Xin Yuan Guan

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Oncogenic role of eIF-5A2 in the development of ovarian cancer
    Xin Yuan Guan
    Department of Clinical Oncology, The University of Hong Kong, People s Republic of China
    Cancer Res 64:4197-200. 2004
  2. doi request reprint Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion
    LeiLei Chen
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Gut 60:534-43. 2011
  3. pmc Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
    Jian Li
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e21816. 2011
  4. pmc Transgenic CHD1L expression in mouse induces spontaneous tumors
    Muhan Chen
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 4:e6727. 2009
  5. pmc Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
    Juan Chen
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, PR China
    Chin J Cancer 31:215-22. 2012
  6. pmc Cell-specific detection of miR-375 downregulation for predicting the prognosis of esophageal squamous cell carcinoma by miRNA in situ hybridization
    Jiangchao Li
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    PLoS ONE 8:e53582. 2013
  7. pmc Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma
    Kai Chen
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e68838. 2013
  8. pmc Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma
    Fajun Xie
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    BMC Cancer 11:86. 2011
  9. pmc Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
    Guo fen Yang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, NO, 651, Dongfeng Road East, 510060 Guangzhou, China
    BMC Cancer 10:133. 2010
  10. ncbi request reprint Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization
    X Y Guan
    Department of Clinical Oncology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Genes Chromosomes Cancer 29:110-6. 2000

Collaborators

  • Dan Xie
  • Yan Li
  • Li Fu
  • Yi Xin Zeng
  • Stephanie Ma
  • Hsiang Fu Kung
  • Yan Ru Qin
  • Yun Fei Yuan
  • Liang Hu
  • Mu Yan Cai
  • Bo Jian Zheng
  • Yi Wang
  • Meng Zhong Liu
  • Annie L M Cheung
  • Jian Dong Huang
  • Jian Ping Chen
  • Jian Wang
  • Irene Oi Lin Ng
  • LeiLei Chen
  • Tim Hon Man Chan
  • Wen Deng
  • Terence K Lee
  • Ying Hui Zhu
  • Kar Lok Kong
  • Sai Wah Tsao
  • Yi Ji Liao
  • Jiangchao Li
  • Li Ru He
  • Jonathan S T Sham
  • Tingting Zeng
  • Yan Fang
  • Kwan Ho Tang
  • Jun Hang Luo
  • Haibo Liu
  • Sui Sui Dong
  • Guo fen Yang
  • Muhan Chen
  • Yongdong Dai
  • Alissa Michelle Go Wong
  • Ning Fang Ma
  • Kwan Man
  • Amy L S Tai
  • Sze Hang Lau
  • Ronnie T P Poon
  • Jiong Bi
  • Lulu Liu
  • Sheung Tat Fan
  • Dora Lai Wan Kwong
  • Dong Jiang Tang
  • Jian Li
  • Zhi Yu Wang
  • Hong Lok Lung
  • Hong Yang
  • Marie C Lin
  • John M Luk
  • Hai Xia Deng
  • Wen Feng Hua
  • Wei Chen
  • Yue Cheng
  • Jian Ming Wen
  • Li Yi Zhang
  • Kai Chen
  • Man Tong
  • Pak Shing Kwan
  • Kwok Wah Chan
  • Jian gang Shen
  • Fajun Xie
  • De po Yang
  • Dong Mei Wang
  • Wai Mui Tjia
  • Wei Peng He
  • Yong Chuan Wong
  • Yue Qiu Tan
  • Ming Tat Ling
  • Shi Juan Mai
  • Xianghong Wang
  • Bin Kui Li
  • Nikki P Lee
  • Hui Lan Rao
  • George Sai Wah Tsao
  • Guo qing Wu
  • Run de Jiang
  • Kok Lung Chan
  • Anthony P Yuen
  • Hiu Wing Cheung
  • Yinghui Zhu
  • Janice Wing Hang Tsang
  • Yuen Piu Chan
  • Chung Mau Lo
  • Si Lok

Detail Information

Publications148 found, 100 shown here

  1. ncbi request reprint Oncogenic role of eIF-5A2 in the development of ovarian cancer
    Xin Yuan Guan
    Department of Clinical Oncology, The University of Hong Kong, People s Republic of China
    Cancer Res 64:4197-200. 2004
    ..These findings suggest that eIF-5A2 plays important roles in ovarian pathogenesis...
  2. doi request reprint Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion
    LeiLei Chen
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Gut 60:534-43. 2011
    ....
  3. pmc Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
    Jian Li
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e21816. 2011
    ..The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC)...
  4. pmc Transgenic CHD1L expression in mouse induces spontaneous tumors
    Muhan Chen
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 4:e6727. 2009
    ..The molecular mechanism of CHD1L in tumorigenesis has been associated with its role in promoting cell proliferation...
  5. pmc Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma
    Juan Chen
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, PR China
    Chin J Cancer 31:215-22. 2012
    ..In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment...
  6. pmc Cell-specific detection of miR-375 downregulation for predicting the prognosis of esophageal squamous cell carcinoma by miRNA in situ hybridization
    Jiangchao Li
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    PLoS ONE 8:e53582. 2013
    ..Our results demonstrated that MISH is a useful and reliable tool to study miRNA expression in solid tumors. Downregulation of miR-375 can be used as a biomarker to predict the outcome of ESCC...
  7. pmc Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma
    Kai Chen
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e68838. 2013
    ..Silencing CRNN expression by RNA interference could effectively inhibit its tumor suppressive effect. In conclusion, our findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. ..
  8. pmc Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma
    Fajun Xie
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    BMC Cancer 11:86. 2011
    ..The aim of this study is to investigate the role of GPR39 in human esophageal cancer development, and to examine the prevalence and clinical significance of GPR39 overexpression in ESCC...
  9. pmc Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
    Guo fen Yang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, NO, 651, Dongfeng Road East, 510060 Guangzhou, China
    BMC Cancer 10:133. 2010
    ....
  10. ncbi request reprint Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization
    X Y Guan
    Department of Clinical Oncology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Genes Chromosomes Cancer 29:110-6. 2000
    ..The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression...
  11. ncbi request reprint Characterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissection
    Xin Yuan Guan
    Department of Clinical Oncology, The University of Hong Kong, Room 122, Professorial Block, Pokfulam Road, Hong Kong, China
    Cancer Genet Cytogenet 134:65-70. 2002
    ..Further characterizations of the breakpoint at 6q16 and molecular cloning breakpoints at 6q27 and 17p13 are in progress...
  12. ncbi request reprint Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma
    Xin Yuan Guan
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer Genet Cytogenet 140:45-8. 2003
    ..3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development...
  13. ncbi request reprint Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer
    X Y Guan
    Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong
    Cancer Res 61:3806-9. 2001
    ..The proliferation-related function of eIF-5A supports that eIF-5A2 is a candidate oncogene related to the development of ovarian cancer...
  14. doi request reprint EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients
    Zhi Yue Rao
    The State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, 510060 Guangzhou, China
    Carcinogenesis 31:1576-83. 2010
    ....
  15. doi request reprint Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma
    Kar Lok Kong
    Department of Clinical Oncology and Center for Cancer Research and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong
    Cancer Res 70:8832-41. 2010
    ..0001). Indeed, multivariate cyclooxygenase regression analysis showed that UPK1A was an independent prognostic factor for overall survival. Taken together, our findings define a function for UPK1A as an important TSG in ESCC development...
  16. pmc CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients
    LeiLei Chen
    Department of Clinical Oncology, University of Hong Kong, China
    J Clin Invest 120:1178-91. 2010
    ..These findings suggest that CHD1L-ARHGEF9-Cdc42-EMT might be a novel pathway involved in HCC progression and metastasis...
  17. doi request reprint Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma
    Ying Hui Zhu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 73:2298-309. 2013
    ..Taken together, our results revealed that DIRAS1 has a pivotal function in ESCC pathogenesis, with possible use as a biomarker and intervention point for new therapeutic strategies...
  18. ncbi request reprint Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma
    Dan Xie
    Cancer Center, Sun Yat Sen University, Guangzhou 510275, China
    Hum Pathol 36:777-83. 2005
    ..These findings suggest a possible convergence of AIB1 with a pathway involving p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs...
  19. ncbi request reprint Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Gastroenterology 132:2542-56. 2007
    ..The aim of this study is to identify, isolate, and characterize the CSC population that drives and maintains hepatocellular carcinoma (HCC) growth and metastasis...
  20. doi request reprint A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Cancer Res 73:2322-32. 2013
    ..Our results prompt further study of this CD90(+) population of esophageal TICs as potential therapeutic targets...
  21. ncbi request reprint Up-regulated expression of cytoplasmic clusterin in human ovarian carcinoma
    Dan Xie
    Department of Pathology, Zhong Shan Medical College, Sun Yat Sen University, Guangzhou, China
    Cancer 103:277-83. 2005
    ..Recently, tumorigenic roles of the clusterin gene in several human malignancies have been suggested, but its potential role in the development and progression of ovarian carcinoma is unclear...
  22. ncbi request reprint Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma
    Ming Liu
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Gastroenterology 146:1084-96. 2014
    ..We used RNA sequence analysis to search for genetic variations associated with pathogenesis of hepatocellular carcinoma (HCC)...
  23. doi request reprint Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma
    Stephanie Ma
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Gastroenterology 143:675-86.e1-12. 2012
    ..We searched for transcripts that were altered in human ESCC samples compared with nontumor tissues...
  24. doi request reprint Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival
    Jun Hang Luo
    The State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Int J Cancer 122:2554-61. 2008
    ..Thus, these findings provide evidence that an overexpression of AIB1, as detected by immunohistochemistry, is an independent molecular marker for poor prognosis (shortened survival time) of patients with UC...
  25. doi request reprint Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma
    Alissa Michelle Go Wong
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Int J Cancer 133:2284-95. 2013
    ..Our study also warrants further exploration in the potential therapeutic use of existing epigenetic targeting drugs (e.g., 5-azacytidine, SAHA) to reconstitute CACNA2D3-associated tumor suppression in NPC. ..
  26. ncbi request reprint Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling
    Lulu Liu
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Hepatology 59:531-43. 2014
    ..Functional study demonstrated that overexpression of MAEL increased self-renewal, chemoresistance, and tumor metastasis...
  27. ncbi request reprint Oncogenic transformation by SEI-1 is associated with chromosomal instability
    Dong Jiang Tang
    Department of Clinical Oncology, The University of Hong Kong Medical Center, Hong Kong SAR, China
    Cancer Res 65:6504-8. 2005
    ..These data strongly suggest that SEI-1 plays an important role in the development and progression of ovarian cancer...
  28. doi request reprint MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN
    Li Yi Zhang
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Carcinogenesis 34:454-63. 2013
    ..Taken together, we provide compelling evidence that miR-144 functions as an onco-miRNA in NPC, and its oncoeffects are mediated chiefly by repressing PTEN expression to activate the PI3K/Akt pathway...
  29. doi request reprint Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma
    Dong Jiang Tang
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Hepatology 51:1255-63. 2010
    ..Conclusion: EIF5A2 plays an important role in HCC invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1...
  30. pmc CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival
    Wei Peng He
    Department of Gynecology, The First Affiliated Hospital, Sun Yat Sen University, NO, 78, Zhongshan Road II, 510080 Guangzhou, China
    BMC Cancer 12:437. 2012
    ..However, the status of CHD1L protein expression in ovarian cancer and its clinical/prognostic significance are obscure...
  31. pmc H3K27me3 protein is a promising predictive biomarker of patients' survival and chemoradioresistance in human nasopharyngeal carcinoma
    Mu Yan Cai
    State Key Laboratory of Oncology in South China Department of Pathology, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Mol Med 17:1137-45. 2011
    ..The combined clinicopathologic prognostic model may become a useful tool for identifying NPC patients with different clinical outcomes...
  32. doi request reprint Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    Stephanie Ma
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Cancer Res 6:1146-53. 2008
    ..ALDH, expressed along CD133, can more specifically characterize the tumorigenic liver CSC population...
  33. doi request reprint Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition
    Wei Zhu
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Gut 61:562-75. 2012
    ..In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms...
  34. ncbi request reprint Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray
    Dan Xie
    Department of Clinical Oncology, 1 F Building, School of Chinese Medicine, University of Hong Kong, 10 Sassoon Road, Hong Kong, China
    Int J Cancer 107:896-902. 2003
    ..05) but not in other pathologic regions of CRCs, suggesting that the tumor microenvironment in different pathologic loci of colorectal tumorigenesis and progression may influence c-myc responsiveness to beta-catenin/Tcf activation...
  35. ncbi request reprint Establishment of cell lines from a primary hepatocellular carcinoma and its metastatis
    Liang Hu
    Department of Clinical Oncology, The University of Hong Kong, Room 109, 1 F, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
    Cancer Genet Cytogenet 148:80-4. 2004
    ..These cell lines provide a very useful tool to identify genetic alterations associated with HCC metastasis...
  36. ncbi request reprint SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas
    Fang ping Xu
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Cancer Lett 245:69-74. 2007
    ..These findings suggest a potential role of SRC-3 in the control of ESCC cell proliferation; such may be responsible, at least in part, for tumorigenesis and/or progression of ESCC...
  37. ncbi request reprint Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model
    Terence K Lee
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 67:8800-9. 2007
    ..Our results suggest that lupeol may be an effective agent either alone or in combination for treatment of advanced tumors...
  38. doi request reprint High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
    Li Ru He
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 127:138-47. 2010
    ..Evaluation of EZH2 expressions might be useful for predicting tumor response to CRT and prognosis for patients with ESCC...
  39. ncbi request reprint Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma
    Terence K Lee
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 12:6910-9. 2006
    ..Recently, Id-1 (inhibitor of differentiation/DNA synthesis) has been suggested to be a key factor in cancer progression but the molecular mechanism remains unknown...
  40. ncbi request reprint Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma
    Li Fu
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 67:10720-6. 2007
    ..014), which was associated with its function in increasing cell adhesion and inhibiting cell mobility. Taken together, our results suggest that PLC delta 1 plays an important suppressive role in the development and progression of ESCC...
  41. ncbi request reprint Up-regulation of fibroblast growth factor 3 is associated with tumor metastasis and recurrence in human hepatocellular carcinoma
    Liang Hu
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Lett 252:36-42. 2007
    ..TMA study showed that overexpression of FGF3 was significantly associated with HCC metastasis and recurrence (p<0.01), suggesting that up-regulation of FGF3 may play an important role in HCC metastasis and recurrence...
  42. ncbi request reprint Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines
    Terence C M Tang
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer Res 62:7157-61. 2002
    ..The proliferation-related function of AKT2 and SEI-1 suggests that both genes are likely to be biological targets of an amplification event at 19q13.1 in ovarian cancer and to play important roles in ovarian tumorigenesis...
  43. doi request reprint The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
    Fang Zheng
    The State Key Laboratory of Oncology in South China, Sun Yat Sen University, Guangzhou, China
    Gut 61:278-89. 2012
    ..Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC)...
  44. doi request reprint Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 70:5695-705. 2010
    ..Taken together, these findings define a novel mechanism of genomic instability and malignant progression in esophageal cancers, a deadly disease of increasing incidence in developed countries...
  45. doi request reprint Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma
    Nikki P Lee
    Department of Surgery and Center for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong
    Int J Cancer 127:968-76. 2010
    ....
  46. doi request reprint Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway
    Li Fu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Gut 60:1635-43. 2011
    ..This study aimed to investigate the effect of TF-secreted Wnt2 in OSCC development via the tumour-stroma interaction...
  47. ncbi request reprint Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma
    Ying Hui Zhu
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
    Carcinogenesis 35:1154-61. 2014
    ..Taken together, our study revealed that LGI1 plays an important tumor suppressive role in the development and progression of ESCC, with possible application in clinics as a biomarker and a potential new therapeutic target. ..
  48. ncbi request reprint Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
    Amy L S Tai
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer 106:146-55. 2006
    ..Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) was established...
  49. ncbi request reprint Recurrent chromosomal imbalances in nonsmall cell lung carcinoma: the association between 1q amplification and tumor recurrence
    Amy L S Tai
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer 100:1918-27. 2004
    ..To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features...
  50. ncbi request reprint Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma
    Yan Ru Qin
    Authors Affiliations Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou State Key Laboratory of Oncology in Southern China, Sun Yat Sen University Cancer Centre Key Laboratory for Major Obstetric Disease of Guangdong Province, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Department of Clinical Oncology, Nanyang city first people s hospital, Henan Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China and Cancer Science Institute of Singapore, National University of Singpaore, Singapore
    Cancer Res 74:840-51. 2014
    ..Our findings reveal that altered gene-specific A-to-I editing events mediated by ADAR1 drive the development of ESCC, with potential implications in diagnosis, prognosis, and treatment of this disease...
  51. doi request reprint CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
    ..Further, in its role as a liver TIC marker CD133 also plays a functional part in regulating tumorigenesis of liver TICs by way of regulating NTS, IL-8, CXCL1, and MAPK signaling...
  52. doi request reprint Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy
    Wei Chen
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Epidemiol Biomarkers Prev 18:400-8. 2009
    ..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in urothelial carcinoma of the bladder (UC) are unclear...
  53. ncbi request reprint COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis
    Ning Fang Ma
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, 651 East Dongfeng Road, Guangzhou, China
    Clin Cancer Res 14:5061-8. 2008
    ..Based on observations that the COOH-terminal truncated HBx was frequently detected in HCC, the aim of this study is to evaluate the function of COOH-terminal truncated HBx in hepatocarcinogenesis...
  54. ncbi request reprint Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma
    Dan Xie
    The State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Hum Pathol 39:80-6. 2008
    ..05). These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression...
  55. doi request reprint Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage
    Meng Zhong Liu
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Am J Clin Pathol 129:728-34. 2008
    ..05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype...
  56. pmc RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis
    Juan Chen
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 7:e44636. 2012
    ..Taken together, our findings define a function for RBMS3 as an important tumor suppressor gene in NPC...
  57. doi request reprint Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma
    Yan Ru Qin
    Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    Clin Cancer Res 17:46-55. 2011
    ..The aim of this study is to investigate the role of SOX6 in human esophageal cancer development, and to examine the prevalence and clinical significance of SOX6 downregulation in ESCC...
  58. doi request reprint miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    Stephanie Ma
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cell Stem Cell 7:694-707. 2010
    ..Silencing TP53INP1 in CD133⁻ cells enhanced both self renewal and tumorigenicity in vivo. Collectively, miR-130b regulates CD133(+) liver TICs, in part, via silencing TP53INP1...
  59. pmc Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
    Li Ru He
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    BMC Cancer 9:461. 2009
    ..We wished to ascertain whether a correlation exists between the expression of H3K27me3 and clinical outcome in a group of patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT)...
  60. ncbi request reprint Association of Vimentin overexpression and hepatocellular carcinoma metastasis
    Liang Hu
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Oncogene 23:298-302. 2004
    ..01). This finding strongly suggests that the overexpression of VIM may play an important role in the metastasis of HCC...
  61. doi request reprint Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma
    Guo qing Wu
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 125:2631-42. 2009
    ....
  62. ncbi request reprint Establishment and characterization of a human non-small cell lung cancer cell line
    Amy Lai Shan Tai
    Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, P R China
    Oncol Rep 13:1029-32. 2005
    ..This cell line may thus provide a useful cellular resource for studying the pathogenesis of SCC of the lung in the future...
  63. ncbi request reprint Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
    Xianghong Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Oncogene 23:474-82. 2004
    ..Our evidence provides a therapeutic strategy to overcome acquired resistance through inactivation of TWIST expression in human cancer...
  64. doi request reprint Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma
    Guo fen Yang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Gynecol Oncol 112:314-8. 2009
    ..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear...
  65. ncbi request reprint Recurrent chromosome alterations in primary ovarian carcinoma in Chinese women
    Jonathan S T Sham
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer Genet Cytogenet 133:39-44. 2002
    ..The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes involved in the development and progression of ovarian cancer...
  66. ncbi request reprint Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma
    Yan Ru Qin
    Department of Clinical Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    Int J Cancer 123:826-30. 2008
    ..Our findings provided evidence that minimal deleted regions at 3p26.3, 3p22, 3p21.3 and 3p14.2 containing potential TSGs may contribute to the pathogenesis of esophageal cancer...
  67. doi request reprint SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice
    Yan Li
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Gastroenterology 144:179-191.e4. 2013
    ..Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) is up-regulated by CHD1L; we investigated its role in hepatocellular carcinogenesis...
  68. doi request reprint Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma
    Li Fu
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Hepatology 51:1624-34. 2010
    ..Further study found that the tumor suppressive mechanism of TAT was associated with its proapoptotic role in a mitochondrial-dependent manner by promoting cytochrome-c release and activating caspase-9 and PARP...
  69. doi request reprint Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma
    Chunyu Zhang
    Department of Surgery, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Clin Cancer Res 15:4017-27. 2009
    ..The aim of the present study was to investigate the specific role of TF in the esophageal cancer microenvironment...
  70. ncbi request reprint Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma
    Terence K Lee
    Department of Surgery, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Cancer Lett 254:308-15. 2007
    ..Fascin was negatively correlated with E-cadherin expression (p=0.018, r=-0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression...
  71. ncbi request reprint Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray
    Yi Wang
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer 95:2346-52. 2002
    ..1, and AIB1 at 20q12 are genetic alterations that are detected frequently in hepatocellular carcinoma (HCC). The authors evaluated the association of these amplifications with the prognosis of patients with HCC...
  72. ncbi request reprint Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Hum Pathol 38:1201-6. 2007
    ..Elevated MIM-B expression may influence the development of hepatocellular carcinoma and may possibly be a powerful indicator for the disease at an early stage...
  73. ncbi request reprint Cytogenetic and molecular genetic alterations in hepatocellular carcinoma
    Sze Hang Lau
    Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Acta Pharmacol Sin 26:659-65. 2005
    ..We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed...
  74. ncbi request reprint Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis
    Irene Oi Lin Ng
    Department of Pathology, The University of Hong Kong, Faculty of Medicine, Queen Mary Hospital, Hong Kong
    J Pathol 199:345-53. 2003
    ..Of these molecular methods, LOH analysis can be used to evaluate tumour clonality in most patients even before surgical resection, since this assay can be readily applied routinely to either liver biopsies or fine needle aspirates...
  75. doi request reprint Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma
    Man Tong
    Department of Pathology, Genome Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Cancer Res 72:6024-35. 2012
    ..Further characterization of Rab25 may provide a prognostic biomarker for ESCC outcome prediction and a novel therapeutic target in ESCC treatment...
  76. doi request reprint Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development
    Tim Hon Man Chan
    State Key Laboratory for Liver Research, Sun Yat sen University Cancer Center, Guangzhou, China
    Hepatology 55:491-505. 2012
    ..The depletion experiment proved that the tumorigenicity of TCTP was linked to its role in mitotic defects...
  77. doi request reprint MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, Hong Kong
    Cancer Res 71:583-92. 2011
    ..Taken together, our findings define a functional involvement for miR-616 and TFPI-2 in the development and maintenance of androgen-independent prostate cancer...
  78. doi request reprint Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 71:6106-15. 2011
    ..Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease...
  79. ncbi request reprint High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers
    Amy L S Tai
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer Res 66:4133-8. 2006
    ..3, CLASP2 at 3p23, and CACNA2D3 at 3p21.1. This study also showed that SMSG technology is a very useful approach to rapidly define the minimal deleted region and to identify target TSGs in a given cancer...
  80. ncbi request reprint Generation of a complete set of human telomeric band painting probes by chromosome microdissection
    Liang Hu
    Department of Clinical Oncology, The University of Hong Kong, Room 109, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
    Genomics 83:298-302. 2004
    ..2. Further application of these TBPs should greatly facilitate the cytogenetic analysis of complex chromosome rearrangements involving telomeric bands...
  81. doi request reprint MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor
    Kar Lok Kong
    Department of Clinical Oncology, University of Hong Kong, Hong Kong, China
    Gut 61:33-42. 2012
    ..To understand the involvement of micro-RNA (miRNA) in the development and progression of oesophageal squamous cell carcinoma (ESCC), miRNA profiles were compared between tumour and corresponding non-tumour tissues...
  82. doi request reprint DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, Hong Kong
    Int J Cancer 124:2323-32. 2009
    ..Further, overexpression of SOX5 is associated with prostate tumor progression and early development of distant metastasis...
  83. doi request reprint LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
    Zhi Yu Wang
    School of Chinese Medicine, The University of Hong Kong, Estates Building, 10 Sassoon Road, Hong Kong, China
    Breast Cancer Res Treat 131:791-800. 2012
    ..Our results suggested that LDH-A inhibition might offer a promising therapeutic strategy for breast cancer...
  84. pmc Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
    Jian Wang
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e24967. 2011
    ..Taken together, our data suggested that CTSZ was a candidate oncogene within the 20q13 amplicon and it played an important role in HCC metastasis...
  85. doi request reprint Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins
    Zhiyu Wang
    School of Chinese Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Biol Ther 13:138-47. 2012
    ..In conclusion, we suggest that PRDX1 and PRDX6 are key targets in the process of dioscin-induced apoptosis that involves intracellular elevated ROS...
  86. doi request reprint Establishment and characterization of human non-small cell lung cancer cell lines
    Jiangchao Li
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou 510060, PR China
    Mol Med Rep 5:114-7. 2012
    ..These newly established cell lines may serve as useful models for studying the molecular pathogenesis of NSCLC...
  87. pmc High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients
    Mu Yan Cai
    Department of Pathology, Sun Yat sen University Cancer Center, Guangzhou, China
    Mol Med 17:12-20. 2011
    ..05). Thus, these findings provide evidence that a high expression of H3K27me3, as detected by IHC, correlates closely with vascular invasion of HCCs and is an independent molecular marker for poor prognosis in patients with HCC...
  88. ncbi request reprint Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines
    Wen Deng
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Oncogene 23:9090-101. 2004
    ....
  89. ncbi request reprint Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis
    Yi Wang
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Oncogene 23:142-8. 2004
    ..This finding suggests that 3'-deleted X gene caused by the HBV integration may play an important role in the HCC development...
  90. pmc Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
    LeiLei Chen
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Nat Med 19:209-16. 2013
    ..Collectively, A→I RNA editing of AZIN1 may be a potential driver in the pathogenesis of human cancers, particularly HCC...
  91. pmc Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region, China
    PLoS ONE 7:e48576. 2012
    ....
  92. pmc Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability
    Muhan Chen
    Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    BMC Cancer 11:199. 2011
    ..In the present study, we aim to investigate the physiological and pathological effect of eIF-5A2 in an eIF-5A2 transgenic mouse model...
  93. ncbi request reprint Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival
    LeiLei Chen
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatology 50:122-9. 2009
    ..Conclusion: We demonstrate in this study that overexpression of CHD1L could sustain tumor cell survival by preventing Nur77-mediated apoptosis...
  94. ncbi request reprint High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma
    Kok Lung Chan
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Hum Pathol 35:1324-31. 2004
    ..Although c-myc was amplified in HCC, there appears to be a tight regulation by independent pathways of c-myc activation in hepatocarcinogenesis...
  95. ncbi request reprint Establishment and characterization of a human cholangiocarcinoma cell line
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, University Pathology Building, Hong Kong, P R China
    Oncol Rep 18:1195-200. 2007
    ..This newly established cell line should serve as a useful model for studying the molecular pathogenesis of CC...
  96. ncbi request reprint Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    Terence K Lee
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 12:5369-76. 2006
    ..However, the actual role of Twist in tumor invasiveness remains unclear. The purpose of this study is to investigate the expression and possible role of Twist in HCC...
  97. ncbi request reprint Role of short telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: A combined telomere quantitative fluorescence in situ hybridization and whole-chromosome painting study
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Genes Chromosomes Cancer 37:92-7. 2003
    ..Our findings suggest that nonrandom chromosome aberrations in HOSE cells occurring before cellular immortalization could be caused by the telomere length heterogeneity...
  98. ncbi request reprint Significance of TWIST expression and its association with E-cadherin in bladder cancer
    Zheng Zhang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Hum Pathol 38:598-606. 2007
    ..Our results demonstrate TWIST as a novel positive factor in the development and progression of bladder cancer and suggest a marker for advanced bladder cancer...
  99. doi request reprint Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma
    Ming Liu
    Department of Clinical Oncology, University of Hong Kong, Hong Kong, China
    Hepatology 55:1754-65. 2012
    ..Further characterization of SGK3 may provide a prognostic biomarker for HCC outcome prediction and a novel therapeutic target in HCC treatment...
  100. ncbi request reprint Comparative proteomic analysis of the esophageal squamous carcinoma cell line EC109 and its multi-drug resistant subline EC109/CDDP
    Jing Wen
    Department of Thoracic Oncology, Cancer Center, Sun Yat Sen University, Guangzhou 510060, P R China
    Int J Oncol 36:265-74. 2010
    ..Our present results lay foundation for future in-depth work on molecular mechanism of ESCC drug resistance, and aid in the identification and use of novel markers in clinical practice...
  101. doi request reprint Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs
    Alissa Michelle Go Wong
    Department of Clinical Oncology and Center for Cancer Research, University of Hong Kong, Pokfulam, Hong Kong
    Cancer 118:698-710. 2012
    ..A proposed network of genes targeted by these microRNAs could also shed light on EBV-associated tumorigenesis...