Maggie Pui Man Hoi
Affiliation: University of Macau
Vong C, Tseng H, Kwan Y, Lee S, Hoi M. Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells. Biomed Pharmacother. 2019;111:1176-1186 pubmed publisher
Hoi P, Li S, Vong C, Tseng H, Kwan Y, Lee S. Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods. 2015;71:85-91 pubmed publisher
..Several representative examples of successful applications on VEGFR2 virtual screening for hit discovery, lead optimization and structure-based design are also presented. ..
Zhou Z, Huang B, Li S, Huang X, Tang J, Kwan Y, et al
. Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish. Toxicol Appl Pharmacol. 2018;350:32-42 pubmed publisher
..Taken together, we investigated the underlying mechanisms of Ator-induced endothelial instability, and provided scientific evidences of STS as potential ICH therapeutics by promoting vascular integrity. ..
Li S, Dang Y, Oi Lam Che G, Kwan Y, Chan S, Leung G, et al
. VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol. 2014;280:408-20 pubmed publisher
..In addition, we showed that VRI-induced blood vessel loss in zebrafish represented a simple and effective in vivo model for studying vascular insufficiency and evaluating cancer drug vascular toxicities. ..
Li S, Zhou X, Dang Y, Kwan Y, Chan S, Leung G, et al
. Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta. 2015;1850:373-84 pubmed publisher
..The roles of Flt1 activity in endothelial cell survival in physiological vascular formation may have been previously under-appreciated. ..
Seto S, Chang D, Ko W, Zhou X, Kiat H, Bensoussan A, et al
. Sailuotong Prevents Hydrogen Peroxide (H?O?)-Induced Injury in EA.hy926 Cells. Int J Mol Sci. 2017;18: pubmed publisher
Huang B, Zhou Z, Li S, Huang X, Tang J, Hoi M, et al
. Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility. Pharmacol Res. 2018;128:389-398 pubmed publisher
..These findings identified Tan I as an endothelial stabilizing agent and suggested Tan I as a potential treatment for vascular leakage in hemorrhagic stroke. ..
Tang F, Zhou X, Wang L, Shan L, Li C, Zhou H, et al
. A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways. Eur J Pharmacol. 2018;820:86-96 pubmed publisher
..Since Dox-induced cardiotoxicity is multifactorial, our results suggest that multi-functional agent such as DT-010 might be an effective therapeutic agent for combating cardiotoxicity associated with chemotherapeutic agents such as Dox. ..