S Y Shiu

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi Autoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis
    S Y Shiu
    Department of Physiology, University of Hong Kong, Hong Kong
    Life Sci 59:1165-74. 1996
  2. ncbi Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 43:1-9. 2007
  3. ncbi Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 35:177-82. 2003
  4. ncbi Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug?
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 35:69-70. 2003
  5. ncbi Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity
    Stephanie W F Siu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Prostate 52:106-22. 2002
  6. ncbi Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 49:301-11. 2010
  7. ncbi Inhibition of malignant trophoblastic cell proliferation in vitro and in vivo by melatonin
    S Y Shiu
    Department of Physiology, The University of Hong Kong, China
    Life Sci 67:2059-74. 2000
  8. ncbi Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis
    S Y Shiu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Signals Recept 9:172-87. 2000
  9. ncbi Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor
    S Y Shiu
    Department of Physiology, The University of Hong Kong, China
    J Pineal Res 27:183-92. 1999
  10. ncbi An updated phylogenetic analysis of vertebrate melatonin receptor sequences: reflection on the melatonin receptor nomenclature by the Nomenclature Subcommittee of the International Union of Pharmacology
    S Y Shiu
    Department of Physiology, University of Hong Kong, Hong Kong, China
    Biol Signals Recept 7:244-8. 1998

Collaborators

Detail Information

Publications15

  1. ncbi Autoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis
    S Y Shiu
    Department of Physiology, University of Hong Kong, Hong Kong
    Life Sci 59:1165-74. 1996
    ..A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated...
  2. ncbi Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 43:1-9. 2007
    ....
  3. ncbi Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 35:177-82. 2003
    ....
  4. ncbi Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug?
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 35:69-70. 2003
  5. ncbi Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity
    Stephanie W F Siu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Prostate 52:106-22. 2002
    ....
  6. ncbi Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins
    Stephen Y W Shiu
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 49:301-11. 2010
    ..Our results also showed that dual activation of Gα(s) and Gα(q) proteins is involved in the signal transduction of MTNR1A receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells...
  7. ncbi Inhibition of malignant trophoblastic cell proliferation in vitro and in vivo by melatonin
    S Y Shiu
    Department of Physiology, The University of Hong Kong, China
    Life Sci 67:2059-74. 2000
    ..Taking into account both the in vitro and in vivo findings, it is likely that the inhibitory effect of melatonin on choriocarcinoma JAr and JEG-3 cell proliferation in vivo is largely a direct action of the hormone on the tumor cells...
  8. ncbi Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis
    S Y Shiu
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Signals Recept 9:172-87. 2000
    ....
  9. ncbi Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor
    S Y Shiu
    Department of Physiology, The University of Hong Kong, China
    J Pineal Res 27:183-92. 1999
    ..Moreover, analysis of melatonin effect on cell cycle kinetics indicated that G1/S transition delay may underlie the observed inhibition of choriocarcinoma cell proliferation by melatonin...
  10. ncbi An updated phylogenetic analysis of vertebrate melatonin receptor sequences: reflection on the melatonin receptor nomenclature by the Nomenclature Subcommittee of the International Union of Pharmacology
    S Y Shiu
    Department of Physiology, University of Hong Kong, Hong Kong, China
    Biol Signals Recept 7:244-8. 1998
    ....
  11. ncbi Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression
    S C Xi
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Li Shu Fan Building, 5 Sassoon Road, Hong Kong, China
    Prostate 46:52-61. 2001
    ....
  12. ncbi 2[125I]Iodomelatonin binding sites in guinea pig platelets
    Mabel Y C Yau
    Department of Physiology, The University of Hong Kong, China
    J Pineal Res 32:97-105. 2002
    ..Pharmocological and physiological data indicate that they may be different from the nanomolar [3H]melatonin binding sites in human platelets previously reported...
  13. ncbi Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance
    Chun W Tam
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 45:403-12. 2008
    ..Collectively, our data support the hypothesis that MLT may function as a negative mitogenic hormonal regulator of human prostate epithelial cell growth...
  14. ncbi Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention
    Chun W Tam
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    J Pineal Res 42:191-202. 2007
    ....
  15. ncbi 2[125I]Iodomelatonin binding and interaction with beta-adrenergic signaling in chick heart/coronary artery physiology
    Celia S Pang
    Department of Physiology, University of Hong Kong, Hong Kong, China
    J Pineal Res 32:243-52. 2002
    ..Activation of these receptors, which include MT1 subtype, may modulate beta-adrenergic receptor-mediated cAMP signaling in the control of chick heart and coronary artery physiology...