Wenwei Tu

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, PR China
    Blood 112:2554-62. 2008
  2. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
  3. doi request reprint Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Immunol 183:3742-50. 2009
  4. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
  5. pmc Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China
    J Virol 85:10109-16. 2011
  6. doi request reprint Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Special Administrative Region, Hong Kong, China
    J Infect Dis 200:858-65. 2009
  7. pmc Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong
    J Virol 84:4148-57. 2010
  8. pmc TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells
    Ping Lung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong Hong Kong SAR, China
    PLoS ONE 8:e67969. 2013
  9. doi request reprint Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P R China
    Eur J Immunol 41:128-39. 2011
  10. doi request reprint Natural killer cells become tolerogenic after interaction with apoptotic cells
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Eur J Immunol 40:1718-27. 2010

Collaborators

Detail Information

Publications25

  1. pmc Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, PR China
    Blood 112:2554-62. 2008
    ..This approach may accelerate the clinical application of Treg-based immunotherapy in transplantation and autoimmune diseases...
  2. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
    ....
  3. doi request reprint Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Immunol 183:3742-50. 2009
    ..This approach may facilitate the clinical application of CD8(+) Treg-based immunotherapy in transplantation and autoimmune diseases...
  4. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
    ..Avian influenza A H9N2 (H9N2/G1) virus has infected humans and has the potential to be the next pandemic virus. Antiviral function and immunomodulatory role of MBL in pdmH1N1 and H9N2/G1 virus infection have not been investigated...
  5. pmc Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China
    J Virol 85:10109-16. 2011
    ..Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection...
  6. doi request reprint Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Special Administrative Region, Hong Kong, China
    J Infect Dis 200:858-65. 2009
    ..gammadelta T cells have potent antiviral activities against different viruses, but no data are available concerning their antiviral activity against influenza viruses...
  7. pmc Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong
    J Virol 84:4148-57. 2010
    ..These findings suggest that influenza virus developed a novel strategy to evade NK cell innate immune defense that is likely to facilitate viral transmission and also contribute to virus pathogenesis...
  8. pmc TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells
    Ping Lung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong Hong Kong SAR, China
    PLoS ONE 8:e67969. 2013
    ....
  9. doi request reprint Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, P R China
    Eur J Immunol 41:128-39. 2011
    ....
  10. doi request reprint Natural killer cells become tolerogenic after interaction with apoptotic cells
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Eur J Immunol 40:1718-27. 2010
    ..We report here a novel interaction between NK cells and AC, resulting in the tolerogenic properties of NK cells required for immune contraction...
  11. doi request reprint CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cell Mol Immunol 7:44-50. 2010
    ..Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases...
  12. doi request reprint Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 000000, China
    Sci Transl Med 5:168ra9. 2013
    ..These CD8(hi) T(regs) induced long-term tolerance effectively without compromising general immunity and graft-versus-tumor activity. Our results support testing of human CD8(hi) T(regs) in GVHD in clinical trials...
  13. pmc Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia
    Yinping Liu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    J Clin Immunol 32:421-9. 2012
    ..Btk is expressed in both B and dendritic cells (DC). However, little is known about the immune response of DC and T cells to influenza virus in XLA patients...
  14. doi request reprint Phenotypic and functional characterization of human γδ T-cell subsets in response to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong
    J Infect Dis 205:1646-53. 2012
    ..Our study provides further evidence for the phenotypic and functional characterization of human Vγ9Vδ2 T-cell subsets during fluA virus infection and may help improve the γδ T-cell-based immunotherapy for viral infection...
  15. pmc The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Exp Med 208:1511-22. 2011
    ..As PAM has been commonly used to treat osteoporosis and Paget's disease, this new application of an old drug potentially offers a safe and readily available option for treating influenza...
  16. pmc Influenza virus directly infects human natural killer cells and induces cell apoptosis
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 83:9215-22. 2009
    ....
  17. pmc Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 8:e60862. 2013
    ..To our knowledge, we identified for the first time the critical role of NK cells in the mechanism of IgG-induced induction of Treg cells in treatment of autoimmunity...
  18. pmc Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6
    Helen K W Law
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, PR China
    BMC Immunol 9:74. 2008
    ..We hypothesized that the effects of IGF-I may be mediated by accessory cells and soluble factors...
  19. doi request reprint H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades
    Kenrie P Y Hui
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
    J Infect Dis 204:1866-78. 2011
    ..Thus, sensitizing neighboring cells by upregulation of RIG-I contributes to the amplified cytokine cascades during H5N1 infection...
  20. doi request reprint Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells
    Gloria Hoi Wan Tso
    Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, HKSAR, China
    Stem Cells 28:939-54. 2010
    ..This data provide a novel insight on the role of AC in modulating MSC osteogenic differentiation and function in inflammatory bone diseases...
  21. pmc Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
    Yuet Wu
    Department of Paediatrics, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    BMC Infect Dis 11:201. 2011
    ..Dendritic cells are key antigen presenting cells but its role in such co-infection is unclear...
  22. doi request reprint γδ-T cells: an unpolished sword in human anti-infection immunity
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Cell Mol Immunol 10:50-7. 2013
    ....
  23. doi request reprint Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation
    Ka Wai Cheung
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Ethnopharmacol 138:463-71. 2011
    ..All these can be linked to the modulation of immune function. Therefore, it will be relevant for us to find out whether there is any novel compound that can account for such action and the mechanism involved...
  24. doi request reprint Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: a randomized controlled trial
    Susan S Chiu
    Department of Pediatric and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    Vaccine 27:4834-9. 2009
    ..We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies...