Suet Yi Leung

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese
    S Y Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital
    Int J Cancer 72:225-30. 1997
  2. ncbi request reprint hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
    S Y Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital
    Cancer Res 59:159-64. 1999
  3. ncbi request reprint Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer
    Suet Yi Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Gastroenterology 127:457-69. 2004
  4. ncbi request reprint Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms
    Vivian S W Li
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Gastroenterology 137:176-87. 2009
  5. ncbi request reprint Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma
    Agnes Sze Wah Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Oncogene 22:6946-53. 2003
  6. ncbi request reprint CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
    Samuel Ko
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Pathol 205:615-22. 2005
  7. pmc MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population
    Tsun Leung Chan
    Department of Pathology, The University of Hong Kong, Hong Kong
    Am J Hum Genet 74:1035-42. 2004
  8. ncbi request reprint Comprehensive analysis of 19q12 amplicon in human gastric cancers
    Suet Yi Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Mod Pathol 19:854-63. 2006
  9. ncbi request reprint Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor--by epithelial cells, T cells, and macrophages--in gastric mucosa
    Harry Hua Xiang Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, S A R, China
    J Infect Dis 190:293-302. 2004
  10. pmc Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E
    Bone S F Tang
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Center of Infection and Immunology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Virol 79:6180-93. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese
    S Y Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital
    Int J Cancer 72:225-30. 1997
    ..The deleted variant, which may have a higher tumorigenic potential, may contribute to the high incidence of NPC, as well as the occurrence of EBV-CA in organs outside the nasopharynx in our locality...
  2. ncbi request reprint hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
    S Y Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital
    Cancer Res 59:159-64. 1999
    ....
  3. ncbi request reprint Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer
    Suet Yi Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China
    Gastroenterology 127:457-69. 2004
    ..We previously analyzed gene-expression patterns in 90 gastric adenocarcinomas by using complementary DNA microarrays and prioritized a list of genes whose expression levels predict patient outcome...
  4. ncbi request reprint Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms
    Vivian S W Li
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Gastroenterology 137:176-87. 2009
    ..RGMA also functions as a bone morphogenetic protein (BMP) coreceptor. We studied the potential roles of RGMA and NEO1 in colorectal cancer (CRC) pathogenesis...
  5. ncbi request reprint Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma
    Agnes Sze Wah Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Oncogene 22:6946-53. 2003
    ..The significant association of ID4 and hMLH1 promoter hypermethylation suggested that ID4 may also be among the genes being targeted in the CpG island methylator phenotype tumorigenic pathway...
  6. ncbi request reprint CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
    Samuel Ko
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Pathol 205:615-22. 2005
    ..Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of CDH17 is significantly associated with CDX2...
  7. pmc MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population
    Tsun Leung Chan
    Department of Pathology, The University of Hong Kong, Hong Kong
    Am J Hum Genet 74:1035-42. 2004
    ..Since there were major emigrations from Hong Kong and Guangdong province during the 19th and 20th centuries, this finding is also significant for Chinese communities worldwide...
  8. ncbi request reprint Comprehensive analysis of 19q12 amplicon in human gastric cancers
    Suet Yi Leung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Mod Pathol 19:854-63. 2006
    ..In addition, our study indicates that amplification at 19q12 is associated with cell proliferation in vivo...
  9. ncbi request reprint Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor--by epithelial cells, T cells, and macrophages--in gastric mucosa
    Harry Hua Xiang Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, S A R, China
    J Infect Dis 190:293-302. 2004
    ..pylori infection...
  10. pmc Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E
    Bone S F Tang
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Center of Infection and Immunology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Virol 79:6180-93. 2005
    ..These transcriptomal changes are compatible with the histological changes of pulmonary vasculitis and microvascular thrombosis in addition to the diffuse alveolar damage involving the pneumocytes...
  11. pmc Mutations of PIK3CA in gastric adenocarcinoma
    Vivian Sze Wing Li
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    BMC Cancer 5:29. 2005
    ..Eighty percent of these reported mutations clustered within 2 regions involving the helical and kinase domains. In vitro study on one of the "hot-spot" mutants has demonstrated it as an activating mutation...
  12. ncbi request reprint Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours
    Dong Li Guo
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Carcinogenesis 27:454-64. 2006
    ..EphB2 may achieve its tumour suppressor function through regulation of cell survival, adhesion and migration...
  13. ncbi request reprint Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
    Tsun Leung Chan
    Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Nat Genet 38:1178-83. 2006
    ....
  14. ncbi request reprint Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers
    Siu Tsan Yuen
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Oncogene 21:7585-92. 2002
    ..These observations have significant implications for management of patients with MSI-H tumours...
  15. ncbi request reprint Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma
    Samuel S M Ng
    Department of Chemistry, Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Natl Cancer Inst 99:936-48. 2007
    ..We investigated the involvement of cell cycle-related kinase (CCRK), a novel protein kinase that is homologous to cyclin-dependent kinase 7, in glioblastoma multiforme carcinogenesis...
  16. ncbi request reprint Antralization at the edge of proximal gastric ulcers: does Helicobacter pylori infection play a role?
    Harry Hua Xinag Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    World J Gastroenterol 9:1265-9. 2003
    ..To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances...
  17. ncbi request reprint De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report
    See Ching Chan
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:320-3. 2004
    ..The patient underwent successful right hepatectomy of the tumor that proved to be sarcoma. The patient is doing well without recurrence 1.5 years after resection and 5 years post transplant...
  18. doi request reprint A 33-year-old Chinese woman with a left frontal tumor
    Yuen Shan Fan
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Brain Pathol 19:337-40. 2009
    ..We believe that on top of the above-mentioned unusual tumors with rhabdoid cells, astroblastoma should also be considered in the list of differential diagnosis...
  19. pmc Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
    Susanna K P Lau
    Department of Microbiology, Research Centre of Infection and Immunology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China
    Proc Natl Acad Sci U S A 102:14040-5. 2005
    ..Neutralizing antibody to human SARS-CoV also was detected in bats with lower viral loads. Precautions should be exercised in the handling of these animals...