Xianghong Wang

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. doi request reprint Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption
    X Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Oncogene 27:4456-66. 2008
  2. pmc Classification between normal and tumor tissues based on the pair-wise gene expression ratio
    YeeLeng Yap
    HKU Pasteur Research Centre, Dexter H, C, Man Building, 8 Sassoon Road Pokfulam, Hongkong, China
    BMC Cancer 4:72. 2004
  3. ncbi request reprint Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
    Xianghong Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Oncogene 23:474-82. 2004
  4. ncbi request reprint Significance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, University of Hong Kong, SAR, China
    Anticancer Drugs 13:957-64. 2002
  5. ncbi request reprint Mitotic checkpoint defects in human cancers and their implications to chemotherapy
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Front Biosci 13:2103-14. 2008
  6. ncbi request reprint Induction of senescent-like growth arrest as a new target in anticancer treatment
    Xianghong Wang
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Curr Cancer Drug Targets 3:153-9. 2003
  7. doi request reprint Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform
    Chee Wai Chua
    Cancer Biology Group, Department of Anatomy and Departments of Pathology and Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Clin Cancer Res 15:4322-35. 2009
  8. doi request reprint Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer
    Edward W Howard
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Int J Cancer 122:1941-8. 2008
  9. ncbi request reprint Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells
    Hiu Wing Cheung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cancer Res 65:1450-8. 2005
  10. doi request reprint Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 125:2576-85. 2009

Collaborators

Detail Information

Publications80

  1. doi request reprint Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption
    X Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Oncogene 27:4456-66. 2008
    ..These results demonstrate a novel function of Id-1 in promoting chromosomal instability through modification of APC/C activity during mitosis and provide a novel molecular mechanism accounted for the function of Id-1 as an oncogene...
  2. pmc Classification between normal and tumor tissues based on the pair-wise gene expression ratio
    YeeLeng Yap
    HKU Pasteur Research Centre, Dexter H, C, Man Building, 8 Sassoon Road Pokfulam, Hongkong, China
    BMC Cancer 4:72. 2004
    ..Numerous efforts have been made to use gene expression profiles to improve precision of tumor classification. However, reliable cancer-related signals are generally lacking...
  3. ncbi request reprint Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
    Xianghong Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Oncogene 23:474-82. 2004
    ..Our evidence provides a therapeutic strategy to overcome acquired resistance through inactivation of TWIST expression in human cancer...
  4. ncbi request reprint Significance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, University of Hong Kong, SAR, China
    Anticancer Drugs 13:957-64. 2002
    ..The differential cytotoxicity was partially explained by the alterations in cell cycle distribution. Our results indicate the importance of scheduling the radiation and cisplatin combination regimens on the survival of NPC cells...
  5. ncbi request reprint Mitotic checkpoint defects in human cancers and their implications to chemotherapy
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Front Biosci 13:2103-14. 2008
    ..In addition, the clinical importance and potential therapeutic implications of targeting the mitotic checkpoint to reverse drug resistance in cancer cells are also discussed...
  6. ncbi request reprint Induction of senescent-like growth arrest as a new target in anticancer treatment
    Xianghong Wang
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Curr Cancer Drug Targets 3:153-9. 2003
    ..In addition, the possible factors and mechanisms involved in this process are also discussed. Finally, the implications on how senescent-like growth arrest might be exploited as a possible new target for anti-cancer drugs are addressed...
  7. doi request reprint Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform
    Chee Wai Chua
    Cancer Biology Group, Department of Anatomy and Departments of Pathology and Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Clin Cancer Res 15:4322-35. 2009
    ....
  8. doi request reprint Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer
    Edward W Howard
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Int J Cancer 122:1941-8. 2008
    ..Our study implies a potential role for SAMC in improving docetaxel based chemotherapy for the treatment of HRPC...
  9. ncbi request reprint Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells
    Hiu Wing Cheung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cancer Res 65:1450-8. 2005
    ..Our evidence further confirms the previous hypothesis that spindle checkpoint plays an important part in DNA damage-induced cell cycle arrest and suggests a novel role of MAD2 in cellular sensitivity to cisplatin...
  10. doi request reprint Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 125:2576-85. 2009
    ..In conclusion, our results provide the first evidence that Id-1 promotes tumorigenicity and metastasis of human esophageal cancer in vivo and that the PI3K inhibitor LY294002 can attenuate these effects...
  11. ncbi request reprint Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents
    Hiu Wing Cheung
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Res 66:4357-67. 2006
    ..Our findings reveal a novel strategy for cancer therapy, in which cancer cells are sensitized to DNA-damaging anticancer drugs through inactivation of the MAD2B gene...
  12. ncbi request reprint FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
    Chee Wai Chua
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Int J Cancer 117:1039-48. 2005
    ..Our results suggest a potential novel agent in the suppression of androgen-independent prostate cancer...
  13. doi request reprint MAD2 interacts with DNA repair proteins and negatively regulates DNA damage repair
    Maggie K L Fung
    Department of Anatomy, Cancer Biology Group, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    J Mol Biol 381:24-34. 2008
    ..Our results suggest a novel function of MAD2 by interfering with DNA repair proteins...
  14. ncbi request reprint Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target
    Wai Kei Kwok
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, SAR, China
    Cancer Res 65:5153-62. 2005
    ....
  15. ncbi request reprint Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells
    Hiu Wing Cheung
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Hong Kong
    Carcinogenesis 25:881-7. 2004
    ..Our evidence also indicates a novel treatment strategy to increase anticancer drug-induced apoptosis through inactivation of the Id-1 protein...
  16. ncbi request reprint Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer
    Edward W Howard
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Clin Cancer Res 13:1847-56. 2007
    ..S-allylmercaptocysteine is therefore a potential antimetastatic drug with broad clinical applications that we tested in vivo for the first time in this study...
  17. ncbi request reprint MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour
    Maggie K L Fung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:821-32. 2007
    ..06) than normal samples. Our results suggest that aberrant MAD2 expression may play an essential role in a defective mitotic checkpoint in TGCT cells, which may contribute to CIN commonly observed in TGCT tumours...
  18. ncbi request reprint Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion
    Yi Ding
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, PR China
    Int J Oncol 28:847-54. 2006
    ..Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells...
  19. pmc Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis
    Hiu Fung Yuen
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Pathol 60:510-4. 2007
    ..Upregulation of Twist, described in several types of human cancer, also acts as a prognostic marker of poor outcome...
  20. ncbi request reprint Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Mol Carcinog 35:42-9. 2002
    ....
  21. ncbi request reprint Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells
    Xiaomeng Zhang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, Pokfulam, University of Hong Kong, Hong Kong, Special Administrative Region, China
    J Biol Chem 282:33284-94. 2007
    ....
  22. ncbi request reprint Id-1 promotes proliferation of p53-deficient esophageal cancer cells
    Cheuk Man Hui
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Cancer 119:508-14. 2006
    ....
  23. ncbi request reprint MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, Hong Kong
    Oncogene 22:109-16. 2003
    ..Our data suggest a role for MAD2 in the sensitization of cancer cells to certain mitotic checkpoint-targeting anticancer drugs...
  24. ncbi request reprint Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Oncogene 22:4498-508. 2003
    ..Our findings also suggest a potential therapeutic strategy in which inactivation of Id-1 may lead to sensitization of prostate cancer cells to chemotherapeutic drug-induced apoptosis...
  25. ncbi request reprint Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth
    Ming Tat Ling
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Oncogene 21:8498-505. 2002
    ..Our results suggest for the first time that the function of Id-1 is associated with MAPK signaling pathway activation and indicate a possible novel mechanism in which Id-1 regulates prostate cancer cell growth and tumorigenesis...
  26. ncbi request reprint Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway
    Xiaomeng Zhang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Int J Cancer 118:2072-81. 2006
    ....
  27. ncbi request reprint A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression
    Qingjun Chu
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong Hong Kong, China
    Carcinogenesis 27:2180-9. 2006
    ..Our results demonstrate a novel anticancer effect of garlic and suggest that certain garlic-derived compounds may be potential agents for suppression of invasive growth through restoration of E-cadherin expression in cancer cells...
  28. doi request reprint TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction
    Hiu Fung Yuen
    Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Carcinogenesis 29:1509-18. 2008
    ....
  29. ncbi request reprint Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Carcinogenesis 28:2313-20. 2007
    ..Inactivation of Id-1 may provide us with a novel strategy to improve the treatment and survival of patients with esophageal cancer...
  30. ncbi request reprint Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis
    Xiaomeng Zhang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Cancer Sci 98:308-14. 2007
    ..Our evidence also provides a possible underlying mechanism responsible for the positive role of Id-1 in the progression of human cancer...
  31. ncbi request reprint Id-1 expression induces androgen-independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R)
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Carcinogenesis 25:517-25. 2004
    ..Inactivation of Id-1 may provide a potential therapeutic strategy leading to inhibition of androgen-independent prostate cancer cell growth...
  32. ncbi request reprint Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells
    Xiaomeng Zhang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 120:1891-8. 2007
    ..Our findings suggest an underlying molecular mechanism responsible for the TWIST-mediated chemodrug resistance and suggest a target for overcoming taxol resistance in cancer cells...
  33. ncbi request reprint Significance of TWIST expression and its association with E-cadherin in bladder cancer
    Zheng Zhang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Hum Pathol 38:598-606. 2007
    ..Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer...
  34. ncbi request reprint Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF)
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Carcinogenesis 26:1668-76. 2005
    ..Since increased Id-1 has been reported in many types of advanced human cancers, our results indicate that downregulation of Id-1 may be a novel target to inhibit the growth of metastatic cancers through the suppression of angiogenesis...
  35. ncbi request reprint Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation
    Hiu Wing Cheung
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Mol Carcinog 43:237-45. 2005
    ..1% (22 out of 36) of primary NPC tumors while it was absent in non-malignant tissues. These findings suggest that downregulation of CHFR is a common event in NPC cells which may be due to hypermethylation of the gene promoter region...
  36. doi request reprint Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma
    Chee Wai Chua
    Department of Anatomy Department of Pathology, The University of Hong Kong, SAR, China
    APMIS 118:918-26. 2010
    ..No correlation between MSX2 nuclear score and Gleason score was found. Taken together, MSX2 may serve as a potential biomarker in predicting primary prostate tumors with higher metastatic capability...
  37. ncbi request reprint Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress
    Hing Lok Wong
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Mol Carcinog 44:92-101. 2005
    ..Our results suggest that EBER expression may confer an apoptotic-resistant phenotype in immortalized nasopharyngeal epithelial cells...
  38. ncbi request reprint ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer
    Shan Yu
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, China
    Cancer Res 67:4904-14. 2007
    ..More importantly, our results suggest that ERRgamma could be a novel therapeutic target for prostate cancer treatment...
  39. doi request reprint Effect of a prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivo
    Suk Ching Lee
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, HKSAR, China
    Nutr Cancer 60:483-91. 2008
    ..Our results suggest that EGCG-P may be a more stable and useful compound for increasing the therapeutic anticancer effects in androgen-independent prostate cancer...
  40. doi request reprint CDC25A functions as a novel Ar corepressor in prostate cancer cells
    Yung Tuen Chiu
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    J Mol Biol 385:446-56. 2009
    ..Taken together, our results demonstrated a novel function of CDC25A in the regulation of androgen signaling in human prostate cancer cells...
  41. ncbi request reprint S-allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions
    Qingjun Chu
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    BJU Int 99:925-32. 2007
    ....
  42. ncbi request reprint FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
    Chun Zhou
    Cancer Biology Group, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Cancer Lett 233:36-47. 2006
    ....
  43. ncbi request reprint Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway
    Xue Song Ouyang
    Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Carcinogenesis 23:721-5. 2002
    ..Given the fact that both Id-1 over-expression and inactivation of p16(INK4a)/pRB are common events in prostate cancer, our results provide a possible mechanism on the molecular basis of prostate carcinogenesis...
  44. ncbi request reprint Anti-apoptotic role of BARF1 in gastric cancer cells
    Qi Wang
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Laboratory Block, 1 F, 21 Sassoon Road, Hong Kong, SAR, China
    Cancer Lett 238:90-103. 2006
    ..Our results suggest that BARF1 expression in gastric cancer cells may provide a protective role against apoptosis through an increased Bcl-2 to Bax ratio, thus promoting cancer cell survival...
  45. ncbi request reprint Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
    Sai Wah Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, 1st Floor, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Biochim Biophys Acta 1590:150-8. 2002
    ..The immortalized NP cell lines are non-tumorigenic and exhibit anchorage-dependent growth. These cell lines may provide a possible cell model system for studying the mechanisms involved in the tumorigenesis of NPC...
  46. ncbi request reprint Id-1 modulates senescence and TGF-beta1 sensitivity in prostate epithelial cells
    Kaijun Di
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Biol Cell 98:523-33. 2006
    ..Here, we investigated the role of Id-1 in cellular sensitivity to TGF-beta1...
  47. ncbi request reprint Id-1 promotes TGF-beta1-induced cell motility through HSP27 activation and disassembly of adherens junction in prostate epithelial cells
    Kaijun Di
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Exp Cell Res 313:3983-99. 2007
    ....
  48. ncbi request reprint Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues
    C P Cheung
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Clin Endocrinol Metab 90:1830-44. 2005
    ..Our study shows that ERRs, which are coexpressed with ERs in prostatic cells, could regulate cell growth and modulate ER-mediated pathways via interference on ERalpha transcription in prostatic cells...
  49. ncbi request reprint Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Cancer Res 62:1662-8. 2002
    ..This provides a novel insight into the molecular basis of CIN in ovarian carcinoma and has implications for effective use of checkpoint-targeting drugs...
  50. doi request reprint The prognostic significance of BMP-6 signaling in prostate cancer
    Hiu Fung Yuen
    Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mod Pathol 21:1436-43. 2008
    ..Our results also imply the potential use of bone-morphogenetic protein-6, noggin and sclerostin expression together as a prognostic predictor for metastatic progression of prostate cancer...
  51. ncbi request reprint Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells
    Yu Liu
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, People s Republic of China
    J Med Virol 66:63-9. 2002
    ..Alternatively, LMP1 alone may not be sufficient to facilitate nasopharyngeal carcinoma cell growth and additional oncogenic factors may be needed along with LMP1 in modulating the malignant property of nasopharyngeal carcinoma...
  52. ncbi request reprint The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
    S W Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Eur J Cancer 39:524-31. 2003
    ..Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC...
  53. doi request reprint Id-1 induces proteasome-dependent degradation of the HBX protein
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    J Mol Biol 382:34-43. 2008
    ..Taken together, our results demonstrated a novel function of Id-1 in regulating HBX protein stability through interaction with the proteasome...
  54. ncbi request reprint Id proteins expression in prostate cancer: high-level expression of Id-4 in primary prostate cancer is associated with development of metastases
    Hiu Fung Yuen
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mod Pathol 19:931-41. 2006
    ..150-8.987, P=0.026). Our results suggest that in prostate cancer patients, differential Id proteins expressions may be a useful marker for poor prognosis, and Id-4 may be a potential prognostic marker for distant metastasis...
  55. ncbi request reprint Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma
    Huichen Feng
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Gynecol Oncol 94:375-82. 2004
    ..To assess the differential gene expression in neoplastic and normal trophoblastic cells and evaluate the effect of methylation on tissue inhibitor of metalloproteinase 3 (TIMP3) expression in choriocarcinoma (CCA) cells...
  56. ncbi request reprint The multiple roles of Id-1 in cancer progression
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Hong Kong, China
    Differentiation 74:481-7. 2006
    ..This review will discuss recent evidence supporting the role of Id-1 in tumor progression and the mechanisms involved...
  57. ncbi request reprint Identification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasia
    Kexin Xu
    Cancer Biology Lab, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, HKSAR, China
    Electrophoresis 24:1311-8. 2003
    ..This shortened PSP61 was not due to alternative splicing of the PSP-94 gene at transcription level. Our results provide first evidence on the possibility of using PSP61 as a specific biological marker for diagnosis of BPH...
  58. ncbi request reprint Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes
    S W Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, Hong Kong, China
    Cancer Genet Cytogenet 130:141-9. 2001
    ..Identification of nonrandom chromosomal imbalance in immortalized HOSE cells may facilitate the identification of specific chromosomes harboring genes involved in the immortalization of human ovarian surface epithelial cells...
  59. ncbi request reprint Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells
    M T Ling
    Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Biochim Biophys Acta 1570:145-52. 2002
    ..Our results provide evidence for the first time that TGF beta 1 may be one of the upstream regulators of Id-1...
  60. ncbi request reprint MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cells
    K W To-Ho
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Oncogene 27:347-57. 2008
    ..The evidence presented here provides a link between MAD2 inactivation and malignant transformation of epithelial cells...
  61. pmc Id-I stimulates cell proliferation through activation of EGFR in ovarian cancer cells
    X Zhang
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, 1 F, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    Br J Cancer 91:2042-7. 2004
    ..Our findings also implicate that Id-1 may be a potential target for the development of novel strategies in the treatment of ovarian cancer...
  62. pmc Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
    H F Yuen
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Cancer 97:1409-15. 2007
    ..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients...
  63. pmc Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells
    M K L Fung
    Cancer Biology Group, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Br J Cancer 95:475-84. 2006
    ..Our results also suggest that downregulation of MAD2 may be an indicator for identification of TGCT cancer cells that are potentially resistant to cisplatin-based therapy...
  64. ncbi request reprint Over expression of ID-1 in prostate cancer
    X S Ouyang
    Cancer Biology Lab, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    J Urol 167:2598-602. 2002
    ..To test this hypothesis we analyzed Id-1 messenger RNA and protein expression by in situ hybridization and immunohistochemical study in human normal prostate, benign prostatic hyperplasia (BPH) and prostate cancer tissues...
  65. ncbi request reprint Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat
    X S Ouyang
    Department of Anatomy, Faculty of Medicine, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Carcinogenesis 22:965-73. 2001
    ..Our results provide the first evidence of up-regulation of TRPM-2, MMP-7 and Id-1 during sex hormone-induced prostate carcinogenesis and strongly suggest their association with the development of prostate cancer...
  66. ncbi request reprint Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization
    A Kwok Fung Lo
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, PR China
    Biochim Biophys Acta 1520:131-40. 2001
    ..The expression profiles of differentially expressed genes identified in this study suggest a role of LMP1 in promotion of cell survival and facilitation of tumor invasion...
  67. ncbi request reprint Effect of p53 on centrosome amplification in prostate cancer cells
    X Ouyang
    Department od Anatomy, Faculty of Medicine, University of Hong Kong, SAR, PR China
    Biochim Biophys Acta 1541:212-20. 2001
    ..Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells...
  68. ncbi request reprint Id-1 expression and cell survival
    Y C Wong
    Department of Anatomy, Cancer Biology Lab, Faculty of Medicine, and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Apoptosis 9:279-89. 2004
    ..Finally, the therapeutic implications through inactivation of Id-1 in the treatment of human cancer will also be addressed...
  69. pmc Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1
    H F Yuen
    Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Cancer 102:332-41. 2010
    ..Id-1 is overexpressed in and correlated with metastatic potential of prostate cancer. The role of Id-1 in this metastatic process was further analysed...
  70. doi request reprint Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer
    Edward W Howard
    Department of Internal Medicine, Georgetown University Hospital, NW, Washington, DC 20007, USA
    Clin Exp Metastasis 25:497-508. 2008
    ..We also indicate the novel involvement of GRP94 suppression in prostate cancer metastasis...
  71. ncbi request reprint Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer
    Shiva S Forootan
    Molecular Pathology Laboratory, School of Cancer Studies, Faculty of Medicine, University of Liverpool, L69 3GA Liverpool, United Kingdom
    Hum Pathol 38:1321-9. 2007
    ..01). These results suggest that Id-1 is a useful prognostic marker to predict the outcomes of patients with prostate cancer...
  72. ncbi request reprint Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells
    Wai Kei Kwok
    Department of Anatomy
    Carcinogenesis 28:2467-75. 2007
    ..This negative effect of TWIST on DNA damage response facilitates uncontrolled cell proliferation with genomic instability and tumorigenesis in non-malignant cells...
  73. ncbi request reprint Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines
    Kexin Xu
    Department of Urology, People s Hospital, Peking University, Beijing 100044, China
    Chin Med J (Engl) 116:1673-7. 2003
    ..To study the effects of an alpha(1)-adrenoceptor antagonist, terazosin on the androgen-independent prostate cancer cell lines PC-3 and DU145...
  74. ncbi request reprint The alpha1-adrenoceptor antagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway
    Kexin Xu
    Department of Urology, People s Hospital, Beijing, China
    Oncol Rep 10:1555-60. 2003
    ..Our results provide evidence for the first time that terazosin may have a therapeutic potential in the treatment of advanced prostate cancer...
  75. ncbi request reprint [Expressions of MAD2 and p55CDC in prostate cancer and their correlations with the prostate cancer grading]
    Kexin Xu
    Department of Urology, Peking University People s Hospital, Beijing 100044, China
    Beijing Da Xue Xue Bao 35:586-90. 2003
    ..To investigate if downregulation of two mitotic checkpoint proteins, MAD2 and p55CDC, is a frequent event in human prostate cancer and whether decreased expression of these two proteins are associated with progression of prostate cancer...
  76. ncbi request reprint Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides
    Elizabeth M Doherty
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 48:71-90. 2005
    ..In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (F(oral) = 39% and 17%, respectively)...
  77. ncbi request reprint Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer
    Xuhui Zhu
    Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing 100034, China
    Anticancer Res 26:1253-9. 2006
    ..These results suggest that PTTG1 may be a potential prognostic marker for prostate cancer and that the down-regulation of PTTG1 may be a therapeutic target in the suppression of prostate cancer growth...
  78. ncbi request reprint Overexpression of Id-1 in gastric adenocarcinoma: implication for a novel diagnostic marker
    Qi Wang
    Laboratory of Medical Genetics, Department of Biology, Harbin Medical University, Harbin, China
    Anticancer Res 24:881-6. 2004
    ..Our results indicate that up-regulation of Id-1 is a frequent event in gastric cancer but its expression levels are not associated with tumour metastasis. Our evidence provides a possible novel marker for the diagnosis of gastric cancer...
  79. doi request reprint Cloning, characterization and expression of the extracellular lipase gene from Aureobasidium pullulans HN2-3 isolated from sea saltern
    Zhiqiang Liu
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, China
    Antonie Van Leeuwenhoek 94:245-55. 2008
    ..coli BL21(DE3) harboring pET-24a(+)LIP1. Optimal pH and temperature of the crude recombinant lipase were 8.0 and 35 degrees C, respectively and the crude recombinant lipase had the highest hydrolytic activity towards peanut oil...
  80. ncbi request reprint Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility
    Xianghong Wang
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Bioorg Med Chem Lett 17:6539-45. 2007
    ..In addition, compound 26 was found to be orally bioavailable (rat F(oral)=24%) and had potent TRPV1 antagonist activity (capsaicin IC(50)=1.5nM) comparable to that of 1...