Research Topics
Genomes and Genes
| Yu WangSummaryAffiliation: University of Hong Kong Country: China Publications
| Collaborators
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Detail Information
Publications
Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic miceYu Wang
Genome Research Center, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region, China
Mol Endocrinol 21:972-86. 2007..In summary, our results suggest that ANGPTL4 might elicit its metabolic effects through modulating the mitochondria functions and methionine metabolic cycles in the liver tissue...- Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent mannerYu Wang
Genome Research Centre and the Departments of Biochemistry and Medicine, The University of Hong Kong, Hong Kong, China
J Biol Chem 280:18341-7. 2005.... - Adiponectin as a negative regulator in obesity-related mammary carcinogenesisYu Wang
Genome Research Center, University of Hong Kong, Hong Kong SAR, China
Cell Res 17:280-2. 2007 - Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectinYu Wang
Genome Research Center and Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, P R China
Proteomics 6:3862-70. 2006..These proteins might serve as the physiological-binding partners of adiponectin and regulate its bioavailability and biological activities... - Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude miceYu Wang
Genome Research Center, University of Hong Kong, China
Cancer Res 66:11462-70. 2006..Taken together, these data support the role of adiponectin as a negative regulator of breast cancer development and also suggest that adiponectin might represent a novel therapeutic target for this disease... - Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complexYu Wang
Departments of Biochemistry and Medicine, Genome Research Centre, Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
J Biol Chem 281:16391-400. 2006.... 
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesityIvy K M Law
Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
Diabetes 59:872-82. 2010..The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic insulin sensitivity and the underlying mechanisms...- Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP KMingyan Zhou
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
PLoS ONE 7:e32349. 2012..The present study was designed to investigate the cellular and molecular mechanisms underlying adiponectin-induced UCP2 expression... 
Uncoupling protein-2 protects endothelial function in diet-induced obese miceXiao Yu Tian
Institute of Vascular Medicine, Hong Kong SAR, China
Circ Res 110:1211-6. 2012..UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear...- Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4Ying Hua Yang
Department of Medicine, The University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong
Arterioscler Thromb Vasc Biol 28:835-40. 2008..This study aimed to investigate the structural and cellular basis underlying the biological actions of Angptl4... - Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectinMingyan Zhou
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
J Hepatol 53:1108-16. 2010..Rosiglitazone treatment stimulates the production of adiponectin, an insulin-sensitizing adipokine with hepatoprotective functions. The present study aims to investigate the hepatic actions of rosiglitazone in mice without adiponectin... - SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cellsYi Zu
Department of Pharmacology, University of Hong Kong, Hong Kong, China
Circ Res 106:1384-93. 2010..SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite that the detailed functional mechanisms are largely uncharacterized... - Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humansYu Wang
Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
Clin Chem 53:34-41. 2007..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies... - Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injuryMingyan Zhou
Department of Pharmacology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong, China
Hepatology 48:1087-96. 2008..CONCLUSION: These results suggest that the hepatoprotective properties of adiponectin are mediated at least in part by an enhancement of the activities of MRC complexes through a mechanism involving UCP2... - Differential genomic changes caused by cholesterol- and PUFA-rich diets in regenerated porcine coronary endothelial cellsMary Y K Lee
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
Physiol Genomics 44:551-61. 2012.... - APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in miceKenneth K Y Cheng
Department of Medicine, The University of Hong Kong, Hong Kong
Cell Metab 9:417-27. 2009..These results suggest that the potentiating effects of APPL1 on insulin-stimulated suppression of hepatic glucose production are attributed to its ability in counteracting the inhibition of Akt activation by TRB3... - Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1Jing Liu
Department of Pharmacology, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China
Carcinogenesis 29:2195-202. 2008..Taken together, these data suggest that ADN might elicit its antitumor activities at least partially through promoting WIF1 expressions... - Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkBMary Y K Lee
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
J Vasc Res 47:287-98. 2010..Endothelial dysfunction occurs following multiple passaging in vitro,but the molecular mechanisms involved remain unidentified. The present study defined the genomic changes related to dysfunction in cultured senescent endothelial cells... - Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese miceAimin Xu
Department of Medicine and Research Center for Heart, Brain, Hormones, and Healthy Aging, University of Hong Kong, Hong Kong
Endocrinology 150:625-33. 2009..The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases... - Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohortAnnette W K Tso
Department of Medicine, University of Hong Kong, Hong Kong, China
Diabetes Care 30:2667-72. 2007..Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study... - Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytesBaoying Chen
Department of Medicine, University of Hong Kong, Hong Kong, China
Biochem Biophys Res Commun 341:549-56. 2006..These effects may contribute to hypoadiponectinemia and elevated PAI-1 levels in obesity, type 2 diabetes, and cardiovascular diseases... - APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in miceKenneth K Y Cheng
Department of Medicine, The University of Hong Kong, Hong Kong, China
Proc Natl Acad Sci U S A 109:8919-24. 2012.... - Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosisBo Bai
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
Circulation 126:729-40. 2012..The present study was designed to investigate the molecular mechanisms contributing to the loss-of-SIRT1 function in senescent endothelial cells... - Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic miceWing Tak Wong
Institute of Vascular Medicine, Chinese University of Hong Kong, Hong Kong, China Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
Cell Metab 14:104-15. 2011..Thus, the adipose tissue represents a promising target for treating diabetic vasculopathy... - A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerizationMing Hon Yau
Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, and Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
J Biol Chem 284:11942-52. 2009.... - Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibitionJacky T C Liu
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
Br J Pharmacol 165:520-31. 2012..Augmented lipocalin-2 has been found in patients with cardiovascular abnormalities.The present study was designed to investigate the role of lipocalin-2 in regulating endothelial function and vascular reactivity... - Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective studyAimin Xu
Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
Circulation 115:1537-43. 2007..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria... - Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activitiesJanice B B Lam
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
PLoS ONE 4:e4968. 2009..A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive... - Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implicationsYu Wang
Department of Pharmacology, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
Arq Bras Endocrinol Metabol 53:201-12. 2009..This review aims to summarize recent advances on delineation of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin... - Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in miceAimin Xu
Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
Proc Natl Acad Sci U S A 102:6086-91. 2005..These results collectively indicate that ANGPTL4 exerts distinct effects on glucose and lipid metabolism, and that its beneficial effect on glucose homeostasis might be useful for the treatment of diabetes... - Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjectsDennis C Y Yeung
Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Clin Endocrinol Metab 94:2531-6. 2009..Animal studies have demonstrated the role of ZAG as a lipid-mobilizing factor involved in regulating lipid metabolism and adiposity. However, the clinical relevance of these findings remains to be established... - Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosisDennis C Y Yeung
Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
Eur Heart J 29:2156-63. 2008..Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans... - Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytesAimin Xu
Department of Medicine and Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong, China
J Biol Chem 280:18073-80. 2005.... - Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1Xiaoyan Hui
Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong
J Biol Chem 285:10273-80. 2010..These findings support the notion that pharmacological inhibition of A-FABP represents a valid strategy for treating inflammation-related disorders such as atherosclerosis... - Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in miceXinmei Zhang
Department of Medicine, University of Hong Kong, Hong Kong, China
J Biol Chem 285:32869-77. 2010..These findings support an indispensable role of HIF1α in maintaining the thermogenic functions of BAT, possibly through promoting angiogenesis and mitochondrial biogenesis in this tissue... - SIRT1 in metabolic syndrome: Where to target mattersYu Wang
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China Electronic address
Pharmacol Ther 136:305-18. 2012..The present review summarizes the recent progress in SIRT1 research with a particular focus on the specificities of this protein in individual tissues as they relate to cardiometabolic control... - A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathwayKim Hei Man Chow
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Res 70:329-37. 2010..These data, in combination with computer modeling, suggest that gold-2a may represent a promising class of anticancer HDAC inhibitor preferentially targeting tumor cells with aberrant Wnt/beta-catenin signaling... - Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuinsIvy K M Law
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
Proteomics 9:2444-56. 2009..Taken together, the present study has identified a number of novel SIRT protein interacting partners, which might be critically involved in the anti-aging and metabolic regulatory activities of sirtuins... - Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in miceDewei Ye
Department of Medicine, The University of Hong Kong, Hong Kong
Gut 61:1058-67. 2012..Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis... - Unraveling the resistance of microbial biofilms: has proteomics been helpful?C Jayampath Seneviratne
The University of Hong Kong, Oral Biosciences, Hong Kong
Proteomics 12:651-65. 2012..We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms... - Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndromeAimin Xu
Department of Medicine, University of Hong Kong, Hong Kong, China
Clin Chem 52:405-13. 2006..Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed... - Proteomics of drug resistance in Candida glabrata biofilmsC Jayampath Seneviratne
Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
Proteomics 10:1444-54. 2010..In conclusion, C. glabrata biofilms possess higher amount of stress response proteins, which may potentially contribute to the higher antifungal resistance seen in C. glabrata biofilms... - Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive ratZhuoming Li
Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong SAR, China
Hypertension 58:926-34. 2011.... - Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytesAimin Xu
Department of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong
FEBS Lett 572:129-34. 2004.... - Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive ratZhuoming Li
Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
Basic Clin Pharmacol Toxicol 109:47-55. 2011..The present findings indicate that the increased oxidative stress in the ageing hypertensive animals contributes to the loss of the beneficial effects and the enhancement of the adverse effects of EGCG... - Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytesXuan Ge
Department of Medicine, University of Hong Kong, Hong Kong, China
J Biol Chem 286:34533-41. 2011..The impairment in this signaling pathway may contribute to FGF21 resistance in obese mice... - Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cellsKenneth K Y Cheng
Department of Medicine, University of Hong Kong, Hong Kong, China
Diabetes 56:1387-94. 2007..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation... - Post-translational modifications of adiponectin: mechanisms and functional implicationsYu Wang
Genome Research Center, University of Hong Kong, Hong Kong, China
Biochem J 409:623-33. 2008.... - Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxidePriscilla T Y Leung
The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Hong Kong, China
Aquat Toxicol 105:49-61. 2011..Our results suggested that investigations on these stress-associated protein changes could be used as a new and complementary approach in pollution monitoring by this popular biomonitor species... - APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in miceYi Wang
Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Diabetes 60:3044-54. 2011..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells... - Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblastsThanuja D K Herath
Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
J Clin Periodontol 38:694-701. 2011..This study investigated the effects of the two isoforms of P. gingivalis LPS on the expression of IL-6, IL-8 and TNF-α in human gingival fibroblasts (HGFs)... - SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working modelYu Wang
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
FEBS Lett 585:986-94. 2011..In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells... - Vascular actions of adipokines molecular mechanisms and therapeutic implicationsAimin Xu
Department of Medicine, University of Hong Kong, Hong Kong, China
Adv Pharmacol 60:229-55. 2010.... - Caspase-3 as a therapeutic target for heart failureBo Yang
The University of Hong Kong, Department of Pharmacology and Pharmacy, Level 2, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
Expert Opin Ther Targets 17:255-63. 2013..Selective inhibition of the proteolytic functions of caspase-3 may represent an attractive approach to attenuate or reverse heart failure... - Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2Yu Wang
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
Br J Pharmacol 165:603-21. 2012..LINKED ARTICLES: This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-3... - Frontal-subcortical protein expression following prenatal exposure to maternal inflammationMichelle Y Deng
Department of Psychiatry, University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
PLoS ONE 6:e16638. 2011..Such conditions are associated with alterations in fronto-subcortical circuits, but their molecular basis is far from clear... - Candida albicans biofilm formation is associated with increased anti-oxidative capacitiesC Jayampath Seneviratne
Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, PR China
Proteomics 8:2936-47. 2008..Taken together, these data imply that the biofilm mode, Candida, compared with their planktonic counterparts, exhibits traits that can sustain oxidative stress (anti-oxidants), and thereby exert resistance to commonly used antifungals... - Phytase activity in tobacco (Nicotiana tabacum) root exudates is exhibited by a purple acid phosphataseShiu Cheung Lung
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China
Phytochemistry 69:365-73. 2008..We conclude that the phytase activity in tobacco root exudates is exhibited by a purple acid phosphatase and its catalytic properties are pertinent to its role in mobilizing organic P in soil... - Methods to investigate the role of SIRT1 in endothelial senescenceBo Bai
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Methods Mol Biol 965:327-39. 2013..The methods can be applied to the investigation of the role of SIRT1 in the development of endothelial senescence and atherosclerosis... - Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndromeYangsoo Jang
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea
Clin Exp Pharmacol Physiol 39:194-9. 2012..A better understanding of how lipocalin-2 is regulated locally and systemically is crucial for adding to our understanding of the pathogenesis of metabolic syndrome, and to uncover potential new avenues for therapeutic approaches... - Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksYu Wang
Department of Chemistry, The University of Hong Kong, China
J Biol Chem 280:19986-91. 2005..These results indicate that OREBP-mediated accumulation of osmolytes is essential during elongation of the lens fiber cells... - Feasibility on systemic delivery of asialoorosomucoid complex to hepatic origin cells mediated by asialoglycoprotein receptorSun Jun
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 25:234-5, 239. 2005..This research testified the feasibility of targeting Asor complex delivery to hepatocyte mediated by ASGP-R in vivo, and provided foundation for the genetic diagnosis and gene therapy of hepatic cell-related diseases... - Effects of human interleukin 10 gene transfer on the expression of Bcl-2 Bax and apoptosis of hepatocyte in rats with acute hemorrhagic necrotizing pancreatitisJun-chao Gu
Department of General Surgery, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
Chin Med J (Engl) 118:1658-60. 2005 - Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferationParamita M Ghosh
Department of Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
Endocr Relat Cancer 12:119-34. 2005..Rapamycin, an mTOR inhibitor, had a growth-inhibitory effect in C4-2 cells, but not in LNCaP cells. Our data suggest a shift from a Casodex-sensitive proliferation pathway in LNCaP cells to a rapamycin-sensitive pathway in C4-2 cells... - The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migrationSilvia Paracchini
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 15:1659-66. 2006..2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex... - [Construction of recombinant replication competent plasmids containing HBV genome with mutations of precore and basic core promoter]Yan Wang
Institute of Hepatology, Peoples Hospital, Peking University, Beijing 100044, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:218-22. 2004..After transfecting into Huh7, the vectors replicated and secreted viral particles. CONCLUSIONS: Ten full-length competent HBV recombinants were obtained, which were harbouring varying mutations within precore and basic core promoter... - Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic modelGilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
Mol Cancer Ther 3:1271-9. 2004..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice... - Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytesKai-Luk Choi
The School of Biological Sciences, University of Auckland, Auckland, New Zealand
Proteomics 4:1840-8. 2004.... - Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinomaGilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
Cancer Gene Ther 11:61-72. 2004..These findings demonstrate that tumor irradiation improves the efficacy of Ad-IL-2 gene therapy for induction of antitumor immune response... - The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in miceAimin Xu
School of Biological Sciences, University of Auckland, Auckland, New Zealand
J Clin Invest 112:91-100. 2003..These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases... - Radiation improves intratumoral gene therapy for induction of cancer vaccine in murine prostate carcinomaGilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
Hum Gene Ther 14:763-75. 2003..Administering radiation before this novel gene therapy approach, that creates an in situ tumor vaccine, holds promise for the treatment of human prostate carcinoma... - Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serumYu Wang
Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland, New Zealand
Proteomics 4:3933-42. 2004..These results provide direct evidence that endogenous bovine adiponectin is a physiological hormone that can regulate lipid and glucose metabolism... - Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2Jing-Mei Su
Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, P. R. China and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, The People's Republic of China
Cancer Res 63:600-7. 2003.... - Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cellsAimin Xu
The School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Biochem Biophys Res Commun 293:1161-7. 2002.... - Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activityYu Wang
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, 1001 New Zealand
J Biol Chem 277:19521-9. 2002.... - Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivoKathleen M Leahy
Pharmacia, Mail Zone AA4C, 700 Chesterfield Parkway, Chesterfield, Missouri 63017, USA
Cancer Res 62:625-31. 2002..2-3.0-fold) in response to celecoxib. Thus, the antitumor activity of celecoxib may be attributable, at least in part, to a direct effect on host stromal elements, such as the angiogenic vasculature... - A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor developmentJennifer M Burns
ChemoCentryx, Inc, Mountain View, CA 94043, USA
J Exp Med 203:2201-13. 2006.... - Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epitheliaShahid Umar
Div of Gastroenterology, Univ of Texas Medical Branch, Galveston, TX 77555 0632, USA
Am J Physiol Gastrointest Liver Physiol 292:G599-607. 2007.... - Comparative proteomic study of acute pulmonary embolism in a rat modelSheng qing Li
Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
Proteomics 7:2287-99. 2007.... - Preclinical antitumor activity of a novel folate-targeted dual drug conjugateChristopher P Leamon
Endocyte Inc, 3000 Kent Avenue, West Lafayette, IN 47906, USA
Mol Pharm 4:659-67. 2007..Overall, EC0225's impressive preclinical activity allowed for its selection as a development candidate and for the start of Phase 1 clinical trials, which began in March of 2007, for the treatment of advanced malignancies... - Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cellsJie Ma
Department of Pediatric Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, Shanghai 200092, China
Neurochem Int 51:57-65. 2007..Although further study is necessary to elucidate the precise mechanisms responsible for this functional recovery, we believe that ES cells have advantages for use as a donor source in HIE... - Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23Zhenhua Miao
ChemoCentryx, Mountain View, CA 94043, USA
J Immunol 178:7395-404. 2007..The sequential activation of a transient FPRL1 ligand and a longer-lived CCR1 ligand within a single chemokine may have important consequences for the development of inflammation or the link between innate and adaptive immunity... - Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytesRengasamy Palanivel
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
Cardiovasc Res 75:148-57. 2007..Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of adiponectin... - [Experimental study of adenovirus-mediated p53 gene on the reversal of multidrug resistance in breast cancer]Shi zhi He
Cancer Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhonghua Yi Xue Za Zhi 87:2935-7. 2007..To explore the effects of adenovirus-mediated wild-type p53 gene (Ad-p53) on the reversal of multidrug resistance (MDR) and multidrug resistance gene-1 (MDR1) in adriamycin (ADM) resistant human breast cancer cell... - Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomasWenhua Piao
First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo 060 8543, Japan
Mol Cancer Ther 7:1483-93. 2008..This compound did not influence hybrid receptor formation. Thus, NVP-AEW541 may have significant therapeutic utility in human GI carcinomas both alone and in combination with chemotherapy... - Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient miceBassil M Kublaoui
Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
Mol Endocrinol 22:1723-34. 2008..Our results support the importance of Oxt neurons in feeding regulation and suggest that reduced Oxt neuropeptide is one mechanism mediating the hyperphagic obesity of Sim1(+/-) mice... - The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in ArabidopsisYu Wang
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Yuanmingyuan Xilu 2, Haidai Dist, Beijing 100094, China
EMBO Rep 8:77-83. 2007..Our results provide direct evidence for a crucial role of the TOUSLED protein kinase in the maintenance of transcriptional gene silencing in some genomic regions in a DNA-methylation-independent manner in Arabidopsis... - AKT regulates androgen receptor-dependent growth and PSA expression in prostate cancerMargarita Mikhailova
Research Services, VA Northern California HCS, Mather, CA, USA
Adv Exp Med Biol 617:397-405. 2008..However, Akt-induced cell survival is largely AR independent, suggesting that the cell stimulates Akt phosphorylation when subjected to androgen deprivation as an alternate pathway to maintain survival... - Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvantsLiang Jin
Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, PR China
Vaccine 25:2043-50. 2007..Specific antibodies were successfully induced and lasted for more than 20 weeks in animals immunized with the fusion protein via intranasal route even in the absence of adjuvants... - Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in miceKrish Chandrasekaran
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 26:13123-7. 2006..More importantly, the development of Dox-inducible, neuron targeted mito/eYFP transgenic mice offer a unique in vivo model for delineating the participation of neuronal mitochondria in neuronal survival and death... - DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoproteinJing An
Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China
Mol Cancer 7:32. 2008..Here we report a novel mechanistic pathway through which DNA-dependent protein kinase catalytic subunit (DNA-PKcs) modulates the stability of c-Myc protein... - Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinomaArisa Imsumran
First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
Carcinogenesis 28:947-56. 2007..Therapeutic blockade of IGF-Ir may be a useful anticancer therapeutic for ESCC... - Moderate wine consumption in the prevention of metabolic syndrome and its related medical complicationsLing Liu
Department of Medicine, The University of Hong Kong, L8 40, 21 Hong Kong
Endocr Metab Immune Disord Drug Targets 8:89-98. 2008.... - Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cellsLiguang Zhou
Departments of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 250012 Jinan, ROC
Anticancer Res 28:1119-27. 2008..In this study, whether silibinin could overcome chemoresistance and reduce the invasiveness of A2780/taxol cells was investigated... - Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock protein 70 in signal transduction during hepatocyte ischemic preconditioningYi Gao
Department of Hepatobiliary Surgery, Zhujiang Hospital, 253 Gongye Road, Guangzhou 510282, Guangdong Province, China
World J Gastroenterol 10:1019-27. 2004..To investigate the significance of protein kinase C(PKC), P44/42 mitogen-activated protein kinase (MAPKs) and heat shock protein (HSP)70 signal transduction during hepatocyte ischemic preconditioning... - Enhanced resistance of restraint-stressed mice to sepsisYu Wang
College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
J Immunol 181:3441-8. 2008.... - Transfer of siRNA against XIAP induces apoptosis and reduces tumor cells growth potential in human breast cancer in vitro and in vivoYingchao Zhang
Department of Surgery, The Second Hospital of Jilin University, Changchun, PR China
Breast Cancer Res Treat 96:267-77. 2006..CONCLUSION: This study represents that MCF-7 transfected cells with siRNA against XIAP remarkably suppress tumor growth and induces apoptosis, both in vitro and in vivo. This novel modality may be a promising tool for cancer therapy... - Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscleYu Wang
Department of Physiology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, 920 8640, Japan
Biochem J 394:581-92. 2006..These results indicate the novel role of PI3K-C2alpha in Ca2+-dependent Rho-mediated negative control of MP and thus VSM contraction... - In vitro resistance to interferon-alpha of hepatitis B virus with basic core promoter double mutationYan Wang
Hepatology Institute, Peking University People s Hospital, Beijing 100044, China
Antiviral Res 75:139-45. 2007..8%, 29.8%, respectively) and the BCP mutant (by 8.4%, 27.4%, 10.1%, respectively). These data indicate that HBV harboring the BCP double mutation has stronger replication competence and lower sensitivity to IFN-alpha than wild-type... - Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technologyYi-Fan Li
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
Methods Mol Med 112:59-79. 2005.... - Proteolytic activation of alternative CCR1 ligands in inflammationRobert D Berahovich
ChemoCentryx, Mountain View, CA 94043, USA
J Immunol 174:7341-51. 2005..These data suggest that alternative CCR1 ligands are converted into potent chemoattractants by proteases released during inflammatory responses in vivo...