Research Topics

Haojun Liang


Affiliation: University of Science and Technology of China
Country: China


  1. Li H, Zhou X, Yao D, Liang H. pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system. Chem Commun (Camb). 2018;54:3520-3523 pubmed publisher
    ..Furthermore, they can exactly image lysosomes in living cells. We next engineered pH-triggered doxorubicin(Dox)-SNA conjugates that could deliver Dox molecules into cancer cells and achieve pH-dependent drug release. ..
  2. Wang B, Wang X, Wei B, Huang F, Yao D, Liang H. DNA photonic nanowires with tunable FRET signals on the basis of toehold-mediated DNA strand displacement reactions. Nanoscale. 2017;9:2981-2985 pubmed publisher
    ..It could also be applied in live cells to monitor MicroRNA with a simple modification which might become a low-cost method for further application in the future. ..
  3. Song T, Tang L, Tan L, Wang X, Satyavolu N, Xing H, et al. DNA-Encoded Tuning of Geometric and Plasmonic Properties of Nanoparticles Growing from Gold Nanorod Seeds. Angew Chem Int Ed Engl. 2015;54:8114-8 pubmed publisher
    ..As a result, the surface plasmon resonance (SPR) peaks of the nanoparticles can be fine-tuned in a wide range, from visible to second near-infrared (NIR-II) region beyond 1000 nm. ..
  4. Li H, Xiao S, Yao D, Lam M, Liang H. A smart DNA-gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance. Chem Commun (Camb). 2015;51:4670-3 pubmed publisher
    ..After optimizing and testing the detection system, it has been successfully applied to detect mutation of a realistic sequence associated with human cancer, thereby indicating that this method has potential applicability in general. ..
  5. Zhou X, Li H, He M, Yin X, Yao D, Xiao S, et al. Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release. Chem Commun (Camb). 2017;54:106-109 pubmed publisher
    ..The photoresponsive SNA realizes temporal regulation of a self-assembly reaction circuit and spatial selectivity of microRNA release in a cell population, respectively. ..
  6. Li H, Shen W, Lam M, Liang H. Localized degradation of foreign DNA strands in cells: Only excising the first nucleotide of 5' region. Anal Biochem. 2017;533:10-17 pubmed publisher
  7. Wang B, Zhou X, Yao D, Sun X, He M, Wang X, et al. Contribution of gold nanoparticles to the catalytic DNA strand displacement in leakage reduction and signal amplification. Chem Commun (Camb). 2017;53:10950-10953 pubmed publisher
    ..This model may help by introducing a proposition of target detection to guide further investigation. ..