Paul Kwong-Hang Tam

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Live donor liver transplantation for fulminant hepatic failure in children
    Chi Leung Liu
    Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Liver Transpl 9:1185-90. 2003
  2. ncbi request reprint Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the selection of multiple marker genes as a potential metric for quality control
    Jianhui Rong
    Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    J Ethnopharmacol 113:35-44. 2007
  3. ncbi request reprint Molecular genetics of Hirschsprung's disease
    Paul K H Tam
    Department of Surgery and Genome Research Centre, The University of Hong Kong, Queen Mary Hospital K15, Pokfulam, Hong Kong, P R China
    Semin Pediatr Surg 13:236-48. 2004
  4. doi request reprint Towards predictive, preventive, and personalized paediatric surgery
    Paul K H Tam
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    J Pediatr Surg 43:267-73. 2008
  5. doi request reprint Mapping of a Hirschsprung's disease locus in 3p21
    Maria Mercè Garcia-Barceló
    Department of Surgery, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Eur J Hum Genet 16:833-40. 2008
  6. doi request reprint Genetic basis of Hirschsprung's disease
    Paul K H Tam
    Division of Paediatric Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam Road, Hong Kong, People s Republic of China
    Pediatr Surg Int 25:543-58. 2009
  7. ncbi request reprint Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus
    Maria Mercè Garcia-Barceló
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine of the University of Hong Kong, Hong Kong SAR, China
    Ann Hum Genet 71:746-54. 2007
  8. doi request reprint Proteomic identification of the Cus system as a major determinant of constitutive Escherichia coli silver resistance of chromosomal origin
    Chun Nam Lok
    The Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Chemistry, Department of Anatomy, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Proteome Res 7:2351-6. 2008
  9. ncbi request reprint Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease
    Merce Garcia-Barcelo
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong SAR, China
    Clin Chem 50:93-100. 2004
  10. ncbi request reprint Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress
    Jianhui Rong
    Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Mol Med 21:405-11. 2008

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Live donor liver transplantation for fulminant hepatic failure in children
    Chi Leung Liu
    Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Liver Transpl 9:1185-90. 2003
    ..051; patient survival, 89%; P =.281). Although survival outcomes are inferior to those in elective situations, LDLT is a timely and lifesaving procedure for children with FHF...
  2. ncbi request reprint Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the selection of multiple marker genes as a potential metric for quality control
    Jianhui Rong
    Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    J Ethnopharmacol 113:35-44. 2007
    ..This approach provides a potential comprehensive and cost-effective quality control metric of the biological activities of botanical drugs...
  3. ncbi request reprint Molecular genetics of Hirschsprung's disease
    Paul K H Tam
    Department of Surgery and Genome Research Centre, The University of Hong Kong, Queen Mary Hospital K15, Pokfulam, Hong Kong, P R China
    Semin Pediatr Surg 13:236-48. 2004
  4. doi request reprint Towards predictive, preventive, and personalized paediatric surgery
    Paul K H Tam
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    J Pediatr Surg 43:267-73. 2008
    ..The next generation paediatric surgeons must seize the opportunities in large-scale biology research to develop the best future treatment for their patients...
  5. doi request reprint Mapping of a Hirschsprung's disease locus in 3p21
    Maria Mercè Garcia-Barceló
    Department of Surgery, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Eur J Hum Genet 16:833-40. 2008
    ..Ranking markers by proximity to candidate genes or by expected functional consequences could be used in follow-up studies to finally pinpoint this HSCR locus...
  6. doi request reprint Genetic basis of Hirschsprung's disease
    Paul K H Tam
    Division of Paediatric Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam Road, Hong Kong, People s Republic of China
    Pediatr Surg Int 25:543-58. 2009
    ..This review will focus on the genes known to be involved in HSCR pathology, how they interact, and on how technology advances are being employed to uncover the pathological processes underlying this disease...
  7. ncbi request reprint Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus
    Maria Mercè Garcia-Barceló
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine of the University of Hong Kong, Hong Kong SAR, China
    Ann Hum Genet 71:746-54. 2007
    ..TITF1 mutations could contribute to HSCR by affecting RET expression through defective interactions with other transcription factors...
  8. doi request reprint Proteomic identification of the Cus system as a major determinant of constitutive Escherichia coli silver resistance of chromosomal origin
    Chun Nam Lok
    The Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Chemistry, Department of Anatomy, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Proteome Res 7:2351-6. 2008
    ..These results suggest that the chromosomally encoded Cus system, which naturally controls the periplasmic copper concentrations, is selectable to confer a constitutive silver resistance phenotype...
  9. ncbi request reprint Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease
    Merce Garcia-Barcelo
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong SAR, China
    Clin Chem 50:93-100. 2004
    ....
  10. ncbi request reprint Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress
    Jianhui Rong
    Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Mol Med 21:405-11. 2008
    ..This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies...
  11. doi request reprint Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 44:1904-12. 2009
    ..In this study, we further delineated Nkx2-1-mediated RET Transcription...
  12. ncbi request reprint Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome
    Merce Garcia-Barcelo
    Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China
    Clin Chem 52:46-52. 2006
    ..The combination of partial absence of the sacrum, anorectal anomalies, and presacral mass constitutes Currarino syndrome (CS), which is associated with mutations in HLXB9...
  13. ncbi request reprint Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong
    Biochim Biophys Acta 1783:467-78. 2008
    ..Taken together, these findings provide evidence that Prok-1 crosstalks with GDNF/Ret signaling and probably provides an additional layer of signaling refinement to maintain proliferation and differentiation of enteric NCCs...
  14. ncbi request reprint Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft
    Lina Tian
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, PR China
    Transplantation 74:133-8. 2002
    ..The CD134/CD134L pathway has been studied in inflammatory, autoimmune diseases, and graft-versus-host disease, but no information exists on the involvement of CD134/CD134L interactions in solid organ transplantation...
  15. ncbi request reprint Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts
    Yan Chen
    Department of Surgery, Faculty of Medicine Building, University of Hong Kong, Pokfulam, Hong Kong, SAR China
    Transplantation 83:1602-10. 2007
    ..Peroxisome proliferator-activated receptor ligands can suppress vascular inflammation. The aim of this study was to analyze the effects of rosiglitazone on chronic transplant dysfunction in a rat cardiac transplant model...
  16. doi request reprint Diagnosing acute appendicitis: are we overusing radiologic investigations?
    Kenneth K Y Wong
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Pediatr Surg 43:2239-41. 2008
    ..The aim of this study is to review the trend of diagnosing appendicitis in a single center and discuss the implications...
  17. ncbi request reprint Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:536-45. 2007
    ..Taken together, it is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric NCCs...
  18. ncbi request reprint Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma
    Yi Xie
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Carcinogenesis 28:2122-30. 2007
    ..These results suggested that distinct roles of proliferative and invasive phenotypes contributed to neuroblastoma progression and strongly demonstrated that VSNL-1 played a very important role in neuroblastoma metastasis...
  19. doi request reprint Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice
    Vincent C H Lui
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 134:1104-15. 2008
    ....
  20. ncbi request reprint Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia
    Ivy H N Wong
    Department of Biochemistry, 3 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, The University of Hong Kong, Hong Kong Special Administrative Region
    Clin Cancer Res 10:994-1002. 2004
    ....
  21. ncbi request reprint Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery
    Lina Tian
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, People s Republic of China
    Transplantation 77:183-9. 2004
    ..Its mechanisms of action are not fully understood. In this article, the authors have investigated the effects of therapeutic doses of Rapa on both thymic and peripheral T-cell populations in the adult rat...
  22. ncbi request reprint Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, SAR, China, and Department of Pediatric Surgery, The Second Affiliated Hospital of China Medical University, Shenyang, China
    Clin Cancer Res 13:868-75. 2007
    ..In this report, we further elucidate its role in neuroblastoma progression...
  23. doi request reprint Should open Kasai portoenterostomy be performed for biliary atresia in the era of laparoscopy?
    Kenneth K Y Wong
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Pediatr Surg Int 24:931-3. 2008
    ..Laparoscopic Kasai portoenterostomy seems to be associated with more post-operative complications and worse early clinical outcome. As a result, we remain guarded about the present-day technique of laparoscopy for biliary atresia...
  24. ncbi request reprint Double intestinal atresia in imperforate anus: a diagnostic conundrum for paediatric surgeons
    Chen lung Steve Lin
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Asian J Surg 27:52-3. 2004
  25. ncbi request reprint Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells
    Yan Liu
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    Transplantation 84:1517-26. 2007
    ..Since dendritic cells (DCs) play a critical role in the initiation of alloimmune responses to foreign grafts, the aim of the present study was to evaluate the effects of TPT in the functional phenotype of bone marrow (BM)-derived DCs...
  26. doi request reprint Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation
    Yan Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transpl Int 21:483-94. 2008
    ..This effect is accompanied by inhibition of DCs maturation, conditioning DCs to adopt tolerogenic phenotype, and the expansion of Tr cells. These results add weight to the application of combination therapy in transplantation...
  27. ncbi request reprint TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease
    Merce Garcia-Barcelo
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Hum Mol Genet 14:191-204. 2005
    ..We also present a detailed profile of the RET gene in our population, which provides an insight into the higher incidence of the disease in China...
  28. doi request reprint Prokineticin-signaling pathway
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Biochem Cell Biol 40:1679-84. 2008
    ..The physiological and patho-physiological roles of prokineticin signaling are just beginning to be revealed and a better understanding of the system should lead to the development of useful therapies for various diseases...
  29. ncbi request reprint Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes
    Vera S F Chan
    Department of Surgery, University of Hong Kong Medical Centre, K 15 Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Int Immunol 18:1627-36. 2006
    ..Furthermore, Shh co-stimulation modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2...
  30. ncbi request reprint Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts
    Xiaosong Li
    Division of Pediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PRC
    Am J Surg 194:248-54. 2007
    ....
  31. doi request reprint A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong, SAR, China
    J Natl Cancer Inst 101:162-75. 2009
    ..Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition...
  32. doi request reprint Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing
    Xuelai Liu
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    ChemMedChem 5:468-75. 2010
    ..These findings further extend our current knowledge of AgNPs in biological and cellular events and also have significant implications for the treatment of wounds in the clinical setting...
  33. ncbi request reprint Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model
    Yan Chen
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
    Transplantation 83:1351-7. 2007
    ..Sonic hedgehog (Shh), a morphogen critical in embryogenesis, also promotes peripheral immunity, which prompted us to investigate if inhibition of Shh signaling could reduce CR and thereby enhance allograft survival...
  34. ncbi request reprint Comparative study of allograft survival of heterotopic and orthotopic small bowel transplantation in rat
    Wei Hong Guo
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, P R China
    Transplantation 75:1895-7. 2003
    ..This study compared the allograft survival of H-SBT and O-SBT and evaluated the effect of retaining the host intestine in O-SBT in an altered O-SBT (AO-SBT) model...
  35. ncbi request reprint Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung disease
    Vincent C H Lui
    Department of Surgery and Genome Research Centre, The University of Hong Kong Pokfulam, Hong Kong SAR, China
    Clin Chem 51:1552-4. 2005
  36. ncbi request reprint Silver nanoparticles: partial oxidation and antibacterial activities
    Chun Nam Lok
    The Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Biol Inorg Chem 12:527-34. 2007
    ..The antibacterial activities of silver nanoparticles are dependent on optimally displayed oxidized surfaces, which are present in well-dispersed suspensions...
  37. ncbi request reprint 3' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice
    King Yiu Lee
    Department of Surgery, The University of Hong Kong, Pokfulam Road, Pokfulam, SAR, Hong Kong, China
    Biochim Biophys Acta 1627:26-38. 2003
    ..In adult mice, ret 9 expression was relatively widespread in many organs while that of ret 51 was rather restricted. Our data indicated that ret isoforms are temporally and spatially regulated in mouse embryos and adult mouse...
  38. ncbi request reprint Analytical application of acetate anion in negative electrospray ionization mass spectrometry for the analysis of triterpenoid saponins--ginsenosides
    Kwan Ming Ng
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong
    Rapid Commun Mass Spectrom 20:1545-50. 2006
    ..Additionally, NH4OAc was found to enhance the sensitivity of detection of ginsenosides in the form of [M-H]- down to the femtomole level...
  39. ncbi request reprint Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis
    Vincent C H Lui
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, SAR, Hong Kong, China
    J Immunol Methods 277:171-83. 2003
    ..The findings suggest that the approach to produce CTLA4Ig in milk by transgenesis is feasible; further studies involving farm animals are warranted...
  40. ncbi request reprint Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation
    Merce Garcia-Barcelo
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 42:666-71. 2007
    ..We conducted a pilot study to investigate whether genes encoding neurotransmitters (TAC1, TAC3, VIP, NOS1) and receptors (TACR1, TACR2, TACR3, KIT) could be responsible for STC...
  41. ncbi request reprint Effective antibiotic regime for postoperative acute cholangitis in biliary atresia--an evolving scene
    Kenneth K Y Wong
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, People s Republic of China
    J Pediatr Surg 39:1800-2. 2004
    ..The authors published findings of their clinical trial in 1991 and established the use of cefoperazone, with a response rate of 88.9%. Here its clinical use since its introduction is reviewed and the trend in its efficacy is assessed...
  42. ncbi request reprint Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
    Vera S F Chan
    Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    Nat Genet 38:38-46. 2006
    ..Thus, homozygosity for L-SIGN plays a protective role during SARS infection...
  43. ncbi request reprint Portoenterostomy for biliary atresia: Long-term survival and prognosis after esophageal variceal bleeding
    L W Ernest van Heurn
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, People s Republic of China
    J Pediatr Surg 39:6-9. 2004
    ..The authors analyzed the long-term survival rate and complications of the procedure in children operated on at The University of Hong Kong Medical Centre between 1979 and 2000...
  44. ncbi request reprint Cholangitis after hepatic portoenterostomy for biliary atresia: a multivariate analysis of risk factors
    L W Ernest van Heurn
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, China
    J Pediatr 142:566-71. 2003
    ..72; 95% CI, 2.89-11.3) or poor (odds ratio, 3.29; 95% CI, 1.89-5.7) bile drainage. Cholangitis was not an independent risk factor for death or liver transplantation...
  45. ncbi request reprint Distribution of carbon monoxide-producing neurons in human colon and in Hirschsprung's disease patients
    Yan Chen
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, and University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Hum Pathol 33:1030-6. 2002
    ..HO-2 and NO synthase were selectively absent in the myenteric and submucosal regions and in the muscle of the aganglionic colon. Our findings suggest involvement of both CO and NO in the pathophysiology of HSCR...
  46. ncbi request reprint Apoptotic cells protect mice against lipopolysaccharide-induced shock
    Yi Ren
    Department of Surgery, University of Hong Kong, Hong Kong, China
    J Immunol 180:4978-85. 2008
    ..Apoptotic cells may therefore have therapeutic potential for the treatment of septic shock...
  47. ncbi request reprint A safe laparoscopic technique for the repair of inguinal hernias in boys
    Kwong L Chan
    Division of Pediatric Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    J Am Coll Surg 196:987-9. 2003
  48. pmc Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury
    Mingyan Zhou
    Department of Pharmacology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong, China
    Hepatology 48:1087-96. 2008
    ..CONCLUSION: These results suggest that the hepatoprotective properties of adiponectin are mediated at least in part by an enhancement of the activities of MRC complexes through a mechanism involving UCP2...
  49. doi request reprint Further evidence of the anti-inflammatory effects of silver nanoparticles
    Kenneth K Y Wong
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    ChemMedChem 4:1129-35. 2009
    ..This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions...
  50. doi request reprint A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1
    Yi Xie
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Biochem Biophys Res Commun 380:243-8. 2009
    ..This study highlights a novel function of DCs and allows a better understanding of the DC-VEGF interaction...
  51. ncbi request reprint Well-differentiated thyroid carcinoma in Hong Kong Chinese patients under 21 years of age: a 35-year experience
    Yee Man Lee
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    J Am Coll Surg 194:711-6. 2002
    ..It is associated with distinct clinicopathologic features and prognosis. The present study reviews our experience in management of this condition in ethnic Chinese in Hong Kong...
  52. ncbi request reprint Spontaneous pneumoperitoneum after pneumonia in a child
    Daniel T I Chan
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    J Paediatr Child Health 43:85-6. 2007
    ..Here we report a rare case of a previously healthy boy with pneumoperitoneum associated with pneumonia and perform a review of the literature to explore the etiological mechanisms and the pathophysiology of non-surgical pneumoperitoneum...
  53. ncbi request reprint Selective upper endoscopy for foreign body ingestion in children: an evaluation of management protocol after 282 cases
    Kenneth K Y Wong
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, SAR, China
    J Pediatr Surg 41:2016-8. 2006
    ..This study aims to evaluate a management protocol where endoscopic examination was only selectively used after routine direct laryngoscopy to minimize patient discomfort and the need for general anesthesia in children...
  54. doi request reprint Suppression of lung tumor growth and metastasis in mice by adeno-associated virus-mediated expression of vasostatin
    Ke Xia Cai
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 14:939-49. 2008
    ..In this study, we determined the effectiveness of vasostatin delivered by recombinant pseudotype adeno-associated virus 2/5 (rAAV2/5-VAS) as a gene therapy approach for lung cancer treatment...
  55. doi request reprint LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages
    Yan Chen
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
    J Leukoc Biol 83:1165-73. 2008
    ..Our data demonstrate a direct effect of TGF-beta signaling via ALK5 on the regulation of TNF-alpha synthesis...
  56. doi request reprint Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages
    Feng Qin Liu
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
    Exp Cell Res 314:1327-36. 2008
    ..These findings provide new insights on the pathophysiological effects of hypoxia in sepsis and septic shock...
  57. ncbi request reprint Altered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction
    Kossen M T Ho
    Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    BJU Int 95:1104-8. 2005
    ..To investigate the distribution of aquaporins, a recently discovered family of transmembrane water channels, in human renal explants, with specific reference to chronic renal allograft dysfunction (CRAD)...
  58. ncbi request reprint Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    J Cell Biochem 95:165-72. 2005
    ..These results demonstrated the potential of serological biomarker identification for neuroblastoma by ProteinChip-SELDI technology...
  59. pmc Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the Chinese population
    Belinda K Cornes
    Paediatric Surgery Division, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e10918. 2010
    ..Due to the high frequency of RET(R114H) in this population, we sought to investigate whether this mutation may be a founder HSCR mutation in the Chinese population...
  60. pmc Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population
    Xiaoping Miao
    Gut 56:736. 2007
  61. ncbi request reprint Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis
    Goncalo Abecasis
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 39:153-5. 2007
    ..The meeting highlighted recent advances in characterization of genetic variation, including genome-wide association studies and structural variation...