Yu Wang

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice
    Yu Wang
    Genome Research Center, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region, China
    Mol Endocrinol 21:972-86. 2007
  2. ncbi request reprint Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex
    Yu Wang
    Departments of Biochemistry and Medicine, Genome Research Centre, Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    J Biol Chem 281:16391-400. 2006
  3. ncbi request reprint Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    Yu Wang
    Genome Research Center, University of Hong Kong, China
    Cancer Res 66:11462-70. 2006
  4. ncbi request reprint Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, P R China
    Proteomics 6:3862-70. 2006
  5. ncbi request reprint Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    Yu Wang
    Genome Research Centre and the Departments of Biochemistry and Medicine, The University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18341-7. 2005
  6. ncbi request reprint Adiponectin as a negative regulator in obesity-related mammary carcinogenesis
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong SAR, China
    Cell Res 17:280-2. 2007
  7. doi request reprint Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4
    Ying Hua Yang
    Department of Medicine, The University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong
    Arterioscler Thromb Vasc Biol 28:835-40. 2008
  8. doi request reprint Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4
    Chao Fan Liang
    Department of Pharmacology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Arterioscler Thromb Vasc Biol 33:777-84. 2013
  9. pmc Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity
    Ivy K M Law
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Diabetes 59:872-82. 2010
  10. ncbi request reprint Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice
    Yu Wang
    Genome Research Center, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region, China
    Mol Endocrinol 21:972-86. 2007
    ..In summary, our results suggest that ANGPTL4 might elicit its metabolic effects through modulating the mitochondria functions and methionine metabolic cycles in the liver tissue...
  2. ncbi request reprint Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex
    Yu Wang
    Departments of Biochemistry and Medicine, Genome Research Centre, Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    J Biol Chem 281:16391-400. 2006
    ....
  3. ncbi request reprint Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    Yu Wang
    Genome Research Center, University of Hong Kong, China
    Cancer Res 66:11462-70. 2006
    ..Taken together, these data support the role of adiponectin as a negative regulator of breast cancer development and also suggest that adiponectin might represent a novel therapeutic target for this disease...
  4. ncbi request reprint Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, P R China
    Proteomics 6:3862-70. 2006
    ..These proteins might serve as the physiological-binding partners of adiponectin and regulate its bioavailability and biological activities...
  5. ncbi request reprint Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    Yu Wang
    Genome Research Centre and the Departments of Biochemistry and Medicine, The University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18341-7. 2005
    ....
  6. ncbi request reprint Adiponectin as a negative regulator in obesity-related mammary carcinogenesis
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong SAR, China
    Cell Res 17:280-2. 2007
  7. doi request reprint Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4
    Ying Hua Yang
    Department of Medicine, The University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong
    Arterioscler Thromb Vasc Biol 28:835-40. 2008
    ..This study aimed to investigate the structural and cellular basis underlying the biological actions of Angptl4...
  8. doi request reprint Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4
    Chao Fan Liang
    Department of Pharmacology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Arterioscler Thromb Vasc Biol 33:777-84. 2013
    ..To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function...
  9. pmc Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity
    Ivy K M Law
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Diabetes 59:872-82. 2010
    ..The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic insulin sensitivity and the underlying mechanisms...
  10. ncbi request reprint Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007
    ..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies...
  11. pmc Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K
    Mingyan Zhou
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e32349. 2012
    ..The present study was designed to investigate the cellular and molecular mechanisms underlying adiponectin-induced UCP2 expression...
  12. doi request reprint Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    Xiao Yu Tian
    Institute of Vascular Medicine, Hong Kong SAR, China
    Circ Res 110:1211-6. 2012
    ..UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear...
  13. pmc Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury
    Mingyan Zhou
    Department of Pharmacology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong, China
    Hepatology 48:1087-96. 2008
    ..Moreover, the effects of adiponectin on mitochondrial activities and on protection against endotoxin-induced liver injuries were significantly attenuated in UCP2 knockout mice...
  14. doi request reprint SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
    Yi Zu
    Department of Pharmacology, University of Hong Kong, Hong Kong, China
    Circ Res 106:1384-93. 2010
    ..SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite that the detailed functional mechanisms are largely uncharacterized...
  15. doi request reprint Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin
    Mingyan Zhou
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    J Hepatol 53:1108-16. 2010
    ..Rosiglitazone treatment stimulates the production of adiponectin, an insulin-sensitizing adipokine with hepatoprotective functions. The present study aims to investigate the hepatic actions of rosiglitazone in mice without adiponectin...
  16. doi request reprint Differential genomic changes caused by cholesterol- and PUFA-rich diets in regenerated porcine coronary endothelial cells
    Mary Y K Lee
    Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Physiol Genomics 44:551-61. 2012
    ....
  17. doi request reprint Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1
    Jing Liu
    Department of Pharmacology, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China
    Carcinogenesis 29:2195-202. 2008
    ..Taken together, these data suggest that ADN might elicit its antitumor activities at least partially through promoting WIF1 expressions...
  18. doi request reprint APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice
    Kenneth K Y Cheng
    Department of Medicine, The University of Hong Kong, Hong Kong
    Cell Metab 9:417-27. 2009
    ..These results suggest that the potentiating effects of APPL1 on insulin-stimulated suppression of hepatic glucose production are attributed to its ability in counteracting the inhibition of Akt activation by TRB3...
  19. doi request reprint Upregulation of heme oxygenase-1 potentiates EDH-type relaxations in the mesenteric artery of the spontaneously hypertensive rat
    Zhuoming Li
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong SAR, China and
    Am J Physiol Heart Circ Physiol 305:H1471-83. 2013
    ..The present findings reveal that HO-1 may be a potential vascular-specific therapeutic strategy for endothelial dysfunction in hypertension...
  20. ncbi request reprint Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort
    Annette W K Tso
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:2667-72. 2007
    ..Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study...
  21. pmc Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    Aimin Xu
    Department of Medicine and Research Center for Heart, Brain, Hormones, and Healthy Aging, University of Hong Kong, Hong Kong
    Endocrinology 150:625-33. 2009
    ..The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases...
  22. ncbi request reprint Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes
    Baoying Chen
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Biochem Biophys Res Commun 341:549-56. 2006
    ..These effects may contribute to hypoadiponectinemia and elevated PAI-1 levels in obesity, type 2 diabetes, and cardiovascular diseases...
  23. doi request reprint Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB
    Mary Y K Lee
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    J Vasc Res 47:287-98. 2010
    ..Endothelial dysfunction occurs following multiple passaging in vitro,but the molecular mechanisms involved remain unidentified. The present study defined the genomic changes related to dysfunction in cultured senescent endothelial cells...
  24. doi request reprint Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis
    Bo Bai
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    Circulation 126:729-40. 2012
    ..The present study was designed to investigate the molecular mechanisms contributing to the loss-of-SIRT1 function in senescent endothelial cells...
  25. pmc APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
    Kenneth K Y Cheng
    Department of Medicine, The University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 109:8919-24. 2012
    ....
  26. doi request reprint Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice
    Wing Tak Wong
    Institute of Vascular Medicine, Chinese University of Hong Kong, Hong Kong, China Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Cell Metab 14:104-15. 2011
    ..Thus, the adipose tissue represents a promising target for treating diabetic vasculopathy...
  27. pmc A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization
    Ming Hon Yau
    Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, and Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
    J Biol Chem 284:11942-52. 2009
    ....
  28. pmc The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts
    Thanuja D K Herath
    Faculty of Dentistry, Periodontology, The University of Hong Kong, Hong Kong SAR, China
    BMC Microbiol 13:73. 2013
    ..gingivalis LPS(1435/1449) and LPS(1690) and hexa-acylated E. coli LPS as a reference. The expression of MMPs 1-3 and TIMP-1 was evaluated by real-time PCR and ELISA...
  29. pmc Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts
    Thanuja D K Herath
    Faculty of Dentistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e58496. 2013
    ..Hitherto, the exact molecular mechanism of P. gingivalis LPS involved in periodontal pathogenesis remains unclear, due to limited understanding of the specific receptors and signaling pathways involved in LPS-host cell interactions...
  30. pmc Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition
    Jacky T C Liu
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
    Br J Pharmacol 165:520-31. 2012
    ..Augmented lipocalin-2 has been found in patients with cardiovascular abnormalities.The present study was designed to investigate the role of lipocalin-2 in regulating endothelial function and vascular reactivity...
  31. pmc Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities
    Janice B B Lam
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    PLoS ONE 4:e4968. 2009
    ..A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive...
  32. ncbi request reprint Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  33. ncbi request reprint Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications
    Yu Wang
    Department of Pharmacology, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Arq Bras Endocrinol Metabol 53:201-12. 2009
    ..This review aims to summarize recent advances on delineation of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin...
  34. doi request reprint Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects
    Dennis C Y Yeung
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Clin Endocrinol Metab 94:2531-6. 2009
    ..Animal studies have demonstrated the role of ZAG as a lipid-mobilizing factor involved in regulating lipid metabolism and adiposity. However, the clinical relevance of these findings remains to be established...
  35. doi request reprint Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
    Dennis C Y Yeung
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Eur Heart J 29:2156-63. 2008
    ..Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans...
  36. ncbi request reprint Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    Aimin Xu
    Department of Medicine and Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18073-80. 2005
    ....
  37. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
    ..These results collectively indicate that ANGPTL4 exerts distinct effects on glucose and lipid metabolism, and that its beneficial effect on glucose homeostasis might be useful for the treatment of diabetes...
  38. pmc Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1
    Xiaoyan Hui
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong
    J Biol Chem 285:10273-80. 2010
    ..These findings support the notion that pharmacological inhibition of A-FABP represents a valid strategy for treating inflammation-related disorders such as atherosclerosis...
  39. pmc Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice
    Xinmei Zhang
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Biol Chem 285:32869-77. 2010
    ..These findings support an indispensable role of HIF1α in maintaining the thermogenic functions of BAT, possibly through promoting angiogenesis and mitochondrial biogenesis in this tissue...
  40. doi request reprint SIRT1 in metabolic syndrome: where to target matters
    Yu Wang
    Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Pharmacol Ther 136:305-18. 2012
    ..The present review summarizes the recent progress in SIRT1 research with a particular focus on the specificities of this protein in individual tissues as they relate to cardiometabolic control...
  41. doi request reprint A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway
    Kim Hei Man Chow
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 70:329-37. 2010
    ..These data, in combination with computer modeling, suggest that gold-2a may represent a promising class of anticancer HDAC inhibitor preferentially targeting tumor cells with aberrant Wnt/beta-catenin signaling...
  42. doi request reprint Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins
    Ivy K M Law
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Proteomics 9:2444-56. 2009
    ..Taken together, the present study has identified a number of novel SIRT protein interacting partners, which might be critically involved in the anti-aging and metabolic regulatory activities of sirtuins...
  43. doi request reprint Methods to investigate the role of SIRT1 in endothelial senescence
    Bo Bai
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Methods Mol Biol 965:327-39. 2013
    ..The methods can be applied to the investigation of the role of SIRT1 in the development of endothelial senescence and atherosclerosis...
  44. doi request reprint Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
    Dewei Ye
    Department of Medicine, The University of Hong Kong, Hong Kong
    Gut 61:1058-67. 2012
    ..Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis...
  45. doi request reprint Unraveling the resistance of microbial biofilms: has proteomics been helpful?
    C Jayampath Seneviratne
    The University of Hong Kong, Oral Biosciences, Hong Kong
    Proteomics 12:651-65. 2012
    ..We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms...
  46. ncbi request reprint Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    Aimin Xu
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Clin Chem 52:405-13. 2006
    ..Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed...
  47. doi request reprint Proteomics of drug resistance in Candida glabrata biofilms
    C Jayampath Seneviratne
    Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
    Proteomics 10:1444-54. 2010
    ..In conclusion, C. glabrata biofilms possess higher amount of stress response proteins, which may potentially contribute to the higher antifungal resistance seen in C. glabrata biofilms...
  48. ncbi request reprint Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes
    Aimin Xu
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong
    FEBS Lett 572:129-34. 2004
    ....
  49. doi request reprint Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat
    Zhuoming Li
    Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Hypertension 58:926-34. 2011
    ....
  50. pmc Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    Xuan Ge
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Biol Chem 286:34533-41. 2011
    ..The impairment in this signaling pathway may contribute to FGF21 resistance in obese mice...
  51. doi request reprint Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat
    Zhuoming Li
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Basic Clin Pharmacol Toxicol 109:47-55. 2011
    ..The present findings indicate that the increased oxidative stress in the ageing hypertensive animals contributes to the loss of the beneficial effects and the enhancement of the adverse effects of EGCG...
  52. ncbi request reprint Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    Kenneth K Y Cheng
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 56:1387-94. 2007
    ..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation...
  53. doi request reprint Post-translational modifications of adiponectin: mechanisms and functional implications
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong, China
    Biochem J 409:623-33. 2008
    ....
  54. doi request reprint Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction
    Yan Liang
    Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Br J Pharmacol 171:498-508. 2014
    ..Here, we have studied a transgenic mouse model overexpressing the constitutively active α1 subunit of AMPK in endothelial cells (EC-AMPK) to elucidate its role in energy homeostasis...
  55. pmc Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation
    Jing Liu
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Oncotarget 4:1804-18. 2013
    ....
  56. doi request reprint Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives
    Y C Woo
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Clin Endocrinol (Oxf) 78:489-96. 2013
    ..This review summarizes recent developments in the understanding of FGF21, from physiological and clinical perspectives...
  57. doi request reprint Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide
    Priscilla T Y Leung
    The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Aquat Toxicol 105:49-61. 2011
    ..Our results suggested that investigations on these stress-associated protein changes could be used as a new and complementary approach in pollution monitoring by this popular biomonitor species...
  58. pmc APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
    Yi Wang
    Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Diabetes 60:3044-54. 2011
    ..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells...
  59. doi request reprint SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
    Yu Wang
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    FEBS Lett 585:986-94. 2011
    ..In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells...
  60. doi request reprint Vascular actions of adipokines molecular mechanisms and therapeutic implications
    Aimin Xu
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Adv Pharmacol 60:229-55. 2010
    ....
  61. doi request reprint Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts
    Thanuja D K Herath
    Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    J Clin Periodontol 38:694-701. 2011
    ..This study investigated the effects of the two isoforms of P. gingivalis LPS on the expression of IL-6, IL-8 and TNF-α in human gingival fibroblasts (HGFs)...
  62. doi request reprint Caspase-3 as a therapeutic target for heart failure
    Bo Yang
    The University of Hong Kong, Department of Pharmacology and Pharmacy, Level 2, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Expert Opin Ther Targets 17:255-63. 2013
    ..Thus, anti-apoptosis has been proposed as a provocative new concept for preventive and therapeutic strategies for heart failure...
  63. pmc Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2
    Yu Wang
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    Br J Pharmacol 165:603-21. 2012
    ..In summary, A-FABP and lipocalin-2 represent potential therapeutic targets to design drugs for preventing vascular diseases associated with obesity...
  64. pmc Frontal-subcortical protein expression following prenatal exposure to maternal inflammation
    Michelle Y Deng
    Department of Psychiatry, University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e16638. 2011
    ..Such conditions are associated with alterations in fronto-subcortical circuits, but their molecular basis is far from clear...
  65. doi request reprint Candida albicans biofilm formation is associated with increased anti-oxidative capacities
    C Jayampath Seneviratne
    Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, PR China
    Proteomics 8:2936-47. 2008
    ..Taken together, these data imply that the biofilm mode, Candida, compared with their planktonic counterparts, exhibits traits that can sustain oxidative stress (anti-oxidants), and thereby exert resistance to commonly used antifungals...
  66. ncbi request reprint Phytase activity in tobacco (Nicotiana tabacum) root exudates is exhibited by a purple acid phosphatase
    Shiu Cheung Lung
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China
    Phytochemistry 69:365-73. 2008
    ..We conclude that the phytase activity in tobacco root exudates is exhibited by a purple acid phosphatase and its catalytic properties are pertinent to its role in mobilizing organic P in soil...
  67. doi request reprint Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome
    Yangsoo Jang
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea
    Clin Exp Pharmacol Physiol 39:194-9. 2012
    ..A better understanding of how lipocalin-2 is regulated locally and systemically is crucial for adding to our understanding of the pathogenesis of metabolic syndrome, and to uncover potential new avenues for therapeutic approaches...
  68. ncbi request reprint Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks
    Yu Wang
    Department of Chemistry, The University of Hong Kong, China
    J Biol Chem 280:19986-91. 2005
    ..These results indicate that OREBP-mediated accumulation of osmolytes is essential during elongation of the lens fiber cells...
  69. ncbi request reprint Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation
    Paramita M Ghosh
    Department of Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Endocr Relat Cancer 12:119-34. 2005
    ..Rapamycin, an mTOR inhibitor, had a growth-inhibitory effect in C4-2 cells, but not in LNCaP cells. Our data suggest a shift from a Casodex-sensitive proliferation pathway in LNCaP cells to a rapamycin-sensitive pathway in C4-2 cells...
  70. ncbi request reprint [Construction of recombinant replication competent plasmids containing HBV genome with mutations of precore and basic core promoter]
    Yan Wang
    Institute of Hepatology, Peoples Hospital, Peking University, Beijing 100044, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:218-22. 2004
    ..To construct a series of recombinant replication competent plasmids of hepatitis B virus (HBV) full-length genome with varying mutations of precore and basic core promoter...
  71. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
    ..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
  72. ncbi request reprint Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum
    Yu Wang
    Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Proteomics 4:3933-42. 2004
    ..These results provide direct evidence that endogenous bovine adiponectin is a physiological hormone that can regulate lipid and glucose metabolism...
  73. ncbi request reprint Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    Kathleen M Leahy
    Pharmacia, Mail Zone AA4C, 700 Chesterfield Parkway, Chesterfield, Missouri 63017, USA
    Cancer Res 62:625-31. 2002
    ..2-3.0-fold) in response to celecoxib. Thus, the antitumor activity of celecoxib may be attributable, at least in part, to a direct effect on host stromal elements, such as the angiogenic vasculature...
  74. ncbi request reprint Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity
    Yu Wang
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, 1001 New Zealand
    J Biol Chem 277:19521-9. 2002
    ....
  75. ncbi request reprint Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells
    Aimin Xu
    The School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Biophys Res Commun 293:1161-7. 2002
    ....
  76. ncbi request reprint Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2
    Jing mei Su
    Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, P R China and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, The People s Republic of China
    Cancer Res 63:600-7. 2003
    ....
  77. ncbi request reprint Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes
    Rengasamy Palanivel
    Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
    Cardiovasc Res 75:148-57. 2007
    ..Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of adiponectin...
  78. ncbi request reprint Radiation improves intratumoral gene therapy for induction of cancer vaccine in murine prostate carcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Hum Gene Ther 14:763-75. 2003
    ..Administering radiation before this novel gene therapy approach, that creates an in situ tumor vaccine, holds promise for the treatment of human prostate carcinoma...
  79. pmc The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    Aimin Xu
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Clin Invest 112:91-100. 2003
    ..These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases...
  80. ncbi request reprint Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
    Cancer Gene Ther 11:61-72. 2004
    ..These findings demonstrate that tumor irradiation improves the efficacy of Ad-IL-2 gene therapy for induction of antitumor immune response...
  81. ncbi request reprint Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes
    Kai Luk Choi
    The School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Proteomics 4:1840-8. 2004
    ....
  82. ncbi request reprint The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
    Silvia Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 15:1659-66. 2006
    ..2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex...
  83. ncbi request reprint Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells
    Jie Ma
    Department of Pediatric Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, Shanghai 200092, China
    Neurochem Int 51:57-65. 2007
    ..Although further study is necessary to elucidate the precise mechanisms responsible for this functional recovery, we believe that ES cells have advantages for use as a donor source in HIE...
  84. ncbi request reprint Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23
    Zhenhua Miao
    ChemoCentryx, Mountain View, CA 94043, USA
    J Immunol 178:7395-404. 2007
    ..The sequential activation of a transient FPRL1 ligand and a longer-lived CCR1 ligand within a single chemokine may have important consequences for the development of inflammation or the link between innate and adaptive immunity...
  85. ncbi request reprint Comparative proteomic study of acute pulmonary embolism in a rat model
    Sheng qing Li
    Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
    Proteomics 7:2287-99. 2007
    ....
  86. doi request reprint Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
    Wenhua Piao
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo 060 8543, Japan
    Mol Cancer Ther 7:1483-93. 2008
    ..This compound did not influence hybrid receptor formation. Thus, NVP-AEW541 may have significant therapeutic utility in human GI carcinomas both alone and in combination with chemotherapy...
  87. ncbi request reprint Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants
    Liang Jin
    Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, PR China
    Vaccine 25:2043-50. 2007
    ..Specific antibodies were successfully induced and lasted for more than 20 weeks in animals immunized with the fusion protein via intranasal route even in the absence of adjuvants...
  88. doi request reprint AKT regulates androgen receptor-dependent growth and PSA expression in prostate cancer
    Margarita Mikhailova
    Research Services, VA Northern California HCS, Mather, CA, USA
    Adv Exp Med Biol 617:397-405. 2008
    ..However, Akt-induced cell survival is largely AR independent, suggesting that the cell stimulates Akt phosphorylation when subjected to androgen deprivation as an alternate pathway to maintain survival...
  89. pmc Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice
    Krish Chandrasekaran
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:13123-7. 2006
    ..More importantly, the development of Dox-inducible, neuron targeted mito/eYFP transgenic mice offer a unique in vivo model for delineating the participation of neuronal mitochondria in neuronal survival and death...
  90. pmc The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis
    Yu Wang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Yuanmingyuan Xilu 2, Haidai Dist, Beijing 100094, China
    EMBO Rep 8:77-83. 2007
    ..Our results provide direct evidence for a crucial role of the TOUSLED protein kinase in the maintenance of transcriptional gene silencing in some genomic regions in a DNA-methylation-independent manner in Arabidopsis...
  91. ncbi request reprint Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia
    Shahid Umar
    Div of Gastroenterology, Univ of Texas Medical Branch, Galveston, TX 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 292:G599-607. 2007
    ....
  92. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
    ....
  93. pmc Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    Bassil M Kublaoui
    Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
    Mol Endocrinol 22:1723-34. 2008
    ..Our results support the importance of Oxt neurons in feeding regulation and suggest that reduced Oxt neuropeptide is one mechanism mediating the hyperphagic obesity of Sim1(+/-) mice...
  94. pmc DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein
    Jing An
    Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China
    Mol Cancer 7:32. 2008
    ..Here we report a novel mechanistic pathway through which DNA-dependent protein kinase catalytic subunit (DNA-PKcs) modulates the stability of c-Myc protein...
  95. ncbi request reprint Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
    Christopher P Leamon
    Endocyte Inc, 3000 Kent Avenue, West Lafayette, IN 47906, USA
    Mol Pharm 4:659-67. 2007
    ..Overall, EC0225's impressive preclinical activity allowed for its selection as a development candidate and for the start of Phase 1 clinical trials, which began in March of 2007, for the treatment of advanced malignancies...
  96. ncbi request reprint Effects of human interleukin 10 gene transfer on the expression of Bcl-2 Bax and apoptosis of hepatocyte in rats with acute hemorrhagic necrotizing pancreatitis
    Jun chao Gu
    Department of General Surgery, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
    Chin Med J (Engl) 118:1658-60. 2005
  97. ncbi request reprint Feasibility on systemic delivery of asialoorosomucoid complex to hepatic origin cells mediated by asialoglycoprotein receptor
    Sun Jun
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 25:234-5, 239. 2005
    ..This research testified the feasibility of targeting Asor complex delivery to hepatocyte mediated by ASGP-R in vivo, and provided foundation for the genetic diagnosis and gene therapy of hepatic cell-related diseases...
  98. ncbi request reprint [Experimental study of adenovirus-mediated p53 gene on the reversal of multidrug resistance in breast cancer]
    Shi zhi He
    Cancer Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:2935-7. 2007
    ..To explore the effects of adenovirus-mediated wild-type p53 gene (Ad-p53) on the reversal of multidrug resistance (MDR) and multidrug resistance gene-1 (MDR1) in adriamycin (ADM) resistant human breast cancer cell...
  99. ncbi request reprint [Protecting effects of p44/42 MAPK signal transduction pathway on hepatocytes in ischemic preconditioning]
    Yi Gao
    Department of Organ Transplantation Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510280, China
    Zhonghua Gan Zang Bing Za Zhi 11:166-9. 2003
    ..To investigate the significance of PKC and p44/42 mitogen-activated protein kinase (MAPK) signal transduction in ischemic preconditioning (IP)...
  100. ncbi request reprint Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells
    Yu Wang
    Department of Medicine, Duke University Medical Center, Durham 27710, USA
    Am J Physiol Gastrointest Liver Physiol 282:G16-22. 2002
    ....
  101. ncbi request reprint Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells
    Liguang Zhou
    Departments of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 250012 Jinan, ROC
    Anticancer Res 28:1119-27. 2008
    ..In this study, whether silibinin could overcome chemoresistance and reduce the invasiveness of A2780/taxol cells was investigated...