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Int J Radiat Oncol Biol Phys 69:469-74. 2007
    ..Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known...
  73. ncbi request reprint Late oral complications following radiotherapy for head and neck cancers
    Daniel T T Chua
    The University of Hong Kong, PB 115, Department of Clinical Oncology, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Expert Rev Anticancer Ther 7:1215-24. 2007
    ..This article examines the current issue of late oral complications after radiotherapy, with an emphasis on the impact of recent advances in cancer treatment...
  74. ncbi request reprint Free posterior tibial flap for head and neck reconstruction after tumor expiration
    Raymond W M Ng
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 118:216-21. 2008
    ..Similar to the radial forearm flap, free tissue transfer of a fasciocutaneous flap is possible if the septocutaneous perforators of the posterior tibial vessels are preserved...
  75. doi request reprint Clinical implications of anterolateral thigh flap shrinkage
    Raymond W M Ng
    Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 118:585-8. 2008
    ..To evaluate anterolateral thigh flap shrinkage after elevation and to develop a predictive model for flap design...
  76. ncbi request reprint Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, PB 115, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong
    Head Neck 25:585-94. 2003
    ..To review the outcome and evaluate the prognostic factors in the treatment of synchronous locoregional failures of nasopharyngeal carcinoma (NPC)...
  77. doi request reprint Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Head Neck 30:863-7. 2008
    ..This single-center, phase II study assessed the safety/tolerability and initial efficacy of gefitinib in patients with nasopharyngeal carcinoma (NPC) pretreated with platinum-based chemotherapy...
  78. ncbi request reprint Current reconstruction options following tumour extirpation in head and neck surgery
    William Ignace Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Asian J Surg 25:41-8. 2002
    ..Contemporary head and neck surgeons should consider all the reconstructive options before deciding on the optimal reconstruction method after adequate tumour resection...
  79. ncbi request reprint Severe acute respiratory syndrome: what have we learned
    William Ignace Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Adv Surg 39:343-54. 2005
  80. doi request reprint Transoral robotic resection of recurrent nasopharyngeal carcinoma
    William I Wei
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Laryngoscope 120:2011-4. 2010
    ..Laryngoscope, 2010...
  81. ncbi request reprint Microvascular free tissue reconstruction following extirpation of head and neck tumour: experience towards an optimal outcome
    L K Lam
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    J Laryngol Otol 116:929-36. 2002
    ..The co-operation between the two surgical teams, together with the timely application of suitable salvage procedures, contribute to an optimal outcome...
  82. pmc Basal cell carcinoma of the head and neck region in ethnic chinese
    Velda Ling Yu Chow
    Division of Head and Neck, Plastic and Reconstructive Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong
    Int J Surg Oncol 2011:890908. 2011
    ..Adequate tumour excision ± reconstruction offered the best chance of cure. Reexcision of those with inadequate skin margins improved local tumour control...
  83. ncbi request reprint High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR China
    Clin Cancer Res 8:433-7. 2002
    ..Death-associated protein (DAP)-kinase gene is frequently inactivated by promoter hypermethylation in cancer. The aim of this study was to evaluate the promoter methylation status of the DAP-kinase gene in nasopharyngeal carcinoma (NPC)...
  84. ncbi request reprint Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure
    Chi Leung Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transplantation 76:1174-9. 2003
    ..This study evaluates the survival outcomes of patients who underwent LDLT using right-lobe liver grafts for acute-on-chronic hepatitis B liver failure...
  85. doi request reprint Esophageal cancers with synchronous or antecedent head and neck cancers: a more formidable challenge?
    Oswens Siu Hung Lo
    Division of Esophageal Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong
    Ann Surg Oncol 15:1750-6. 2008
    ..The presence of synchronous or antecedent head and neck cancers may complicate management of patients with primary esophageal cancer...
  86. pmc A chopstick in the nose
    William Ignace Wei
    Division of Otorhinolaryngology, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    J R Soc Med 95:614-5. 2002
  87. ncbi request reprint Superiority of bilateral cochlear implantation over unilateral cochlear implantation in tone discrimination in chinese patients
    Dennis Kin Kwok Au
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Am J Otolaryngol 24:19-23. 2003
    ..The benefits of bilateral cochlear implants (CIs) versus unilateral CIs were evaluated by comparing the Cantonese lexical tone discrimination scores conducted in a quiet environment and against a background noise...
  88. ncbi request reprint Permeatal temporalis fascia graft harvesting for minimally invasive myringoplasty
    Lawrence Chun Kuen Chow
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, China
    Laryngoscope 114:386-8. 2004
  89. ncbi request reprint Neurothekeoma of the paranasal sinuses in a 3-year-old boy
    Birgitta Yee Hang Wong
    Department of Otorhinolaryngology, Division of Otorhinolaryngology Head and Neck Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, SAR, Hong Kong, People s Republic of China
    Int J Pediatr Otorhinolaryngol 62:69-73. 2002
    ..This uncommon lesion should be considered as the differential diagnosis of pediatric soft tissue tumors in the head and neck region...
  90. ncbi request reprint Treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children
    X J Yuan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Hong Kong Med J 14:116-23. 2008
    ..To review the treatment outcome of rhabdomyosarcoma in Hong Kong Chinese children...
  91. ncbi request reprint Randomized evaluation of the audiologic outcome of ventilation tube insertion for middle ear effusion in patients with nasopharyngeal carcinoma
    Wai Kuen Ho
    Department of Surgery, Division of Otorhinolaryngology Head and Neck Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, PR China
    J Otolaryngol 31:287-93. 2002
    ..This study evaluates the hearing improvement after tube insertion compared with observation alone to see if the benefits of the procedure outweigh its potential complications...
  92. ncbi request reprint Medialization thyroplasty for cancer-related unilateral vocal fold paralysis
    Paul K Y Lam
    Division of Otorhinolaryngology, Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Otolaryngol Head Neck Surg 136:440-4. 2007
    ..To justify the application of medialization thyroplasty in Chinese patients with symptomatic cancer-related unilateral vocal fold paralysis (UVFP)...
  93. ncbi request reprint Outcome analysis of patients with craniofacial resection: Hong Kong experience
    Ling Yuen Wong
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    ANZ J Surg 76:313-7. 2006
    ....
  94. ncbi request reprint Methylation status of Reprimo in head and neck carcinomas
    Thian Sze Wong
    Int J Cancer 117:697. 2005
  95. ncbi request reprint [Radiological study of temporal bone in children with profound deafness before cochlear implant: CT vs magnetic resonance imaging]
    Wendy Wai man Lam
    Department of Otorhinolaryngology, Queen Mary Hospital, Hongkong, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 37:440-2. 2002
    ..To evaluate the clinical application of magnetic resonance imaging (MRI) and CT in children with profound deafness before cochlear implant and their impact on surgical decision...
  96. ncbi request reprint Classification of in vivo autofluorescence spectra using support vector machines
    Wumei Lin
    Hong Kong University of Science and Technology, Department of Electrical and Electronic Engineering, Clear Water Bay, Kowloon, Hong Kong, China
    J Biomed Opt 9:180-6. 2004
    ..In addition, we investigated a method combining PCA and SVM techniques for reducing the complexity of the SVM algorithms...
  97. ncbi request reprint A randomized treatment-placebo study of the effectiveness of acupuncture for benign vocal pathologies
    Edwin Yiu
    Voice Research Laboratory, Division of Speech and Hearing Sciences, The University of Hong Kong, Hong Kong, China
    J Voice 20:144-56. 2006
    ..Results revealed significant improvement in the treatment group in all three aspects when compared with the placebo group. The acupuncture effect was maintained into the second week after the completion of acupuncture treatment...
  98. ncbi request reprint Change in olfaction after radiotherapy for nasopharyngeal cancer--a prospective study
    Wai Kuen Ho
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Pokfulam, Hong Kong, PR China
    Am J Otolaryngol 23:209-14. 2002
    ..To evaluate the changes in olfactory function in patients with nasopharyngeal carcinoma who have received radiation to the head and neck...
  99. doi request reprint A decade of right liver adult-to-adult living donor liver transplantation: the recipient mid-term outcomes
    See Ching Chan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Ann Surg 248:411-9. 2008
    ..We analyzed a single center's experience over a decade of right liver living donor liver transplantation (RLDLT)...
  100. ncbi request reprint Cross-cultural adaptation and validation of the Chinese Voice Handicap Index-10
    Paul K Y Lam
    Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Laryngoscope 116:1192-8. 2006
    ..The VHI has been used worldwide; however, the psychometric properties of the Chinese version of VHI remains untested. This study aimed to investigate such properties of the Chinese VHI-30 and VHI-10 in the Hong Kong Chinese population...