Pak Leung Ho

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc Novel selective medium for isolation of Staphylococcus lugdunensis from wound specimens
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Clin Microbiol 52:2633-6. 2014
  2. ncbi request reprint High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong Special Administrative Region, PR China
    J Med Microbiol 63:878-83. 2014
  3. pmc Panton-valentine leukocidin-positive MRSA, shanghai
    Li Zhong Han
    Ruijin Hospital, Shanghai, People s Republic of China L Z Han, Y X Ni, Y B Zhang University of Hong Kong, Hong Kong Special Administrative Region, PRC P L Ho Shanghai Children s Hospital, Shanghai H Zhang Sixth People s Hospital of Shanghai, Shanghai Y Q Jiang Shanghai Pulmonary Hospital, Shanghai H Q Chu and Minhang Central Hospital, Shanghai Y Sun
    Emerg Infect Dis 16:731-3. 2010
  4. doi request reprint Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital and Carol Yu Centre for Infection, The University of Hong Kong, China
    Curr Microbiol 67:493-8. 2013
  5. doi request reprint Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    J Appl Microbiol 114:695-702. 2013
  6. pmc Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Clin Microbiol 50:3735-7. 2012
  7. ncbi request reprint Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, China
    Vet Microbiol 162:964-7. 2013
  8. doi request reprint Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong
    Pak Leung Ho
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 71:327-34. 2011
  9. doi request reprint Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, China
    Vet Microbiol 158:172-9. 2012
  10. doi request reprint Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008
    Pak Leung Ho
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    Diagn Microbiol Infect Dis 73:182-6. 2012

Collaborators

Detail Information

Publications90

  1. pmc Novel selective medium for isolation of Staphylococcus lugdunensis from wound specimens
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Clin Microbiol 52:2633-6. 2014
    ..lugdunensis in 990 clinical specimens (from tissue, pus, or wound swabs). Significantly more S. lugdunensis isolates were detected on SSL medium (34/990) than on routine medium (7/990) (P = 0.001, McNemar's test). ..
  2. ncbi request reprint High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong Special Administrative Region, PR China
    J Med Microbiol 63:878-83. 2014
    ..7 per 10 000 admissions and 178.7 per 10 000 admissions among patients aged 0-74 years and ≥75 years, respectively. In conclusion, a rapidly expanding elderly population would substantially add to the burden of ESBL...
  3. pmc Panton-valentine leukocidin-positive MRSA, shanghai
    Li Zhong Han
    Ruijin Hospital, Shanghai, People s Republic of China L Z Han, Y X Ni, Y B Zhang University of Hong Kong, Hong Kong Special Administrative Region, PRC P L Ho Shanghai Children s Hospital, Shanghai H Zhang Sixth People s Hospital of Shanghai, Shanghai Y Q Jiang Shanghai Pulmonary Hospital, Shanghai H Q Chu and Minhang Central Hospital, Shanghai Y Sun
    Emerg Infect Dis 16:731-3. 2010
    ..CA-MRSA strains usually possess the Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCC) mec type IV or V (1,2)...
  4. doi request reprint Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital and Carol Yu Centre for Infection, The University of Hong Kong, China
    Curr Microbiol 67:493-8. 2013
    ..In conclusion, the findings contribute to a better understanding of the plasmid platforms carrying bla KPC and of variations in the backbone of the IncX3 plasmids. ..
  5. doi request reprint Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    J Appl Microbiol 114:695-702. 2013
    ..To investigate plasmid-mediated fosfomycin resistance related to fosA3 in Escherichia coli isolates collected from different animals in Hong Kong, China, 2008-2010...
  6. pmc Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Clin Microbiol 50:3735-7. 2012
    ..The predominant S. aureus CCs among dog and cat isolates were similar. Among rodent isolates, CC398 predominated, with spa t034 the most frequent spa type detected...
  7. ncbi request reprint Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, China
    Vet Microbiol 162:964-7. 2013
    ..Since IncFII plasmids spread efficiently in Enterobacteriaceae, the detection of fosA3 with bla(CTX-M) is worrisome and might become a public health concern...
  8. doi request reprint Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong
    Pak Leung Ho
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 71:327-34. 2011
    ..5; P = 0.001). In period 2, high rates of dual penicillin/erythromycin nonsusceptibility were found in serotypes 6B (77.3%), 14 (100%), 19F (100%), 23F (78%), 19A (75%), 6A (87.8%), 6C (59.3%), and 23A (78.9%)...
  9. doi request reprint Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, China
    Vet Microbiol 158:172-9. 2012
    ..In conclusion, this study highlights the importance of the IncFII group, pHK01-like plasmids in the dissemination of CTX-M-14 among isolates from diverse sources...
  10. doi request reprint Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008
    Pak Leung Ho
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    Diagn Microbiol Infect Dis 73:182-6. 2012
    ..These pHK01-like plasmids were found to have spread to the major clones (ST68, ST405, and ST131) and multiple singleton isolates of all 4 phylogenetic groups...
  11. ncbi request reprint Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Carol Yu Centre for Infection and Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, PR China
    J Infect 64:500-6. 2012
    ..To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children...
  12. pmc Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    BMC Infect Dis 10:263. 2010
    ..After renovation of the adult intensive care unit (ICU) with installation of ten single rooms, an enhanced infection control program was conducted to control the spread of methicillin-resistant Staphylococcus aureus (MRSA) in our hospital...
  13. pmc Use of antibiotics by primary care doctors in Hong Kong
    Tai Pong Lam
    Family Medicine Unit, Department of Medicine, The University of Hong Kong, Hong Kong
    Asia Pac Fam Med 8:5. 2009
    ..To determine the use of antibiotics by primary care doctors...
  14. pmc DNA typing of cytological samples for retrospective identification of an early case of Panton-Valentine leucocidin-positive, community-associated methicillin-resistant Staphylococcus aureus pneumonia
    P L Ho
    Departments of Microbiology, Paediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 46:2457-8. 2008
    ..Stored cytological materials prepared from the pleural fluid were retrieved for molecular analysis. The result indicates the presence of a Panton-Valentine leucocidin-positive, spa type 019 MRSA...
  15. ncbi request reprint Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Hong Kong
    P L Ho
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR, China
    Hong Kong Med J 15:9-11. 2009
    ..Community-associated methicillin resistant Staphylococcus aureus is an emerging cause of skin and soft tissue infections in Hong Kong, especially among certain ethnic minorities...
  16. ncbi request reprint Molecular epidemiology of community-associated methicillin-resistant Staphylococcus aureus
    P L Ho
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR, China
    Hong Kong Med J 15:6-8. 2009
    ..1. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains with diverse genetic backgrounds are emerging in Hong Kong. 2. Intra-familial spread of community-associated MRSA is common...
  17. ncbi request reprint Genetic identity of aminoglycoside-resistance genes in Escherichia coli isolates from human and animal sources
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, and Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR
    J Med Microbiol 59:702-7. 2010
    ..An IncFII plasmid of 140 kb in size was shared by one human and three animal isolates. In summary, this study showed that human and animal isolates share the same pool of resistance genes...
  18. ncbi request reprint Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong
    Pak Leung Ho
    Centre of Infection, Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Infect Control Hosp Epidemiol 28:671-8. 2007
    ..To determine the prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) strains among residents in residential care homes for the elderly in Hong Kong...
  19. ncbi request reprint Pediatric hospitalization for pneumococcal diseases preventable by 7-valent pneumococcal conjugate vaccine in Hong Kong
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, SAR, China
    Vaccine 25:6837-41. 2007
    ..3 (95% CI, 16.7-21.9) for IPD, 58.5 (95% CI, 57.3-59.6) for clinical pneumonia and 40.6 (95% CI, 59-82.2) for radiological pneumonia...
  20. ncbi request reprint Antibiotic resistance in community-acquired pneumonia caused by Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, People s Republic of China
    Chest 136:1119-27. 2009
    ..This review discusses their recent epidemiology, microbiology, clinical features, and treatment of CAP caused by these antimicrobial-resistant pathogens...
  21. doi request reprint Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    J Infect 60:140-5. 2010
    ..To assess whether vancomycin MIC creeps among blood methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered from 5 hospitals in Hong Kong from 1997 to 2008...
  22. doi request reprint Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 66:87-93. 2010
    ..4-5.7; P = 0.003) and ciprofloxacin resistance (OR, 2.5; 95% CI, 1.1-5.8; P = 0.03). Knowledge of the resistance data and risk factors could inform better use of antibiotics for empiric therapy for acute uncomplicated cystitis...
  23. ncbi request reprint Distribution of integron-associated trimethoprim-sulfamethoxazole resistance determinants among Escherichia coli from humans and food-producing animals
    P L Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong, China
    Lett Appl Microbiol 49:627-34. 2009
    ..To compare the distribution of integrons and trimethoprim-sulfamethoxazole resistance genes among Escherichia coli isolates from humans and food-producing animals...
  24. ncbi request reprint CTX-M type beta-lactamases among fecal Escherichia coli and Klebsiella pneumoniae isolates in non-hospitalized children and adults
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    J Microbiol Immunol Infect 41:428-32. 2008
    ..The present study shows fecal carriage of organisms producing bla(CTX-M) determinants and underscores the role that commensals could play as a reservoir for their dissemination...
  25. ncbi request reprint Invasive pneumococcal disease burden in Hong Kong children
    Pak Leung Ho
    University of Hong Kong, SAR, China
    Pediatr Infect Dis J 25:454-5. 2006
    ..9-23.3) for children aged <or=2 years, 15.6 (95% CI, 12.8-18.6) for children aged <or=5 years and 1 (95% CI, 0.52-1.7) for children aged 6-14 years. The findings indicate a significant disease burden...
  26. ncbi request reprint Optimising antimicrobial prescription in hospitals by introducing an antimicrobial stewardship programme in Hong Kong: consensus statement
    P L Ho
    Subcommittee for Health Protection Programme on Antimicrobial Resistance, Centre for Health Protection, Department of Health, Hong Kong
    Hong Kong Med J 12:141-8. 2006
    ..To discuss the implementation of an 'antimicrobial stewardship programme' as a means to improve the quality of antimicrobial use in a hospital setting in Hong Kong...
  27. ncbi request reprint Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones
    P L Ho
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Antimicrob Chemother 47:655-8. 2001
    ..Among clinical isolates of S. pneumoniae, accumulation of target site mutations in strains with an efflux mechanism was associated with increasing MICs of fluoroquinolones...
  28. ncbi request reprint Characterization of a laboratory-generated variant of BPS beta-lactamase from Burkholderia pseudomallei that hydrolyses ceftazidime
    P L Ho
    Department of Microbiology and HKU Pasteur Research Centre, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    J Antimicrob Chemother 50:723-6. 2002
    ..coli conferred resistance to ceftazidime (MIC >or= 32 mg/L). The amino acid sequence of BPS-1m differed from that of BPS-1 by a Pro-to-Ser change at position 167 in the omega loop...
  29. pmc Epidemiologic analysis of invasive and noninvasive group a streptococcal isolates in Hong Kong
    P L Ho
    Center of Infection, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    J Clin Microbiol 41:937-42. 2003
    ..Minor emm gene sequence alterations were noted for 31 isolates, and for 13 of these isolates, deletion, insertion, or point mutations were seen in the hypervariable 50 N-terminal residues...
  30. ncbi request reprint Comparison of a novel, inhibitor-potentiated disc-diffusion test with other methods for the detection of extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae
    P L Ho
    Department of Microbiology, University of Hong Kong
    J Antimicrob Chemother 42:49-54. 1998
    ..coli and K. pneumoniae isolates, with potential for incorporation into routine clinical laboratory service...
  31. pmc Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:1250-7. 2004
    ..5% from children < or = 5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine...
  32. pmc Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong
    Pak Leung Ho
    Department of Microbiology, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e17989. 2011
    ..Since they mediate resistance to virtually all β-lactam antibiotics and there is often co-resistance to other antibiotic classes, the therapeutic options for infections caused by these organisms are very limited...
  33. pmc Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:1960-2. 2004
    ..9%) had decreased susceptibility to quinolones. The five strains had a Ser-84-Lys or Asp-88-Asn substitution in GyrA. Pulsed-field gel electrophoresis showed that the isolates are genetically diverse...
  34. ncbi request reprint Detection and characterization of extended-spectrum beta-lactamases among bloodstream isolates of Enterobacter spp. in Hong Kong, 2000-2002
    P L Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, United Christian Hospital, University of Hong Kong, Hong Kong SAR, China
    J Antimicrob Chemother 55:326-32. 2005
    ..A total of 139 consecutive and non-duplicate bloodstream isolates of Enterobacter spp. collected from inpatients in Hong Kong during 2000-2002 were studied for production of extended-spectrum beta-lactamases (ESBLs)...
  35. doi request reprint Extensive dissemination of CTX-M-producing Escherichia coli with multidrug resistance to 'critically important' antibiotics among food animals in Hong Kong, 2008-10
    P L Ho
    Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    J Antimicrob Chemother 66:765-8. 2011
    ..To assess the occurrence of faecal carriage of Escherichia coli with resistance to 'critically important' antibiotics in various animals...
  36. ncbi request reprint Occurrence and molecular analysis of extended-spectrum {beta}-lactamase-producing Proteus mirabilis in Hong Kong, 1999-2002
    P L Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    J Antimicrob Chemother 55:840-5. 2005
    ..A study was conducted to evaluate the occurrence and characterization of extended-spectrum beta-lactamases (ESBLs) among blood isolates of Proteus mirabilis collected over a 4 year period in Hong Kong...
  37. doi request reprint Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009
    Pak Leung Ho
    Department of Microbiology, University of Hong Kong, Hong Kong SAR, China
    Vaccine 29:3270-5. 2011
    ..1% to 64.2% (P=0.01). The types that often had dual penicillin/erythromycin resistance were 6B, 14, 19F, 23F, 6A and 19A. The emergence of serotype 19A was associated with expansion of sequence type 320...
  38. ncbi request reprint The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine
    Pak Leung Ho
    Department of Microbiology, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 68:439-44. 2010
    ..Nonetheless, results from the molecular studies indicated that the evolution of the capsular genes have involved complex pathways...
  39. doi request reprint Epidemiology and clonality of multidrug-resistant Acinetobacter baumannii from a healthcare region in Hong Kong
    P L Ho
    Department of Microbiology and Center of Infection, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Hosp Infect 74:358-64. 2010
    ..Both clones were found to have disseminated widely. In conclusion, clonal expansion is playing major roles in the increase of MDR-AB in these hospitals in Hong Kong. The findings highlight the need to enhance infection control measures...
  40. ncbi request reprint Detection and characterisation of extended-spectrum beta-lactamases among blood stream isolates of Enterobacter species in Hong Kong
    P L Ho
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR, China
    Hong Kong Med J 15:4-5. 2009
    ..1. Extended-spectrum beta-lactamase(ESBL) resistance in Enterobacter spp may be under-recognised. 2. Detection methods for ESBL resistance in Enterobacter spp may need to be modified...
  41. ncbi request reprint Antimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 59:439-45. 2007
    ..Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment...
  42. doi request reprint Complete sequencing of the FII plasmid pHK01, encoding CTX-M-14, and molecular analysis of its variants among Escherichia coli from Hong Kong
    P L Ho
    Department of Microbiology, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, People s Republic of China
    J Antimicrob Chemother 66:752-6. 2011
    ..We characterized plasmids encoding CTX-M-14 β-lactamase originating from Escherichia coli isolates recovered from patients with uncomplicated cystitis or individuals with faecal colonization in Hong Kong from 2002 to 2004...
  43. ncbi request reprint Community emergence of CTX-M type extended-spectrum beta-lactamases among urinary Escherichia coli from women
    P L Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, China
    J Antimicrob Chemother 60:140-4. 2007
    ..To conduct a territory-wide study of extended-spectrum beta-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong...
  44. ncbi request reprint Bacteremia caused by Escherichia coli producing extended-spectrum beta-lactamase: a case-control study of risk factors and outcomes
    Pak Leung Ho
    Scand J Infect Dis 34:567-73. 2002
    ..2; p < 0.001). Treatment failed in 4/7 case patients treated with ceftazidime to which the isolate was susceptible in vitro. Our findings have implications for the choice of empirical therapy in nosocomial urinary tract infection...
  45. ncbi request reprint Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multicentre study in 2000
    P L Ho
    Department of Microbiology, Division of Infectious Diseases, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    J Antimicrob Chemother 48:659-65. 2001
    ..pneumoniae was found in Hong Kong. Typing analysis suggests that this is due to the pan-regional dissemination of a fluoroquinolone-resistant variant (designated Hong Kong(23F)-1) of the globally distributed Spain(23)F-1 clone...
  46. pmc Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong
    P L Ho
    Department of Microbiology, Division of Infectious Diseases, University of Hong Kong, Hong Kong
    Antimicrob Agents Chemother 43:1310-3. 1999
    ..1, 5.5, or 2.2% of the strains, respectively. These high rates of resistance raise concerns for the future...
  47. doi request reprint Molecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 61:135-42. 2008
    ..In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns...
  48. pmc Fluoroquinolone resistance among Streptococcus pneumoniae in Hong Kong linked to the Spanish 23F clone
    P L Ho
    University of Hong Kong Special Administrative Region, China
    Emerg Infect Dis 7:906-8. 2001
    ..These strains exhibited capsular switching and were highly similar to the Spanish 23F clone...
  49. ncbi request reprint Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 61:245-50. 2008
    ..In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-beta-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA...
  50. ncbi request reprint Serotype distribution and antimicrobial resistance patterns of nasopharyngeal and invasive Streptococcus pneumoniae isolates in Hong Kong children
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, PR China
    Vaccine 22:3334-9. 2004
    ..7 and 66.1% of the invasive and carriage isolates, respectively. The same seven serotypes comprised 87.5% invasive isolates and 82.8% carriage isolates with resistance to penicillin, erythromycin and/or cefotaxime...
  51. ncbi request reprint Comparison of screening methods for detection of extended-spectrum beta-lactamases and their prevalence among Escherichia coli and Klebsiella species in Hong Kong
    P L Ho
    Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Pokfulam, China
    APMIS 108:237-40. 2000
    ..8%). As a second test for confirming ESBL activity in strains with reduced susceptibility to beta-lactams, the inhibitor-potentiated disc diffusion test is therefore a simple and reliable option...
  52. doi request reprint Changes in the epidemiology of methicillin-resistant Staphylococcus aureus associated with spread of the ST45 lineage in Hong Kong
    Pak Leung Ho
    Department of Microbiology and Centre of Infection, The University of Hong Kong, SAR, China
    Diagn Microbiol Infect Dis 64:131-7. 2009
    ..Two other epidemic clones, EMRSA-16 (ST36/SCCmec II) and CC398 (ST1277/SCCmec V), were detected as sporadic isolates for the first time in Hong Kong...
  53. ncbi request reprint Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance
    P L Ho
    Centre of Infection and Department of Microbiology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    Eur J Clin Microbiol Infect Dis 25:323-7. 2006
    ..2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality...
  54. doi request reprint Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates
    Pak Leung Ho
    1Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, PR China
    J Med Microbiol 62:1707-13. 2013
    ..This study demonstrated the dissemination of fosA3 genes in diverse E. coli clones on multiple blaCTX-M-carrying plasmid types, of which F2:A-:B- plasmids closely related to pHK23a were shared by isolates from human and animal sources. ..
  55. ncbi request reprint Molecular epidemiology and household transmission of community-associated methicillin-resistant Staphylococcus aureus in Hong Kong
    Pak Leung Ho
    Department of Microbiology and Centre of Infection, University of Hong Kong, Hong Kong SAR, PR China
    Diagn Microbiol Infect Dis 57:145-51. 2007
    ..In conclusion, CA-MRSA has a propensity to spread within families. Our findings showed that CA-MRSA strains in Hong Kong have diverse genetic backgrounds...
  56. ncbi request reprint Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong, China Infection Control Team, Queen Mary Hospital, Hong Kong, China
    Chin Med J (Engl) 126:4504-9. 2013
    ....
  57. pmc Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong
    Antimicrob Agents Chemother 49:1957-64. 2005
    ..The beta-lactamase characterized from strain HLHK5 was named LHK-5 (gene, bla(LHK-5)) and represents the first example of AmpC beta-lactamase in the beta subdivision of proteobacteria...
  58. doi request reprint Fecal carriage of CTXM type extended-spectrum beta-lactamase-producing organisms by children and their household contacts
    Wai U Lo
    Division of Infectious Diseases, Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    J Infect 60:286-92. 2010
    ..To investigate the epidemiology of fecal carriage of CTX-M type extended-spectrum beta-lactamases (ESBL)-producing organisms among children and their household contacts...
  59. ncbi request reprint Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP
    Eric Tung Yiu Leung
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    J Med Microbiol 52:999-1003. 2003
    ..RFLP patterns of katG amplicons from respiratory specimens were identical to those of the corresponding MTB cultured colonies. This method has potential application for rapid diagnosis of INH resistance due to katG Ser315Thr mutation...
  60. ncbi request reprint Diagnostic application of genotypic identification of mycobacteria
    Wing Cheong Yam
    Centre of Infection and Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, China
    J Med Microbiol 55:529-36. 2006
    ....
  61. doi request reprint Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity
    Kelvin K W To
    Research Centre of Infection and Immunology, Pokfulam, Hong Kong Special Administrative Region, China
    Int J Infect Dis 17:e120-4. 2013
    ..This study assessed the impact of discordant empirical antibiotic therapy on the outcome of bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli...
  62. doi request reprint Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis
    Gilman Kit Hang Siu
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Antimicrob Chemother 66:730-3. 2011
    ..Our study aims to identify the mutations outside the RRDR that are associated with rifampicin resistance in M. tuberculosis...
  63. ncbi request reprint Carriage of methicillin-resistant Staphylococcus aureus, ceftazidime-resistant Gram-negative bacilli, and vancomycin-resistant enterococci before and after intensive care unit admission
    Pak Leung Ho
    Centre of Infection and Department of Microbiology, Faculty of Medicine, University of Hong Kong, People s Republic of China
    Crit Care Med 31:1175-82. 2003
    ..To measure patients' risk for acquiring antibiotic-resistant microorganisms associated with intensive care unit admission...
  64. pmc Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 50:1571-9. 2012
    ..oxytoca developed antibiotic-associated hemorrhagic colitis, suggesting that K. oxytoca can cause a mild disease manifesting as uncomplicated antibiotic-associated diarrhea with winter seasonality...
  65. ncbi request reprint Increase in methicillin-resistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndrome
    Florence H Y Yap
    Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Clin Infect Dis 39:511-6. 2004
    ....
  66. ncbi request reprint Fulminant community-acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome
    Wah Shing Leung
    Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, Peoples Republic of China
    Chest 129:102-9. 2006
    ..To better characterize CAP-AB, we compared its clinical features and outcomes with a control group of HAP-AB patients...
  67. pmc Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74
    Ricky W T Lau
    Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Antimicrob Agents Chemother 55:608-14. 2011
    ..A number of gyrA mutations (Glu21Gln, Ser95Thr, and Gly668Asp) were also characterized to be natural polymorphisms not associated with fluoroquinolone resistance...
  68. doi request reprint Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific polymerase chain reaction
    Gilman Kit Hang Siu
    Department of Microbiology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 69:51-8. 2011
    ..The technical simplicity, short turnaround time, and low cost of this molecular strategy should facilitate routine diagnostic services in developing areas with a high prevalence of drug-resistant tuberculosis...
  69. ncbi request reprint SARS: hospital infection control and admission strategies
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Respirology 8:S41-5. 2003
    ..As SARS might re-emerge, all hospitals should take advantage of the current SARS-free interval to review their infection control programmes, alert mechanisms, response capability and to repair any identified inadequacies...
  70. pmc Transmission of methicillin-resistant Staphylococcus aureus in the long term care facilities in Hong Kong
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    BMC Infect Dis 13:205. 2013
    ..The relative contribution of long term care facilities (LTCFs) and hospitals in the transmission of methicillin-resistant Staphylococcus aureus (MRSA) is unknown...
  71. ncbi request reprint An unprecedented outbreak investigation for nosocomial and community-acquired legionellosis in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong, China
    Chin Med J (Engl) 125:4283-90. 2012
    ....
  72. ncbi request reprint Evolution of antibiotic resistance mechanisms and their relevance to dialysis-related infections
    Samson S Y Wong
    Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 27:S272-80. 2007
    ..Novel approaches such as antibiotic-impregnated Tenckhoff catheters, biocompatible dialysis fluid, and peritoneal immuno-augmentation strategies are eagerly awaited...
  73. doi request reprint Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study
    Ivan F N Hung
    Infectious Disease Division, Queen Mary Hospital, State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, China
    Clin Infect Dis 51:1007-16. 2010
    ..The efficacy of dual vaccination remains unknown...
  74. pmc Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems
    Jonathan H K Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 51:1733-9. 2013
    ....
  75. ncbi request reprint Risk factors for community-associated methicillin-resistant Staphylococcus aureus infection in Hong Kong
    Yiu Hong Leung
    Centre for Health Protection, Department of Health, Kowloon, Hong Kong
    J Infect 64:494-9. 2012
    ..The risk factors for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection were not well understood. The objective of this study was to identify risk factors associated with CA-MRSA infection in Hong Kong...
  76. pmc Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
    Yuet Wu
    Department of Paediatrics, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    BMC Infect Dis 11:201. 2011
    ..Dendritic cells are key antigen presenting cells but its role in such co-infection is unclear...
  77. pmc Introduction of an electronic monitoring system for monitoring compliance with Moments 1 and 4 of the WHO "My 5 Moments for Hand Hygiene" methodology
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    BMC Infect Dis 11:151. 2011
    ..Unlike previous electronic monitoring systems, MedSense operates in open cubicles with multiple beds and does not disrupt existing workflows...
  78. ncbi request reprint Fatal co-infection with swine origin influenza virus A/H1N1 and community-acquired methicillin-resistant Staphylococcus aureus
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong, China
    J Infect 59:366-70. 2009
    ..Since early empirical treatment with beta-lactam plus fluoroquinolone or macrolides is often initiated before specimen collections, bacterial co-infection in S-OIV may have been under-reported...
  79. ncbi request reprint Recurrent bacteraemia caused by different Salmonella species in a systemic lupus erythematosus patient
    Teresa K F Wang
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    New Microbiol 28:151-6. 2005
    ..Detailed food history and education on food hygiene is essential in making the diagnosis and preventing recurrence. A prolonged course of antibiotics may be needed to manage these cases...
  80. doi request reprint Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009
    Ivan F N Hung
    Department of Microbiology, The University of Hong Kong, Hong Kong
    Clin Infect Dis 51:274-9. 2010
    ..The relative lack of background neutralizing antibody against this novel virus provides a unique opportunity for understanding this issue...
  81. doi request reprint Susceptibility patterns of clinical and fish isolates of Laribacter hongkongensis: comparison of the Etest, disc diffusion and broth microdilution methods
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
    J Antimicrob Chemother 63:704-8. 2009
    ....
  82. ncbi request reprint Extensive contact tracing and screening to control the spread of vancomycin-resistant Enterococcus faecium ST414 in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Chin Med J (Engl) 125:3450-7. 2012
    ..The objective of this study was to illustrate the control measures used to eradicate a VRE outbreak in a hospital network in Hong Kong...
  83. ncbi request reprint T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 182:834-40. 2010
    ..Silicosis is a well-recognized risk factor for tuberculosis (TB)...
  84. ncbi request reprint Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
    Godfrey Chi Fung Chan
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Hemoglobin 33:352-60. 2009
    ..Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients...
  85. doi request reprint HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction
    James C B Li
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, China
    AIDS 25:15-25. 2011
    ....
  86. ncbi request reprint Excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in Hong Kong
    Florence H Y Yap
    Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
    J Med Virol 73:617-23. 2004
    ..The findings support a wider application of annual influenza vaccination in this region...
  87. ncbi request reprint Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci
    Bengang Xing
    Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    J Med Chem 46:4904-9. 2003
    ..The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors...
  88. ncbi request reprint Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: a potential candidate for biomaterials
    Bengang Xing
    Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, ROC
    J Am Chem Soc 124:14846-7. 2002
    ..Antibiotic hydrogels based on a vancomycin (Van) derivative, formed by self-assembling Van-pyrene (1) in water, using the pi-pi interaction of pyrene moieties and hydrogen bonding of Vans, promise a new way to make novel biomaterials...
  89. ncbi request reprint Using beta-lactamase to trigger supramolecular hydrogelation
    Zhimou Yang
    Department of Chemistry and Center for Cancer Research, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
    J Am Chem Soc 129:266-7. 2007