Affiliation: University of Macau
Zhang Y, Zhang Z, Ge W. An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing. J Biol Chem. 2018;293:6611-6622 pubmed publisher
..In summary, we have developed an efficient procedure for creating point mutations and differentiating mutant individuals from those carrying knockouts of entire genes. ..
Zhou R, Yu S, Ge W. Expression and functional characterization of intrafollicular GH-IGF system in the zebrafish ovary. Gen Comp Endocrinol. 2016;232:32-42 pubmed publisher
..In conclusion, the present study revealed an intrafollicular network involving GH-IGF mini-axis in the zebrafish ovary; however, it might not work in the same way as that of the systemic somatotrophic axis. ..
Chen W, Lau S, Fan Y, Wu R, Ge W. Juvenile exposure to bisphenol A promotes ovarian differentiation but suppresses its growth - Potential involvement of pituitary follicle-stimulating hormone. Aquat Toxicol. 2017;193:111-121 pubmed publisher
..Our data in the zebrafish suggest that sex differentiation involves estrogens and it is a sensitive window for evaluating estrogenic activities of compounds and their impacts on wildlife reproduction...
Liu K, Lau S, Ge W. Spatiotemporal expression analysis of nuclear estrogen receptors in the zebrafish ovary and their regulation in vitro by endocrine hormones and paracrine factors. Gen Comp Endocrinol. 2017;246:218-225 pubmed publisher
..Our present study suggests that nERs, especially esr2a, provide potential target points for other hormones and factors to modulate E2 activity during folliculogenesis in the zebrafish. ..
Zhu B, Ge W. Genome editing in fishes and their applications. Gen Comp Endocrinol. 2018;257:3-12 pubmed publisher
Sun M, Wang Y, Zhang Q, Xia Y, Ge W, Guo D. Prediction of reversible disulfide based on features from local structural signatures. BMC Genomics. 2017;18:279 pubmed publisher
..A web server named RevssPred can be accessed freely from: http://biocomputer.bio.cuhk.edu.hk/RevssPred . ..