Ronnie Tung Ping Poon

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Prevention of pancreatic anastomotic leakage after pancreaticoduodenectomy
    Ronnie Tung Ping Poon
    Department of Surgery, Centre for Study of Liver Disease, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Am J Surg 183:42-52. 2002
  2. pmc Clinical implications of angiogenesis in cancers
    Roberta W C Pang
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Vasc Health Risk Manag 2:97-108. 2006
  3. pmc A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma
    Thomas Yau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Invest New Drugs 31:99-107. 2013
  4. ncbi request reprint Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma
    Roberta W C Pang
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Curr Cancer Drug Targets 12:1081-94. 2012
  5. pmc Intramuscular recurrence in a hepatocellular carcinoma patient with indolent disease course
    Thomas Yau
    University Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong
    World J Surg Oncol 6:42. 2008
  6. pmc A protein-based set of reference markers for liver tissues and hepatocellular carcinoma
    Stella Sun
    Department of Surgery, LKS Faculty of Medicine, Jockey Club Clinical Research Centre, The University of Hong Kong, Pokfulam, Hong Kong
    BMC Cancer 9:309. 2009
  7. pmc Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters
    Ke Hao
    1Rosetta Inpharmatics LLC, Merck Research Laboratories, Seattle, WA, USA
    BMC Cancer 9:389. 2009
  8. pmc Radiofrequency ablation combined with resection enhances chance for curative treatment of hepatocellular carcinoma
    Ronnie T P Poon
    Ann Surg Oncol 14:3299-300. 2007
  9. ncbi request reprint Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 9:5339-45. 2003
  10. pmc Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial
    R T P Poon
    Surgical Endoscopy Unit, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Gut 52:1768-73. 2003

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Prevention of pancreatic anastomotic leakage after pancreaticoduodenectomy
    Ronnie Tung Ping Poon
    Department of Surgery, Centre for Study of Liver Disease, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Am J Surg 183:42-52. 2002
    ..Over the past decade, various measures directed towards prevention of pancreatic leakage have been studied. This article reviews the available data on the efficacy of these measures...
  2. pmc Clinical implications of angiogenesis in cancers
    Roberta W C Pang
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Vasc Health Risk Manag 2:97-108. 2006
    ..The clinical implications of angiogenesis in cancer are reviewed in this article...
  3. pmc A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma
    Thomas Yau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Invest New Drugs 31:99-107. 2013
    ..The current study evaluated safety, pharmacokinetics (PK)/ pharmacodynamics (PD) parameters, and potential anti-tumor activity of pegylated recombinant human arginase 1 (peg-rhArg1) in advanced HCC patients...
  4. ncbi request reprint Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma
    Roberta W C Pang
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Curr Cancer Drug Targets 12:1081-94. 2012
    ..Therapeutic targeting of CSCs may provide a novel strategy that is more effective than the current drugs targeting the bulk mature cancer cells in treatment of HCC...
  5. pmc Intramuscular recurrence in a hepatocellular carcinoma patient with indolent disease course
    Thomas Yau
    University Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong
    World J Surg Oncol 6:42. 2008
    ..In general, the prognosis of HCC patients with extra-hepatic metastasis is poor. The most common sites of extra-hepatic metastasis are the lung, abdominal lymph nodes and bone...
  6. pmc A protein-based set of reference markers for liver tissues and hepatocellular carcinoma
    Stella Sun
    Department of Surgery, LKS Faculty of Medicine, Jockey Club Clinical Research Centre, The University of Hong Kong, Pokfulam, Hong Kong
    BMC Cancer 9:309. 2009
    ..This is the first study employed 2-DE analysis to screen for potential reference markers and aims to correlate the abundance of these proteins with their level of transcript expression...
  7. pmc Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters
    Ke Hao
    1Rosetta Inpharmatics LLC, Merck Research Laboratories, Seattle, WA, USA
    BMC Cancer 9:389. 2009
    ..However, the results are not consistent due to lack of systemic approach to establish a prediction model incorporating all these parameters...
  8. pmc Radiofrequency ablation combined with resection enhances chance for curative treatment of hepatocellular carcinoma
    Ronnie T P Poon
    Ann Surg Oncol 14:3299-300. 2007
  9. ncbi request reprint Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 9:5339-45. 2003
    ..This study evaluated whether TF expression correlates with microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, tumor invasiveness, and prognosis in human HCC...
  10. pmc Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial
    R T P Poon
    Surgical Endoscopy Unit, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Gut 52:1768-73. 2003
    ..This study evaluated whether intravenous bolus somatostatin given after diagnostic cholangiopancreatography could reduce the incidence of pancreatitis in a group of patients undergoing therapeutic ERCP procedures...
  11. ncbi request reprint Decreasing the pancreatic leak rate after pancreaticoduodenectomy
    Ronnie T P Poon
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Adv Surg 42:33-48. 2008
    ..Nonetheless, further high-quality randomized controlled trials are needed to evaluate the benefit of these technical modifications in decreasing the pancreatic leakage rate after pancreaticoduodenectomy...
  12. ncbi request reprint Lyso-thermosensitive liposomal doxorubicin: a novel approach to enhance efficacy of thermal ablation of liver cancer
    Ronnie T P Poon
    University of Hong Kong, Queen Mary Hospital, Department of Surgery, 102 Pokfulam Road, Hong Kong, China
    Expert Opin Pharmacother 10:333-43. 2009
    ..Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. No more than 30% of HCC patients receive curative treatment. Factors limiting curative therapy include tumor size and degree of liver impairment...
  13. pmc Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches
    Ronnie Tung Ping Poon
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Ann Surg 238:9-28. 2003
    ..To review the current data on the prognostic and therapeutic implications of tumor angiogenesis in gastrointestinal cancers...
  14. ncbi request reprint Antisecretory agents for prevention of post-ERCP pancreatitis: rationale for use and clinical results
    Ronnie Tung Ping Poon
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    JOP 4:33-40. 2003
    ..Further studies should focus on the elucidation of the most cost-effective dosage regimen of somatostatin and it efficacy in patients at high risk for post-ERCP pancreatitis...
  15. ncbi request reprint Liver resection using a saline-linked radiofrequency dissecting sealer for transection of the liver
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Am Coll Surg 200:308-13. 2005
  16. ncbi request reprint Radiofrequency ablation for subcapsular hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and the Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg Oncol 11:281-9. 2004
    ..Limited data from recent studies suggested an increased risk of bleeding complications, needle-track seeding, and local recurrence after radiofrequency ablation (RFA) of subcapsular hepatocellular carcinoma (HCC)...
  17. ncbi request reprint Effectiveness of radiofrequency ablation for hepatocellular carcinomas larger than 3 cm in diameter
    Ronnie T P Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, People s Republic of China
    Arch Surg 139:281-7. 2004
    ..Radiofrequency ablation is a safe and effective treatment for hepatocellular carcinomas 3.1 to 8.0 cm in diameter...
  18. ncbi request reprint Optimal initial treatment for early hepatocellular carcinoma in patients with preserved liver function: transplantation or resection?
    Ronnie T P Poon
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Ann Surg Oncol 14:541-7. 2007
    ..Resection first and salvage transplantation for recurrent tumors or liver failure has been shown to be a feasible strategy in the majority of patients, and this appears to be the optimal strategy with the best use of organs...
  19. ncbi request reprint Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement
    Ronnie T Poon
    Department of Surgery and Centre for the Study of Liver Disease, Queen Mary Hospital, University of Hong Kong Medical Centre, Hong Kong, China
    World J Surg 28:602-8. 2004
    ....
  20. ncbi request reprint High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies
    Ronnie T P Poon
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Ann Surg Oncol 14:1835-45. 2007
    ..This study investigated the prognostic significance of pre-treatment serum VEGF level in patients with HCC undergoing RFA treatment...
  21. ncbi request reprint Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Clin Cancer Res 10:4150-7. 2004
    ..The possible role of THBS 1 in the angiogenesis of HCC was also studied by correlating its expression with vascular endothelial growth factor (VEGF) expression...
  22. ncbi request reprint Liver transplantation for solitary hepatocellular carcinoma less than 3 cm in diameter in Child A cirrhosis
    Ronnie T P Poon
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Dig Dis 25:334-40. 2007
    ..However, the long-term survival result of such a strategy compared with primary liver transplantation remains unclear...
  23. pmc Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival
    Ronnie T P Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 245:51-8. 2007
    ..This study compared the tumor characteristics of patients with HCC within the Milan criteria treated by resection or transplantation, and elucidated their impact on long-term survival...
  24. ncbi request reprint High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolization in hepatocellular carcinoma: a prospective study
    Ronnie Tung Ping Poon
    Department of Surgery, Queen Mary Hospital, Hong Kong, China
    Oncol Rep 11:1077-84. 2004
    ..In conclusion, the results of this study suggest that serum VEGF level may be useful as a novel prognostic predictor of tumor response and survival of patients with inoperable HCC undergoing TACE treatment...
  25. ncbi request reprint Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial
    R T P Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Aliment Pharmacol Ther 19:779-88. 2004
    ..The role of nutritional supplements for such patients is unclear...
  26. pmc Learning curve for radiofrequency ablation of liver tumors: prospective analysis of initial 100 patients in a tertiary institution
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 239:441-9. 2004
    ..This study aims to evaluate the effect of operator experience on the treatment outcomes of radiofrequency ablation (RFA) for malignant liver tumors...
  27. ncbi request reprint Evaluation of the new AJCC/UICC staging system for hepatocellular carcinoma after hepatic resection in Chinese patients
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Surg Oncol Clin N Am 12:35-50, viii. 2003
    ..This article evaluates the prognostic value of the new AJCC/UICC TNM staging and the new Japanese staging in a large cohort of Chinese patients who underwent hepatectomy for HCC in a single institution...
  28. pmc Prognosis after hepatic resection for stage IVA hepatocellular carcinoma: a need for reclassification
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 237:376-83. 2003
    ....
  29. ncbi request reprint Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosis
    R T Poon
    Centre of Liver Disease, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Oncol 18:1094-101. 2000
    ..This study evaluated the long-term results and prognostic factors after resection of HCC complicating HBV-related cirrhosis...
  30. pmc Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 235:466-86. 2002
    ..This article reviews the current results of various locoregional therapies for hepatocellular carcinoma (HCC), with special reference to the implications for surgeons...
  31. ncbi request reprint Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study
    Ronnie Tung Ping Poon
    Department of Surgery and Pathology, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    J Clin Oncol 20:1775-85. 2002
    ..This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients undergoing resection of hepatocellular carcinoma (HCC)...
  32. pmc Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 235:373-82. 2002
    ....
  33. pmc External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial
    Ronnie T P Poon
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Ann Surg 246:425-33; discussion 433-5. 2007
    ..This single-center prospective randomized trial compared the results of pancreaticoduodenectomy with external drainage stent versus no stent for pancreaticojejunal anastomosis...
  34. ncbi request reprint Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma
    R T Poon
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Am J Surg 182:298-304. 2001
    ..This study evaluated the role of serum bFGF as a biological marker of tumor invasiveness and postresection recurrence in hepatocellular carcinoma (HCC)...
  35. ncbi request reprint Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohort
    R T Poon
    Center for Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    J Clin Oncol 19:3037-44. 2001
    ..This study aims to clarify the clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma (HCC)...
  36. ncbi request reprint A prospective longitudinal study of quality of life after resection of hepatocellular carcinoma
    R T Poon
    Department of Surgery, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Arch Surg 136:693-9. 2001
    ..Hepatic resection improves quality of life (QOL) in patients with resectable hepatocellular carcinoma (HCC)...
  37. ncbi request reprint Clinical implications of circulating angiogenic factors in cancer patients
    R T Poon
    Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    J Clin Oncol 19:1207-25. 2001
    ..Angiogenesis, a process fundamental to tumor growth, is regulated by angiogenic factors. This article reviews prognostic and other clinical implications of circulating angiogenic factors in cancer patients...
  38. pmc Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study
    R T Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Ann Surg 233:227-35. 2001
    ..To evaluate the correlation between serum vascular endothelial growth factor (VEGF) level and the clinicopathologic features in patients with hepatocellular carcinoma (HCC)...
  39. pmc Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    R Tung-Ping Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Surg 232:10-24. 2000
    ..To evaluate the current knowledge on the risk factors for recurrence, efficacy of adjuvant therapy in preventing recurrence, and the optimal management of recurrence after resection of hepatocellular carcinoma (HCC)...
  40. ncbi request reprint Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 63:3121-6. 2003
    ..This study provides strong evidence that supports the use of serum VEGF level as an indirect estimate of tumor VEGF expression...
  41. pmc Extended hepatic resection for hepatocellular carcinoma in patients with cirrhosis: is it justified?
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 236:602-11. 2002
    ..To evaluate the perioperative outcomes and long-term survival of extended hepatic resection for hepatocellular carcinoma (HCC) in patients with cirrhosis...
  42. doi request reprint Lyso-thermosensitive liposomal doxorubicin: an adjuvant to increase the cure rate of radiofrequency ablation in liver cancer
    Ronnie Tp Poon
    Celsion Corp, Columbia, MD, USA
    Future Oncol 7:937-45. 2011
    ..5%) had tumors >3 cm. RFA plus LTLD is currently being evaluated in a 600-patient randomized, double-blind, dummy-controlled trial...
  43. ncbi request reprint Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma
    Yi Ren
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Hong Kong SAR, China
    Int J Cancer 107:22-9. 2003
    ..A more detailed understanding of the MIF regulatory mechanisms involved may provide insight into new direction in the treatment of HCC...
  44. ncbi request reprint Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center
    Kelvin Kwok Chai Ng
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Surg 139:193-200. 2004
    ..Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC)...
  45. ncbi request reprint Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma
    Chi Keung Lau
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Biol Ther 6:1900-7. 2007
    ..This finding provides insight into design of a new therapeutic strategy to improve efficacy of chemotherapy in HCC patients...
  46. ncbi request reprint Value of live donor liver transplantation experience in major hepatectomy for hepatocellular carcinoma
    See Ching Chan
    Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, People s Republic of China
    Arch Surg 138:265-71. 2003
    ..Live donor liver transplantation (LDLT) mandates conversance in liver anatomy and major hepatectomy. Hepatocellular carcinoma is most reliably treated by hepatectomy...
  47. doi request reprint Can positron emission tomography with the dual tracers [11 C]acetate and [18 F]fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma?
    Tan To Cheung
    Department of Surgery, University of Hong Kong, Hong Kong, China
    Liver Transpl 17:1218-25. 2011
    ..Preoperative [(18) F]FDG PET may predict microvascular invasion. The addition of [(11) C]acetate improves the overall sensitivity of PET, but it has no incremental value in predicting microvascular invasion...
  48. ncbi request reprint Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Hepatol 45:553-9. 2006
    ..This study aimed to measure the intrahepatic total hepatitis B virus (HBV) DNA and covalently closed circular DNA (cccDNA) levels in tumor and non-tumor tissues in hepatocellular carcinoma (HCC) patients...
  49. ncbi request reprint Hepatic resection for combined hepatocellular and cholangiocarcinoma
    Chi Leung Liu
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Surg 138:86-90. 2003
    ..The clinical significance of this disease entity is poorly understood. The aim of the present study was to determine the operative and survival outcomes of patients with HCC-CC who underwent hepatic resection...
  50. ncbi request reprint Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    J Am Coll Surg 194:592-602. 2002
    ..The role of hepatic resection for large hepatocellular carcinoma (HCC) larger than 10 cm remains unclear...
  51. ncbi request reprint Thermal ablative therapy for malignant liver tumors: a critical appraisal
    Kelvin Kwok Chai Ng
    Departments of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 18:616-29. 2003
    ..As each of the loco-regional therapies has its own advantages and limitations, a multidisciplinary approach using a combination of therapies will be the future trend for the management of malignant liver tumors...
  52. ncbi request reprint Hepatic resection for bilobar hepatocellular carcinoma: is it justified?
    Chi Leung Liu
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Arch Surg 138:100-4. 2003
    ..The aim of the present study was to evaluate the operative outcome and survival benefits of hepatic resection for patients with bilobar HCC...
  53. pmc Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases
    Chi Leung Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 239:194-201. 2004
    ..The aim of this study was to determine whether abdominal drainage is beneficial after elective hepatic resection in patients with underlying chronic liver diseases...
  54. ncbi request reprint Intraoperative iatrogenic rupture of hepatocellular carcinoma
    Chi Leung Liu
    Department of Surgery, Centre of Liver Diseases, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    World J Surg 26:348-52. 2002
    ..Extreme care should be taken during mobilization of the tumor, and an alternative operative approach in the presence of a difficult hepatic resection of a large HCC may be required to avoid the complication...
  55. doi request reprint Re-resection for metachronous primary hepatocellular carcinoma: is it justified?
    Kenneth Siu Ho Chok
    Department of Surgery, University of Hong Kong, Hong Kong, China
    ANZ J Surg 82:63-7. 2012
    ..This study aimed to determine the long-term outcomes of re-resection in these patients...
  56. ncbi request reprint Choledochal cysts in adults
    Chi Leung Liu
    Centre for Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong
    Arch Surg 137:465-8. 2002
    ..Choledochal cyst is rarely diagnosed in adulthood. When complicated by biliary tract malignancy, the disease has a distinct presentation and carries a dismal prognosis despite radical surgical resection...
  57. ncbi request reprint Aggressive management of patients with extrahepatic and intrahepatic recurrences of hepatocellular carcinoma by combined resection and locoregional therapy
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    J Am Coll Surg 195:311-8. 2002
    ..This study evaluated the role of combined resection and locoregional therapy in the management of selected patients with extrahepatic and intrahepatic recurrences...
  58. ncbi request reprint Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    Chung Mau Lo
    Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Hepatology 35:1164-71. 2002
    ..In conclusion, in Asian patients with unresectable hepatocellular carcinoma, transarterial Lipiodol chemoembolization significantly improves survival and is an effective form of treatment...
  59. pmc Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process
    Wing Lung Yau
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e57882. 2013
    ..Our results suggested that miR-106b expression contributed to HCC metastasis by activating the EMT process promoting cell migration in vitro and metastasis in vivo...
  60. pmc A case of laparoscopic hepatectomy for recurrent hepatocellular carcinoma
    Tan To Cheung
    Department of Surgery, The University of Hong Kong, 102 Pok Fu Lam Road, Queen Mary Hospital, Hong Kong, China
    World J Gastroenterol 16:526-30. 2010
    ....
  61. ncbi request reprint Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis
    Yi Ren
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong Medical Centre, Hong Kong SAR, China
    Clin Cancer Res 9:5996-6001. 2003
    ..In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate its correlation with clinicopathological features and prognosis...
  62. ncbi request reprint Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:S39-45. 2004
    ..The improved perioperative and long-term survival results have strengthened the role of hepatectomy as the mainstay of treatment for HCC despite the availability of a number of other treatment options for localized HCC...
  63. ncbi request reprint Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma
    Terence Kin Wah Lee
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    Oncol Rep 12:25-31. 2004
    ..001, r=0.776) and apoptosis (p=0.003, r=0.639). Our findings suggest that disruption of p53-p21/WAF1 cell cycle pathways contributes to tumor progression and worse clinical outcome of HCC...
  64. ncbi request reprint Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway
    Terence Kin Wah Lee
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Carcinogenesis 24:1729-36. 2003
    ..In conclusion, the results provided an insight for the understanding of the role of Id-1 in functional inactivation of p16INK4a in HCC...
  65. doi request reprint Cardiotrophin-1 enhances regeneration of cirrhotic liver remnant after hepatectomy through promotion of angiogenesis and cell proliferation
    Zhen Fan Yang
    Department of Surgery, Centre for Cancer Research, Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam, Hong Kong, China
    Liver Int 28:622-31. 2008
    ..The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on improving the function of CCl(4)-induced cirrhotic liver remnant after major hepatectomy...
  66. ncbi request reprint Portal vein thrombosis after radiofrequency ablation for recurrent hepatocellular carcinoma
    Kelvin Kwok Chai Ng
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Asian J Surg 26:50-3; discussion 54. 2003
    ..We present a case of portal vein thrombosis as a complication of RFA treatment for recurrent HCC and illustrate its underlying possible mechanism...
  67. ncbi request reprint Does diabetes mellitus influence the perioperative outcome or long term prognosis after resection of hepatocellular carcinoma?
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    Am J Gastroenterol 97:1480-8. 2002
    ..This study aims to evaluate whether diabetes mellitus has a significant influence on the perioperative outcome or long term prognosis after resection of hepatocellular carcinoma (HCC)...
  68. ncbi request reprint A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, Center for the Study of Liver Disease, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hepatology 36:687-91. 2002
    ..Further studies should be performed in patients with less advanced disease and/or different etiology to evaluate its benefit...
  69. doi request reprint Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma
    Kevin Tak Pan Ng
    Department of Surgery and Centre for Cancer Research, LKS Faculty of Medicine, The University of Hong Kong, China
    Eur J Cancer 47:2299-305. 2011
    ..Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection...
  70. doi request reprint The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization
    Thomas Yau
    Department of Medicine, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Cancer 115:5507-15. 2009
    ..The authors evaluated and compared the treatment outcomes of transarterial chemoembolization (TACE) between young (<or=70 years) and elderly (>70 years) patients at their institute over an 18-year period...
  71. doi request reprint Tolerance of radiofrequency ablation by patients of hepatocellular carcinoma
    Tan To Cheung
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Hepatobiliary Pancreat Surg 16:655-60. 2009
    ..In this study, we analyzed results from use of RFA on HCC patients and determined the lower limit of liver function with which HCC patients can tolerate RFA...
  72. ncbi request reprint Perioperative and long-term outcome of major hepatic resection for small solitary hepatocellular carcinoma in patients with cirrhosis
    Brian Hung Hin Lang
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Surg 138:1207-13. 2003
    ..Major hepatic resection is safe and provides favorable long-term survival for cirrhotic patients with a small solitary hepatocellular carcinoma...
  73. ncbi request reprint Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis
    Irene Oi Lin Ng
    Department of Pathology, The University of Hong Kong, Faculty of Medicine, Queen Mary Hospital, Hong Kong
    J Pathol 199:345-53. 2003
    ..Of these molecular methods, LOH analysis can be used to evaluate tumour clonality in most patients even before surgical resection, since this assay can be readily applied routinely to either liver biopsies or fine needle aspirates...
  74. pmc Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection
    Kelvin Yuen Kwong Chan
    State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e28798. 2011
    ..In summary, our study suggests that variations at chromosome 8p12 may promote HCC in patients with HBV. Further functional studies of this region may help understand HBV-associated hepatocarcinogenesis...
  75. ncbi request reprint Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma
    Ching Tung Lum
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong, People s Republic of China
    Int J Cancer 118:1527-38. 2006
    ..Results from our study demonstrated that gold-1a might be a novel promising chemocytotoxic agent for treating HCC...
  76. ncbi request reprint Antiinflammatory properties of IL-10 rescue small-for-size liver grafts
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Transpl 13:558-65. 2007
    ....
  77. ncbi request reprint Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma
    Yuqing Liu
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, ROC
    Am J Gastroenterol 99:1111-21. 2004
    ..Hepatocellular carcinoma (HCC) is a rapidly progressive malignancy. Chemokine receptors are important mediators of lymphocyte migration in cancer. This study evaluated expression of chemokine receptors on lymphocytes of HCC patients...
  78. doi request reprint Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma
    Edmund Kwok Kwan Tung
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Int 31:1494-504. 2011
    ..Although Dickkopf-1 (DKK1) is known to be a negative regulator of the Wnt/β-catenin pathway, it has been recently found to be upregulated in cancers...
  79. doi request reprint Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma
    Danny Ka Ho Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Hepatology 54:829-36. 2011
    ..The low intrahepatic HBV DNA and pgRNA levels indicated that persistent viral replication and possibly HBV integration are the likely causes of HCC in OBI patients...
  80. doi request reprint The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2
    Carmen Chak Lui Wong
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong
    Gastroenterology 140:322-31. 2011
    ..We investigated mechanisms of hepatocellular carcinoma (HCC) metastasis and identified an antimetastatic microRNA (miRNA), miR-139, that is down-regulated in human HCC samples...
  81. ncbi request reprint Acute intraoperative hemolysis and hemoglobinuria during radiofrequency ablation of hepatocellular carcinoma
    Siu Lun Tsui
    Department of Anaesthesiology, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hepatogastroenterology 50:526-9. 2003
    ..Literature search revealed that radiofrequency ablation can induce hemolysis in experimental setting, but this is the first clinical report of acute hemolysis during radiofrequency ablation for liver tumors...
  82. ncbi request reprint Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2)
    Chi Keung Lau
    Center for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Biochem Biophys Res Commun 348:1443-8. 2006
    ..In conclusion, YC-1 suppressed both protein synthesis and stability of HIF-1alpha in HCC cells, and its inhibitory effects on HIF-1alpha were dependent on Mdm2...
  83. doi request reprint Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma
    Frankie Chi Fat Ko
    Liver Cancer and Hepatitis Research Laboratory, Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Int 30:139-48. 2010
    ..Deleted in liver cancer (DLC) is a family of tumour suppressors that plays a critical role in hepatocellular carcinoma (HCC)...
  84. ncbi request reprint Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway
    Zhen Fan Yang
    Center for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Hong Kong, China
    J Immunol 173:2507-15. 2004
    ..In conclusion, the present study showed that the up-regulated expression of VEGF and its interaction with Flk-1 in small-for-size liver grafts might facilitate the activities of macrophages...
  85. ncbi request reprint Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma
    Kelvin K Ng
    Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Gastrointest Surg 12:183-91. 2008
    ..There is no data on the analysis of recurrence pattern and its influence on long-term survival outcome after RFA in HCC patients...
  86. doi request reprint p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells
    Xiao Qi Wang
    Department of Surgery, University of Hong Kong, Hong Kong, SAR, China
    Tumour Biol 29:217-23. 2008
    ..However, it is controversial whether p27 promotes or inhibits cell migration. This study investigates the migration regulatory role of p27 in metastatic hepatocellular carcinoma (HCC) cells...
  87. ncbi request reprint Hepatic angiomyolipoma
    Kevin Kwok Chai Ng
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Surgery 133:594-5. 2003
  88. ncbi request reprint Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database
    Kelvin K Ng
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg Oncol 12:364-73. 2005
    ..This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database...
  89. ncbi request reprint Selective portal vein clamping for radiofrequency ablation of hepatocellular carcinoma with portal vein invasion
    Kenneth S Chok
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Gastrointest Surg 9:489-93. 2005
    ..Complete tumor ablation was achieved after RFA with left portal vein clamping. He remained disease free both radiologically and biochemically 6 months after the operation...
  90. ncbi request reprint Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma
    Yuqing Liu
    Department of Surgery, The University of Hong Kong, Centre for the Study of Liver Disease, L9 57, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Clin Immunol 114:174-82. 2005
    ..This study demonstrates the role of chemokine receptors in the recruitment of specific lymphocyte subsets to the liver in HCC and suggests the importance of these receptors in regulation of immune defense against HCC...
  91. ncbi request reprint Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?
    Chi Ming Lam
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Gastroenterol 39:533-9. 2005
    ..Hepatocellular carcinoma (HCC) has an indisputable male predominance. "Gender" as an independent prognostic factor for survival is, however, controversial...
  92. ncbi request reprint Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10
    Zhen Fan Yang
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 13:571-8. 2007
    ..Supplementary exogenous IL-10 administration combined with low-dose immunosuppressive drug may be a useful strategy to induce long-term liver allograft survival...
  93. ncbi request reprint Assessment of hepatic reserve for indication of hepatic resection: how I do it
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Hepatobiliary Pancreat Surg 12:31-7. 2005
    ....
  94. doi request reprint Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation
    Chris K Sun
    Department of Surgery and Centre for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Carcinogenesis 29:2096-105. 2008
    ..In conclusion, our results showed that Pyk2 promoted cell proliferation and invasiveness by upregulation of the c-Src and ERK/MAPK-signaling pathways...
  95. pmc Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 240:698-708; discussion 708-10. 2004
    ..To assess the trends in perioperative outcome of hepatectomy for hepatobiliary diseases...
  96. pmc Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: prognosis and outcomes
    Tan To Cheung
    Department of Surgery, The University of Hong Kong, 102 Pok Fu Lam Road, Queen Mary Hospital, Hong Kong, China
    World J Gastroenterol 16:3056-62. 2010
    ..To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes...
  97. ncbi request reprint Duodenopleural fistula formation after percutaneous radiofrequency ablation for recurrent hepatocellular carcinoma
    Fion S Chan
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Asian J Surg 30:278-82. 2007
    ..Subsequent uncontrolled infection resulted in empyema thoracis and led to the death of the patient...
  98. doi request reprint Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma
    Thomas Yau
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 116:5022-9. 2010
    ..This phase 1-2 trial assessed the efficacy and tolerability of an oral angiogenesis inhibitor-PTK787/ZK222584 (PTK)-in combination with intravenous doxorubicin for the treatment of advanced hepatocellular carcinoma (HCC) patients...
  99. ncbi request reprint Repeated resections of extrahepatic metastases after hepatic resection: an aggressive approach to hepatocellular carcinoma
    Criostoir B O'Suilleabhain
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatogastroenterology 51:825-9. 2004
    ..These two cases illustrate that an aggressive surgical approach of repeated resections of extrahepatic recurrences after curative resection of hepatocellular carcinoma can result in long-term survival in selected patients...
  100. ncbi request reprint Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    Yuqing Liu
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 65:3691-9. 2005
    ..Our data suggest that blockage of VEGF receptors may provide an effective therapeutic approach for human hepatocellular carcinoma...
  101. ncbi request reprint Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver
    Joanna W Ho
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    World J Gastroenterol 11:176-81. 2005
    ....