Yok Lam Kwong

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. doi request reprint SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Blood 120:2973-80. 2012
  2. doi request reprint Pathogenesis and treatment of leukemia: an Asian perspective
    Yok Lam Kwong
    Queen Mary Hospital, Department of Medicine, Professorial Block, Pokfulam Road, Hong Kong, China
    Expert Opin Ther Targets 16:S37-43. 2012
  3. ncbi request reprint Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia
    Y L Kwong
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Genes Chromosomes Cancer 25:70-4. 1999
  4. doi request reprint High-dose chemotherapy and hematopoietic SCT in the management of natural killer-cell malignancies
    Y L Kwong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Bone Marrow Transplant 44:709-14. 2009
  5. doi request reprint Intrathecal chemotherapy for hematologic malignancies: drugs and toxicities
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 88:193-201. 2009
  6. doi request reprint Arsenic trioxide: safety issues and their management
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Acta Pharmacol Sin 29:296-304. 2008
  7. ncbi request reprint Predicting the outcome in non-Hodgkin lymphoma with molecular markers
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Br J Haematol 137:273-87. 2007
  8. ncbi request reprint Natural killer-cell malignancies: diagnosis and treatment
    Y L Kwong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Leukemia 19:2186-94. 2005
  9. ncbi request reprint Arsenic trioxide in the treatment of haematological malignancies
    Yok Lam Kwong
    University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Expert Opin Drug Saf 3:589-97. 2004
  10. ncbi request reprint The diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Exp Hematop 51:21-8. 2011

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. doi request reprint SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Blood 120:2973-80. 2012
    ..Multivariate analysis showed that international prognostic index was the most significant factor impacting on outcome and survivals...
  2. doi request reprint Pathogenesis and treatment of leukemia: an Asian perspective
    Yok Lam Kwong
    Queen Mary Hospital, Department of Medicine, Professorial Block, Pokfulam Road, Hong Kong, China
    Expert Opin Ther Targets 16:S37-43. 2012
    ..Leukemias occur worldwide, but there are important geographic differences in incidences...
  3. ncbi request reprint Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia
    Y L Kwong
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Genes Chromosomes Cancer 25:70-4. 1999
    ..5%) in AML, even in a population where it was considered to be more prevalent. Two breakpoints in NUP98 may occur, and this is of importance in the design of primers to amplify t(7;11)...
  4. doi request reprint High-dose chemotherapy and hematopoietic SCT in the management of natural killer-cell malignancies
    Y L Kwong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Bone Marrow Transplant 44:709-14. 2009
    ..Whether poor risk patients will have improved outcome with autologous HSCT remains to be defined. The role of allogeneic HSCT requires more rigorous future studies...
  5. doi request reprint Intrathecal chemotherapy for hematologic malignancies: drugs and toxicities
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 88:193-201. 2009
    ..Knowledge of the pharmacokinetics, dosing schedules and potential toxicities of IT chemotherapeutic drugs is important in the design of CNS prophylaxis and treatment in hematologic malignancies...
  6. doi request reprint Arsenic trioxide: safety issues and their management
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Acta Pharmacol Sin 29:296-304. 2008
    ..However, if the blood brain barrier is breached, elemental arsenic may enter the cerebrospinal fluid. As2O3 is predominantly excreted in the kidneys, and dose adjustment is required when renal function is impaired...
  7. ncbi request reprint Predicting the outcome in non-Hodgkin lymphoma with molecular markers
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Br J Haematol 137:273-87. 2007
    ..Molecular markers together with patient and clinicopathological features will provide more accurate prognostic models for risk stratification, in order to improve treatment outcome...
  8. ncbi request reprint Natural killer-cell malignancies: diagnosis and treatment
    Y L Kwong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Leukemia 19:2186-94. 2005
    ..The International Prognostic Index and presentation EBV DNA load is of prognostic significance and may be useful in the stratification of patients for various treatment modalities...
  9. ncbi request reprint Arsenic trioxide in the treatment of haematological malignancies
    Yok Lam Kwong
    University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Expert Opin Drug Saf 3:589-97. 2004
    ..Arsenic trioxide is partly renally excreted and, therefore, dose adjustment is required when renal function is impaired. In addition to its use in APL, arsenic trioxide is now tested in other malignancies, notably multiple myeloma...
  10. ncbi request reprint The diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Exp Hematop 51:21-8. 2011
    ..Epstein-Barr virus DNA load as a surrogate marker for prognostication, and clinical stratification of patients should be incorporated in clinical management algorithms...
  11. doi request reprint Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia
    Yok Lam Kwong
    Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Rheumatol 37:485-90. 2010
    ..A recognized carcinogen, azathioprine is also associated with the development of therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/AML)...
  12. ncbi request reprint Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study
    Y L Kwong
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 66:274-9. 2001
    ..This regimen avoids the possible long-term toxicities of As2O3 and mutagenicity of combination chemotherapy, a strategy that might be suitable for this potentially curable leukaemia...
  13. ncbi request reprint Chronic T-cell lymphoproliferative disease expressing natural killer cell receptors: clinicopathological and molecular features
    Y L Kwong
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 129:168-72. 2001
    ....
  14. ncbi request reprint Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia
    W Y Au
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Neurology 63:588-9. 2004
  15. doi request reprint Hematopoietic stem cell transplantation in natural killer cell lymphoma and leukemia
    Yok Lam Kwong
    Department of Medicine, Professorial Block, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong
    Int J Hematol 92:702-7. 2010
    ..Continuous efforts should be devoted to risk stratification for identifying high-risk individuals for HSCT, and defining the optimal conditioning regimen for NK cell lymphomas...
  16. ncbi request reprint Candida tropicalis fungaemia in adult patients with haematological malignancies: clinical features and risk factors
    A Y H Leung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Hosp Infect 50:316-9. 2002
    ..The clinicopathologic features and risk factors identified in this study may help design better treatment strategies for this often-lethal complication...
  17. doi request reprint T-cell lymphoma forum
    Yok Lam Kwong
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Expert Rev Anticancer Ther 10:493-8. 2010
    ..The combination of novel therapeutic agents with chemotherapy, and the judicious use of high-dose chemotherapy and hematopoietic stem cell transplantation, may improve the outcome of patients with T-cell and NK-cell lymphomas...
  18. doi request reprint T-cell large granular lymphocyte leukemia: an Asian perspective
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    Ann Hematol 89:331-9. 2010
    ..001) and recurrent infections (81/272, 30% versus 3/107, 3%; p<0.001). These clinicopathologic differences have important implications on disease pathogenesis and treatment...
  19. ncbi request reprint Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient population
    Shing Yan Ma
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Transplantation 76:169-76. 2003
    ..The role of liver biopsy in such cases has not been defined in hepatitis B virus (HBV)-prevalent patients. The impact of liver biopsy in the management of LFT derangement after HSCT in an HBV-prevalent population was examined...
  20. doi request reprint Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients
    Thomas S Y Chan
    Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China
    Ann Hematol 93:493-8. 2014
    ..Breakthrough IFD during echinocandin treatment occurred infrequently (1.5 %), caused predominantly by Candida species. Clofarabine usage was an important risk factor...
  21. doi request reprint Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor
    Anskar Y H Leung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 88:485-91. 2013
    ..011) on CR/CRi. RIC-HSCT as primary treatment for acute leukemic relapses post-HSCT induced a high CR rate with low TRM. Optimal postremission treatment remains to be defined...
  22. ncbi request reprint Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Hong Kong
    Br J Haematol 131:632-5. 2005
    ..At first or subsequent relapses, owing to highly effective salvage by arsenic trioxide, CDKN2B methylation did not impact on event-free survival or overall survival...
  23. ncbi request reprint High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantation
    George K K Lau
    Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, People s Republic of China
    Blood 99:2324-30. 2002
    ..A high HBV DNA level (>10(5) copies/mL) was the most important risk factor for HBV reactivation, and its lowering by administration of nucleoside analogues before transplantation should be considered...
  24. ncbi request reprint Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gastroenterology 129:2058-63. 2005
    ..Epstein-Barr virus (EBV) infection has been associated with some cases of gastric cancer...
  25. ncbi request reprint Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization
    Yuesheng Jin
    Department of Medicine, University of Hong Kong, China
    Cancer Genet Cytogenet 163:30-7. 2005
    ..Telomeric dysfunction may be an important mechanism leading to the acquisition of complex karyotypical aberrations...
  26. ncbi request reprint Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia
    Wing Yan Au
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Leuk Res 29:1213-5. 2005
    ..There were no significant side effects, and normalization of erythropoiesis was durable. Alemtuzumab is active in PRCA that is idiopathic or secondary to T-cell lymphoproliferative diseases...
  27. ncbi request reprint Cytogenetic aberrations in immortalization of esophageal epithelial cells
    Hao Zhang
    Department of Medicine, University of Hong Kong, Professorial Block, Pockfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 165:25-35. 2006
    ..These alterations might be valuable models for further study of molecular mechanisms contributing to esophageal carcinogenesis...
  28. ncbi request reprint Alemtuzumab induced complete remission of autoimmune hemolytic anemia refractory to corticosteroids, splenectomy and rituximab
    Winnie W Cheung
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Haematologica 91:ECR13. 2006
    ..The major side effect was reactivation of cytomegalovirus, which was controlled with intravenous and oral ganciclovir. This case showed that alemtuzumab might be of use in therapy-refractory AIHA...
  29. ncbi request reprint Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Blood 104:243-9. 2004
    ..During treatment, patients with EBV DNA that showed further increases or failed to become undetectable had significantly inferior OS. In EBV-positive lymphomas, plasma EBV DNA is valuable as a tumor biomarker and for prognostication...
  30. ncbi request reprint Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy
    Chee Kin Hui
    Centre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 131:59-68. 2006
    ..De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy...
  31. ncbi request reprint Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation
    Anskar Y H Leung
    Department of Medicine, University of Hong Kong, China
    Clin Infect Dis 40:528-37. 2005
    ..The objective of this study was to test whether standard-dose ciprofloxacin might suppress reactivation of BKV infection during HSCT...
  32. pmc Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 5:28. 2012
    ..Here we compared the outcomes of the staged approach with frontline PAD (bortezomib/doxorubicin/dexamethasone) or VTD (bortezomib/thalidomide/dexamethasone) induction, and analysed prognostic factors for outcome...
  33. ncbi request reprint Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis
    Roberta Pang
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gastroenterology 132:1088-103. 2007
    ..The role of Pin1 in hepatocarcinogenesis, particularly in HBV-related HCC, was investigated...
  34. ncbi request reprint Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Am J Cardiol 98:60-2. 2006
    ..Autologous bone marrow cell implantation into the ischemic human myocardium was not associated with long-term major adverse events regarding tumor, scar, or calcification formation, and the arrhythmogenic risk was low...
  35. ncbi request reprint Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation
    Chee Kin Hui
    Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR, China
    J Clin Virol 32:173-8. 2005
    ..After hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the initial 12 months after transplantation...
  36. ncbi request reprint Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20
    Yuesheng Jin
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Gynecol Oncol 92:183-91. 2004
    ..This study aimed at identifying the genetic events involved in immortalization of ovarian epithelial cells, which might be important steps in ovarian carcinogenesis...
  37. pmc Specific patterns of gene methylation in natural killer cell lymphomas : p73 is consistently involved
    Lisa Lai Ping Siu
    Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    Am J Pathol 160:59-66. 2002
    ..These results suggest that p73 may be an important target in the neoplastic transformation of NK cells, and the demonstration of its methylation may serve as a potential molecular tool for NK cell lymphoma detection...
  38. ncbi request reprint Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas
    Yuesheng Jin
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 148:21-8. 2004
    ..These observed chromosomal aberrations and imbalances thus provide important information for further molecular genetic investigation of esophageal SCC...
  39. ncbi request reprint Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs
    Wing Yan Au
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 81:5-11. 2006
    ....
  40. doi request reprint Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment
    Thomas S Y Chan
    Department of Medicine, Queen Mary Hospital Department of Pathology, Queen Mary Hospital, Hong Kong, China
    Clin Transplant 26:679-83. 2012
    ..EBV-positive PTLD occurred much later in Asian patients. Treatment results of PTLD were favorable...
  41. doi request reprint Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Blood 118:6535-43. 2011
    ..Prolonged oral As(2)O(3) maintenance was feasible and safe and resulted in favorable outcomes when used with a simple induction and consolidation regimen compared with other protocols composed of multiple chemotherapeutic agents...
  42. doi request reprint Successful engraftment by leukemia initiating cells in adult acute lymphoblastic leukemia after direct intrahepatic injection into unconditioned newborn NOD/SCID mice
    Alice M S Cheung
    Department of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 38:3-10. 2010
    ..In this study, we reported an undescribed model in which adult ALL cells were injected into unconditioned newborn nonobese diabetic severe combined immunodeficient mice via an intrahepatic route...
  43. ncbi request reprint Regular virologic surveillance showed very frequent cytomegalovirus reactivation in patients treated with alemtuzumab
    Winnie W Cheung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 82:108-11. 2007
    ..Frequent monitoring for and early treatment of CMV reactivation is necessary during alemtuzumab therapy...
  44. ncbi request reprint Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene
    Hao Zhang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21, Sassoon Road, Hong Kong, China
    Cancer Genet Cytogenet 150:144-52. 2004
    ..Our observations suggest that serial transformation of NP cell lines might provide a useful in vitro model for the study of the multistep neoplastic transformation of NP cells...
  45. ncbi request reprint Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety
    Chung Wah Siu
    Divisions of Cardiology, Hematology, and Clinical Pharmacology, Department of Medicine, University of Hong Kong, Hong Kong
    Blood 108:103-6. 2006
    ..No ventricular proarrhythmias were observed. These observations, due to the lower peak plasma arsenic reached during oral As2O3, may explain the relative cardiac safety of oral As2O3...
  46. ncbi request reprint High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Leuk Res 32:547-51. 2008
    ..Tuberculosis reactivation should be considered for unexplained fever and symptoms after alemtuzumab treatment...
  47. ncbi request reprint Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 103:216-21. 2004
    ..4% versus 27.6%, P = 0.012), as well as for patients treated with chemotherapy/radiotherapy (IPI <or= 1 superior to IPI >or= 2 for CR: 76.7% versus 35.7%, P =.017; and 10-year OS: 63.8% versus 26.8%, P =.003)...
  48. pmc Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma
    Chor Sang Chim
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong
    J Clin Pathol 60:664-9. 2007
    ..To study the role of gene promoter hypermethylation of the putative tumour suppressor genes involved in the death-associated protein (DAP) kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma (MM)...
  49. ncbi request reprint Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells
    Jordy Leung
    Department of Medicine, University of Hong Kong, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Blood 109:740-6. 2007
    ..However, APL and AML with maturation expressed comparable AQP9 levels, suggesting that AQP9 expression was related to granulocytic maturation...
  50. doi request reprint CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
    Xiao Tong Hu
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 115:2458-61. 2010
    ..The ectopic expression of CD44DeltaEx1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation...
  51. doi request reprint Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells
    Lijun Shen
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, People s Republic of China
    Mol Cancer Ther 7:3807-15. 2008
    ..Hence, activating mitotic catastrophe by bortezomib may provide a novel therapeutic approach for treating apoptosis-resistant NK-cell malignancies and other cancers...
  52. doi request reprint Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Blood 112:3587-90. 2008
    ..Plasma arsenic was the only significant determinant of CSF arsenic levels. CSF arsenic was present at therapeutically meaningful levels, implying that As2O3 therapy might be beneficial in CNS APL...
  53. ncbi request reprint Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 10:2401-6. 2004
    ..This study aims at evaluation of the potential use of methylated gene promoter DNA as a serological tumor marker of primary and potentially salvageable local or nodal recurrent NPC...
  54. ncbi request reprint Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Lancet 361:47-9. 2003
    ..After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result...
  55. doi request reprint Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group
    Eric Tse
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Am J Hematol 87:663-8. 2012
    ..Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P = 0.03), and response to initial treatment led to better OS and PFS (P < 0.001)...
  56. ncbi request reprint Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am Heart J 154:982.e1-6. 2007
    ..In both therapeutic approaches, direct local myocardial injury might be a common mechanism to induce therapeutic angiogenesis...
  57. ncbi request reprint Long-term outcome of 231 patients with essential thrombocythemia: prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, ROC
    Arch Intern Med 165:2651-8. 2005
    ..Essential thrombocythemia (ET) is a clonal myeloproliferative disease associated with thrombohemorrhagic complications and myeloid transformation to diseases such as myelofibrosis and acute myeloid leukemia...
  58. ncbi request reprint Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation
    Hao Zhang
    Department of Medicine, University of Hong Kong, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Cancer Lett 245:184-94. 2007
    ..In addition to supporting the role of HPV and telomerase in esophageal carcinogenesis, our cell lines may also be useful in vitro models for further studies of esophageal carcinogenesis...
  59. pmc Frequent deletion of Fas gene sequences encoding death and transmembrane domains in nasal natural killer/T-cell lymphoma
    Lijun Shen
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital Compound, 102 Pokfulam Road, Hong Kong, People s Republic of China
    Am J Pathol 161:2123-31. 2002
    ..396). Taken together, the findings in this study suggest that frequent Fas gene mutations in NL can result in resistance to apoptosis and may contribute to the pathogenesis of NL by adding to the tumor immune privilege...
  60. ncbi request reprint SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Blood 103:4630-5. 2004
    ..SHP1 methylation leading to epigenetic activation of the Jak/STAT pathway might have a tentative role in the pathogenesis of myeloma, which should be further confirmed by functional studies in primary myeloma samples...
  61. ncbi request reprint Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas
    Yuesheng Jin
    Department of Medicine, Professional Block, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 156:1-7. 2005
    ....
  62. doi request reprint Management of T-cell and natural-killer-cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009
    Yok Lam Kwong
    Department of Medicine, University of Hong Kong, China
    Lancet Oncol 10:1093-101. 2009
    ..For patients not in clinical trials, consensus opinions offer useful guidelines on optimum management...
  63. pmc Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
    Carmen Wing Sze Chan
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Cardiovasc Magn Reson 12:6. 2010
    ..This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR)...
  64. ncbi request reprint Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
    Hung Fat Tse
    Division of Cardiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Eur J Heart Fail 9:747-53. 2007
    ..To determine the optimal bone marrow (BM) cell types, and their potential mechanisms of action for neovascularization in chronic ischaemic myocardium...
  65. doi request reprint Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies
    Pek Lan Khong
    Department of Diagnostic Radiology, Queen Mary Hospital, Hong Kong, China
    Ann Hematol 87:613-21. 2008
    ..These observations defined the pre-treatment value of PET-CT in T-cell and NK-cell lymphomas. The post-treatment role requires further studies...
  66. doi request reprint Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas
    Winnie K S Chan
    Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong S A R, China
    Clin Nucl Med 35:571-5. 2010
    ....
  67. ncbi request reprint Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B
    Chee Kin Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Hepatol 47:191-202. 2007
    ..We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts...
  68. ncbi request reprint Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation
    Anders S Y Wong
    Department of Medicine, University of Hong Kong, China
    Clin Infect Dis 44:830-7. 2007
    ..In this study, we examined the relationship of reactivation of BKV infection with pre-HSCT serologic findings of BKV antibody...
  69. doi request reprint PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin
    Chi Wai Cheng
    Division of Haematology and Medical Oncology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Pathol 182:765-75. 2013
    ..Such functional interaction between PIN1 and survivin may therefore play an important role in hepatocarcinogenesis and chemoresistance...
  70. pmc Epigenetic inactivation of the MIR129-2 in hematological malignancies
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 6:16. 2013
    ..MIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers...
  71. doi request reprint Oral arsenic trioxide for relapsed acute promyelocytic leukemia in pediatric patients
    Wing Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Pediatr Blood Cancer 58:630-2. 2012
    ..Oral As(2) O(3) , particularly in prolonged maintenance with oral ATRA may obviate the need of stem cell transplantation in relapsed pediatric APL...
  72. doi request reprint Quantification of BK viral load in asymptomatic renal allograft recipients
    Gary C W Chan
    Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Ren Fail 34:550-4. 2012
    ..However, the presence and level of BKV DNA in renal allograft patients with good and stable renal function have remained undetermined...
  73. doi request reprint Use of fludarabine-containing chemotherapeutic regimen results in durable complete remission of subcutaneous panniculitis-like T-cell lymphoma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Clin Dermatol 9:396-8. 2008
    ..The patient achieved complete remission after one course of treatment. After completion of six courses of FND, the patient has remained in remission for more than 3 years. FND may be an effective treatment for aggressive SPTCL...
  74. ncbi request reprint Transvenous cryoablation reduces platelet activation during pulmonary vein ablation compared with radiofrequency energy in patients with atrial fibrillation
    Hung Fat Tse
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong
    J Cardiovasc Electrophysiol 16:1064-70. 2005
    ..The objective of this study was to compare the thrombogenic potential of transvenous cryoablation versus RF ablation during pulmonary vein (PV) isolation...
  75. doi request reprint Differential NOD/SCID mouse engraftment of peripheral blood CD34+ cells and JAK2V617F clones from patients with myeloproliferative neoplasms
    Tsz Kan Fung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong, China
    Leuk Res 34:1390-4. 2010
    ..9% versus 6-week: 13.0%, P=0.001). Essential thrombocythemia (ET) BM cells also exhibited a similar decrease in JAK2V617F clone. The results suggested that events in addition to JAK2V617F are involved in the pathogenesis of PV and ET...
  76. pmc Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results
    Harinder Gill
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 90:1399-407. 2011
    ..Early stage, good performance status, and low international prognostic index risk scores significantly impacted on CR rate and survivals. Rituximab and fludarabine were safe for non-gastric MZL and resulted in more durable remissions...
  77. pmc Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia
    Eric Tse
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Ann Hematol 90:1277-81. 2011
    ..Disease status, number of prior therapies, and cytogenetic aberrations were not associated with the outcome. However, remission was only achieved with Ara-C at 2 g/m(2)/day and not 1 g/m(2)/day (9/15 versus 0/4, P = 0.03)...
  78. ncbi request reprint Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia
    Wing Yan Au
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Leuk Res 31:105-8. 2007
    ..Compared against matched background population, there was an increased risk of second cancer (p=0.012, standard incidence ratio=6.5; 95% confidence interval=1.4-19.0)...
  79. doi request reprint Absence of NPM1 promoter hypermethylation in human myelodysplastic syndrome
    Yuen Yee Cheng
    Division of Haematology and Medical Oncology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Clin Pathol 63:1008-11. 2010
    ..There was no significant difference in NPM1 mRNA expression between MDS and normal blood samples. In conclusion, the finding suggests that NPM1 methylation is rare in MDS and does not play a major role in its pathogenesis...
  80. doi request reprint Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
    Ka Kui Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Pathol 221:164-74. 2010
    ..Our findings provide insight into a molecular network within the NF-kappaB signalling pathway that promotes the pathogenesis of NK cell lymphomas...
  81. doi request reprint Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma
    Jing Gu
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Rm 406, Block K, Hong Kong
    AJR Am J Roentgenol 197:W384-91. 2011
    ..The second protocol used the same sequences as the first protocol but also included DWI...
  82. ncbi request reprint Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Br J Haematol 137:475-8. 2007
    ..ADAMTS13 levels were low in all evaluable patients, and only one patient showed significant anti-ADAMTS13 antibody. The levels of ADAMTS13 and anti-ADAMTS13 antibody did not change significantly with rituximab-induced remission...
  83. doi request reprint Treatment algorithms for mature T-cell and natural killer-cell neoplasms
    Eric Tse
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Future Oncol 7:1101-12. 2011
    ..Non-multidrug resistance-dependent regimens and L-asparaginase-based protocols have been shown to be highly active. Autologous HSCT is not routinely performed. The role of allogeneic HSCT is being examined...
  84. doi request reprint Practical management of natural killer/T-cell lymphoma
    Eric Tse
    Division of Haematology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Curr Opin Oncol 24:480-6. 2012
    ..Data on gene and micro-RNA expression profiling studies are also discussed which may impact the development of new drugs targeting specific oncogenic pathways...
  85. ncbi request reprint Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines
    Ying Chuan Hu
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer Genet Cytogenet 135:120-7. 2002
    ..These two newly established cell lines will be useful tools in the study of the molecular pathogenesis and biological behavior of ESCC cells and for testing new therapeutic reagents for ESCC in the future...
  86. ncbi request reprint Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians
    Wing Yan Au
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    J Gerontol A Biol Sci Med Sci 61:1086-9. 2006
    ..Age-related skewing of X-chromosome inactivation leading to glucose-6-phosphate dehydrogenase (G6PD) deficiency in elderly women in a population with prevalent G6PD gene mutations was investigated...
  87. doi request reprint Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies
    Anskar Y H Leung
    Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Br Med Bull 93:85-103. 2010
    ....
  88. ncbi request reprint Pentasomy 8q in therapy-related myelodysplastic syndrome due to cyclophosphamide therapy for fibrosing alveolitis
    Wing Y Au
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer Genet Cytogenet 141:79-82. 2003
    ..Increasing copy numbers of chromosome 8/8q may therefore be a marker of advanced leukemic evolution, exposure to toxins, underlying myelodysplasia, and an overall poor prognosis...
  89. doi request reprint FLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID mice
    Alice M S Cheung
    Division of Hematology, Department of Medicine, University of Hong Kong, Hong Kong
    Leuk Res 34:119-22. 2010
    ..Their different engraftment capabilities in NOD/SCID mice supported the proposition that FLT3/ITD might occur at different stages during leukemogenesis...
  90. ncbi request reprint Acute disseminated encephalomyelitis after para-influenza infection post bone marrow transplantation
    Wing Y Au
    University Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    Leuk Lymphoma 43:455-7. 2002
    ..There was a rapid and complete response to pulse high-dose corticosteriod and intravenous immunoglobulin. The importance of recognition and early treatment of this rare condition in transplantation practice is emphasized...
  91. ncbi request reprint Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma
    David Gisselsson
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Genes Chromosomes Cancer 42:22-33. 2005
    ..That the model did not produce any of the whole-chromosome gains observed in OC indicates that these changes develop through a different mechanism...
  92. ncbi request reprint Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial)
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Eur Heart J 28:2998-3005. 2007
    ..Recently, several non-randomized pilot studies have also suggested that direct BM cells implantation appears to be feasible and safe in patients with severe coronary artery diseases (CAD)...
  93. ncbi request reprint Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese
    Chloe M Mak
    Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong SAR, China
    Amyloid 14:293-7. 2007
    ..We conclude that ATTR remains largely underdiagnosed in the Chinese population. A high clinical suspicion is crucial for a timely diagnosis and can thus lead to a significant decrease in morbidity and mortality...
  94. doi request reprint Common misdiagnoses in lymphomas and avoidance strategies
    John K C Chan
    Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China
    Lancet Oncol 11:579-88. 2010
    ..The aim of this review is to provide pathologists and clinicians with a concise account of these pitfalls and avoidance strategies...
  95. pmc Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Pathol 60:104-6. 2007
    ..Methylation of DAP kinase and oestrogen receptor genes was comparable in multiple myeloma and MGUS. In conclusion, methylation of p16, SHP1 and E-cadherin genes might be involved in the progression of MGUS to multiple myeloma...
  96. ncbi request reprint PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma
    Roberta Pang
    Department of Medicine, Division of Haematology Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Oncogene 23:4182-6. 2004
    ..These results showed that PIN1 overexpression leading to beta-catenin accumulation might be a critical event in hepatocarcinogenesis, and that PIN1 is a potential target for therapeutic intervention in HCC...
  97. ncbi request reprint Therapy-related acute myeloid leukemia after single-agent treatment with fludarabine for chronic lymphocytic leukemia
    Clarence C K Lam
    Department of Pathology, University of Hong Kong, Hong Kong
    Am J Hematol 79:288-90. 2005
    ..Together with previous reports of secondary cancers after fludarabine treatment and the association of monosomy 7/7q- with another purine analogue azathioprine, results suggest that t-AML might develop after fludarabine therapy...
  98. ncbi request reprint Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge
    Wing Yan Au
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    J Am Acad Dermatol 53:890-2. 2005
    ..There was no preferential dermatome involvement or systemic spread. The actuarial risk of VZV reactivation at 1 year was 26%. No VZV reactivation occurred after the first year of initial treatment with As2(O3)...
  99. ncbi request reprint Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Leuk Res 32:357-8. 2008
  100. doi request reprint Retracted: outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen
    Chee Kin Hui
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Special Administrative Region, China
    Hepatology 48:1-10. 2008
    ..Loss of HBsAg occurred after recovery of the CD4+T cell count and increased CD4+T cell reactivity against HBcAg 9 months after the end of chemotherapy...
  101. doi request reprint Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes
    Ching Yuen Wong
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Mol Nutr Food Res 52:1421-7. 2008
    ..026, relative increase = 63.5%). This study demonstrated that daily thiamine intake was positively correlated with the circulating number of EPCs and FMD in patients with type II diabetes, independent of other dietary nutrients intake...