Js Malik Peiris

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 6:82. 2006
  2. ncbi Evaluation of three commercially available influenza A type-specific blocking enzyme-linked immunosorbent assays for seroepidemiological studies of influenza A virus infection in pigs
    Maying Tse
    State Key Laboratory of Emerging Infectious Diseases and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 19:334-7. 2012
  3. ncbi Heterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in trans
    Stella S F Ng
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Virol J 5:2. 2008
  4. ncbi Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
    Suki M Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
    Respir Res 11:147. 2010
  5. ncbi Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
    Michael C W Chan
    Departments of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Respir Res 10:102. 2009
  6. ncbi Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses
    John M Nicholls
    Pathology Department, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong SAR
    Respir Res 8:73. 2007
  7. ncbi Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
  8. ncbi Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities
    Lin Yang
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, 5 F William Mong Block, 21 Sassoon Road, Hong Kong, China
    BMC Infect Dis 11:342. 2011
  9. ncbi Is respiratory viral infection really an important trigger of asthma exacerbations in children?
    So Lun Lee
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Eur J Pediatr 170:1317-24. 2011
  10. ncbi The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
    Man Wai Ng
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 7:50. 2007

Collaborators

Detail Information

Publications33

  1. ncbi The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 6:82. 2006
    ..Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  2. ncbi Evaluation of three commercially available influenza A type-specific blocking enzyme-linked immunosorbent assays for seroepidemiological studies of influenza A virus infection in pigs
    Maying Tse
    State Key Laboratory of Emerging Infectious Diseases and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 19:334-7. 2012
    ....
  3. ncbi Heterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in trans
    Stella S F Ng
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Virol J 5:2. 2008
    ..The observations suggested that, with the cooperation between the homologous 5' and 3'segment-specific sequences, the introduced mutations could specifically enhance the replication of NA and NS vRNA...
  4. ncbi Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
    Suki M Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
    Respir Res 11:147. 2010
    ..However a comprehensive gene expression profile of pdmH1N1 in relevant primary human cells in vitro has not been reported. Type I alveolar epithelial cells are a key target cell in pdmH1N1 pneumonia...
  5. ncbi Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
    Michael C W Chan
    Departments of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Respir Res 10:102. 2009
    ..These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease...
  6. ncbi Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses
    John M Nicholls
    Pathology Department, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong SAR
    Respir Res 8:73. 2007
    ....
  7. ncbi Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
    ..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...
  8. ncbi Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities
    Lin Yang
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, 5 F William Mong Block, 21 Sassoon Road, Hong Kong, China
    BMC Infect Dis 11:342. 2011
    ..Environmental factors have been associated with transmission and survival of influenza viruses but no studies have ever explored the role of environmental factors on severity of influenza infection...
  9. ncbi Is respiratory viral infection really an important trigger of asthma exacerbations in children?
    So Lun Lee
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Eur J Pediatr 170:1317-24. 2011
    ....
  10. ncbi The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
    Man Wai Ng
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 7:50. 2007
    ..Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  11. ncbi Seasonal effects of influenza on mortality in a subtropical city
    Lin Yang
    Department of Community Medicine and School of Public Health, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    BMC Infect Dis 9:133. 2009
    ..In this paper we explored this seasonal effect of influenza...
  12. ncbi Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus
    Emily H M Wong
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong, China
    BMC Evol Biol 10:253. 2010
    ..A better understanding of viral evolution and host adaptive responses might help control this disease...
  13. ncbi Confronting SARS: a view from Hong Kong
    J S M Peiris
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong, Hong Kong Special Administrative Region, China
    Philos Trans R Soc Lond B Biol Sci 359:1075-9. 2004
    ..The pattern of disease emergence and strategies for control of SARS provides lessons for coping with future emerging infectious disease threats...
  14. ncbi A novel H1N1 virus causes the first pandemic of the 21st century
    J S Malik Peiris
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China
    Eur J Immunol 39:2946-54. 2009
    ....
  15. ncbi Innate immune responses to influenza A H5N1: friend or foe?
    Joseph Sriyal Malik Peiris
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong SAR
    Trends Immunol 30:574-84. 2009
    ....
  16. ncbi Coronavirus as a possible cause of severe acute respiratory syndrome
    J S M Peiris
    Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong, Special Administrative Region, Hong Kong, China
    Lancet 361:1319-25. 2003
    ..An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients...
  17. ncbi Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract
    Michael C W Chan
    Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Pathol 176:1828-40. 2010
    ..These findings are therefore relevant for understanding transmission and therapy...
  18. ncbi Host response to influenza virus: protection versus immunopathology
    J S M Peiris
    Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Curr Opin Immunol 22:475-81. 2010
    ..Understanding pathogenesis will help develop novel therapeutic options that minimize immunopathology without impairing beneficial host defenses...
  19. ncbi Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans
    J S Malik Peiris
    State Key Laboratory for Emerging Infectious Disease and Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    J Clin Virol 45:169-73. 2009
    ..The virus appears to retain the potential to transmit back to swine and thus continued reassortment with swine viruses is a cause for concern...
  20. ncbi Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?
    J S Peiris
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    J Virol 75:9679-86. 2001
    ..Cocirculation of avian H9N2 and human H3N2 viruses in pigs provides an opportunity for genetic reassortment leading to the emergence of viruses with pandemic potential...
  21. ncbi Severe acute respiratory syndrome
    J S M Peiris
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfualm, Hong Kong Special Administrative Region of China
    Nat Med 10:S88-97. 2004
    ....
  22. ncbi Re-emergence of fatal human influenza A subtype H5N1 disease
    J S M Peiris
    Department of Microbiology and Pathology, University of Hong Kong and Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    Lancet 363:617-9. 2004
    ..Development of vaccines against influenza A (H5N1) virus should be made a priority...
  23. ncbi Avian influenza virus (H5N1): a threat to human health
    J S Malik Peiris
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, People s Republic of China
    Clin Microbiol Rev 20:243-67. 2007
    ....
  24. ncbi Avian coronavirus in wild aquatic birds
    Daniel K W Chu
    State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Chin
    J Virol 85:12815-20. 2011
    ..Our analysis of these avian viral and host mitochondrial DNA sequences also suggests that some, but not all, coronaviruses may have coevolved with birds from the same order...
  25. ncbi An update on avian influenza in Hong Kong 2002
    L D Sims
    Agriculture, Fisheries, and Conservation Department, 303 Cheung Sha Wan Road, Kowloon, Hong Kong SAR, China
    Avian Dis 47:1083-6. 2003
    ..Vaccination using a killed H5 vaccine was introduced in April 2002 to farms in one zone where infection has persisted. None of the viruses isolated contained the internal genes found in the 1997 H5N1 virus...
  26. ncbi Molecular evolution of H6 influenza viruses from poultry in Southeastern China: prevalence of H6N1 influenza viruses possessing seven A/Hong Kong/156/97 (H5N1)-like genes in poultry
    P S Chin
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Virol 76:507-16. 2002
    ..the A/Hong Kong/156/97 (H5N1) virus raises the following fundamental questions relevant to influenza pandemic preparedness: could the pathogenic H5N1 virus reemerge and could the H6N1 viruses directly cross the species barrier to mammals?..
  27. ncbi Avian influenza in Hong Kong 1997-2002
    L D Sims
    Agriculture, Fisheries, and Conservation Department, 303 Cheung Sha Wan Road, Kowloon, Hong Kong SAR, China
    Avian Dis 47:832-8. 2003
    ..This paper provides an overview and chronology of the events in Hong Kong relating to avian influenza, covering the period from March 1997 to March 2002...
  28. ncbi H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to ducks
    Y Guan
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Hong Kong SAR, People's Republic of China
    Virology 292:16-23. 2002
    ..For pandemic preparedness, it is important to monitor whether these reassortant viruses have the capacity for interspecies transmission to terrestrial poultry or mammals...
  29. ncbi Influenza A infection is an important cause of febrile seizures
    S S Chiu
    Department of Pediatrics, University of Hong Kong, Hong Kong SAR, China
    Pediatrics 108:E63. 2001
    ....
  30. ncbi Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis
    Chris Ka Pun Mok
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    J Virol 85:9641-5. 2011
    ..Taken together, our studies help define the viral genetic determinants that contribute to pathogenicity of H9N2 viruses...
  31. ncbi The quest of influenza A viruses for new hosts
    M Liu
    St. Jude Children's Research Hospital, Division of Virology, Department of Infectious Diseases, 332 N. Lauderdale, Memphis, TN 38105, USA
    Avian Dis 47:849-56. 2003
    ..Thus, quail may play an important role in the natural history of influenza viruses. The pros and cons of the use of inactivated and recombinant fowl pox-influenza vaccines to control the spread of avian influenza are also evaluated...
  32. ncbi Avian influenza H5N1: is it a cause for concern?
    L C Jennings
    Intern Med J 36:145-7. 2006
  33. ncbi Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses
    R G Webster
    St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Avian Dis 51:269-72. 2007
    ..This article provides an overview of the changing properties that have been observed during the current H5N1 outbreaks...