H F Tse

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model
    Hung Fat Tse
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Circulation 114:1000-11. 2006
  2. ncbi request reprint Prevention of ventricular fibrillation by pacing in a man with Brugada syndrome
    K L Lee
    University Department of Medicine, Queen Mary Hospital, Hong Kong, Peoples Republic of China
    J Cardiovasc Electrophysiol 11:935-7. 2000
  3. ncbi request reprint Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Coll Cardiol 40:1451-8. 2002
  4. ncbi request reprint Impedance cardiography for atrioventricular interval optimization during permanent left ventricular pacing
    Hung Fat Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 26:189-91. 2003
  5. ncbi request reprint Clinical predictors and time course of arrhythmia recurrence in patients with early reinitiation of atrial fibrillation after successful internal cardioversion
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 26:1809-14. 2003
  6. doi request reprint Worsened arterial stiffness in high-risk cardiovascular patients with high habitual carbohydrate intake: a cross-sectional vascular function study
    Hiu Ting Chan
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    BMC Cardiovasc Disord 14:24. 2014
  7. pmc Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus
    Kai Hang Yiu
    Division of Cardiology, Department of Medicine, The University of Hong Kong, Rm 1929b, Block K, Queen Mary Hospital, China
    Cardiovasc Diabetol 12:94. 2013
  8. doi request reprint Prospective randomized study to assess the efficacy of site and rate of atrial pacing on long-term progression of atrial fibrillation in sick sinus syndrome: Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) Study
    Chu Pak Lau
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Circulation 128:687-93. 2013
  9. doi request reprint Stroke prevention in atrial fibrillation--an Asian stroke perspective
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong
    Heart Rhythm 10:1082-8. 2013
  10. doi request reprint Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hum Mol Genet 22:1395-403. 2013

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model
    Hung Fat Tse
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Circulation 114:1000-11. 2006
    ..We hypothesized that overexpression of an engineered HCN construct via somatic gene transfer offers a flexible approach for fine-tuning cardiac pacing in vivo...
  2. ncbi request reprint Prevention of ventricular fibrillation by pacing in a man with Brugada syndrome
    K L Lee
    University Department of Medicine, Queen Mary Hospital, Hong Kong, Peoples Republic of China
    J Cardiovasc Electrophysiol 11:935-7. 2000
    ..We present the first report on prevention of ventricular fibrillation in a man with Brugada syndrome by overdrive pacing from his dual chamber implantable cardioverter defibrillator...
  3. ncbi request reprint Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Coll Cardiol 40:1451-8. 2002
    ..We sought to evaluate the long-term effects of alternative right ventricular pacing sites on myocardial function and perfusion...
  4. ncbi request reprint Impedance cardiography for atrioventricular interval optimization during permanent left ventricular pacing
    Hung Fat Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 26:189-91. 2003
    ..67, P < 0.001). In conclusion, our initial experience suggests that IC is a reliable method of AV interval optimization during LV pacing. IC and echo measurements of CO during LV pacing were closely correlated...
  5. ncbi request reprint Clinical predictors and time course of arrhythmia recurrence in patients with early reinitiation of atrial fibrillation after successful internal cardioversion
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 26:1809-14. 2003
    ..The difference in the time course of AF recurrence in patients with ERAF from those with long AF duration suggests distinct arrhythmogenic mechanisms...
  6. doi request reprint Worsened arterial stiffness in high-risk cardiovascular patients with high habitual carbohydrate intake: a cross-sectional vascular function study
    Hiu Ting Chan
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    BMC Cardiovasc Disord 14:24. 2014
    ..However, the relation between carbohydrate intake and arterial stiffness has not been established. The purpose of this study was to examine this relation among high-risk cardiovascular patients...
  7. pmc Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus
    Kai Hang Yiu
    Division of Cardiology, Department of Medicine, The University of Hong Kong, Rm 1929b, Block K, Queen Mary Hospital, China
    Cardiovasc Diabetol 12:94. 2013
    ..We postulated that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis may contribute to subclinical myocardial injury in patients with T2DM...
  8. doi request reprint Prospective randomized study to assess the efficacy of site and rate of atrial pacing on long-term progression of atrial fibrillation in sick sinus syndrome: Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) Study
    Chu Pak Lau
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Circulation 128:687-93. 2013
    ..We evaluated whether long-term atrial pacing at the right atrial (RA) appendage versus the low RA septum with (ON) or without (OFF) a continuous atrial overdrive pacing algorithm can prevent the development of persistent AF...
  9. doi request reprint Stroke prevention in atrial fibrillation--an Asian stroke perspective
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong
    Heart Rhythm 10:1082-8. 2013
    ..Moreover, there is scope to improve physician perceptions and patient knowledge, as well as considering alternative new oral anticoagulants, for example, direct thrombin inhibitors or factor Xa inhibitors. ..
  10. doi request reprint Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hum Mol Genet 22:1395-403. 2013
    ..This is the first demonstration that patient-specific iPSC-derived cardiomyocytes can be used to provide histological and functional confirmation of a suspected genetic basis for DCM identified by WES...
  11. pmc Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress
    Chun Ting Zhao
    Shan Dong University School of Medicine, Shandong, China
    Cardiovasc Diabetol 11:147. 2012
    ..Their relation to myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is nonetheless unknown...
  12. pmc Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium
    Yuan Liu
    Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, HKSAR, China
    J Cardiovasc Transl Res 5:359-64. 2012
    ....
  13. doi request reprint Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel
    Jiao Zhang
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong
    Am J Physiol Cell Physiol 303:C115-25. 2012
    ..These findings demonstrate that the hEAG1 channel plays a crucial role in controlling the proliferation rate of human iPSC-MSCs and to a lesser extent in BM-MSCs...
  14. pmc Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
    Carmen Wing Sze Chan
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Cardiovasc Magn Reson 12:6. 2010
    ..This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR)...
  15. doi request reprint Impact of right ventricular pacing sites on exercise capacity during ventricular rate regularization in patients with permanent atrial fibrillation
    Hung Fat Tse
    Department of Medicine, Cardiology Division, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 32:1536-42. 2009
    ..The deleterious effects of right ventricular apical (RVA) pacing may offset the potential benefit of ventricular rate (VR) regularization and rate adaptation during an exercise in patient's atrial fibrillation (AF)...
  16. doi request reprint Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus
    Kai Hang Yiu
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Rheumatol 38:621-7. 2011
    ..We investigated the prevalence of valvular calcification in patients with RA and SLE and its relationship with arterial atherosclerotic calcification...
  17. ncbi request reprint Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Pacing Clin Electrophysiol 28:421-4. 2005
    ..However, the impacts of this procedure on quality-of-life (QoL) have not been evaluated...
  18. ncbi request reprint Effects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Cardiovasc Electrophysiol 16:201-4. 2005
    ..Lesion dimension of cryoablation...
  19. ncbi request reprint Blood pressure response to transition from supine to standing posture using an orthostatic response algorithm
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Pacing Clin Electrophysiol 28:S242-5. 2005
    ..4 vs -10.3 mmHg), 1.5 minutes (+7.0 vs -4.9 mmHg), 2 minutes (+1.6 vs -6.7 mmHg), and 3 minutes (+2.5 vs -8.5 mmHg). These preliminary results suggest that the OSR algorithm maintains BP upon standing in patients with OH...
  20. doi request reprint Determinants of lesion dimensions during transcatheter microwave ablation
    Hung Fat Tse
    Department of Medicine, Cardiology Division, University of Hong Kong, Hong Kong, China
    Pacing Clin Electrophysiol 32:201-8. 2009
    ..Transcatheter microwave ablation is a novel technique for treating cardiac arrhythmias...
  21. ncbi request reprint Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial)
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Eur Heart J 28:2998-3005. 2007
    ..Recently, several non-randomized pilot studies have also suggested that direct BM cells implantation appears to be feasible and safe in patients with severe coronary artery diseases (CAD)...
  22. pmc Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
    Wen Sheng Yue
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 10:113. 2011
    ..Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown...
  23. pmc Deep vein thrombosis demonstrated by contrast enhanced helical computed tomographic venography
    H F Tse
    Heart 90:251. 2004
  24. ncbi request reprint Area of left ventricular regional conduction delay and preserved myocardium predict responses to cardiac resynchronization therapy
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Cardiovasc Electrophysiol 16:690-5. 2005
    ..Cardiac resynchronization therapy...
  25. doi request reprint Muscle noise effects on atrial evoked response sensing: implications on atrial auto-threshold and auto-capture determination
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Pacing Clin Electrophysiol 34:460-6. 2011
    ..The aim of this study is to evaluate the impact of myopotential noise induced by various maneuvers on the atrial evoked response (AER) signal...
  26. ncbi request reprint Transient overdrive pacing upon standing prevents orthostatic hypotension in elderly pacemaker patients with chronotropic incompetence
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 30:188-92. 2007
    ..The objective of this study was to determine whether a transient increase in heart rate (HR) by overdrive pacing upon standing prevents OH in elderly pacemaker patients...
  27. doi request reprint Stem cells for myocardial repair
    Chung Wah Siu
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Thromb Haemost 104:6-12. 2010
    ..Furthermore, the optimal timing, cell types and mode of delivery need to be addressed, and strategies to improve cell survival and engraftment should also be developed to overcome the potential hurdles related to cell-based therapy...
  28. ncbi request reprint Bone marrow stem cell therapy for myocardial angiogenesis
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, China
    Curr Vasc Pharmacol 5:103-12. 2007
    ..Emerging, rationally designed, randomized clinical trials are required to assess the clinical implication of BM derived stem cells therapy in treatment of CAD...
  29. ncbi request reprint Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
    Hung Fat Tse
    Division of Cardiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Eur J Heart Fail 9:747-53. 2007
    ..To determine the optimal bone marrow (BM) cell types, and their potential mechanisms of action for neovascularization in chronic ischaemic myocardium...
  30. ncbi request reprint Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am Heart J 154:982.e1-6. 2007
    ..In both therapeutic approaches, direct local myocardial injury might be a common mechanism to induce therapeutic angiogenesis...
  31. ncbi request reprint Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Am J Cardiol 98:60-2. 2006
    ..Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low...
  32. doi request reprint Upgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacity
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Cardiovasc Electrophysiol 20:901-5. 2009
    ..Chronic RV septal pacing has been shown to be superior to RV apical pacing in newly implanted patients. However, whether RV septal pacing can reverse deleterious effects of RV apical pacing remain unclear...
  33. ncbi request reprint Transvenous cryoablation reduces platelet activation during pulmonary vein ablation compared with radiofrequency energy in patients with atrial fibrillation
    Hung Fat Tse
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong
    J Cardiovasc Electrophysiol 16:1064-70. 2005
    ..The objective of this study was to compare the thrombogenic potential of transvenous cryoablation versus RF ablation during pulmonary vein (PV) isolation...
  34. doi request reprint Impacts of ventricular rate regularization pacing at right ventricular apical vs. septal sites on left ventricular function and exercise capacity in patients with permanent atrial fibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People s Republic of China
    Europace 11:594-600. 2009
    ....
  35. ncbi request reprint JTV-519 Japan Tobacco
    H F Tse
    Queen Mary Hospital, University Department of Medicine, Pokfulam, Hong Kong
    Curr Opin Investig Drugs 2:936-9. 2001
    ..In experimental myofibrillar overcontraction models, it demonstrated greater cardioprotectant effects than propranolol, verapamil and diltiazem [171668]...
  36. ncbi request reprint Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation
    H F Tse
    Division of Cardiology, Department of Medicine and the Institute of Cardiovascular Science and Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Exp Pharmacol Physiol 28:446-50. 2001
    ..However, both were less efficacious during exercise and did not significantly affect rhythm irregularity, exercise capacity, quality of life and AF symptomatology in patients with chronic AF...
  37. ncbi request reprint A cephalic vein cutdown and venography technique to facilitate pacemaker and defibrillator lead implantation
    H F Tse
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, Institute of Cardiovascular Science and Medicine, University of Hong Kong
    Pacing Clin Electrophysiol 24:469-73. 2001
    ..This technique is safe and applicable in the majority of patients and avoids the risk of subclavian puncture...
  38. ncbi request reprint Electrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, China
    J Am Coll Cardiol 40:2150-5. 2002
    ..We sought to determine the electrophysiologic actions of sotalol in the remodeled atrium of humans...
  39. ncbi request reprint Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Lancet 361:47-9. 2003
    ..After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result...
  40. ncbi request reprint Bleeding and thromboembolic risks of internal cardioversion for persistent atrial fibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 25:1752-5. 2002
    ..However, the use of periprocedural heparin therapy was associated with an increase risk of procedure related bleeding complications...
  41. ncbi request reprint Effects of different atrioventricular intervals during dual-site right atrial pacing on left atrial mechanical function
    P C Ho
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 23:1748-51. 2000
    ..This observation has important implications with respect to the programming of dual-site RA pacemakers implanted to prevent AF for hemodynamic purpose...
  42. pmc Sudden cardiac death caused by hypertrophic cardiomyopathy associated with midventricular obstruction and apical aneurysm
    H F Tse
    Heart 89:178. 2003
  43. ncbi request reprint Effect of coronary sinus electrode on the optimal atrial defibrillation pathway for an atrioventricular defibrillator
    Hung Fat Tse
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    J Cardiovasc Electrophysiol 14:32-7. 2003
    ..The aim of this study was to assess the benefit of incorporating a coronary sinus (CS) lead into the atrial defibrillation pathway in atrial defibrillation threshold (ADFT) reduction in patients with persistent AF...
  44. ncbi request reprint Recurrence of atrial fibrillation after pulmonary vein isolation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Cardiovasc Electrophysiol 14:691-2. 2003
  45. ncbi request reprint Atrial tachycardia arising from an epicardial site with venous connection between the left superior pulmonary vein and superior vena cava
    Hung Fat Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Cardiovasc Electrophysiol 14:540-3. 2003
    ..An application of radiofrequency energy with a saline-irrigated ablation catheter delivered at the earliest activation site in the LAA terminated the tachycardia. The tachycardia did not recur during 18-month follow-up...
  46. ncbi request reprint Dose-response relationship for successful internal atrial defibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 26:1249-53. 2003
    ....
  47. ncbi request reprint Prospective observational study of isoflavone and the risk of stroke recurrence: potential clinical implications beyond vascular function
    Y H Chan
    School of Public Health, The University of Hong Kong, Hong Kong, China
    J Nutr Health Aging 16:383-8. 2012
    ..Whether isoflavone has any effect on recurrent cardiovascular events is unknown...
  48. ncbi request reprint Burden of carotid atherosclerosis in patients with stroke: relationships with circulating endothelial progenitor cells and hypertension
    K K Lau
    Division of Cardiology, The University of Hong Kong, Hong Kong, China
    J Hum Hypertens 21:445-51. 2007
    ..5% versus 28.6%; P=0.001). Our observations suggested that reduced circulating EPC may contribute to the progression of carotid atherosclerosis. Circulating EPC count may provide a novel marker for the burden of carotid atherosclerosis...
  49. ncbi request reprint Adverse systemic arterial function in patients with selenium deficiency
    Y H Chan
    School of Public Health, University of Hong Kong, 21 Sassoon Road, Hong Kong
    J Nutr Health Aging 16:85-8. 2012
    ..However, the relationship between selenium deficiency and vascular function in clinical context remains unknown...
  50. ncbi request reprint Initial clinical experience with a new self-retaining left ventricular lead for permanent left ventricular pacing
    H F Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pacing Clin Electrophysiol 23:1738-40. 2000
    ....
  51. ncbi request reprint Low circulating level of CD133+KDR+cells in patients with systemic sclerosis
    M Y Mok
    Division of Rheumatology and Immunology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Clin Exp Rheumatol 28:S19-25. 2010
    ..Results of previous studies on the level of circulating endothelial progenitor cells (EPCs), which are involved in vascular repair, in scleroderma (SSc) patients have been controversial...
  52. ncbi request reprint Reversal of left ventricular remodeling by synchronous biventricular pacing in heart failure
    C P Lau
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Pacing Clin Electrophysiol 23:1722-5. 2000
    ..Synchronous biventricular pacing for 3 months was associated with hemodynamic improvements, reversal of left ventricular remodeling, and increase in left ventricular systolic function, and a decrease in secondary mitral regurgitation...
  53. ncbi request reprint Reversible impairment of left and right ventricular systolic and diastolic function during short-lasting atrial fibrillation in patients with an implantable atrial defibrillator: a tissue Doppler imaging study
    C M Yu
    Division of Cardiology, Dept. of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Pacing Clin Electrophysiol 24:979-88. 2001
    ..Early restoration of sinus rhythm by an IAD minimizes ventricular dysfunction. TDI is a sensitive tool to assess early systolic and diastolic dysfunction...
  54. doi request reprint Prevalence and extent of subclinical atherosclerosis in patients with psoriasis
    K H Yiu
    Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Intern Med 273:273-82. 2013
    ..Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown...
  55. doi request reprint Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke
    K K Lau
    Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Nutr Health Aging 17:600-4. 2013
    ..To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS)...
  56. ncbi request reprint Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production
    Ruby L C Hoo
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Arterioscler Thromb Vasc Biol 27:2777-82. 2007
    ....
  57. ncbi request reprint Control of paroxysmal atrial fibrillation recurrence using combined administration of propafenone and quinidine
    C P Lau
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Am J Cardiol 86:1327-32. 2000
    ..The use of a standard dose of propafenone, followed by low-dose quinidine combination to reduce propafenone degradation, and the combined standard dose of propafenone and quinidine may be used to maximize efficacy and tolerability...
  58. ncbi request reprint Defibrillation-guided radiofrequency ablation of atrial fibrillation secondary to an atrial focus
    C P Lau
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    J Am Coll Cardiol 33:1217-26. 1999
    ....
  59. ncbi request reprint Functional ion channels in mouse bone marrow mesenchymal stem cells
    Rong Tao
    Department of Medicine and Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Am J Physiol Cell Physiol 293:C1561-7. 2007
    ..These results demonstrate that three types of functional ion channel currents (i.e., I(Kir), I(KCa), and I(Cl)) are present in mouse bone marrow MSCs...
  60. doi request reprint Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease
    Ting Hin Luk
    Cardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Eur J Cardiovasc Prev Rehabil 16:464-71. 2009
    ....
  61. doi request reprint Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
    A W K Tso
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    Neurology 76:1968-75. 2011
    ..However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality...
  62. pmc Recurrent acute heart failure caused by sliding hiatus hernia
    C W Siu
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Postgrad Med J 81:268-9. 2005
    ..Cardiac catheterisation confirmed the diagnosis by showing a pronounced rise of pulmonary capillary wedge pressure in the recumbent position compared with the sitting up position...
  63. ncbi request reprint Prognostic role of coronary calcification in patients with rheumatoid arthritis and systemic lupus erythematosus
    K H Yiu
    Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    Clin Exp Rheumatol 30:345-50. 2012
    ....
  64. doi request reprint Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
    K H Yiu
    Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Br J Dermatol 164:514-20. 2011
    ..Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear...
  65. ncbi request reprint Dual-site atrial pacing for atrial fibrillation in patients without bradycardia
    C P Lau
    Queen Mary Hospital, Hong Kong, China
    Am J Cardiol 88:371-5. 2001
    ..The absence of a major impact on symptom control suggests that pacing should be used as an adjunctive therapy with other treatment modalities for AF...
  66. doi request reprint Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension
    L Y Ho
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Hum Hypertens 25:304-10. 2011
    ....
  67. pmc Automaticity and conduction properties of bio-artificial pacemakers assessed in an in vitro monolayer model of neonatal rat ventricular myocytes
    Yau Chi Chan
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR
    Europace 12:1178-87. 2010
    ..Here, we attempted to better define the relative contribution of I(f) and I(K1) in the generation of spontaneous action potentials (SAPs) in cardiomyocytes (CMs)...
  68. ncbi request reprint First human demonstration of cardiac stimulation with transcutaneous ultrasound energy delivery: implications for wireless pacing with implantable devices
    Kathy L Lee
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    J Am Coll Cardiol 50:877-83. 2007
    ..The purpose of this study was to evaluate the feasibility and safety of a novel technology that uses energy transfer from an ultrasound transmitter to achieve cardiac stimulation without the use of a pacing lead in humans...
  69. doi request reprint Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis
    C T Zhao
    Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China Traffic Hospital in Shan Dong Province, China
    J Eur Acad Dermatol Venereol 28:461-8. 2014
    ..We hypothesized that vit-D deficiency and/or elevated PTH in psoriasis may contribute to left ventricular (LV) dysfunction...
  70. doi request reprint Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct
    K K Lau
    Neurology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    Eur J Neurol 21:319-25. 2014
    ..The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown...
  71. doi request reprint Incremental predictive value of vascular assessments combined with the Framingham Risk Score for prediction of coronary events in subjects of low-intermediate risk
    K K Lau
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Postgrad Med J 84:153-7. 2008
    ..In patients with low-intermediate risk, the use of the Framingham Risk Score (FRS) may not allow accurate prediction of the occurrence of coronary events...
  72. ncbi request reprint P wave polarity during pacing in pulmonary veins
    H F Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital
    J Interv Card Electrophysiol 5:167-72. 2001
    ..Among the 12 ECG leads, I, II, III, aVL, and V1 are the most helpful in regionalizing premature depolarizations arising in the pulmonary veins...
  73. ncbi request reprint Sudden cardiac death: prevention and treatment
    K M Kwok
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, ROC
    Hong Kong Med J 9:357-62. 2003
    ..Furthermore, for individuals at significant risk of sudden cardiac death, primary prevention of sudden cardiac death through the placement of an implantable cardioverter defibrillator is increasingly being used...
  74. doi request reprint Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease
    Wen Sheng Yue
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Am J Cardiol 106:1248-54. 2010
    ..This suggests that in smokers, depletion of circulating EPCs might be linked to the occurrence of pulmonary vascular dysfunction...
  75. doi request reprint Analysis of ventricular performance as a function of pacing site and mode
    Chung Wah Siu
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Prog Cardiovasc Dis 51:171-82. 2008
    ....
  76. doi request reprint Relationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythm
    Chung Wah Siu
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Europace 12:517-21. 2010
    ..To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV)...
  77. ncbi request reprint Transient atrial fibrillation complicating acute inferior myocardial infarction: implications for future risk of ischemic stroke
    Chung Wah Siu
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Chest 132:44-9. 2007
    ..It nonetheless remains uncertain whether AF that occurs transiently during MI is associated with a subsequent increased risk of the development of AF and ischemic stroke...
  78. doi request reprint Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitus
    C Y Wong
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabet Med 27:54-60. 2010
    ..However, the effects of fish-oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear...
  79. doi request reprint Hypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications
    Y F Lau
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Hum Hypertens 26:563-9. 2012
    ..In addition, optimal antithrombotic therapy, blood pressure control as well as rate control for AF are key to the management of patients with AF...
  80. doi request reprint Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with Type 2 diabetes mellitus
    H T Chan
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Diabet Med 30:100-8. 2013
    ..However, the relationship between fruit intake and carotid atherosclerosis in these patients is unknown. We studied the relationship between dietary fruit intake and carotid intima-media thickness in patients with Type 2 diabetes...
  81. ncbi request reprint Effect of verapamil on prevention of atrial fibrillation in patients implanted with an implantable atrial defibrillator
    H F Tse
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Cardiol 24:503-5. 2001
    ..4 vs. 1.8 +/- 2.1 p = 0.7) with or without treatment with verapamil. CONCLUSIONS: The results of the present study suggest that treatment with verapamil has no significant effect on the prevention of AF in patients treated with an LAD...
  82. doi request reprint Temporary leadless pacing in heart failure patients with ultrasound-mediated stimulation energy and effects on the acoustic window
    Kathy L Lee
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Heart Rhythm 6:742-8. 2009
    ..Left ventricular stimulation for cardiac resynchronization therapy is largely limited by access and anatomy of coronary veins...
  83. doi request reprint Are MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for Chinese patients?
    Chung Wah Siu
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Cardiovasc Electrophysiol 21:231-5. 2010
    ..It remains unclear whether the MADIT-II criteria for ICD implantation are appropriate for Chinese patients...
  84. ncbi request reprint Therapeutic angiogenesis with bone marrow--derived stem cells
    Hung Fat Tse
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China hftse hkucc hku hk
    J Cardiovasc Pharmacol Ther 12:89-97. 2007
    ..Nevertheless, many obstacles remain, such as long-term safety and optimal timing and treatment strategies for BM cell therapy, and these issues need to be addressed in rationally designed, randomized clinical trials...
  85. pmc Synergistic effects of inward rectifier (I) and pacemaker (I) currents on the induction of bioengineered cardiac automaticity
    Yau Chi Chan
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong
    J Cardiovasc Electrophysiol 20:1048-54. 2009
    ..Although the 2 strategies have been largely assumed synergistic, their complementarity has not been investigated...
  86. ncbi request reprint The CEPHEUS Pan-Asian survey: high low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre
    Raymond H W Chan
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    Hong Kong Med J 18:395-406. 2012
    ....
  87. doi request reprint Use of aspirin in Chinese after recovery from primary intracranial haemorrhage
    Boon Hor Chong
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Thromb Haemost 107:241-7. 2012
    ..4 per 1,000 patient-aspirin years, vs. 112.8 per 1,000 patient-years, p=0.04). In conclusion, we observed in a cohort of Chinese post-ICH patients that aspirin use was not associated with an increased risk for a recurrent ICH...
  88. ncbi request reprint Electrical remodelling of chronic atrial fibrillation
    C P Lau
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Exp Pharmacol Physiol 24:982-3. 1997
    ....
  89. ncbi request reprint Continuous calcium chloride infusion for massive nifedipine overdose
    Y M Lam
    Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Chest 119:1280-2. 2001
    ....
  90. ncbi request reprint Endothelial function in obstructive sleep apnea and response to treatment
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 169:348-53. 2004
    ..02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use...
  91. ncbi request reprint Ion channels in mesenchymal stem cells from rat bone marrow
    Gui Rong Li
    Department of Medicine, The University of Hong Kong, Pokfulam, China
    Stem Cells 24:1519-28. 2006
    ..e., I(KCa), I(to), IK(DR), I(Na.TTX), and I(Ca.L)) are present in rat MSCs from bone marrow; however, physiological roles of these ion channels remain to be studied...
  92. ncbi request reprint Automatic mode switching of implantable pacemakers: II. Clinical performance of current algorithms and their programming
    Chu Pak Lau
    Department of Medicine, Queen Mary Hospital, and the Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong
    Pacing Clin Electrophysiol 25:1094-113. 2002
    ..Appropriate programming of atrial sensitivity, and the avoidance of ventriculoatrial cross-talk are essential for optimal AMS performance...
  93. ncbi request reprint Impact of duration of cryothermal application on clinical efficacy of pulmonary vein isolation using transvenous cryoablation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Pacing Clin Electrophysiol 28:839-43. 2005
    ..The aim of this study was to determine the effect of duration of cryoablation application with double freeze-thaw cycles on clinical efficacy for PV isolation for treatment of AF...
  94. doi request reprint Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs
    Gui Rong Li
    Department of Medicine, Li Ka Shing Faculty of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
    Circulation 117:2449-57. 2008
    ..The present study investigated whether the natural flavone acacetin from the traditional Chinese medicine Xuelianhua would be an atrium-selective anti-AF agent...
  95. ncbi request reprint Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes
    Gui Rong Li
    Department of Medicine Institute of Cardiovascular Science and Medicine, L8 01, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    J Mol Cell Cardiol 36:495-504. 2004
    ....
  96. doi request reprint Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway
    Yee Ki Lee
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Mol Endocrinol 24:1728-36. 2010
    ..Our results show that T(3) supplementation promotes cardiac differentiation of ESCs and enhances maturation of electrophysiological, as well as calcium homeostasis, properties of ESC-derived cardiomyocytes...
  97. ncbi request reprint Automatic mode switching of implantable pacemakers: I. Principles of instrumentation, clinical, and hemodynamic considerations
    Chu Pak Lau
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Pacing Clin Electrophysiol 25:967-83. 2002
    ....
  98. ncbi request reprint Impaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
    Rui Hu
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Int J Cardiol 120:351-6. 2007
    ..To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients...
  99. doi request reprint A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation
    Chu Pak Lau
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Cardiovasc Electrophysiol 20:1020-5. 2009
    ....
  100. pmc Characterization of multiple ion channels in cultured human cardiac fibroblasts
    Gui Rong Li
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
    PLoS ONE 4:e7307. 2009
    ..The present study was therefore designed to characterize ion channels in cultured human cardiac fibroblasts...
  101. doi request reprint Characterization of ion channels in human preadipocytes
    Hao Hu
    Department of Medicine, Research Centre of Heart, Brain, Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Cell Physiol 218:427-35. 2009
    ....