Research Topics
Genomes and Genes
| Xin Yuan GuanSummaryAffiliation: University of Hong Kong Country: China Publications
| Collaborators
|
Detail Information
Publications
Oncogenic role of eIF-5A2 in the development of ovarian cancerXin Yuan Guan
Department of Clinical Oncology, The University of Hong Kong, People s Republic of China
Cancer Res 64:4197-200. 2004..These findings suggest that eIF-5A2 plays important roles in ovarian pathogenesis...
Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletionLeiLei Chen
State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
Gut 60:534-43. 2011....
Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinomaFajun Xie
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
BMC Cancer 11:86. 2011..The aim of this study is to investigate the role of GPR39 in human esophageal cancer development, and to examine the prevalence and clinical significance of GPR39 overexpression in ESCC...- Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinomaLi Ru He
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
BMC Cancer 9:461. 2009..We wished to ascertain whether a correlation exists between the expression of H3K27me3 and clinical outcome in a group of patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT)... - Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinomaGuo fen Yang
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, NO, 651, Dongfeng Road East, 510060 Guangzhou, China
BMC Cancer 10:133. 2010.... - Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridizationX Y Guan
Department of Clinical Oncology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
Genes Chromosomes Cancer 29:110-6. 2000..The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression... - Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathwayLi Fu
State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
Gut 60:1635-43. 2011..This study aimed to investigate the effect of TF-secreted Wnt2 in OSCC development via the tumour-stroma interaction... - Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinomaXin Yuan Guan
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
Cancer Genet Cytogenet 140:45-8. 2003..3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development... - Characterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissectionXin Yuan Guan
Department of Clinical Oncology, The University of Hong Kong, Room 122, Professorial Block, Pokfulam Road, Hong Kong, China
Cancer Genet Cytogenet 134:65-70. 2002..Further characterizations of the breakpoint at 6q16 and molecular cloning breakpoints at 6q27 and 17p13 are in progress... - Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancerX Y Guan
Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong
Cancer Res 61:3806-9. 2001..The proliferation-related function of eIF-5A supports that eIF-5A2 is a candidate oncogene related to the development of ovarian cancer... - Identification and characterization of tumorigenic liver cancer stem/progenitor cellsStephanie Ma
Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
Gastroenterology 132:2542-56. 2007..The aim of this study is to identify, isolate, and characterize the CSC population that drives and maintains hepatocellular carcinoma (HCC) growth and metastasis... - CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patientsLeiLei Chen
Department of Clinical Oncology, University of Hong Kong, China
J Clin Invest 120:1178-91. 2010..These findings suggest that CHD1L-ARHGEF9-Cdc42-EMT might be a novel pathway involved in HCC progression and metastasis... - Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinomaKar Lok Kong
Department of Clinical Oncology and Center for Cancer Research and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong
Cancer Res 70:8832-41. 2010..0001). Indeed, multivariate cyclooxygenase regression analysis showed that UPK1A was an independent prognostic factor for overall survival. Taken together, our findings define a function for UPK1A as an important TSG in ESCC development... - Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinomaStephanie Ma
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Gastroenterology 143:675-86.e1-12. 2012..We searched for transcripts that were altered in human ESCC samples compared with nontumor tissues... - MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTENLi Yi Zhang
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
Carcinogenesis 34:454-63. 2013..Taken together, we provide compelling evidence that miR-144 functions as an onco-miRNA in NPC, and its oncoeffects are mediated chiefly by repressing PTEN expression to activate the PI3K/Akt pathway... - Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinomaLi Fu
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Res 67:10720-6. 2007..014), which was associated with its function in increasing cell adhesion and inhibiting cell mobility. Taken together, our results suggest that PLC delta 1 plays an important suppressive role in the development and progression of ESCC... - Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survivalJun Hang Luo
The State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
Int J Cancer 122:2554-61. 2008..Thus, these findings provide evidence that an overexpression of AIB1, as detected by immunohistochemistry, is an independent molecular marker for poor prognosis (shortened survival time) of patients with UC... - Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinomaDong Jiang Tang
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
Hepatology 51:1255-63. 2010..Conclusion: EIF5A2 plays an important role in HCC invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1... - CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signalingKwan Ho Tang
Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
Hepatology 55:807-20. 2012..CONCLUSION: CD133(+) liver TICs promote angiogenesis, tumorigenesis, and self-renewal through NTS-induced activation of the IL-8 signaling cascade... - Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomyWei Chen
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Epidemiol Biomarkers Prev 18:400-8. 2009..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in urothelial carcinoma of the bladder (UC) are unclear... - COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesisNing Fang Ma
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, 651 East Dongfeng Road, Guangzhou, China
Clin Cancer Res 14:5061-8. 2008..Based on observations that the COOH-terminal truncated HBx was frequently detected in HCC, the aim of this study is to evaluate the function of COOH-terminal truncated HBx in hepatocarcinogenesis... - Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populationsStephanie Ma
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
Mol Cancer Res 6:1146-53. 2008..ALDH, expressed along CD133, can more specifically characterize the tumorigenic liver CSC population... - Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinomaDan Xie
The State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
Hum Pathol 39:80-6. 2008..05). These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression... - Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarrayDan Xie
Department of Clinical Oncology, 1 F Building, School of Chinese Medicine, University of Hong Kong, 10 Sassoon Road, Hong Kong, China
Int J Cancer 107:896-902. 2003..05) but not in other pathologic regions of CRCs, suggesting that the tumor microenvironment in different pathologic loci of colorectal tumorigenesis and progression may influence c-myc responsiveness to beta-catenin/Tcf activation... - Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse modelTerence K Lee
Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Res 67:8800-9. 2007..Our results suggest that lupeol may be an effective agent either alone or in combination for treatment of advanced tumors... - Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinomaTerence K Lee
Department of Surgery, The University of Hong Kong, Hong Kong, China
Clin Cancer Res 12:6910-9. 2006..Recently, Id-1 (inhibitor of differentiation/DNA synthesis) has been suggested to be a key factor in cancer progression but the molecular mechanism remains unknown... - Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancersYan Li
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Res 70:5695-705. 2010..Taken together, these findings define a novel mechanism of genomic instability and malignant progression in esophageal cancers, a deadly disease of increasing incidence in developed countries... - Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expressionJian Li
Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
PLoS ONE 6:e21816. 2011..CONCLUSIONS: IL-17A could promote HCC metastasis by the upregulation of MMP2 and MMP9 expression via activating NF-κB signaling pathway... - Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinomaYan Ru Qin
Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Int J Cancer 123:826-30. 2008..Our findings provided evidence that minimal deleted regions at 3p26.3, 3p22, 3p21.3 and 3p14.2 containing potential TSGs may contribute to the pathogenesis of esophageal cancer... - Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cellsXianghong Wang
Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
Oncogene 23:474-82. 2004..Our evidence provides a therapeutic strategy to overcome acquired resistance through inactivation of TWIST expression in human cancer... - Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinomaGuo fen Yang
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Gynecol Oncol 112:314-8. 2009..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear... - SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in miceYan Li
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
Gastroenterology 144:179-191.e4. 2013..Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) is up-regulated by CHD1L; we investigated its role in hepatocellular carcinogenesis... - Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinomaStephanie Ma
Department of Pathology, The University of Hong Kong, Hong Kong, China
Hum Pathol 38:1201-6. 2007..Elevated MIM-B expression may influence the development of hepatocellular carcinoma and may possibly be a powerful indicator for the disease at an early stage... - miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1Stephanie Ma
Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
Cell Stem Cell 7:694-707. 2010..Silencing TP53INP1 in CD133⁻ cells enhanced both self renewal and tumorigenicity in vivo. Collectively, miR-130b regulates CD133(+) liver TICs, in part, via silencing TP53INP1... - Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinomaNikki P Lee
Department of Surgery and Center for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong
Int J Cancer 127:968-76. 2010.... - Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinomaChunyu Zhang
Department of Surgery, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Clin Cancer Res 15:4017-27. 2009..The aim of the present study was to investigate the specific role of TF in the esophageal cancer microenvironment... - Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinomaLi Fu
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Hepatology 51:1624-34. 2010..CONCLUSION: Taken together, our findings suggest that TAT plays an important suppressive role in the development and progression of HCC... - Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasisIrene Oi Lin Ng
Department of Pathology, The University of Hong Kong, Faculty of Medicine, Queen Mary Hospital, Hong Kong
J Pathol 199:345-53. 2003..Of these molecular methods, LOH analysis can be used to evaluate tumour clonality in most patients even before surgical resection, since this assay can be readily applied routinely to either liver biopsies or fine needle aspirates... - Fascin over-expression is associated with aggressiveness of oral squamous cell carcinomaTerence K Lee
Department of Surgery, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
Cancer Lett 254:308-15. 2007..Fascin was negatively correlated with E-cadherin expression (p=0.018, r=-0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression... - RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosisJuan Chen
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
PLoS ONE 7:e44636. 2012..Taken together, our findings define a function for RBMS3 as an important tumor suppressor gene in NPC... - Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinomaMan Tong
Department of Pathology, Genome Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Cancer Res 72:6024-35. 2012..Further characterization of Rab25 may provide a prognostic biomarker for ESCC outcome prediction and a novel therapeutic target in ESCC treatment... - Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinomaLiang Hu
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Lett 252:36-42. 2007..TMA study showed that overexpression of FGF3 was significantly associated with HCC metastasis and recurrence (p<0.01), suggesting that up-regulation of FGF3 may play an important role in HCC metastasis and recurrence... - Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma developmentTim Hon Man Chan
State Key Laboratory for Liver Research, Sun Yat sen University Cancer Center, Guangzhou, China
Hepatology 55:491-505. 2012..CONCLUSION: Collectively, we reveal a novel molecular pathway (CHD1L/TCTP/Cdc25C/Cdk1), which causes the malignant transformation of hepatocytes with the phenotypes of accelerated mitotic progression and the production of aneuploidy... - MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2Stephanie Ma
Department of Pathology, The University of Hong Kong, Hong Kong
Cancer Res 71:583-92. 2011..Taken together, our findings define a functional involvement for miR-616 and TFPI-2 in the development and maintenance of androgen-independent prostate cancer... - Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinomaYan Li
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Res 71:6106-15. 2011..Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease... - MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptorKar Lok Kong
Department of Clinical Oncology, University of Hong Kong, Hong Kong, China
Gut 61:33-42. 2012..To understand the involvement of micro-RNA (miRNA) in the development and progression of oesophageal squamous cell carcinoma (ESCC), miRNA profiles were compared between tumour and corresponding non-tumour tissues... - LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosisZhi Yu Wang
School of Chinese Medicine, The University of Hong Kong, Estates Building, 10 Sassoon Road, Hong Kong, China
Breast Cancer Res Treat 131:791-800. 2012..Our results suggested that LDH-A inhibition might offer a promising therapeutic strategy for breast cancer... - DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancerStephanie Ma
Department of Pathology, The University of Hong Kong, Hong Kong
Int J Cancer 124:2323-32. 2009..Further, overexpression of SOX5 is associated with prostate tumor progression and early development of distant metastasis... - Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinomaJian Wang
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
PLoS ONE 6:e24967. 2011..Taken together, our data suggested that CTSZ was a candidate oncogene within the 20q13 amplicon and it played an important role in HCC metastasis... - Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxinsZhiyu Wang
School of Chinese Medicine, The University of Hong Kong, Hong Kong, China
Cancer Biol Ther 13:138-47. 2012..In conclusion, we suggest that PRDX1 and PRDX6 are key targets in the process of dioscin-induced apoptosis that involves intracellular elevated ROS... - Establishment and characterization of human non-small cell lung cancer cell linesJiangchao Li
State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou 510060, PR China
Mol Med Rep 5:114-7. 2012..These newly established cell lines may serve as useful models for studying the molecular pathogenesis of NSCLC... - High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patientsMu Yan Cai
Department of Pathology, Sun Yat sen University Cancer Center, Guangzhou, China
Mol Med 17:12-20. 2011..05). Thus, these findings provide evidence that a high expression of H3K27me3, as detected by IHC, correlates closely with vascular invasion of HCCs and is an independent molecular marker for poor prognosis in patients with HCC... - Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survivalLeiLei Chen
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
Hepatology 50:122-9. 2009..Conclusion: We demonstrate in this study that overexpression of CHD1L could sustain tumor cell survival by preventing Nur77-mediated apoptosis... - Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinomaYan Ru Qin
Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Clin Cancer Res 17:46-55. 2011..The aim of this study is to investigate the role of SOX6 in human esophageal cancer development, and to examine the prevalence and clinical significance of SOX6 downregulation in ESCC... - Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instabilityMuhan Chen
Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
BMC Cancer 11:199. 2011..In the present study, we aim to investigate the physiological and pathological effect of eIF-5A2 in an eIF-5A2 transgenic mouse model... - Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transitionTerence K Lee
Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Clin Cancer Res 12:5369-76. 2006..CONCLUSION: This study shows that Twist overexpression was correlated with HCC metastasis through induction of EMT changes and HCC cell invasiveness... - Establishment and characterization of a human cholangiocarcinoma cell lineStephanie Ma
Department of Pathology, The University of Hong Kong, University Pathology Building, Hong Kong, P R China
Oncol Rep 18:1195-200. 2007..This newly established cell line should serve as a useful model for studying the molecular pathogenesis of CC... - Significance of TWIST expression and its association with E-cadherin in bladder cancerZheng Zhang
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
Hum Pathol 38:598-606. 2007..Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer... - Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinomaMing Liu
Department of Clinical Oncology, University of Hong Kong, Hong Kong, China
Hepatology 55:1754-65. 2012..Further characterization of SGK3 may provide a prognostic biomarker for HCC outcome prediction and a novel therapeutic target in HCC treatment... - Comparative proteomic analysis of the esophageal squamous carcinoma cell line EC109 and its multi-drug resistant subline EC109/CDDPJing Wen
Department of Thoracic Oncology, Cancer Center, Sun Yat Sen University, Guangzhou 510060, P R China
Int J Oncol 36:265-74. 2010..Our present results lay foundation for future in-depth work on molecular mechanism of ESCC drug resistance, and aid in the identification and use of novel markers in clinical practice... - Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirsAlissa Michelle Go Wong
Department of Clinical Oncology and Center for Cancer Research, University of Hong Kong, Pokfulam, Hong Kong
Cancer 118:698-710. 2012..A proposed network of genes targeted by these microRNAs could also shed light on EBV-associated tumorigenesis... - Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathwayDan Xie
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Acta Neuropathol 110:481-9. 2005.... - Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21Jackie Mei Wah Fung
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
Clin Cancer Res 15:797-803. 2009..The purpose of this study was to determine the tumor-suppressive potential of PDSS2 in the development of melanoma... - Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probesWai Mui Tjia
Department of Clinical Oncology, Centre for Cancer Research, The University of Hong Kong, Room L10 56, 10 F, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
Cancer Lett 250:92-9. 2007..This study demonstrated that the combination of CGH, M-FISH and BAC-FISH is a very useful tool to detect and characterize translocation breakpoint... - Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell CarcinomaYing Hui Zhu
Authors Affiliations State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou Department of Clinical Oncology, The University of Hong Kong, Hong Kong and Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Cancer Res 73:2298-309. 2013..Taken together, our results revealed that DIRAS1 has a pivotal function in ESCC pathogenesis, with possible use as a biomarker and intervention point for new therapeutic strategies. Cancer Res; 73(7); 2298-309. ©2013 AACR... - Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progressionDan Xie
Department of Clinical Oncology, The University of Hong Kong, Room 109, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
World J Gastroenterol 11:3285-9. 2005..To investigate the expression pattern of clusterin in colorectal adenoma-carcinoma-metastasis series, and to explore the potential role of clusterin in multistage colorectal tumorigenesis and progression... - Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, ChinaYan Ru Qin
Department of Clinical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
World J Gastroenterol 14:1828-35. 2008..To characterize cytogenetic alterations in esophageal squamous cell carcinoma (ESCC) and its metastasis... - Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stageMeng Zhong Liu
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Am J Clin Pathol 129:728-34. 2008..05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype... - A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal CancerKwan Ho Tang
Authors Affiliations Departments of Pathology, Clinical Oncology, Anatomy, and Surgery, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou and Department of Clinical Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Cancer Res 73:2322-32. 2013..Our results prompt further study of this CD90(+) population of esophageal TICs as potential therapeutic targets. Cancer Res; 73(7); 2322-32. ©2013 AACR... - Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expressionJian Li
State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
PLoS ONE 7:e46264. 2012..CONCLUSIONS: IL-23 could promote HCC metastasis by the upregulation of MMP9 expression via activating NF-κB/p65 signaling pathway. At the same time, IL-17A could further promote IL-23 expression in HCC tumor cells... - Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agentsHiu Wing Cheung
Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Cancer Res 66:4357-67. 2006..Our findings reveal a novel strategy for cancer therapy, in which cancer cells are sensitized to DNA-damaging anticancer drugs through inactivation of the MAD2B gene... - Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladderJun Hang Luo
The State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
Cancer Sci 100:896-902. 2009.... - Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinomaNing Fang Ma
Department of Histology and Embryology, Guangzhou Medical College, Guangzhou, China
Hepatology 47:503-10. 2008..Conclusion: These results suggest that ALC1 is the target oncogene within the 1q21 amplicon and plays a pivotal role in HCC pathogenesis... - Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinomaLeiLei Chen
1 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore 3 State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China 4
Nat Med 19:209-16. 2013..Collectively, A→I RNA editing of AZIN1 may be a potential driver in the pathogenesis of human cancers, particularly HCC... - Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumorSiu Tim Cheung
Department of Surgery, Centre for the Study of Liver Disease, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
Cancer Res 62:4711-21. 2002..These metastasis-associated genes may provide clues to reveal patients with increased risk of developing metastasis, and to identify novel therapeutic targets for the treatment of metastasis... - Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approachesLi Fu
Department of Clinical Oncology, University of Hong Kong, Pokfulam, Hong Kong, China
Cancer 110:2672-81. 2007..Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation... - Increased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumorsBetty H Y Chow
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, P R China
Proteomics Clin Appl 3:654-62. 2009..001) and poor prognosis (p<0.001), respectively. Taken together, our findings suggest that ANX-I plays an important role in drug resistance... - Biology of hepatic cancer stem cellsCarol Man Tong
Department of Pathology, Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
J Gastroenterol Hepatol 26:1229-37. 2011..In this review, a detailed summary of the recent progress in liver CSC research with regard to identification, regulation and therapeutic implications will be discussed... - Establishment and characterization of human metastatic hepatocellular carcinoma cell lineJian Ming Wen
Department of Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou, China
Cancer Genet Cytogenet 135:91-5. 2002..The results showed that the hsr was composed of amplified DNA sequences from 11q13. Further characterization of the hsr may lead to the isolation of the putative amplified oncogene at 11q13... - Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cellsWen Deng
Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
Cancer Res 68:7200-9. 2008..These results together suggest an important role of TGF-beta1 in the early process of cervical carcinogenesis... - Transgenic CHD1L expression in mouse induces spontaneous tumorsMuhan Chen
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
PLoS ONE 4:e6727. 2009..The molecular mechanism of CHD1L in tumorigenesis has been associated with its role in promoting cell proliferation... - Chromosome 1q21 amplification and oncogenes in hepatocellular carcinomaLeiLei Chen
Department of Clinical Oncology, The University of Hong Kong, Pokfulam, China
Acta Pharmacol Sin 31:1165-71. 2010..In this review, we will summarize the current scientific knowledge of known target genes within 1q21 amplicon and the precise oncogenic mechanisms of CHD1L will be discussed in detail... - Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthoodSong Lu
Department of Biochemistry, University of Hong Kong, Faculty of Medicine Building, Pokfulam, Hong Kong, China
Neurobiol Dis 45:219-33. 2012.... - Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expressionTerence K Lee
Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Clin Cancer Res 12:5082-9. 2006.... - Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpointZhi Yu Wang
School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
J Ethnopharmacol 133:751-8. 2011..The chinese herb Spatholobus suberectus (SS) is commonly prescribed to cancer patients. In this study, the anti-cancer effect of SS and its molecular mechanisms have been investigated... - Oncogenic transformation by SEI-1 is associated with chromosomal instabilityDong-Jiang Tang
Department of Clinical Oncology, The University of Hong Kong Medical Center, Hong Kong SAR, China
Cancer Res 65:6504-8. 2005..These data strongly suggest that SEI-1 plays an important role in the development and progression of ovarian cancer... - Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infectionJie Zhou
Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Pokfulam, Hong Kong
J Hepatol 51:322-32. 2009..We aimed to elucidate the mechanism by which -3 and/or -408 C/T SNPs had such profound effects... - Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern ChineseYan Li
Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
PLoS ONE 6:e14562. 2011..05). Our study demonstrates that multiple chromosome 6p susceptibility loci contribute to the risk of NPC, possibly though GABBR1 and NEDD9 loss of function... - Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell linesTerence C-M Tang
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
Cancer Res 62:7157-61. 2002..The proliferation-related function of AKT2 and SEI-1 suggests that both genes are likely to be biological targets of an amplification event at 19q13.1 in ovarian cancer and to play important roles in ovarian tumorigenesis... - Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinomaJuan Chen
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, PR China
Chin J Cancer 31:215-22. 2012..In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment... - Role of translationally controlled tumor protein in cancer progressionTim Hon Man Chan
Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Biochem Res Int 2012:369384. 2012..In this paper, we will summarize the current scientific knowledge of TCTP in different aspects, and the precise oncogenic mechanisms of TCTP will be discussed in detail... - Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cellsWen Deng
Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region, China
PLoS ONE 7:e48576. 2012.... - In search of liver cancer stem cellsStephanie Ma
Departments of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Stem Cell Rev 4:179-92. 2008.... - High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapyLi Ru He
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Int J Cancer 127:138-47. 2010..Evaluation of EZH2 expressions might be useful for predicting tumor response to CRT and prognosis for patients with ESCC... - Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinomaGuo qing Wu
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Int J Cancer 125:2631-42. 2009.... - SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomasFang ping Xu
Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
Cancer Lett 245:69-74. 2007..These findings suggest a potential role of SRC-3 in the control of ESCC cell proliferation; such may be responsible, at least in part, for tumorigenesis and/or progression of ESCC... - Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosisYi Wang
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
J Gastroenterol Hepatol 25:1123-8. 2010..We aimed to evaluate the clinical use of serum clusterin levels as a surveillance tool for HCC with hepatitis B virus (HBV) related cirrhosis... - Overexpression of AIB1 predicts resistance to chemoradiotherapy and poor prognosis in patients with primary esophageal squamous cell carcinomaLi Ru He
State Key Laboratory of Oncology in South China, Guangzhou, China
Cancer Sci 100:1591-6. 2009..These findings suggest that overexpression of AIB1 is a useful predictor of CRT resistance and an independent molecular marker of poor prognosis for ESCC patients... - Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarrayYi Wang
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
Cancer 95:2346-52. 2002..CONCLUSIONS: The current results strongly suggest that amplifications of the c-myc and AIB1 oncogenes are late genetic alterations in the progression of HCC and are correlated with a poor prognosis... - Characterization of 3p, 5p, and 3q in two nasopharyngeal carcinoma cell lines, using region-specific multiplex fluorescence in situ hybridization probesWai Mui Tjia
Department of Clinical Oncology, The University of Hong Kong, Room 109, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
Cancer Genet Cytogenet 158:61-6. 2005..M-FISH with CRPs is thus not only useful in revealing a comprehensive picture of structural aberrations in target chromosomes, but also in narrowing down the minimal region for screening cancer-related genes... - Cytogenetic and molecular genetic alterations in hepatocellular carcinomaSze-Hang Lau
Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Acta Pharmacol Sin 26:659-65. 2005..We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed...