C L Lai

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Viral hepatitis B
    Ching Lung Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Lancet 362:2089-94. 2003
  2. ncbi request reprint Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B
    Ching Lung Lai
    University Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    Clin Infect Dis 36:687-96. 2003
  3. ncbi request reprint Therapeutic advances in chronic hepatitis B
    Ching Lung Lai
    Division of Hepatology, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, China
    J Gastroenterol Hepatol 19:S5-9. 2004
  4. ncbi request reprint Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection
    Ching Lung Lai
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Gastroenterology 123:1831-8. 2002
  5. ncbi request reprint A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B
    Ching Lung Lai
    University of Hong Kong, China
    Gastroenterology 129:528-36. 2005
  6. ncbi request reprint Comparison of the efficacy of lamivudine and famciclovir in Asian patients with chronic hepatitis B: results of 24 weeks of therapy
    Ching Lung Lai
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Med Virol 67:334-8. 2002
  7. ncbi request reprint Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    Ching Lung Lai
    Queen Mary Hospital, Hong Kong, China
    N Engl J Med 354:1011-20. 2006
  8. ncbi request reprint A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Hepatology 40:719-26. 2004
  9. ncbi request reprint The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Ann Intern Med 147:58-61. 2007
  10. ncbi request reprint Antiviral therapy for hepatitis B and C in Asians
    C L Lai
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 14:S19-21. 1999

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Viral hepatitis B
    Ching Lung Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Lancet 362:2089-94. 2003
    ..Lamivudine, and presumably other nucleoside analogues, can reverse cirrhosis of the liver...
  2. ncbi request reprint Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B
    Ching Lung Lai
    University Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    Clin Infect Dis 36:687-96. 2003
    ..Patients with YMDD variants losing clinical response with a significant increase in the HBV DNA and ALT levels may require additional therapy...
  3. ncbi request reprint Therapeutic advances in chronic hepatitis B
    Ching Lung Lai
    Division of Hepatology, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, China
    J Gastroenterol Hepatol 19:S5-9. 2004
    ..In patients with decompensated CHB the combination of lamivudine and adefovir dipivoxil showed significant efficacy. After only 24 weeks, clinical improvements in liver function were seen...
  4. ncbi request reprint Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection
    Ching Lung Lai
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Gastroenterology 123:1831-8. 2002
    ..Entecavir is a novel and selective nucleoside analogue with potent activity against hepatitis B virus (HBV)...
  5. ncbi request reprint A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B
    Ching Lung Lai
    University of Hong Kong, China
    Gastroenterology 129:528-36. 2005
    ..A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial...
  6. ncbi request reprint Comparison of the efficacy of lamivudine and famciclovir in Asian patients with chronic hepatitis B: results of 24 weeks of therapy
    Ching Lung Lai
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Med Virol 67:334-8. 2002
    ..It was concluded that in Chinese patients with chronic hepatitis B infection, lamivudine achieved effective suppression of HBV DNA levels within 4 weeks of therapy whereas famciclovir had a significantly weaker action...
  7. ncbi request reprint Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    Ching Lung Lai
    Queen Mary Hospital, Hong Kong, China
    N Engl J Med 354:1011-20. 2006
    ..Entecavir is a potent and selective antiviral agent that has demonstrated efficacy in phase 2 studies in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B...
  8. ncbi request reprint A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Hepatology 40:719-26. 2004
    ..In conclusion, these results support expanded clinical studies of this new agent for the treatment of hepatitis B...
  9. ncbi request reprint The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points
    Ching Lung Lai
    University of Hong Kong, Hong Kong, China
    Ann Intern Med 147:58-61. 2007
    ..5 times the upper limit of normal...
  10. ncbi request reprint Antiviral therapy for hepatitis B and C in Asians
    C L Lai
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 14:S19-21. 1999
    ..However, lamivudine may have to be given on a long-term basis, as withdrawal of lamivudine results in rebound of HBV-DNA to pretreatment levels. The long-term effects of lamivudine are currently being assessed...
  11. ncbi request reprint The natural history of chronic hepatitis B
    C L Lai
    Department of Medicine, The University of Hong Kong, Hong Kong
    J Viral Hepat 14:6-10. 2007
    ..However, continuing viral replication, even at a relatively low level of <10(4) copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications...
  12. ncbi request reprint Telbivudine versus lamivudine in patients with chronic hepatitis B
    Ching Lung Lai
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 357:2576-88. 2007
    ..Reducing hepatitis B virus (HBV) replication to minimal levels is emerging as a key therapeutic goal for chronic hepatitis B...
  13. pmc Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    Gut 54:1610-4. 2005
    ..Identifying risk factors for the development of complications of chronic hepatitis B (CHB) is important for setting up treatment criteria...
  14. ncbi request reprint Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: The effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 34:139-45. 2001
    ..062). In Chinese HBsAg carriers, IFN-alpha was of no long-term benefit in inducing HBeAg seroconversion or in the prevention of hepatoma and other cirrhosis-related complications...
  15. ncbi request reprint Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 12:513-8. 2005
    ..034), but not with HAI-F score (P = 0.3). CP mutations were associated with more severe necroinflammation. The association between genotype C and poor histology was probably because of the association between genotype C and CP mutations...
  16. ncbi request reprint Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 21:841-9. 2005
    ..Long-term effect of YMDD mutations on liver histology in Chinese hepatitis B patients is unknown...
  17. pmc Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxis
    C M Lo
    Centre of Liver Diseases, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 233:276-81. 2001
    ..To report the results of liver transplantation in 31 Asian patients with chronic hepatitis B using lamivudine prophylaxis in an open-label study...
  18. pmc A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gut 52:416-9. 2003
    ..In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients...
  19. ncbi request reprint The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B
    H J Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR
    J Viral Hepat 12:373-9. 2005
    ..The major factor for the development of cirrhotic complications was viral loads but cirrhotic complications continued to develop in patients with HBVDNA levels below 10(4) copies/mL...
  20. ncbi request reprint Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 12:41-6. 2007
    ....
  21. ncbi request reprint Retained common bile duct stones: a comparison between biliary stenting and complete clearance of stones by electrohydraulic lithotripsy
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 17:289-96. 2003
    ....
  22. ncbi request reprint Treatment of chronic hepatitis B
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Lancet Infect Dis 1:232-41. 2001
    ..Combination therapy with two or three nucleoside analogues or immunomodulators plus nucleoside analogues will be the future direction of treatment of chronic hepatitis B...
  23. ncbi request reprint Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial
    Henry L Y Chan
    The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Ann Intern Med 147:745-54. 2007
    ..The efficacy of nucleoside and nucleotide analogues for hepatitis B has been linked to the magnitude and durability of hepatitis B virus (HBV) suppression...
  24. pmc A randomised controlled trial of endoscopic sphincterotomy in acute cholangitis without common bile duct stones
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gut 51:245-7. 2002
    ..However, it is not known whether EPT with decompression of the bile duct is beneficial in patients with acute cholangitis and gall bladder stones but without evidence of CBD stones...
  25. ncbi request reprint Low serum HBV DNA levels and development of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study
    J Fung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 26:377-82. 2007
    ..To investigate the level of hepatitis B virus (HBV) DNA in Chinese chronic hepatitis B (CHB) patients below which hepatocellular carcinoma (HCC) is unlikely to occur...
  26. ncbi request reprint Prevalence and characteristics of familial hepatocellular carcinoma caused by chronic hepatitis B infection in Hong Kong
    A O O Chan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 19:401-6. 2004
    ..Hepatitis B virus infection is an important aetiological factor for hepatocellular carcinoma. Clusters of hepatocellular carcinoma have been observed in families infected with hepatitis B virus...
  27. ncbi request reprint Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Hepatol 41:119-25. 2004
    ..We conducted a population study to document the prevalence of hepatitis B virus (HBV) genotypes in Hong Kong...
  28. ncbi request reprint Impact of precore and core promoter mutations on hepatic histology in patients with chronic hepatitis B
    H J Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital
    Aliment Pharmacol Ther 22:301-7. 2005
    ..The details of liver histology of patients with precore and core promoter mutations are still not clear...
  29. ncbi request reprint Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 14:269-75. 2007
    ..038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B...
  30. ncbi request reprint Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong
    T K Cheung
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 24:573-83. 2006
    ..Clinical features of hepatocellular carcinoma patients are changing because of screening...
  31. ncbi request reprint Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Aliment Pharmacol Ther 24:1179-86. 2006
    ..Safety of traditional Chinese medicine in patients with chronic hepatitis B is unknown...
  32. ncbi request reprint Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Aliment Pharmacol Ther 16:929-36. 2002
    ..Complications of endoscopic sphincterotomy are closely related to the endoscopic technique. To date, there have been no studies to indicate that aspirin increases the risk of bleeding after endoscopic sphincterotomy...
  33. doi request reprint Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3-year follow-up study
    J Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Viral Hepat 18:e200-5. 2011
    ..Antiviral therapy and follow-up ALT levels were independent significant factors associated with a decline in LSM...
  34. ncbi request reprint Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy
    M F Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hepatology 34:785-91. 2001
    ..There was no increase in the rate of development of YMDD variants or L528M mutation in patients receiving lamivudine 25 mg daily or famciclovir 500 mg 3 times a day before being given lamivudine 100 mg daily...
  35. ncbi request reprint Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment
    W M Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital
    Am J Med 92:265-74. 1992
    ..We performed a randomized controlled trial to compare the efficacy of seven forms of maintenance treatment of duodenal ulcer, including a mealtime regimen of antacids...
  36. ncbi request reprint One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Antivir Ther 11:909-16. 2006
    ..CccDNA becomes the dominant form of HBV DNA during viral suppression and is possibly responsible for viral rebound after short-term antiviral therapy...
  37. pmc Determinants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearance
    He Jun Yuan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong, China
    J Clin Microbiol 43:1594-9. 2005
    ..Patients with delayed HBeAg seroclearance had a higher frequency of HBeAg seroreversion...
  38. doi request reprint Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection
    W K Seto
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong
    J Viral Hepat 20:470-7. 2013
    ..640). In chronic HCV genotype 6 infection, IL28B polymorphisms were associated with response to therapy. ITPA polymorphisms influenced the degree of anaemia but not thrombocytopenia during therapy...
  39. ncbi request reprint HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 39:1694-701. 2004
    ..Intrahepatic HBV DNA level was low and predominantly in the form of cccDNA. However, HCC could still develop, particularly in patients with cirrhosis who had HBsAg seroclearance at an older age...
  40. ncbi request reprint Adefovir dipivoxil in chronic hepatitis B infection
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Expert Opin Pharmacother 5:2361-7. 2004
    ..Adefovir dipivoxil can be recommended as a first-line treatment but can also be used in patients with chronic hepatitis B infection who are failing lamivudine therapy...
  41. pmc Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong
    J Clin Microbiol 42:5036-40. 2004
    ....
  42. ncbi request reprint Long-term lamivudine therapy reduces the risk of long-term complications of chronic hepatitis B infection even in patients without advanced disease
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 12:1295-303. 2007
    ..Our aim was to investigate the effects of long-term lamivudine treatment and lamivudine-resistant virus (YMDD) on the development of cirrhosis and hepatocellular carcinoma (HCC) in asymptomatic patients without advanced disease...
  43. ncbi request reprint Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Hepatol 45:553-9. 2006
    ..This study aimed to measure the intrahepatic total hepatitis B virus (HBV) DNA and covalently closed circular DNA (cccDNA) levels in tumor and non-tumor tissues in hepatocellular carcinoma (HCC) patients...
  44. pmc Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection
    Danny Ka Ho Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    J Clin Microbiol 45:3942-7. 2007
    ..In conclusion, serum HBcrAg levels correlated with HBV virological markers and reflected the chronic hepatitis B disease activity in the liver...
  45. ncbi request reprint Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR, China
    J Hepatol 39:850-5. 2003
    ..To study the outcome and the virologic profiles of severe hepatitis exacerbations due to YMDD mutants in lamivudine-treated patients...
  46. ncbi request reprint Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Gut 57:98-102. 2008
    ..To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis...
  47. ncbi request reprint Ten-year experience with liver transplantation at Queen Mary Hospital: retrospective study
    C M Lo
    Liver Transplant Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hong Kong Med J 8:240-4. 2002
    ..To report the experience with liver transplantation at the Queen Mary Hospital from 1991 to 2000...
  48. ncbi request reprint Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy
    B C Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 15:1251-6. 2000
    ..A study on the outcome of open-access upper endoscopy in contrast with the conventional referral system was conducted...
  49. ncbi request reprint Acute cholangitis--predictive factors for emergency ERCP
    C K Hui
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Aliment Pharmacol Ther 15:1633-7. 2001
    ..8% and a specificity of 59.6%. CONCLUSIONS: As patients with severe acute cholangitis show a higher mortality, we recommend that emergency ERCP be performed in patients with one or more of the four prognostic factors...
  50. doi request reprint Hepatitis B and C virus-related carcinogenesis
    J Fung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    Clin Microbiol Infect 15:964-70. 2009
    ..For HBV infection, antiviral therapy and vaccination have been shown to decrease the risk of HCC. Antiviral therapy for HCV can also reduce the risk of HCC...
  51. doi request reprint Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B
    J Fung
    Department of Medicine, The University of Hong Kong, Pokfulam Road Queen Mary Hospital, Hong Kong SAR
    J Viral Hepat 18:738-44. 2011
    ..In HBeAg-negative CHB patients, a liver stiffness measurement of ≥ 10 kPa was associated with a significantly increased risk of subsequent HCC development and mortality...
  52. ncbi request reprint Low molecular weight heparin-induced liver toxicity
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102, Pokfulam Road, Hong Kong, China
    J Clin Pharmacol 41:691-4. 2001
    ..Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complement-mediated hepatocellular damage...
  53. ncbi request reprint Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B
    He Jun Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    J Infect 54:497-503. 2007
    ..To determine the prevalence of precore and core promoter (CP) mutations before, at and after HBeAg seroclearance in Chinese patients...
  54. pmc Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, Peoples Republic of China
    J Clin Microbiol 42:3932-6. 2004
    ..Biochemical flares were common, with 16% being severe in nature. High pretreatment ALT levels were associated with a higher chance of biochemical flares...
  55. ncbi request reprint Hepatitis B virus genotypes B and C do not affect the antiviral response to lamivudine
    Man Fung Yuen
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 8:531-4. 2003
    ..Determination of HBV genotypes before lamivudine therapy was probably not an important pretreatment investigation to predict antiviral responses in Chinese patients...
  56. ncbi request reprint Hepatitis B genotypes in chronic hepatitis B and lamivudine therapy
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR
    Intervirology 46:373-6. 2003
    ..5 months). In conclusion, there is no influence of HBV genotypes on the development of long-term complications and lamivudine therapy in Hong Kong...
  57. ncbi request reprint Specific considerations in the design of hepatitis B virus clinical studies in the far East
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Hong Kong
    Methods Mol Med 96:457-64. 2004
  58. ncbi request reprint Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Ann Oncol 14:1463-7. 2003
    ..The prognosis for patients with hepatocellular carcinoma (HCC) is poor by the time they present with symptoms. This review examines the usefulness of screening programs from the perspectives of survival benefit and of cost-effectiveness...
  59. ncbi request reprint Acute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosis
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Viral Hepat 8:459-64. 2001
    ..In conclusion, acute pancreatitis complicating acute exacerbation of chronic HBV infection carried an extremely poor prognosis with high mortality...
  60. ncbi request reprint Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 100:1099-103. 2005
    ..To determine the effect of 1-yr lamivudine treatment on serum covalently closed-circular DNA (cccDNA) level...
  61. ncbi request reprint Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Carcinogenesis 25:1593-8. 2004
    ..The association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of CP mutations in patients with genotype C...
  62. ncbi request reprint Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 46:1695-703. 2007
    ..The treatment can be continued for those with HBV DNA levels of less than 4 log copies/mL (2000 IU/mL). The addition of or switch to alternative antiviral agents should be considered for patients who fail to achieve this early target...
  63. ncbi request reprint Significance of HBV DNA levels in liver histology of HBeAg and Anti-HBe positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Am J Gastroenterol 99:2032-7. 2004
    ..To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores...
  64. doi request reprint Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Gastroenterol 103:1421-6. 2008
    ..To document the prevalence and factors associated with severe fibrosis and cirrhosis in a large population of Asian chronic hepatitis B (CHB) patients...
  65. pmc Detection of intrahepatic hepatitis B virus DNA and correlation with hepatic necroinflammation and fibrosis
    Danny Ka Ho Wong
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    J Clin Microbiol 42:3920-4. 2004
    ..842; P < 0.001) and with the degree of fibrosis (P = 0.014). We conclude that the method that we describe is reliable and convenient for the measurement of intrahepatic HBV DNA levels and has potential clinical significance...
  66. doi request reprint Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection
    Ivan F N Hung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 103:1663-73. 2008
    ..To identify the risk factors for recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after resection...
  67. ncbi request reprint Current seroepidemiology of hepatitis A in Hong Kong
    K P Chin
    Department of Medicine, University of Hong Kong
    J Med Virol 34:191-3. 1991
    ..In view of the changing epidemiology, postexposure prophylaxis will be necessary for young adults and children, and hepatitis A vaccine may be indicated for high risk groups when it is generally available...
  68. pmc Soluble E-cadherin is a valid prognostic marker in gastric carcinoma
    A O Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gut 48:808-11. 2001
    ..CONCLUSION: Serum soluble E-cadherin is a potential valid prognostic marker for gastric cancer. A high concentration predicts palliative/conservative treatment and T4 invasion...
  69. pmc Health-related quality of life of Southern Chinese with chronic hepatitis B infection
    Elegance T P Lam
    Department of Medicine Family Medicine Unit, The University of Hong Kong, Ap Lei Chau Clinic, Ap Lei Chau, Hong Kong
    Health Qual Life Outcomes 7:52. 2009
    ..Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection...
  70. pmc Recombinant alpha 2 interferon is superior to doxorubicin for inoperable hepatocellular carcinoma: a prospective randomised trial
    C L Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital
    Br J Cancer 60:928-33. 1989
    ..8% of patients. In the treatment of inoperable HCC, rIFN is superior to doxorubicin in causing more tumour regression, less serious marrow suppression and less fatal complications...
  71. ncbi request reprint Response to combined interferon and ribavirin is better in patients infected with hepatitis C virus genotype 6 than genotype 1 in Hong Kong
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Intervirology 49:96-8. 2006
    ..In conclusion, patients with HCV genotype 6 gain a better response to combined treatment with IFN-alpha and ribavirin than those with HCV genotype 1 and achieve a significantly higher rate of sustained virological response...
  72. ncbi request reprint Recommendations and potential future options in the treatment of hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Expert Opin Pharmacother 7:2225-31. 2006
    ..Nucleotide/nucleoside analogues will become the mainstay of treatment. Future treatment strategic plans should target maximising antiviral potency and minimising the chance of drug resistance...
  73. ncbi request reprint Significance of viral load, core promoter/precore mutations and specific sequences of polymerase gene in HBV-infected patients on 3-year lamivudine treatment
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:779-86. 2006
    ..Comprehensive study on viral factors predicting treatment responsiveness to lamivudine is lacking...
  74. ncbi request reprint A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Antivir Ther 11:977-83. 2006
    ..It is effective against both wild-type and YMDD mutant HBV. LB80380 is converted to its parent drug, LB80331, after oral absorption, and further metabolized to its active form, LB80317...
  75. ncbi request reprint Prognostic factors in severe exacerbation of chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Infect Dis 36:979-84. 2003
    ..3%; P=.004). Patients with severe exacerbation of hepatitis B with poor prognostic factors should be considered for early liver transplantation...
  76. doi request reprint HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gastroenterology 135:1192-9. 2008
    ..Our aims were to study the virologic, histologic, and clinical outcome in chronic hepatitis B (CHB) patients with hepatitis B surface antigen (HBsAg) seroclearance...
  77. doi request reprint Chronic hepatitis C virus genotype 6 infection: response to pegylated interferon and ribavirin
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Infect Dis 198:808-12. 2008
    ..We aimed to determine the efficacy of pegylated interferon plus ribavirin for treating infection with genotype 6 versus genotype 1...
  78. ncbi request reprint Development of antibody to hepatitis B surface antigen after liver transplantation for chronic hepatitis B
    Chung Mau Lo
    Department of Surgery, Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, China
    Hepatology 37:36-43. 2003
    ..The antibody is likely to be of donor origin, suggesting the possibility of adoptive immunity transfer through a liver graft...
  79. ncbi request reprint Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure
    Chi Leung Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transplantation 76:1174-9. 2003
    ..This study evaluates the survival outcomes of patients who underwent LDLT using right-lobe liver grafts for acute-on-chronic hepatitis B liver failure...
  80. ncbi request reprint Telbivudine: an upcoming agent for chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Expert Rev Anti Infect Ther 3:489-94. 2005
    ..2%, with only 4.5% showing alanine aminotransferase flares. Telbivudine is probably one of the most potent antiviral agents for hepatitis B virus that will become available in the near future...
  81. ncbi request reprint Prophylaxis and treatment of recurrent hepatitis B after liver transplantation
    Chung Mau Lo
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Transplantation 75:S41-4. 2003
    ....
  82. pmc HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection
    Man Fung Yuen
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People s Republic of China
    J Clin Microbiol 42:4882-4. 2004
    ..In conclusion, lamivudine therapy can result in HBsAg seroclearance at an early age even though the phenomenon is rare...
  83. ncbi request reprint Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin
    Chung Mau Lo
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:557-63. 2004
    ..With combination of adefovir and high-dose HBIG, however, long-term survival can be achieved after retransplantation...
  84. ncbi request reprint Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: a comparison with genotype 1
    Chee Kin Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    J Infect Dis 187:1071-4. 2003
    ..05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P=.04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR...
  85. ncbi request reprint Expression of c-Myc, c-Fos, and c-jun in hepatocellular carcinoma
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China
    Cancer 91:106-12. 2001
    ..The coordinated expression of c-fos and c-jun in HCC may reflect the coordinated tumor cell cycle of progression and proliferation; however, future studies are required to elucidate this possibility...
  86. ncbi request reprint Living donor liver transplantation without the use of blood products
    C L Liu
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hong Kong Med J 8:192-5. 2002
    ..All involved recovered uneventfully from their respective operations...
  87. ncbi request reprint 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children
    Man Fung Yuen
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Clin Gastroenterol Hepatol 2:941-5. 2004
    ..The long-term immunogenicity and efficacy of hepatitis B virus (HBV) vaccination remain to be defined. We aimed to examine the long-term immunogenicity and efficacy of HBV vaccination with 3 different regimens over 18 years of follow-up...
  88. ncbi request reprint Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Infect Dis 37:593-7. 2003
    ..Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P=.05)...
  89. pmc Natural history of hepatitis-related hepatocellular carcinoma
    David Yiu Kuen But
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    World J Gastroenterol 14:1652-6. 2008
    ..Combined with markers of liver reserve and performance status, accurate scoring systems and models have been developed to predict patients' survival and match best treatment option...
  90. ncbi request reprint Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients
    Danny Ka Ho Wong
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatology 40:727-37. 2004
    ..Serum and intrahepatic total HBV DNA and cccDNA levels become lower as the disease progresses from HBeAg-positive to anti-HBe-positive phase, with cccDNA becoming the predominant form of intrahepatic HBV DNA...
  91. ncbi request reprint Prevalence and significance of hepatitis GB virus-c/hepatitis G virus viremia in a large cohort of patients with chronic hepatitis B infection, with chronic hepatitis C infection, and on renal replacement therapy in Hong Kong
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Dig Dis Sci 47:432-7. 2002
    ..1%) probably because of a higher susceptibility as a result of immunosuppression. However, hepatitis GB virus-C viraemia did not cause liver biochemistry derangement in renal transplanted patients...
  92. pmc Clinical evaluation of the digene hybrid capture II test and the COBAS AMPLICOR monitor test for determination of hepatitis B virus DNA levels
    He Jun Yuan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, People s Republic of China
    J Clin Microbiol 42:3513-7. 2004
    ..The cost for assaying each serum sample by using different strategies was calculated. The COBAS-AM assay was more sensitive than the Digene HC II assay and more suitable for monitoring low levels of HBV viremia...
  93. ncbi request reprint Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus
    Man Fung Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Infect Dis 186:1335-8. 2002
    ..The development of complications was not related to precore mutations but was probably due to the persistence of significant viremia after HBeAg seroconversion...
  94. ncbi request reprint Current and future antiviral agents for chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Antimicrob Chemother 51:481-5. 2003
  95. ncbi request reprint The role of cholecystectomy in reducing recurrent gallstone pancreatitis
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Endoscopy 36:206-11. 2004
    ..This is a retrospective study to assess whether cholecystectomy can decrease the incidence of RAP in patients with gallstone-related pancreatitis...
  96. ncbi request reprint Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis
    A O O Chan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, ROC
    Hong Kong Med J 9:377-80. 2003
    ..Extreme caution should be taken when a patient develops allergy to one type of antithyroid drug, because cross-reactivity may develop to the other type...
  97. ncbi request reprint The accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus
    M F Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Am J Gastroenterol 96:838-41. 2001
    ..9%, respectively. CONCLUSIONS: SM-HCV Rapid Test is a reliable test with high sensitivity and specificity. The anti-HCV result can be available within a very short period of time. It is a useful screening test for anti-HCV...
  98. ncbi request reprint A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma
    Man Fung Yuen
    Department of Medicine, Center for the Study of Liver Disease, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hepatology 36:687-91. 2002
    ..Further studies should be performed in patients with less advanced disease and/or different etiology to evaluate its benefit...
  99. ncbi request reprint Cholangiocarcinoma in liver cirrhosis
    Chee Kin Hui
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 18:337-41. 2003
    ..The purpose of the present study was to evaluate CC in liver cirrhosis...
  100. ncbi request reprint Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion
    Annie Pang
    University Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China
    J Hepatol 40:1008-17. 2004
    ..We tested the hypothesis that the quantity of A(1762)T-G(1764)A and G(1896)A mutants might have clinical impact, by quantifying these mutants before and after HBe antigen (HBeAg) seroconversion in 58 patients...
  101. ncbi request reprint A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma
    Annie O Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cancer 94:1747-52. 2002
    ..Transcatheter intraarterial lipiodol chemoembolization (TACE) has been reported to be one of the most effective palliative measures for HCC. However, its severe side effects continue to make its use controversial...