George Sai Wah Tsao
Affiliation: University of Hong Kong
Tsao S, Tsang C, Pang P, Zhang G, Chen H, Lo K. The biology of EBV infection in human epithelial cells. Semin Cancer Biol. 2012;22:137-43 pubmed
Tsang C, Cheung K, Cheung Y, Man K, Lui V, Tsao S, et al
. Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. Biochim Biophys Acta. 2015;1852:541-51 pubmed publisher
..Lastly, berberine's anti-proliferative and anti-invasive activities could be partially rescued by Id-1 overexpression in HCC models, revealing a novel anti-cancer/anti-invasive mechanism of berberine via Id-1 suppression. ..
Fang C, Wu C, Hsu H, Chuang H, Huang S, Tsai C, et al
. EGCG inhibits proliferation, invasiveness and tumor growth by up-regulation of adhesion molecules, suppression of gelatinases activity, and induction of apoptosis in nasopharyngeal carcinoma cells. Int J Mol Sci. 2015;16:2530-58 pubmed publisher
..These results indicate that EGCG can inhibit the proliferation and invasiveness, and induce apoptosis, of NPC cells, making it a promising agent for chemoprevention or adjuvant therapy of NPC. ..
Hong M, Li S, Tan H, Wang N, Tsao S, Feng Y. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. Int J Mol Sci. 2015;16:28705-45 pubmed publisher
Zhang J, Jia L, Lin W, Yip Y, Lo K, Lau V, et al
. Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-ÎºB Signaling Pathways. J Virol. 2017;91: pubmed publisher
..Our results reveal novel therapeutic targets against the mTORC1/NF-ÎºB/Glut-1 signaling axis in the treatment of EBV-infected NPC. ..
Hong M, Wang N, Tan H, Tsao S, Feng Y. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy. Cancers (Basel). 2015;7:1643-57 pubmed publisher
Friboulet L, Gourzones C, Tsao S, Morel Y, Paturel C, Temam S, et al
. Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells. BMC Cancer. 2010;10:327 pubmed publisher
..In light of our observations, combined use of both types of compounds should be considered for treatment of human malignancies including carcinomas and melanomas. ..