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Zhi Yong Han
Affiliation: University of Science and Technology of China
Su Y, Li Y, Chen Y, Han Z. Ir/PTC cooperatively catalyzed asymmetric umpolung allylation of Î±-imino ester enabled synthesis of Î±-quaternary amino acid derivatives bearing two vicinal stereocenters. Chem Commun (Camb). 2017;53:1985-1988 pubmed publisher
..The reaction features good yields, high diastereo- and enantio-selectivities, ease of scale-up to gram scale and further transformation of the products (e.g. to quaternary proline analogues with multi stereocenters). ..
Adili A, Tao Z, Chen D, Han Z. Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile. Org Biomol Chem. 2015;13:2247-50 pubmed publisher
..Moreover, this reaction can be performed in up to 6 mmol scale without any noticeable loss of yield and stereoselectivity. ..