Research Topics
Species | M L FungSummaryAffiliation: University of Hong Kong Country: China Publications
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Detail Information
Publications
Pontine cholinergic respiratory depression in neonatal and young ratsM L Fung
Department of Physiology, The University of Hong Kong
Life Sci 62:2249-56. 1998..The site of injection in the pontine reticular formation was confirmed by histology. Results suggest that cholinergic mechanisms in the medial pons depress respiratory activity in the neonate...- Forskolin fails to activate L-type calcium current in hypertrophied cardiomyocytes of chronically hypoxic ratsMan Lung Fung
Department of Physiology, Institute of Cardiovascular Science and Medicine, University of Hong Kong, Pokfulam, People s Republic of China
Life Sci 70:1801-9. 2002..The failure of activation of the Ca2+ current is consistent with the idea that adenylyl cyclase function is down-regulated in CH hypertrophied myocytes... - Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia?Man Lung Fung
Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong, China
Curr Drug Targets Cardiovasc Haematol Disord 3:254-9. 2003..In addition, HIF-1-targeted genes are expressed in the carotid body and the expression is modulated by chronic hypoxemia, suggesting an active role for HIF-1 in moderate levels of hypoxic stress... - Absence of MK801-induced inspiratory prolongation in chronically hypoxic ratsM L Fung
Department of Physiology, University of Hong Kong, Pokfulam
Life Sci 69:2319-26. 2001..Results suggest that brainstem mechanisms underlying inspiratory termination mediated by NMDA receptors are modulated by early chronic hypoxia... - Functional expression of angiotensin II receptors in type-I cells of the rat carotid bodyM L Fung
Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Pokfulam, SAR
Pflugers Arch 441:474-80. 2001..It is concluded that angiotensin II modulates carotid body chemoreceptor function directly via AT1 receptors in the type-I cell... - Role of voltage-gated Na+ channels in hypoxia-induced neuronal injuriesM L Fung
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam
Clin Exp Pharmacol Physiol 27:569-74. 2000..These improve the ionic homeostasis and cellular energy levels and, thus, prevent hypoxia-induced neuronal injury and neuronal damage mediated by Ca2+ overload... - Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid bodyP S Leung
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
J Endocrinol 167:517-24. 2000..This might be important in the modulation of cardiorespiratory functions as well as fluid and electrolyte homeostasis during chronic hypoxia... 
Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic ratsH M Yeung
Department of Physiology, University of Hong Kong, Hong Kong SAR, China
J Pineal Res 45:373-82. 2008..The results suggest that melatonin is cardioprotective against CH-induced myocardial injury by improving calcium handling in the SR of cardiomyocytes via an antioxidant mechanism...- Role of HIF-1 in physiological adaptation of the carotid body during chronic hypoxiaMan-Lung Fung
Department of Physiology, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
Adv Exp Med Biol 536:593-601. 2003 - Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymisP S Leung
Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
Regul Pept 96:143-9. 2001..It was concluded that chronic hypoxia decreases the transcriptional and translational expression of angiotensinogen, and thus local formation of angiotensin II, in the rat epididymis... - Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD)G L Tipoe
Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
Histol Histopathol 24:1161-9. 2009..We propose that female rats fed with a diet containing highly unsaturated fatty acids are an extremely useful model for the study of NAFLD... - Upregulation of erythropoietin and its receptor expression in the rat carotid body during chronic and intermittent hypoxiaS Y Lam
Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong, China
Adv Exp Med Biol 648:207-14. 2009..The increased EPO binding to its receptor might play a role in the enhancement of CB excitability during the early pathogenesis in patients with sleep-disordered breathing... - Expression and functions of vasoactive substances regulated by hypoxia-inducible factor-1 in chronic hypoxemiaGeorge L Tipoe
Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Cardiovasc Hematol Agents Med Chem 4:199-218. 2006..In conclusion, the adaptive response to long-term hypoxemia involves compensatory mechanisms mediated by expressing significant levels of HIF-1alpha and vasoactive substances regulated by HIF-1... - Acute hypoxia elevates nitric oxide generation in rat carotid body in vitroM L Fung
Department of Medicine, University of Hong Kong, Pokfulam
Pflugers Arch 442:903-9. 2001..Hence, NO may play an active inhibitory role in the control of carotid chemoreceptor activity during hypoxia... - Expression of HIF-1alpha, VEGF and VEGF receptors in the carotid body of chronically hypoxic ratGeorge L Tipoe
Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong
Respir Physiol Neurobiol 138:143-54. 2003..Hence, HIF-1 may activate the expression of VEGF and VEGFR-1 in the CB and the expression of VEGF in the chemoreceptors may play a paracrine role in the vascular remodeling during chronic hypoxia... - Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: an involvement of constitutive and inducible nitric oxide synthasesJian Shan Ye
Department of Medicine, Faculty of Medicine, University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong
Pflugers Arch 444:178-85. 2002..The enhancement of NO generation may play a physiological role in blunting the hypoxic chemosensitivity during chronic hypoxia... - Attenuated "cross talk" between kappa-opioid receptors and beta-adrenoceptors in the heart of chronically hypoxic ratsJian Shan
Department of Physiology, Faculty of Medicine, The University of Hong Kong, SAR, China
Pflugers Arch 444:126-32. 2002..The attenuation may be due to decreased responses of Gs-protein and adenylyl cyclase to kappa-opioid receptor activation in addition to desensitization of the receptor itself... - Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxiaSiu Yin Lam
Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong, China
Histol Histopathol 23:271-80. 2008..This differential regulation of the HIF-alpha subtypes and pathways could account for the morphological and neurochemical discrepancy in the CB responses to IH and CH... - Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protectionGeorge L Tipoe
Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
Cardiovasc Hematol Disord Drug Targets 7:135-44. 2007..Green tea is proposed to be a dietary supplement in the prevention of cardiovascular diseases in which oxidative stress and proinflammation are the principal causes... - Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expressionYueping Chen
Department of Physiology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong
Pflugers Arch 443:565-73. 2002..The enhancement of the paracrine/autocrine effect of ET-1 on the chemoreceptors is consistent with an excitatory and mitogenic role of the ET-1 and ETA receptor in the CB during chronic hypoxia... - Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxiaY W Tjong
Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
J Pineal Res 44:234-43. 2008..Collectively, these results suggest that melatonin ameliorates the constitutive NO production and BK channel activity via an antioxidant mechanism against an IH-induced down-regulation of nNOS expression in hippocampal neurons... - Expression of HIF-2alpha and HIF-3alpha in the rat carotid body in chronic hypoxiaSiu-Yin Lam
Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
Adv Exp Med Biol 580:29-36; discussion 351-9. 2006 - Nitric oxide deficit in chronic intermittent hypoxia impairs large conductance calcium-activated potassium channel activity in rat hippocampal neuronsYung Wui Tjong
Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Free Radic Biol Med 44:547-57. 2008.... - Hypoxia-inducible factor (HIF)-1alpha and endothelin-1 expression in the rat carotid body during intermittent hypoxiaSiu-Yin Lam
Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
Adv Exp Med Biol 580:21-7; discussion 351-9. 2006 - Elevated endogenous nitric oxide increases Ca2+ flux via L-type Ca2+ channels by S-nitrosylation in rat hippocampal neurons during severe hypoxia and in vitro ischemiaYung Wui Tjong
Department of Physiology, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
Free Radic Biol Med 42:52-63. 2007..Taken together, the results suggest that an elevated endogenous NO production enhances the influx of Ca(2+) via the hippocampal L-type Ca(2+) channel by S-nitrosylation during an initial phase of energy deprivation... - Chronic hypoxia modulates the function and expression of melatonin receptors in the rat carotid bodyYung-Wui Tjong
Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong, China
J Pineal Res 40:125-34. 2006..Taken together, our results suggest an upregulation of the carotid expression of melatonin receptors by chronic hypoxia, which modulates the carotid response to melatonin for the circadian influence on breathing... - Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injuryG L Tipoe
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR
Histol Histopathol 21:1157-65. 2006.... - Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid bodySiu Yin Lam
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
J Appl Physiol 96:809-13. 2004..This may be important in the modulation of cardiopulmonary adaptation in the hypoxic ventilatory response as well as for electrolyte and water homeostasis during chronic hypoxia... - Melatonin enhances the hypoxic response of rat carotid body chemoreceptorYueping Chen
Department of Physiology, University of Hong Kong, Hong Kong, China
J Pineal Res 38:157-63. 2005..Hence, the circadian rhythm of melatonin in arterial blood can modulate the carotid chemoreceptor response to hypoxia. This modulation may be a physiological mechanism involved in the day-light differences in ventilatory activities... - Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxiaMing Wai Hung
Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
J Pineal Res 44:214-21. 2008.... 
Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosisTung Ming Leung
Department of Pathology and Laboratory Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
Int J Exp Pathol 89:241-50. 2008..Our results showed that the reduced eNOS expression in CCl(4)-treated mice was reversed by L-arginine. Furthermore, L-arginine also reversed the reduced AP-1 activity, an eNOS promoter...- Nitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neuronsKuihuan Jian
Department of Anatomy and Neurobiology, Southern Medical University, Guangzhou 510515, China
Biochem Biophys Res Commun 359:481-5. 2007..Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current...