K N Lai

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products
    Kar Neng Lai
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 32:280-91. 2012
  2. doi request reprint Pathogenesis of IgA nephropathy
    Kar Neng Lai
    Nephrology Center, 10th Floor, Li Shu Pui Block, Hong Kong Sanatorium and Hospital, 2 Village Road, Happy Valley, Hong Kong
    Nat Rev Nephrol 8:275-83. 2012
  3. pmc Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature
    Chi Yuen Cheung
    Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong
    Int Urol Nephrol 43:675-80. 2011
  4. ncbi request reprint Characteristics of polymeric lambda-IgA binding to leukocytes in IgA nephropathy
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Am Soc Nephrol 13:2309-19. 2002
  5. ncbi request reprint Mediators of inflammation and fibrosis
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 27:S65-71. 2007
  6. ncbi request reprint Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro
    K N Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Am Soc Nephrol 12:1036-45. 2001
  7. doi request reprint Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, 102 Pokfulam Road, Hong Kong
    Pediatr Nephrol 26:257-66. 2011
  8. ncbi request reprint Increased survival of mesothelial cells from the peritoneum in peritoneal dialysis fluid
    K N Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Cell Biol Int 25:445-50. 2001
  9. ncbi request reprint Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, University of Hong Kong, Room 409 Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, People s Republic of China
    Kidney Int 62:1431-9. 2002
  10. ncbi request reprint Effect of low molecular weight heparin on bone metabolism and hyperlipidemia in patients on maintenance hemodialysis
    K N Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, China
    Int J Artif Organs 24:447-55. 2001

Collaborators

Detail Information

Publications142 found, 100 shown here

  1. pmc A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products
    Kar Neng Lai
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 32:280-91. 2012
    ..Short-term studies of new biocompatible PDFs low in glucose degradation products (GDPs) reveal divergent results with respect to peritoneal integrity...
  2. doi request reprint Pathogenesis of IgA nephropathy
    Kar Neng Lai
    Nephrology Center, 10th Floor, Li Shu Pui Block, Hong Kong Sanatorium and Hospital, 2 Village Road, Happy Valley, Hong Kong
    Nat Rev Nephrol 8:275-83. 2012
    ..This Review summarizes the latest findings in the pathogenesis of IgA nephropathy...
  3. pmc Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature
    Chi Yuen Cheung
    Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong
    Int Urol Nephrol 43:675-80. 2011
    ..To present and discuss the epidemiological and clinical aspects, as well as therapeutic options and outcome of de novo renal cell carcinoma (RCC) of the native kidneys in a series of Chinese renal transplant recipients...
  4. ncbi request reprint Characteristics of polymeric lambda-IgA binding to leukocytes in IgA nephropathy
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Am Soc Nephrol 13:2309-19. 2002
    ..These immunologic abnormalities might contribute to the glomerulointerstitial injury in IgAN, in the presence of leukocytic infiltration...
  5. ncbi request reprint Mediators of inflammation and fibrosis
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 27:S65-71. 2007
    ..Furthermore, new data are emerging to support a proinflammatory role for peritoneal adipocytes...
  6. ncbi request reprint Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro
    K N Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Am Soc Nephrol 12:1036-45. 2001
    ..Osmotic agents upregulate both mRNA and protein expression of this aquaporin. The role of AQP1 in HPMC in maintaining the ultrafiltration of the peritoneal membrane is potentially of clinical interest...
  7. doi request reprint Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, 102 Pokfulam Road, Hong Kong
    Pediatr Nephrol 26:257-66. 2011
    ..Our animal study suggests combined PPAR-γ agonist and ARB holds promise for future therapy for IgAN...
  8. ncbi request reprint Increased survival of mesothelial cells from the peritoneum in peritoneal dialysis fluid
    K N Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Cell Biol Int 25:445-50. 2001
    ..These experimental conditions simulating CAPD may allow future in vitro studies of mesothelial physiology and peritonitis related to CAPD treatment...
  9. ncbi request reprint Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, University of Hong Kong, Room 409 Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, People s Republic of China
    Kidney Int 62:1431-9. 2002
    ....
  10. ncbi request reprint Effect of low molecular weight heparin on bone metabolism and hyperlipidemia in patients on maintenance hemodialysis
    K N Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, China
    Int J Artif Organs 24:447-55. 2001
    ..Our study suggests LMWH may partially alleviate hyperlipidemia and, perhaps, osteoporosis associated with UFH administration in patients on maintenance hemodialysis...
  11. ncbi request reprint Future directions in the treatment of IgA nephropathy
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Rm 409 Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Nephron 92:263-70. 2002
    ..Future therapeutic attempts to slow down the renal deterioration should target at prevention of mesangial IgA deposition and the amelioration of inflammatory injury induced by infiltrating neutrophils and the released cytokines...
  12. doi request reprint Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy
    Kar Neng Lai
    Dept of Medicine, Rm 411, Professorial Block, Queen Mary Hospital, Univ of Hong Kong, Hong Kong
    Am J Physiol Renal Physiol 294:F945-55. 2008
    ....
  13. ncbi request reprint Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system
    Kar Neng Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Am Soc Nephrol 14:3127-37. 2003
    ..The findings support a pathogenetic role of pIgA1 in IgAN through upregulation of the RAS and TGF-beta, leading to chronic renal failure with renal fibrosis...
  14. ncbi request reprint Peritoneal function: the role of aquaporins
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Perit Dial Int 23:S20-5. 2003
    ..The expression of those AQPs is upregulated by hyperosmolality. Reduced expression or function of AQP1 may be responsible for some cases of ultrafiltration failure, but further evidence is required to establish that link...
  15. doi request reprint Recent advances in IgA nephropathy--the glomerulopodocytic-tubular communication
    Kar Neng Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR, China
    Adv Otorhinolaryngol 72:40-4. 2011
    ..These mediators released from mesangial cells after IgA deposition further activate TEC leading to subsequent inflammatory changes in the renal tubulointerstitium...
  16. ncbi request reprint Membranous nephropathy: when and how to treat
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Kidney Int 71:841-3. 2007
    ..Currently, combinations of steroids with alkylating agents are best studied. Newer forms of immunosuppressive treatment are currently under study...
  17. doi request reprint Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy
    Kar Neng Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Nephrol Dial Transplant 24:62-72. 2009
    ..With the strategic position of podocytes, we further examined the function of podocytes in IgAN...
  18. ncbi request reprint Gene expression of the renin-angiotensin system in human kidney
    K N Lai
    Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong
    J Hypertens 16:91-102. 1998
    ....
  19. ncbi request reprint Treatment for lupus nephritis: a revisit
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrology (Carlton) 10:180-8. 2005
    ..The potential of other new therapeutic agents is discussed together with the need for patient recruitment in future trials of lupus nephritis to address the importance of ethnicity as well as histological grading...
  20. ncbi request reprint Role for macrophage migration inhibitory factor in acute respiratory distress syndrome
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    J Pathol 199:496-508. 2003
    ..These findings suggest that MIF plays a crucial pathological role leading to alveolar inflammation in ARDS. Anti-MIF and early glucocorticoid therapy may represent a novel therapeutic approach for reducing alveolar inflammation in ARDS...
  21. ncbi request reprint Increased production of hyaluronan by peritoneal cells and its significance in patients on CAPD
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Shatin
    Am J Kidney Dis 33:318-24. 1999
    ..We conclude that elevated levels of HA found in the PDE of stable CAPD patients originate from increased synthesis by peritoneal mesothelial cells. This event may serve as a marker of regeneration and remodeling of the peritoneal lining...
  22. ncbi request reprint Pathogenic IgA in IgA nephropathy: still the blind men and the elephant?
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Kidney Int 69:1102-3. 2006
    ..The immunochemical nature of the IgA molecule and its mesangial uptake command a pivotal role in the pathogenesis of IgAN...
  23. ncbi request reprint Growth factors in continuous ambulatory peritoneal dialysis effluent. Their relation with peritoneal transport of small solutes
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Am J Nephrol 19:416-22. 1999
    ..Such action of TGF-beta1 could reduce the risk of peritoneal sclerosis and hence, maintains a satisfactory peritoneal permeability to small solutes...
  24. ncbi request reprint Gene expression and synthesis of natriuretic peptides by cultured human glomerular cells
    K N Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Hypertens 17:575-83. 1999
    ..Whereas immunoreactive human forms of these three natriuretic peptides are found in renal tubules, it is not clear whether they are derived from the systemic circulation or from local production...
  25. ncbi request reprint Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Nephrol Dial Transplant 21:1188-97. 2006
    ..In this study, we explored the protective effect of Ganoderma extract (LZ) on albumin-induced kidney epithelial injury...
  26. ncbi request reprint Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells
    J C Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam
    J Am Soc Nephrol 11:241-9. 2000
    ..The present study concluded that there was an absence of Fc alphaR1, ASGPR, or pIgR on human mesangial cells. These findings suggest that the predominant binding of human IgA to human mesangial cells is mediated by other mechanisms...
  27. ncbi request reprint Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1
    Kar Neng Lai
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Kidney Int 66:1403-16. 2004
    ..Preliminary studies showed a reduced glomerular gene expression of angiotensin II subtype 1 receptor (AT1R), suggesting a regulatory response to high intrarenal angiotensin II (Ang II) concentration in IgAN...
  28. ncbi request reprint Changes of cytokine profiles during peritonitis in patients on continuous ambulatory peritoneal dialysis
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Am J Kidney Dis 35:644-52. 2000
    ..The peritoneal cytokine networks after peritonitis may potentially affect the physiological properties of the peritoneal membrane...
  29. doi request reprint Inflammation in peritoneal dialysis
    Kar Neng Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR, China
    Nephron Clin Pract 116:c11-8. 2010
    ..Finally, there are emerging new data supporting a pro-inflammatory role of peritoneal adipocytes...
  30. pmc Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products
    K N Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Clin Exp Immunol 138:466-75. 2004
    ..Different GDPs exert differential regulation on the expression of these receptors on HPMC. The interactions between GDPs and AGE receptors may bear biological relevance to the intraperitoneal homeostasis and membrane integrity...
  31. doi request reprint The renin-angiotensin system
    Kar Neng Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Contrib Nephrol 170:135-44. 2011
    ..These enzymatic activities are altered in a nonphysiological environment such as hyperglycemia that mimics diabetic kidney disease. An understanding of the local intraglomerular RAS will provide a novel approach for early stages of DN...
  32. ncbi request reprint Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy
    Loretta Y Y Chan
    Department of Medicine, Room 411, Professorial Block, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong
    J Am Soc Nephrol 16:2306-17. 2005
    ..The data suggest that appropriate control of Ang II receptor activities in PTEC may ameliorate tubulointerstitial injury in IgAN...
  33. ncbi request reprint Dialysate hyaluronan concentration predicts survival but not peritoneal sclerosis in continuous ambulatory peritoneal dialysis
    C C Szeto
    Departments of Medicine and Therapeutics and Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Kidney Dis 36:609-14. 2000
    ..We conclude that PDE hyaluronan level during stable phase of CAPD does not predict the risk of postperitonitis adhesion. However, it is a strong independent predictor of survival in CAPD patients...
  34. ncbi request reprint Star fruit intoxication in uraemic patients: case series and review of the literature
    K C Tse
    Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Intern Med J 33:314-6. 2003
    ..The clinical manifestations of other reported series and current evidence for the possible candidate(s) of the neurotoxin are discussed...
  35. ncbi request reprint Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group
    T M Chan
    Department of Medicine, University of Hong Kong and Queen Mary Hospital, Hong Kong, China
    N Engl J Med 343:1156-62. 2000
    ..The combination of cyclophosphamide and prednisolone is effective for the treatment of severe lupus nephritis but has serious adverse effects. Whether mycophenolate mofetil can be substituted for cyclophosphamide is not known...
  36. ncbi request reprint Hepatitis B virus-related nephropathy and lupus nephritis: morphologic similarities of two clinical entities
    F M Lai
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin
    Mod Pathol 13:166-72. 2000
    ..This study focused on the use of specific monoclonal antisera to detect glomerular hepatitis B virus antigens, which contribute to the diagnosis of hepatitis B virus-related nephritis...
  37. ncbi request reprint Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cells in the proteinuric state
    K N Lai
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Kidney Int 71:526-38. 2007
    ..These interactions are pivotal in the development of tubulointerstitial injury...
  38. ncbi request reprint Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria
    K C Tse
    Nephrology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Lupus 14:947-52. 2005
    ..We conclude that ACEI/ARB effectively reduces proteinuria and improves serum albumin in patients with persistent proteinuria despite quiescent lupus nephritis...
  39. ncbi request reprint Emodin ameliorates glucose-induced morphologic abnormalities and synthesis of transforming growth factor beta1 and fibronectin by human peritoneal mesothelial cells
    S Yung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Perit Dial Int 21:S41-7. 2001
    ..CONCLUSIONS: These findings provide the first evidence that emodin can ameliorate high glucose-induced matrix synthesis in HPMCs by suppression of TGFbeta1. Emodin may thus be useful in preserving peritoneal integrity in PD...
  40. ncbi request reprint Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy
    S C W Tang
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Kidney Int 73:288-99. 2008
    ..The addition of receptor blocker and/or statin failed to potentiate such effects...
  41. ncbi request reprint In vitro studies of aquaporins 1 and 3 expression in cultured human proximal tubular cells: upregulation by transferrin but not albumin
    S Tang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong
    Am J Kidney Dis 38:317-30. 2001
    ..The pathophysiological significance of heightened AQP1 and AQP3 expression in PTECs on protein challenge as occurs in the nephrotic state requires further investigation...
  42. doi request reprint Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model
    H Guo
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Surg 96:1323-35. 2009
    ..In this study the therapeutic potential of exogenous Smad7 in preventing fibrogenesis in postoperative intra-abdominal adhesion was investigated...
  43. ncbi request reprint Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice
    H Guo
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Lupus 14:583-92. 2005
    ..Our findings provide experimental data suggesting a beneficial potential of MMF therapy in pulmonary involvement of lupus...
  44. ncbi request reprint Coexistence of Kaposi's sarcoma and tuberculosis in a renal transplant recipient
    A Y Wang
    Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong
    Transplantation 66:115-8. 1998
    ..We describe a case of Kaposi's sarcoma that developed in a renal transplant recipient as early as 5 months after the transplant...
  45. ncbi request reprint The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis
    H Guo
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Rheumatology (Oxford) 43:286-93. 2004
    ..To investigate the pathophysiological effect of immunoglobulin G (IgG) from systemic lupus erythematosus (SLE) patients on pleural mesothelial cells and related mechanisms...
  46. ncbi request reprint Electrophysiology and glucose transport of human peritoneal mesothelial cells: implications for peritoneal dialysis
    F K Li
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam
    Perit Dial Int 21:115-21. 2001
    ....
  47. ncbi request reprint Ultrasound-contrast agent mediated naked gene delivery in the peritoneal cavity of adult rat
    H Guo
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Gene Ther 14:1712-20. 2007
    ..Overall, the effectiveness and simplicity of the ultrasound-microbubble-mediated system may provide a promising nonviral means for improving gene delivery for treating peritoneal diseases in vivo...
  48. ncbi request reprint Tuberculosis infection in Chinese patients undergoing continuous ambulatory peritoneal dialysis
    S L Lui
    Division of Nephrology, University Department of Medicine, Tung Wah Hospital, Sheung Wan, Hong Kong
    Am J Kidney Dis 38:1055-60. 2001
    ....
  49. ncbi request reprint Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy
    Loretta Y Y Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Kidney Int 67:602-12. 2005
    ..The direct toxicity by IgA on renal tubules remains uncertain. We hypothesize that mediators released from human mesangial cells (HMC) triggered by IgA deposition may lead to activation of proximal tubular epithelial cells (PTEC)...
  50. doi request reprint In vitro enhanced chemotaxis of CD25+ mononuclear cells in patients with familial IgAN through glomerulotubular interactions
    Ka Ying Tam
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Am J Physiol Renal Physiol 299:F359-68. 2010
    ..A long-term follow-up is needed to better define the prognostic course for familial IgAN and to clarify the risk of developing IgAN in initially asymptomatic relatives from a multiplex IgAN family...
  51. doi request reprint Crosstalk between peroxisome proliferator-activated receptor-gamma and angiotensin II in renal tubular epithelial cells in IgA nephropathy
    Jing Xiao
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Clin Immunol 132:266-76. 2009
    ..Our data suggest that rosiglitazone trans-represses AngII signaling and may offer additional potential when combined with ARB in treating IgAN...
  52. doi request reprint Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Nephrol Dial Transplant 24:458-69. 2009
    ..In this study, we examined the CCN2 expression and its regulation in peritoneal resident cells using a cell culture model...
  53. ncbi request reprint Recurrent glomerulonephritis after kidney transplantation
    B Y Choy
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Am J Transplant 6:2535-42. 2006
    ..This review discusses commonly encountered recurrent glomerulonephritides, with special emphasis on the influence of post-transplant prophylactic immunosuppression and emerging treatments...
  54. ncbi request reprint CAPD-associated peritonitis caused by Alcaligenes xylosoxidans sp. xylosoxidans
    S Tang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, People's Republic of China
    Am J Nephrol 21:502-6. 2001
    ..We report 2 patients with CAPD-associated peritonitis due to A. xylosoxidans sp. xylosoxidans who were successfully cured with a combination of piperacillin and tazobactam. One of them subsequently returned uneventfully to CAPD...
  55. ncbi request reprint Superior mesenteric artery syndrome complicating dialysis patients with peritoneal failure--report of 3 cases
    D Y H Yap
    Division of Nephrology, Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Clin Nephrol 75:37-41. 2011
    ..Aggressive parenteral nutrition should be considered to build up the general status before proceeding to surgical intervention...
  56. ncbi request reprint Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Nephrol Dial Transplant 18:36-45. 2003
    ..We hypothesized that deposition of pIgA within the kidney may lead to enhanced synthesis of MIF by mesangial cells...
  57. ncbi request reprint Transferrin up-regulates chemokine synthesis by human proximal tubular epithelial cells: implication on mechanism of tubuloglomerular communication in glomerulopathic proteinura
    Sydney Tang
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Kidney Int 61:1655-65. 2002
    ....
  58. ncbi request reprint IL2-receptor antagonist (basiliximab) induction therapy is associated with lower morbidity and mortality in renal transplant recipients
    B Y Choy
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Transplant Proc 35:195. 2003
  59. ncbi request reprint Majocchi's granuloma and posttransplant lymphoproliferative disease in a renal transplant recipient
    K C Tse
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Am J Kidney Dis 38:E38. 2001
    ..Majocchi's granuloma was probably associated with PTLD as a reflection of overimmunosuppression...
  60. ncbi request reprint Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine
    T M Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Lupus 14:265-72. 2005
    ....
  61. ncbi request reprint Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell
    J C K Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Kidney Int 69:2078-86. 2006
    ..The leptin-induced TGF-beta synthesis in mesothelial cells is associated with the expression of leptin receptor and the activation of the JAK-STAT signal transduction pathway...
  62. ncbi request reprint Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy
    J C Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Kidney Int 59:277-85. 2001
    ..Preincubation with polyanion decreased the binding of polymeric IgA to HMCs. These results suggest an important role for anionic charge in IgA1 deposition onto the kidney mesangial cells...
  63. ncbi request reprint Comparison of double-bag and Y-set disconnect systems in continuous ambulatory peritoneal dialysis: a randomized prospective multicenter study
    P K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Am J Kidney Dis 33:535-40. 1999
    ..This is probably the first multicenter randomized study comparing the double-bag and Y-set disconnect system using only new patients who had never used other systems of continuous ambulatory peritoneal dialysis...
  64. ncbi request reprint Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury
    S L Lui
    Division of Nephrology, University Department of Medicine, Queen Mary Hospital, Hong Kong
    Nephrol Dial Transplant 16:1577-82. 2001
    ..CONCLUSIONS: We conclude that pre-treatment with MMF inhibits the production of NO and the induction of iNOS gene expression in the kidney during IRI. These results suggest that MMF might have the potential to ameliorate renal IRI...
  65. doi request reprint Macromolecular IgA1 taken from patients with familial IgA nephropathy or their asymptomatic relatives have higher reactivity to mesangial cells in vitro
    Ka Ying Tam
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Kidney Int 75:1330-9. 2009
    ....
  66. ncbi request reprint Necrotizing fasciitis in a renal transplant recipient treated with FK 506: the first reported case
    S Tang
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, China
    Clin Nephrol 56:481-5. 2001
    ..The importance of prompt diagnosis, antimicrobial treatment and early surgical intervention in achieving a successful outcome is discussed...
  67. ncbi request reprint Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis
    Anskar Y H Leung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam Road, Hong Kong, Hong Kong
    Histochem Cell Biol 124:105-11. 2005
    ..Therefore, PCNA can be used to mark cell proliferation in zebrafish hematopoietic tissues and to identify a population of progenitor cells whose significance would have to be further investigated...
  68. ncbi request reprint Pain perception following subcutaneous injections of citrate-buffered and phosphate-buffered epoetin alpha
    A W Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Int J Artif Organs 21:341-3. 1998
    ..It is possible that sodium citrate which is present in the EPO-alpha may be the agent that causes discomfort in the patients...
  69. doi request reprint Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Room 409, Professorial Block, 102 Pokfulam Road, Hong Kong, China
    J Clin Immunol 29:365-78. 2009
    ..We measured the neutrophil gelatinase-associated lipocalin (NGAL) concentration in peritoneal dialysate effluent (PDE) collected following an acute episode of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis...
  70. ncbi request reprint Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Nephrol Dial Transplant 19:1976-85. 2004
    ..Herein, we examined whether IgA deposition and the subsequent renal injury can be ameliorated with anti-MIF treatment in an experimental murine model of IgAN...
  71. ncbi request reprint Rhodococcus lung abscess complicating kidney transplantation: successful management by combination antibiotic therapy
    K C Tse
    Department of Medicine, Nephrology Division, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Transpl Infect Dis 10:44-7. 2008
    ..A high clinical suspicion and appropriate combination antibiotic therapy obviated the need for surgical intervention and was associated with a good clinical outcome. The optimal regimen of combination antibiotic therapy is discussed...
  72. ncbi request reprint Mycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis
    S Tang
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Nephrol 18:429-32. 2005
    ..Its efficacy requires validation in randomized, controlled trials. The current armamentaria for the treatment of this condition are also discussed...
  73. ncbi request reprint Alloimmune hemolysis after renal transplantation
    F K Li
    Division of Nephrology, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Am J Nephrol 20:473-5. 2000
    ..The present case underscores the potential complication of ABO blood group-compatible but nonidentical organ transplantation. Clinical vigilance is important to differentiate from other more sinister causes of posttransplant hemolysis...
  74. ncbi request reprint Hyperleptinaemia and chronic inflammation after peritonitis predicts poor nutritional status and mortality in patients on peritoneal dialysis
    Man Fai Lam
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, NO 102, Pokfulam Road, Hong Kong
    Nephrol Dial Transplant 22:1445-50. 2007
    ..The nutritional status of PD patients may further be worsened following peritonitis. We investigated the association between hyperleptinaemia, inflammation and malnourishment in PD-related peritonitis...
  75. ncbi request reprint Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF
    Joseph C K Leung
    Department of Medicine, University of Hong Kong, Room 409, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Nephrol Dial Transplant 20:1336-49. 2005
    ..The role of the vascular endothelial growth factor (VEGF) induced by GDPs in the expression of ZO-1 was also examined...
  76. ncbi request reprint Burkholderia urinary tract infection after renal transplantation
    F K Li
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Transpl Infect Dis 5:59-61. 2003
    ..A graft nephrectomy was eventually required to clear the infection. The consequence of some fastidious infection may be catastrophic and early recognition and treatment is necessary to optimize the treatment...
  77. ncbi request reprint Association of IgA nephropathy with T-cell receptor constant alpha chain gene polymorphism
    P K Li
    Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Am J Kidney Dis 30:260-4. 1997
    ..It is concluded that the TCR C-alpha gene is associated with IgAN but not with the prognosis of the disease...
  78. ncbi request reprint Effect of mycophenolate mofetil on severity of nephritis and nitric oxide production in lupus-prone MRL/lpr mice
    S L Lui
    Division of Nephrology, University Department of Medicine, Queen Mary Hospital, Hong Kong, Republic of China
    Lupus 11:411-8. 2002
    ..The inhibitory effect of MMF on NO production diminishes as the disease progresses. MMF probably has additional, as yet undefined mode of actions to fully account for its beneficial effects on lupus nephritis...
  79. ncbi request reprint Acute renal failure after immersion in seawater polluted by diesel oil
    F K Li
    Departments of Medicine and Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Am J Kidney Dis 34:E26. 1999
    ..The patient recovered uneventfully and did not require dialysis. This case highlighted the unusual consequence of isolated renal involvement resulting from hydrocarbon toxicity...
  80. ncbi request reprint Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit
    S L Lui
    Department of Medicine, Queen Mary Hospital and The University of Hong Kong, Pokfulam, SAR, China
    Transplantation 71:59-64. 2001
    ..The clinical and virological response to i.v. immunoglobulin therapy is variable and depends on the overall level of immunosuppression of the patient...
  81. ncbi request reprint Progressive demyelinating neuropathy after initiation of continuous ambulatory peritoneal dialysis--report of two cases
    S L Lui
    University Department of Medicine, Tung Wah Hospital, Hong Kong
    Clin Nephrol 56:407-10. 2001
    ..The close temporal relationship between the initiation of peritoneal dialysis and the onset of neuropathy suggests that these two events may be causally related...
  82. ncbi request reprint The importance of residual renal function in dialysis patients
    A Y M Wang
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Kidney Int 69:1726-32. 2006
    ....
  83. doi request reprint Bradykinin and high glucose promote renal tubular inflammation
    Sydney C W Tang
    Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrol Dial Transplant 25:698-710. 2010
    ..The role of the kallikrein-kinin system in diabetic nephropathy remains controversial. Methods and..
  84. doi request reprint Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy
    Jing Xiao
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Nephrol Dial Transplant 24:2067-77. 2009
    ..The present study aims to explore any possible beneficial effect of a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist in alleviating the tubulointerstitial inflammation in IgAN...
  85. doi request reprint Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
    Arthur C K Chung
    Department of Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China
    Nephrol Dial Transplant 24:1443-54. 2009
    ..The present study tested the hypothesis that disruption of Smad7 function may accelerate renal fibrosis and inflammation...
  86. ncbi request reprint Prospective controlled study on mycophenolate mofetil and prednisolone in the treatment of membranous nephropathy with nephrotic syndrome
    Tak Mao Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrology (Carlton) 12:576-81. 2007
    ..Retrospective and anecdotal data suggest that mycophenolate mofetil (MMF) might be effective when given as rescue therapy for membranous nephropathy (MN). Prospective controlled data on MMF and prednisolone as primary therapy are lacking...
  87. doi request reprint Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: Role of STAT1 inhibition and nephrin restoration
    Sydney C W Tang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, SAR, China
    Am J Nephrol 32:145-55. 2010
    ..The present study explores whether this can be translated into renoprotection in vivo. Uninephrectomized (Unx) type 2 diabetic db/db mice were chosen as a model of accelerated diabetic nephropathy...
  88. ncbi request reprint Pilot study of pegylated interferon-alpha 2a in dialysis patients with chronic hepatitis C virus infection
    Tak Mao Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Nephrology (Carlton) 12:11-7. 2007
    ..The optimal treatment of hepatitis C in dialysis patients remains to be established. A high incidence of adverse effects has been observed with conventional interferon and PEG-IFN alpha-2b in dialysis patients...
  89. doi request reprint Long-term study of mycophenolate mofetil treatment in IgA nephropathy
    Sydney C W Tang
    Nephrology Division, Department of Medicine, The University of Hong Kong and Queen Mary Hospital, Hong Kong, China
    Kidney Int 77:543-9. 2010
    ....
  90. doi request reprint Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation
    Gavin S W Chan
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Nephrology (Carlton) 13:322-30. 2008
    ..We aimed to study the clinicopathologic features of renal biopsies after HSCT by reviewing 13 percutaneous renal biopsies in our institute (Queen Mary Hospital)...
  91. ncbi request reprint Role of complement in tubulointerstitial injury from proteinuria
    Sydney Tang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, People s Republic of China
    Kidney Blood Press Res 25:120-6. 2002
    ..The possibility of complement inhibition intervening in progressive tubulointerstitial injury due to proteinuric glomerular disease will also be considered...
  92. ncbi request reprint Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy
    Sydney Tang
    Nephrology Division, Department of Medicine, University of Hong Kong and Queen Mary Hospital, Hong Kong, China
    Kidney Int 68:802-12. 2005
    ..Mycophenolate mofetil (MMF) is increasingly used to treat primary glomerulopathies. Its effectiveness in IgA nephropathy (IgAN) remains unclear...
  93. ncbi request reprint Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist
    Sydney C W Tang
    Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Am Soc Nephrol 17:1633-43. 2006
    ..Such proinflammatory phenotype may be partially modified by PPAR-gamma ligation through STAT-1 inhibition independent of NF-kappaB transcriptional activity and MAPK signaling...
  94. ncbi request reprint Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis
    Wai Kei Lo
    Renal Unit, Department of Medicine, Tung Wah Hospital, The University of Hong Kong, Hong Kong
    Kidney Int 67:2032-8. 2005
    ..There has been little data to support a target level of peritoneal clearance. A retrospective study was therefore conducted to see how the peritoneal Kt/V had affected the survival of anuric patients in our center...
  95. ncbi request reprint Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice
    Joseph Ck Leung
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Nephrology (Carlton) 10:63-72. 2005
    ..The downregulation of aquaporins is often observed in polyuria associated with acquired nephrogenic diabetes insipidus. In this study, we examined the expression of AQP1, AQP2, AQP3 and AQP4 in streptozotocin (STZ)-induced diabetic mice...
  96. ncbi request reprint The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy
    Qing Zhong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Am J Chin Med 33:613-26. 2005
    ..This beneficial effect was due to reduced glomerular IgA deposition and TGF-beta1 expression. Our preliminary findings hold promise for future human therapy...
  97. ncbi request reprint Molecular basis of IgA nephropathy
    Andrew S H Lai
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Curr Mol Med 5:475-87. 2005
    ..These novel findings regarding the molecular pathogenesis of IgAN will be helpful in designing future directions for therapy...
  98. ncbi request reprint Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure
    Loretta Y Y Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 409, Professorial Block, Hong Kong
    Clin Exp Nephrol 8:297-303. 2004
    ..These novel findings may provide clinicians new therapeutic approach for selective blockade of the RAS in IgAN...
  99. ncbi request reprint Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient
    Sing Leung Lui
    Department of Medicine, Tung Wah Hospital, Hong Kong, China
    Am J Kidney Dis 40:E14. 2002
    ....
  100. ncbi request reprint Size-dependent binding of IgA to HepG2, U937, and human mesangial cells
    Joseph C K Leung
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong
    J Lab Clin Med 140:398-406. 2002
    ..These characteristic properties may alter the catabolism of circulating IgA and, hence, predispose their deposition in the kidney mesangium in IgAN...
  101. ncbi request reprint In vitro study examining the effect of sub-lethal QS 755 nm lasers on the expression of p16INK4a on melanoma cell lines
    Henry H L Chan
    Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong
    Lasers Surg Med 32:88-93. 2003
    ..The p16 gene has been proposed as the candidate gene for melanoma. Our objective is to examine the effect of sub-lethal laser damage on p16 expression in melanoma cell lines...