Edmond Shiu Kwan Ma

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Hematological features and treatment outcome in acute myeloid leukemia with t(8;21)
    S K Ma
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hematol Oncol 15:93-103. 1997
  2. ncbi request reprint Clinical phenotype of triplicated alpha-globin genes and heterozygosity for beta0-thalassemia in Chinese subjects
    S K Ma
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, P R China
    Int J Mol Med 8:171-5. 2001
  3. ncbi request reprint Molecular characterization of Hb Val de Marne [alpha133(H16)Ser-->Arg; AGC-->AGA; (alpha2)] in a Chinese family
    Edmond Shiu Kwan Ma
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, P R China
    Hemoglobin 28:213-6. 2004
  4. ncbi request reprint Haemoglobin H disease due to (--SEA) alpha-globin gene deletion and alpha2-codon 30 (DeltaGAG) mutation: a family study
    S K Ma
    Haematology Section, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Lab Haematol 23:325-7. 2001
  5. ncbi request reprint Dutcher-Fahey intranuclear inclusions in multiple myeloma
    Edmond S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Br J Haematol 129:164. 2005
  6. ncbi request reprint Acute myeloid leukaemia with giant granules: association with t(10; 11)(p13; q14) and disseminated intravascular coagulation
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Lab Haematol 22:303-5. 2000
  7. ncbi request reprint beta-thalassemia intermedia caused by compound heterozygosity for Hb Malay (beta codon 19 AAC-->AGC; asn-->Ser) and codons 41/42 (-CTTT) beta(0)-thalassemia mutation
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Am J Hematol 64:206-9. 2000
  8. ncbi request reprint Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Leuk Res 22:961-4. 1998
  9. ncbi request reprint Myelodysplastic syndrome with myelofibrosis and basophilia: detection of trisomy 8 in basophils by fluorescence in-situ hybridization
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Leuk Lymphoma 31:429-32. 1998
  10. ncbi request reprint Thalassemia intermedia due to co-inheritance of beta0/beta(+)-thalassemia and (- -SEA) alpha-thalassemia/Hb Westmead [alpha122(H5)His > Gln (alpha2)] in a Chinese family
    Wai Shan Wong
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China
    Hemoglobin 28:151-6. 2004

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Hematological features and treatment outcome in acute myeloid leukemia with t(8;21)
    S K Ma
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hematol Oncol 15:93-103. 1997
    ..1 +/- 15.6 per cent respectively with a median duration of follow-up of 22 months. When compared with AML having no t(8;21) treated similarly in the same period, we could not demonstrate a better clinical outcome for t(8;21) AML...
  2. ncbi request reprint Clinical phenotype of triplicated alpha-globin genes and heterozygosity for beta0-thalassemia in Chinese subjects
    S K Ma
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, P R China
    Int J Mol Med 8:171-5. 2001
    ..Finally, triplication of alpha-globin genes should be looked for in families with children affected by beta-thalassemia intermedia in which only one parent showed a picture of beta-thalassemia on Hb analysis...
  3. ncbi request reprint Molecular characterization of Hb Val de Marne [alpha133(H16)Ser-->Arg; AGC-->AGA; (alpha2)] in a Chinese family
    Edmond Shiu Kwan Ma
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, P R China
    Hemoglobin 28:213-6. 2004
    ....
  4. ncbi request reprint Haemoglobin H disease due to (--SEA) alpha-globin gene deletion and alpha2-codon 30 (DeltaGAG) mutation: a family study
    S K Ma
    Haematology Section, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Lab Haematol 23:325-7. 2001
    ..Correlation of genotype with phenotype in Hb H disease is important for genetic counselling, especially in the antenatal setting...
  5. ncbi request reprint Dutcher-Fahey intranuclear inclusions in multiple myeloma
    Edmond S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Br J Haematol 129:164. 2005
  6. ncbi request reprint Acute myeloid leukaemia with giant granules: association with t(10; 11)(p13; q14) and disseminated intravascular coagulation
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Lab Haematol 22:303-5. 2000
    ..Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation...
  7. ncbi request reprint beta-thalassemia intermedia caused by compound heterozygosity for Hb Malay (beta codon 19 AAC-->AGC; asn-->Ser) and codons 41/42 (-CTTT) beta(0)-thalassemia mutation
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Am J Hematol 64:206-9. 2000
    ..The possible presence of this mutation should also be considered in appropriate cases for genetic counseling in couples at risk of conceiving fetuses with beta-thalassemia major or intermedia...
  8. ncbi request reprint Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Leuk Res 22:961-4. 1998
    ..Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined...
  9. ncbi request reprint Myelodysplastic syndrome with myelofibrosis and basophilia: detection of trisomy 8 in basophils by fluorescence in-situ hybridization
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Leuk Lymphoma 31:429-32. 1998
    ..By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone...
  10. ncbi request reprint Thalassemia intermedia due to co-inheritance of beta0/beta(+)-thalassemia and (- -SEA) alpha-thalassemia/Hb Westmead [alpha122(H5)His > Gln (alpha2)] in a Chinese family
    Wai Shan Wong
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China
    Hemoglobin 28:151-6. 2004
    ....
  11. ncbi request reprint Detection of a small novel deletion in the alpha-globin gene and type II-alpha(3.7) deletion by heteroduplex formation
    Amy Yuk Yin Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Hemoglobin 26:311-6. 2002
  12. pmc A laboratory strategy for genotyping haemoglobin H disease in the Chinese
    Amy Yuk Yin Chan
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People s Republic of China
    J Clin Pathol 60:931-4. 2007
    ..The thalassaemias are the commonest blood disorders worldwide, with South East Asia and southern China as areas of high prevalence. Accurate diagnosis of these disorders helps in clinical management with improved outcome...
  13. ncbi request reprint Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family
    K F Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China
    Clin Lab Haematol 23:53-5. 2001
    ..2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS...
  14. ncbi request reprint Eosinophilic leukemic transformation in polycythemia rubra vera (PRV)
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 46:447-50. 2005
    ..The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies...
  15. ncbi request reprint Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 23:57-60. 2005
    ..We hypothesized that AML in this case resulted from a complex pre-disposition by the natural progression of ET, prolonged use of HU, and the prior evolution into MF. The leukemogenic risk of HU is critically appraised...
  16. ncbi request reprint Acute biphenotypic leukaemia
    C S Chim
    Honorary Clinical Associate Professor, Department of Medicine, Queen Mary Hospital, Hong Kong, ROC
    Haematologica 87:EIM03. 2002
  17. ncbi request reprint Derivative (1;18)(q10;q10): a recurrent and novel unbalanced translocation involving 1q in myeloid disorders
    T S Wan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China
    Cancer Genet Cytogenet 128:35-8. 2001
    ..Finally, chromosomes with large constitutive heterochromatin bands such as chromosome 1 may be at risk of centromeric instability and be predisposed to centromeric fusion with other chromosomes...
  18. ncbi request reprint Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong
    Leuk Lymphoma 33:385-8. 1999
    ..We describe a patient with chronic myeloid leukemia on interferon treatment, who developed BMN with symptoms and signs masquerading as interferon toxicity. This is followed by a literature review of BMN in CML...
  19. ncbi request reprint Primary CD56 positive lymphomas of the gastrointestinal tract
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Cancer 91:525-33. 2001
    ..However, they have a considerable degree of morphologic and immunophenotypic overlap, making a definitive diagnosis difficult...
  20. ncbi request reprint Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Hum Pathol 35:900-3. 2004
    ..The overall features suggest instead separate lymphoma and leukemic evolution from a common mutated B-cell precursor rather than transformation of DLBC lymphoma to ALL...
  21. ncbi request reprint Pathogenesis of jumping translocations: a molecular cytogenetics study
    T S K Wan
    Department of Pathology, Division of Haematology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China
    Leuk Res 28:1075-9. 2004
    ..We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph translocation...
  22. ncbi request reprint Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease
    W Y Au
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 84:671-4. 2005
    ..2%), but not heterozgyotes (42.2%), were found to have a significantly increased risk of gallstones and jaundice. However, common Chinese Gilbert syndrome alleles do not completely explain the variable risks...
  23. ncbi request reprint Trisomy 21 and other chromosomal abnormalities in acute promyelocytic leukemia
    T S K Wan
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Cancer Genet Cytogenet 140:170-3. 2003
    ..As APL is now considered a curable disease, any confirmed long-term survival impact of additional cytogenetic changes is expected to have important management implications...
  24. ncbi request reprint Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome
    C Hon
    Department of Ophthalmology, Queen Mary Hospital, Hong Kong, China
    Ann Hematol 83:481-3. 2004
    ....
  25. pmc Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?
    L C Chan
    Department of Pathology, University of Hong Kong and Queen Mary Hospital, Hong Kong, People s Republic of China
    J Clin Pathol 54:317-20. 2001
    ..To investigate whether it is worthwhile, in areas where thalassaemia is common, to screen for globin gene mutations in subjects with a mean corpuscular volume (MCV) above 80 fL, especially in partners of known thalassaemia carriers...
  26. ncbi request reprint Two balanced and novel chromosomal translocations in myeloid malignancies. characterization by multiplex fluorescence in situ hybridization
    T S K Wan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, People s Republic of, Hong Kong, China
    Cancer Genet Cytogenet 139:52-6. 2002
    ....
  27. ncbi request reprint Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Br J Haematol 119:777-80. 2002
    ..Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia...
  28. ncbi request reprint Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study
    S K Ma
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, People's Republic of China
    Leukemia 15:1442-7. 2001
    ..Our findings confirm that additional or secondary genetic changes including AML1 amplification are commonly encountered in childhood ALL with TEL/AML1 gene fusion, which are envisaged to play significant roles in disease progression...
  29. ncbi request reprint Routine screening of (--(SEA)) alpha-thalassemia deletion by an enzyme-linked immunosorbent assay for embryonic zeta-globin chains
    S K Ma
    Division of Hematology, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Acta Haematol 108:8-12. 2002
    ..In areas with a high prevalence of alpha-thalassemia, improved detection of SEA deletion carriers would ultimately facilitate the identification of pregnancies at risk of hydrops fetalis and its prevention through prenatal diagnosis...
  30. ncbi request reprint Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X
    T S K Wan
    Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People s Republic of China
    Ann Hematol 81:167-9. 2002
    ..We speculate that tissue damage by cellular constituents of the abnormal eosinophils that were released on cell lysis after chemotherapy might be etiologically linked to the occurrence of fatal pulmonary complications...
  31. pmc Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 5:28. 2012
    ..Here we compared the outcomes of the staged approach with frontline PAD (bortezomib/doxorubicin/dexamethasone) or VTD (bortezomib/thalidomide/dexamethasone) induction, and analysed prognostic factors for outcome...
  32. doi request reprint Inherited thrombophilic factors do not increase central venous catheter blockage in children with malignancy
    Brian Hon Yin Chung
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    Pediatr Blood Cancer 51:509-12. 2008
    ..Central venous catheter (CVC) blockage is a common complication in pediatric oncology patients. We investigated whether inherited thrombophilic factors may predispose Chinese children with cancer to CVC blockage...
  33. ncbi request reprint Chronic myeloid leukemia in an adolescent with Ollier's disease after intensive X-ray exposure
    W Y Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, SAR, China
    Leuk Lymphoma 45:613-6. 2004
    ....
  34. ncbi request reprint Philadelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantation
    W Y Au
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Haematol 114:365-8. 2001
    ....
  35. ncbi request reprint Disseminated hepatosplenic mycobacterial infection masking myeloproliferative diseases as leukemoid reaction: a diagnostic pitfall
    W Y Au
    Department of Medicine, University Department of Medicine, Queen Mary Hospital, Hong Kong
    Leuk Lymphoma 42:805-8. 2001
    ..Clinicians and hematologist should be aware of such a predisposition and possible dual pathology for proper diagnosis, therapy and monitoring of both the infection and the myeloproliferation...
  36. ncbi request reprint Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations
    W Y Au
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Br J Haematol 120:1062-5. 2003
    ..Bone marrow transplantation led to the disappearance of p15 methylation in one patient. These results showed that p15 methylation was an early event in the evolution of some t-MDS/AML patients...
  37. pmc Derivative chromosome 9 deletions in chronic myeloid leukaemia: interpretation of atypical D-FISH pattern
    T S K Wan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    J Clin Pathol 56:471-4. 2003
    ..This report describes the interpretation of atypical signal patterns encountered using BCR-ABL dual colour dual fusion fluorescence in situ hybridisation (D-FISH) translocation probes in chronic myeloid leukaemia (CML)...
  38. ncbi request reprint Patients presenting with CNS lesions. Case 3. Sequential myeloproliferative disease and glioblastoma multiforme in a renal transplant recipient
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Oncol 21:4062-3. 2003
  39. ncbi request reprint Nodal plasmacytoma with significant paraproteinaemia
    T W Shek
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Leuk Lymphoma 40:425-8. 2001
    ..The differential diagnoses of plasmacytosis in the lymph node are also discussed...
  40. pmc Reassortment of pandemic H1N1/2009 influenza A virus in swine
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Science 328:1529. 2010
    ..Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted...
  41. ncbi request reprint Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Bone Marrow Transplant 28:417-9. 2001
    ..Of further interest is that recipient lymphoid regeneration had accompanied autologous haematopoietic regeneration and become a target for subsequent neoplastic transformation...
  42. ncbi request reprint Treatment of postrenal transplantation lymphoproliferative disease manifesting as plasmacytoma with nonmyeloablative hematopoietic stem cell transplantation from the same kidney donor
    W Y Au
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 74:283-6. 2003
    ..Nonmyeloablative HSCT might be considered a cellular therapy for PTLD, but possible CNS relapse must be effectively tackled...
  43. ncbi request reprint Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation
    W Y Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Am J Hematol 81:880-2. 2006
    ..Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT...
  44. ncbi request reprint Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: a cautionary tale
    W Y Au
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Leuk Lymphoma 43:1679-81. 2002
    ..The long-term use of immunodulating agents in patients with CD is not without risks, and early therapy related myelodysplasia might not be easily detected by blood count and morphology assessment alone...
  45. ncbi request reprint Subvalvular pulmonary stenosis, demyelination and myelodysplasia with monosomy 7
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    Leuk Lymphoma 43:1505-7. 2002
    ..The importance of recognition of rare clinical syndromes that may predispose to leukemia is discussed...
  46. ncbi request reprint Potential role for platelet apheresis for post-liver transplant thrombocytosis complicating portal vein thrombosis
    W Y Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    J Clin Apher 19:192-6. 2004
    ..The use of cell separation procedures may be a relatively rapid, reversible, and reasonably safe way to control platelet counts peri-operatively in liver transplant recipients...
  47. ncbi request reprint The (--(SEA)) alpha-thalassemia (SEA) deletion ameliorates the clinical phenotype of beta(0)/beta(+) but not necessarily beta(0)/beta(0) thalassemia
    Edmond Shiu Kwan Ma
    Haematologica 87:443-4. 2002