W K Lam

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Overview on SARS in Asia and the world
    W K Lam
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Respirology 8:S2-5. 2003
  2. ncbi request reprint Serial HRCT lung changes after 3-field radiation treatment of breast cancer
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China
    Clin Radiol 55:817-24. 2000
  3. pmc Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature
    B Lam
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Postgrad Med J 77:708-12. 2001
  4. ncbi request reprint Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy
    K W Tsang
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Tuberc Lung Dis 8:1301-7. 2004
  5. ncbi request reprint Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD
    J C W Mak
    Division of Respiratory Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Eur Respir J 30:684-90. 2007
  6. ncbi request reprint Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
    K H Chan
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Int J Tuberc Lung Dis 14:1193-200. 2010
  7. ncbi request reprint Respiratory ciliary function in bone marrow recipients
    W Y Au
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Bone Marrow Transplant 27:1147-51. 2001
  8. ncbi request reprint Severe bronchiectasis in patients with "cystlike" structures within the ciliary shafts
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 161:1300-5. 2000
  9. ncbi request reprint Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics
    J C W Mak
    Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Clin Exp Allergy 37:1150-7. 2007
  10. ncbi request reprint A community study of sleep-disordered breathing in middle-aged Chinese men in Hong Kong
    M S Ip
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Chest 119:62-9. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Overview on SARS in Asia and the world
    W K Lam
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Respirology 8:S2-5. 2003
    ..The SARS-CoV has probably jumped from an animal host to humans. There is an urgent need to evaluate the human-animal habitat in southern China and to remove animal reservoirs if found...
  2. ncbi request reprint Serial HRCT lung changes after 3-field radiation treatment of breast cancer
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China
    Clin Radiol 55:817-24. 2000
    ..To document serial high resolution computed tomography (HRCT) features of lung injury after 3-field radiotherapy for breast cancer...
  3. pmc Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature
    B Lam
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Postgrad Med J 77:708-12. 2001
    ..05) than those with squamous cell lung cancer (n=128). CONCLUSION: The clinical profile of Chinese adenocarcinoma patients should help clinicians in the diagnosis and management of these patients...
  4. ncbi request reprint Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy
    K W Tsang
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Tuberc Lung Dis 8:1301-7. 2004
    ..While exhaled nitric oxide (eNO) levels are reduced by inhaled corticosteroid therapy in asthma, such treatment effect is unclear in bronchiectasis...
  5. ncbi request reprint Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD
    J C W Mak
    Division of Respiratory Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Eur Respir J 30:684-90. 2007
    ....
  6. ncbi request reprint Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
    K H Chan
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Int J Tuberc Lung Dis 14:1193-200. 2010
    ..Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis...
  7. ncbi request reprint Respiratory ciliary function in bone marrow recipients
    W Y Au
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Bone Marrow Transplant 27:1147-51. 2001
    ..Further studies are indicated to evaluate this important phenomenon, which could be an important cause of the susceptibility for BMT recipients to respiratory infections...
  8. ncbi request reprint Severe bronchiectasis in patients with "cystlike" structures within the ciliary shafts
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 161:1300-5. 2000
    ..Our newly described ciliary abnormality appears to be a primary defect and more systematic studies should be performed to evaluate this further...
  9. ncbi request reprint Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics
    J C W Mak
    Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Clin Exp Allergy 37:1150-7. 2007
    ..The glutathione S-transferases (GST) are a group of enzymes that protect cells from oxidative stress. Functional genetic polymorphisms of GST genes (GSTT1, GSTM1 and GSTP1) have previously been reported...
  10. ncbi request reprint A community study of sleep-disordered breathing in middle-aged Chinese men in Hong Kong
    M S Ip
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Chest 119:62-9. 2001
    ..Sleep-disordered breathing (SDB) in Asian populations is being increasingly recognized. This study investigated the prevalence of SDB in Chinese middle-aged office-based male workers in Hong Kong...
  11. doi request reprint Effects of azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT--a randomized double-blinded placebo-controlled study
    D C L Lam
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Bone Marrow Transplant 46:1551-6. 2011
    ..In conclusion, there was no significant benefit of 3 months of oral azithromycin on the respiratory symptoms and lung function in patients with relatively late BOS after HSCT in this randomized placebo-controlled study...
  12. doi request reprint Endobronchial ultrasound for diagnosis of synchronous primary lung cancers
    Matthew K Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Lung Cancer 63:154-7. 2009
    ..The potential pitfall of missing synchronous lung tumour if the diagnosis is based either on sampling from intrathoracic lymph node or from endobronchial lesion alone is discussed...
  13. ncbi request reprint Pulmonary cryptococcosis: a case report and review of the Asian-Pacific experience
    C L Lam
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Respirology 6:351-5. 2001
    ..Contrary to formal belief, there was evidence of residual lung fibrosis 12 months after initial presentation. The features of pulmonary cryptococcosis reported in the Asian Pacific region are also reviewed...
  14. ncbi request reprint The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia
    J C Ho
    University Departments of Medicine, Pediatrics, and Anatomy, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Respir Crit Care Med 163:983-8. 2001
    ..05). These findings may help explain the frequent occurrence of respiratory infection in the elderly...
  15. ncbi request reprint Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma
    J C Ho
    University Department of Medicine, Division of Respiratory and Critical Care Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Eur Respir J 29:273-8. 2007
    ..In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis...
  16. ncbi request reprint Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo
    L Zheng
    University Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Respir Med 95:792-8. 2001
    ..Our original findings suggest that airway macrophages could contribute to neutrophil influx into airway walls through their production of TNFalpha and therefore play an important role in the pathogenesis of bronchiectasis...
  17. ncbi request reprint Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure
    M S Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 162:2166-71. 2000
    ..The findings offer support for nitric oxide being one of the mediators involved in the acute hemodynamic regulation and long-term vascular remodeling in OSA...
  18. ncbi request reprint Risk factors associated with lung cancer in Hong Kong
    Moira Chan-Yeung
    Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, 4 F, Professorial Block, Queen Mary Hospital, Hong Kong SAR, China
    Lung Cancer 40:131-40. 2003
    ....
  19. ncbi request reprint Helicobacter pylori sero-prevalence in asthma
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, SAR, China
    Respir Med 94:756-9. 2000
    ..43, P = 0.004). Despite the sero-epidemiological association of H. pylori infection with many inflammatory conditions, our data showed no such association for middle age asthmatic patients with mild intermittent asthma in our locality...
  20. ncbi request reprint Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong
    James C Ho
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Thorac Oncol 1:648-53. 2006
    ..We investigated the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms and their association with erythrocyte antioxidant activities...
  21. pmc Erlotinib as salvage treatment after failure to first-line gefitinib in non-small cell lung cancer
    Matthew K Wong
    Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer Chemother Pharmacol 65:1023-8. 2010
    ..The purpose of this study is to evaluate the efficacy of erlotinib, another EGFR-TKI, after failed first-line use of gefitinib...
  22. ncbi request reprint Pulmonary sequelae of treatment for breast cancer: a prospective study
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, SAR, China
    Int J Radiat Oncol Biol Phys 50:411-9. 2001
    ..These changes are accompanied by radiological evidence of persistent lung injury. Further studies should be performed to evaluate the incidence and long-term pulmonary sequelae of current treatment for breast cancer...
  23. ncbi request reprint Pseudomonas aeruginosa adherence to human basement membrane collagen in vitro
    K W Tsang
    University Dept of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Eur Respir J 21:932-8. 2003
    ....
  24. ncbi request reprint Pulmonary iron overload in thalassemia major presenting as small airway disease
    G C Ooi
    Department of Diagnostic Radiology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Acta Haematol 108:43-6. 2002
    ..We report a case of thalassemia major with biopsy-proven pulmonary iron overload, in which thoracic high-resolution computed tomography revealed a morphological-functional correlation consistent with small airway disease...
  25. ncbi request reprint Overexpression of matrix metalloproteinase-8 and -9 in bronchiectatic airways in vivo
    L Zheng
    University Dept of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Eur Respir J 20:170-6. 2002
    ..In view of the clinical availability of matrix metalloproteinase antagonists, the results presented here could have a significant impact on the development of novel therapies of this untreatable disease...
  26. ncbi request reprint Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma
    G C Ooi
    Department of Diagnostic Radiology, HKU, Room 405, Block K, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR
    Eur Radiol 13:522-6. 2003
    ..Advanced primary pulmonary LELC has distinct radiological features, and can appear as well-defined tumour closely associated with the mediastinum, with peribronchovascular spread and vascular encasement...
  27. ncbi request reprint Interstitial lung disease in systemic sclerosis
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, SAR China
    Acta Radiol 44:258-64. 2003
    ..To evaluate high-resolution CT (HRCT) parameters of inflammation and fibrosis in systemic sclerosis (SSc), for correlation with lung function, skin scores and exercise tolerance...
  28. ncbi request reprint Determinants of chronic obstructive pulmonary disease in Chinese patients in Hong Kong
    M Chan-Yeung
    Respiratory Division, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Int J Tuberc Lung Dis 11:502-7. 2007
    ..The prevalence of chronic obstructive pulmonary disease (COPD) is rising in many parts of the world. This is a study of risk factors for COPD in Chinese patients in Hong Kong...
  29. ncbi request reprint Down-regulation of aquaporin 3 in bronchiectatic airways in vivo
    K W Tsang
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Respir Med 97:59-64. 2003
    ..004, 0.24). Our findings suggest that AQP3 could have an important role in the pathogenesis of increased mucus production in bronchiectasis...
  30. ncbi request reprint Effects of erythromycin on Pseudomonas aeruginosa adherence to collagen and morphology in vitro
    K W Tsang
    Dept of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Eur Respir J 21:401-6. 2003
    ..Therefore, this could help explain the clinical efficacy of low-dose erythromycin therapy on patients with Pseudomonas aeoruginosa infection...
  31. ncbi request reprint Lung cancer epidemiology and risk factors in Asia and Africa
    W K Lam
    Department of Medicine, Division of Respiratory and Critical Care Medicine, The University of Hong Kong, Hong Kong SAR, China
    Int J Tuberc Lung Dis 8:1045-57. 2004
    ....
  32. ncbi request reprint Increasing use of inhaled steroids associated with declining asthma mortality
    C R Kumana
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, SAR, China
    J Asthma 38:161-7. 2001
    ..001). In Hong Kong, despite increasing asthma prevalence, more intensive use of anti-asthmatic drugs (especially inhaled steroids) was associated with declining asthma mortality...
  33. ncbi request reprint Pentaglobin in steroid-resistant severe acute respiratory syndrome
    J C Ho
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Int J Tuberc Lung Dis 8:1173-9. 2004
    ..Some patients deteriorate relentlessly despite treatment with antibiotic, corticosteroid and mechanical ventilation...
  34. ncbi request reprint The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer
    B Lam
    Dept of Medicine, University of Hong Kong, Hong Kong SAR, China
    Eur Respir J 28:915-9. 2006
    ..A combination of white-light and autofluorescence bronchoscopy can increase the diagnostic yield of this invasive procedure in patients exhibiting abnormal sputum cytology...
  35. ncbi request reprint Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis
    M Wong
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan, and Queen Mary Hospital, Hong Kong SAR, China
    Eur Respir J 29:1182-6. 2007
    ..8%) of the patients. No complications were reported. Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis...
  36. ncbi request reprint A prospective study of respiratory ciliary structure and function after stem cell transplantation
    W Y Au
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Bone Marrow Transplant 38:243-8. 2006
    ..We conclude that structural and functional ciliary abnormalities are common in recipients of HSCT, and predict post-HSCT deterioration. However, there is no evidence to show that CBF monitoring may be of prospective benefit...
  37. ncbi request reprint Lymphoepithelioma-like carcinoma of the lung: experience with ten cases
    J C Ho
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR China
    Int J Tuberc Lung Dis 8:890-5. 2004
    ..We investigated tumour response, time to progression and survival of LELC patients who received such treatment...
  38. ncbi request reprint In vitro study of regulation of IL-6 production in bronchiectasis
    James C Ho
    Division of Respiratory and Critical Care Medicine, University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Respir Med 98:334-41. 2004
    ..The suppressive effects observed with ibuprofen, triptolide and MK-663 warrant further study...
  39. ncbi request reprint Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis
    J C Ho
    University Dept of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Eur Respir J 22:383-6. 2003
    ..A combination of 5-fluorouracil, cisplatin and calcium folinate resulted in partial tumour response...
  40. ncbi request reprint Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer
    K W Tsang
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Respir Med 97:618-24. 2003
    ..Although polysaccharide peptides (PSP), isolated from the fungus Coriolus versicolor, have been reported to have anti-tumor effects, its clinical efficacy has not been properly evaluated...
  41. ncbi request reprint A multicenter phase II study of the efficacy and safety of docetaxel plus cisplatin in Asian chemonaïve patients with metastatic or locally advanced non-small cell lung cancer
    James C M Ho
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong, China
    Respir Med 97:796-803. 2003
    ..To evaluate the efficacy and safety of docetaxel-cisplatin in patients with metastatic or locally advanced non-small cell lung cancer (NSCLC)...
  42. ncbi request reprint High resolution CT of Weil's disease
    M W C Yiu
    Department of Radiology, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    Lancet 362:117. 2003
  43. pmc Inhaled fluticasone in bronchiectasis: a 12 month study
    K W Tsang
    Department of Respiratory and Critical Care Medicine, University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Thorax 60:239-43. 2005
    ..The clinical efficacy of inhaled corticosteroid (ICS) treatment has not been evaluated in bronchiectasis, despite the presence of chronic airway inflammation...
  44. pmc Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays
    Yee Leng Yap
    HKU Pasteur Research Centre Dexter H C Man Building, 8 Sassoon Road Pokfulam, Hong Kong, China
    Nucleic Acids Res 33:409-21. 2005
    ..This study searched beyond phenotypic gene expression profiles in cancer cells, in order to identify the more important regulatory transcription factors that caused these aberrations in gene expression...
  45. ncbi request reprint Vitamin B12 deficiency--need for a new guideline
    C H Chui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
    Nutrition 17:917-20. 2001
    ..8% to 9.8% among the different subgroups. CONCLUSIONS: Whatever screening criteria were used, a significant number of B12-deficient patients will be missed. Therefore, there may be a case for universal vitamin B12 screening...
  46. ncbi request reprint Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse
    D J Scott
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, England, UK
    Gastroenterology 121:889-99. 2001
    ..Therefore, we determined the effect of a null Nos2 genotype on intestinal tumorigenesis and Cox-2 expression/activity in the Apc(Min/+) mouse model of familial adenomatous polyposis...
  47. ncbi request reprint Possible case scenarios and logistic issues in H5N1 pandemic
    Kenneth W Tsang
    Respirology 11:520-2. 2006