K Y Lam

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi A critical examination of adrenal tuberculosis and a 28-year autopsy experience of active tuberculosis
    K Y Lam
    Faculty of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 54:633-9. 2001
  2. ncbi Double sarcomatoid carcinomas of the oesophagus
    K Y Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Pathol Res Pract 192:604-9. 1996
  3. ncbi Esophageal blue nevus: an isolated endoscopic finding
    K Y Lam
    Department of Pathology, Rm 313, Clinical Pathology Building, Queen Mary Hospital, Hong Kong, SAR
    Head Neck 23:506-9. 2001
  4. pmc Telomerase activity in pancreatic endocrine tumours: a potential marker for malignancy
    K Y Lam
    Department of Pathology, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, SAR
    Mol Pathol 53:133-6. 2000
  5. ncbi Molecular biology of esophageal squamous cell carcinoma
    A K Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Crit Rev Oncol Hematol 33:71-90. 2000
  6. pmc Oesophageal mesenchymal tumours: clinicopathological features and absence of Epstein-Barr virus
    K Y Lam
    Department of Pathology, University of Hong Kong, Hong Kong
    J Clin Pathol 52:758-60. 1999
  7. ncbi Esophageal small cell carcinomas: clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesis
    K Y Lam
    Department of Pathology, University of Hong Kong, Hong Kong
    Arch Pathol Lab Med 124:228-33. 2000
  8. ncbi Splenic vascular lesions: unusual features and a review of the literature
    K Y Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Aust N Z J Surg 69:422-5. 1999
  9. ncbi Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients
    K Y Lam
    Department of Pathology, University of Hong Kong
    Int J Cancer 74:212-9. 1997
  10. ncbi C-erbB-2 protein expression in oesophageal squamous epithelium from oesophageal squamous cell carcinomas, with special reference to histological grade of carcinoma and pre-invasive lesions
    K Y Lam
    Department of Pathology, University of Hong Kong
    Eur J Surg Oncol 24:431-5. 1998

Collaborators

Detail Information

Publications39

  1. ncbi A critical examination of adrenal tuberculosis and a 28-year autopsy experience of active tuberculosis
    K Y Lam
    Faculty of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 54:633-9. 2001
    ..The aims of the current study were to define the characteristics of tuberculosis in hospitalized patients and to analyse the features of adrenal tuberculosis...
  2. ncbi Double sarcomatoid carcinomas of the oesophagus
    K Y Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Pathol Res Pract 192:604-9. 1996
    ..The clinicopathological features of multiple primary tumours and sarcomatoid carcinoma of the oesophagus are also reviewed...
  3. ncbi Esophageal blue nevus: an isolated endoscopic finding
    K Y Lam
    Department of Pathology, Rm 313, Clinical Pathology Building, Queen Mary Hospital, Hong Kong, SAR
    Head Neck 23:506-9. 2001
    ..The occurrence of blue nevus has seldom been reported in extracutaneous sites and with no record in the esophagus...
  4. pmc Telomerase activity in pancreatic endocrine tumours: a potential marker for malignancy
    K Y Lam
    Department of Pathology, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, SAR
    Mol Pathol 53:133-6. 2000
    ..The aim of this study was to investigate the role of testing telomerase activity in pancreatic endocrine tumours...
  5. ncbi Molecular biology of esophageal squamous cell carcinoma
    A K Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Crit Rev Oncol Hematol 33:71-90. 2000
    ..Further investigations, education and collaborations between the various scientific and clinical disciplines are important to successful application of these molecular findings aiming at improving management of patients with ESCC...
  6. pmc Oesophageal mesenchymal tumours: clinicopathological features and absence of Epstein-Barr virus
    K Y Lam
    Department of Pathology, University of Hong Kong, Hong Kong
    J Clin Pathol 52:758-60. 1999
    ..Leiomyoma is the most common mensenchymal tumour found in the oesophagus...
  7. ncbi Esophageal small cell carcinomas: clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesis
    K Y Lam
    Department of Pathology, University of Hong Kong, Hong Kong
    Arch Pathol Lab Med 124:228-33. 2000
    ..To evaluate the clinicopathologic features and the roles of p53 and MIB-1 in esophageal small cell carcinoma...
  8. ncbi Splenic vascular lesions: unusual features and a review of the literature
    K Y Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Aust N Z J Surg 69:422-5. 1999
    ..A re-evaluation of the features of the splenic hamartomas documented in the English literature was also done...
  9. ncbi Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients
    K Y Lam
    Department of Pathology, University of Hong Kong
    Int J Cancer 74:212-9. 1997
    ..p53 mutations also appear to play a role in predicting the survival of patients with stage III oesophageal squamous cell carcinomas...
  10. ncbi C-erbB-2 protein expression in oesophageal squamous epithelium from oesophageal squamous cell carcinomas, with special reference to histological grade of carcinoma and pre-invasive lesions
    K Y Lam
    Department of Pathology, University of Hong Kong
    Eur J Surg Oncol 24:431-5. 1998
    ..Its role in activation of oesophageal squamous cell carcinoma is poorly understood. The aim of this study was to evaluate the part played by c-erbB-2 in oesophageal squamous cell carcinoma in Hong Kong Chinese patients...
  11. ncbi Oesophageal basaloid squamous cell carcinoma: a unique clinicopathological entity with telomerase activity as a prognostic indicator
    K Y Lam
    Department of Pathology, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    J Pathol 195:435-42. 2001
    ..3). In conclusion, BSCC has distinctive clinicopathological features and its long-term prognosis is no worse than SCC. The level of telomerase activity may have a prognostic role...
  12. ncbi Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC
    Y C Hu
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam Road, Hong Kong
    Clin Cancer Res 7:2213-21. 2001
    ....
  13. ncbi Telomerase activity in small cell esophageal carcinoma
    V Chow
    Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    Dis Esophagus 14:139-42. 2001
    ..Telomerase activation is common in small cell carcinoma of the esophagus. This fact may find application in anti-telomerase treatment for this aggressive tumor...
  14. ncbi Expression of p21/waf1 in oral squamous cell carcinomas--correlation with p53 and mdm2 and cellular proliferation index
    I O Ng
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, People s Republic of China
    Oral Oncol 35:63-9. 1999
    ..Overexpression of p21 alone appeared to be insufficient to suppress tumor progression...
  15. ncbi Detection of genetic alterations in esophageal squamous cell carcinomas and adjacent normal epithelia by comparative DNA fingerprinting using inter-simple sequence repeat PCR
    J C Tang
    Department of Pathology, The University of Hong Kong, Hong Kong
    Clin Cancer Res 7:1539-45. 2001
    ..This approach is also suitable for detection of somatic mutations preceding the onset of morphologically detectable neoplasia in ESCC...
  16. ncbi Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC
    Y C Hu
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pok Fu Lam Road, Hong Kong, ROC
    Clin Cancer Res 7:3519-25. 2001
    ....
  17. ncbi Clinicopathological significance of p53 and p21 expression in the surgical treatment of laryngeal carcinoma
    P W Yuen
    Division of Otorhinolaryngology, Department of Surgery, University of Hong Kong, Hong Kong, SAR, PR China
    Anticancer Res 20:4863-6. 2000
    ..This study aimed at resolving the clinicopathological significance of p53 and p21 expression in patients undergoing surgical treatment for laryngeal carcinoma...
  18. pmc The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas
    K Y Lam
    Department of Pathology, University of Hong Kong, Hong Kong, China
    J Clin Pathol 54:443-8. 2001
    ..Phaeochromocytomas and paragangliomas are uncommon. The aims of this study were to analyse the characteristics and the possible roles of p53, Rb, and mdm2 alterations in these tumours...
  19. ncbi Prognostic significance of serum p53 protein and p53 antibody in patients with surgical treatment for head and neck squamous cell carcinoma
    V Chow
    Department of Surgery, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR China
    Head Neck 23:286-91. 2001
    ..002). CONCLUSION: Preoperative serum p53 antibody was a significant prognostic factor for nodal metastasis of HNSCC...
  20. ncbi A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma
    V Chow
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR China
    J Cancer Res Clin Oncol 127:59-63. 2001
    ..gamma-catenin had predictive value for nodal metastasis. E-cadherin was, however, a more important prognostic factor for recurrence and survival...
  21. ncbi Coinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: reassessment of the viral carrier state
    G Srivastava
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 95:2443-5. 2000
    ..These data indicate that coinfection with multiple EBV strains is much more prevalent in normal carriers than previously appreciated, which in turn has direct implications on EBV persistence, host-viral interaction and pathogenesis...
  22. ncbi Malignant melanoma of the oesophagus: clinicopathological features, lack of p53 expression and steroid receptors and a review of the literature
    K Y Lam
    Department of Pathology, University of Hong Kong
    Eur J Surg Oncol 25:168-72. 1999
    ..The aims of this study were to evaluate the clinicopathological features, p53 over-expression and steroid receptors in oesophageal melanomas and to review the reported cases in the literature...
  23. ncbi Morphological analysis of adrenal glands: a prospective analysis
    K Y Lam
    Department of Pathology, University of Hong Kong
    Endocr Pathol 12:33-8. 2001
    ..Adrenal weight may be affected by patients' gender, age, laterality of adrenal gland and presence of systemic disease...
  24. ncbi The clinicopathologic significance of p53 and p21 expression in the surgical management of lingual squamous cell carcinoma
    P W Yuen
    Dept of Surgery, Queen Mary Hospital, Pokfulam Rd, Hong Kong, People's Republic of China
    Am J Clin Pathol 116:240-5. 2001
    ..Overexpression of p21 but not p53 has prognostic value for survival in the surgical treatment of lingual carcinomas. The combination of stage with p21 expression is recommended for evaluation of prognosis and for management planning...
  25. ncbi Microsatellite alterations in squamous cell carcinoma of the head and neck - clustering of loss of heterozygosity in a distinct subset
    I O Ng
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Room 127B UPB, Pokfulam, Hong Kong
    Oral Oncol 36:484-90. 2000
    ..Our data show that the incidence of microsatellite alterations in SCCHN from Hong Kong Chinese is low. However, LOH may be one of the genetic mechanisms in the carcinogenesis of a subset of SCCHN (hypopharyngeal-laryngeal cancers)...
  26. pmc Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding
    K Y Lam
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Clin Pathol 54:966-9. 2001
    ..This is the first example of such a tumour being reported in the adrenal gland. The adrenal tumour was also the cause of the fever, which subsided after the removal of the tumour...
  27. pmc Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma
    F B F Law
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Oncogene 26:5877-88. 2007
    ....
  28. pmc Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas
    Y C Hu
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Mol Pathol 52:353-6. 1999
    ..To investigate whether PTEN/MMAC1 mutations play a role in the carcinogenesis of oesophageal squamous cell carcinoma...
  29. pmc Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution
    K Y Lam
    Department of Pathology, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Clin Pathol 54:707-12. 2001
    ..Fatty tumours of the adrenal gland are uncommon and their features have received little attention in the literature. The aim of this study is to analyse the features of adrenal lipomatous tumours...
  30. ncbi Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles
    K Y Lam
    University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Histopathology 39:279-86. 2001
    ..Primary squamous cell carcinoma of the thyroid gland is uncommon. This study aims to identify the clinicopathological features and the pattern of expression of cytokeratins and oncoproteins in this tumour...
  31. ncbi Solid-cystic papillary tumor of the pancreas in children
    H Zhou
    Division of Pediatric Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong Medical Centre, Hong Kong, China
    Pediatr Surg Int 17:614-20. 2001
    ..SCPT may thus be the most common pancreatic tumor in the Asian pediatric population. The pathological origin of the tumor remains unclear and requires further investigations...
  32. ncbi Image analysis system for assessment of immunohistochemically stained proliferative marker (MIB-1) in oesophageal squamous cell carcinoma
    Albert K W Law
    Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong
    Comput Methods Programs Biomed 70:37-45. 2003
    ..Overlapped or missed counting of nuclei by the observer were eliminated. The image analysis system can really assist experts in obtaining reliable data for the prognosis of oesophageal cancer patients quickly...
  33. ncbi Mature teratomas of the adrenal gland: imaging features
    P L Khong
    Department of Diagnostic Radiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, 102 Pokfulam Road, Hong Kong
    Abdom Imaging 27:347-50. 2002
    ....
  34. ncbi Cushing's syndrome secondary to adrenal adenoma during pregnancy
    C Y Lo
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong
    Surg Endosc 16:219-20. 2002
    ....
  35. ncbi The pancreatic renin-angiotensin system: does it play a role in endocrine oncology?
    K Y Lam
    Department of Pathology, University of Hong Kong Medical Center, Queen Mary Hospital Hong Kong
    JOP 2:40-2. 2001
    ..Thus, the direction of future research should be based on in-depth and collaborative efforts between researchers in the various disciplines in order to apply the newly acquired scientific knowledge to the patient...
  36. ncbi Routine parathyroid autotransplantation during thyroidectomy
    C Y Lo
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Surgery 129:318-23. 2001
    ..001). CONCLUSIONS: A low incidence of permanent hypoparathyroidism can be achieved by either routine or selective PTHAT during thyroidectomy but routine PTHAT is associated with a high incidence of postoperative hypocalcemia...
  37. ncbi Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma
    A P W Yuen
    Division of Otorhinolaryngology, Department of Surgery, The University of Hong Kong, China
    Eur J Surg Oncol 28:667-72. 2002
    ....
  38. ncbi Characteristics of malignant tumors in young people, with particular emphasis on carcinomas and sarcomas
    K Y Lam
    Department of Pathology, Queen Mary Hospital, Hong Kong
    Cancer Detect Prev 25:223-30. 2001
    ..In conclusion, malignant tumor is a common cause of death in young patients. Different types of malignant tumors were seen in various groups of young patients...
  39. ncbi E-cadherin expression is commonly downregulated by CpG island hypermethylation in esophageal carcinoma cells
    H X Si
    Department of Anatomy, the University of Hongkong, Li Shu Fan Building, 5 Sassoon Road, Hong Kong SAR, PR China
    Cancer Lett 173:71-8. 2001
    ..Our results indicate that 5' CpG island methylation is common in esophageal carcinoma and may play an important role in downregulation of E-cadherin...