M L Fung

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc Carotid Body AT(4) Receptor Expression and its Upregulation in Chronic Hypoxia
    Man Lung Fung
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong
    Open Cardiovasc Med J 1:1-7. 2007
  2. pmc Increased endogenous nitric oxide release by iron chelation and purinergic activation in the rat carotid body
    Man Lung Fung
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong, China
    Open Biochem J 1:1-6. 2007
  3. ncbi request reprint Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia?
    Man Lung Fung
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 3:254-9. 2003
  4. ncbi request reprint Forskolin fails to activate L-type calcium current in hypertrophied cardiomyocytes of chronically hypoxic rats
    Man Lung Fung
    Department of Physiology, Institute of Cardiovascular Science and Medicine, University of Hong Kong, Pokfulam, People s Republic of China
    Life Sci 70:1801-9. 2002
  5. ncbi request reprint Pontine cholinergic respiratory depression in neonatal and young rats
    M L Fung
    Department of Physiology, The University of Hong Kong
    Life Sci 62:2249-56. 1998
  6. ncbi request reprint Absence of MK801-induced inspiratory prolongation in chronically hypoxic rats
    M L Fung
    Department of Physiology, University of Hong Kong, Pokfulam
    Life Sci 69:2319-26. 2001
  7. ncbi request reprint Functional expression of angiotensin II receptors in type-I cells of the rat carotid body
    M L Fung
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Pokfulam, SAR
    Pflugers Arch 441:474-80. 2001
  8. ncbi request reprint Role of voltage-gated Na+ channels in hypoxia-induced neuronal injuries
    M L Fung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam
    Clin Exp Pharmacol Physiol 27:569-74. 2000
  9. ncbi request reprint Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Endocrinol 167:517-24. 2000
  10. doi request reprint Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats
    H M Yeung
    Department of Physiology, University of Hong Kong, Hong Kong SAR, China
    J Pineal Res 45:373-82. 2008

Collaborators

Detail Information

Publications34

  1. pmc Carotid Body AT(4) Receptor Expression and its Upregulation in Chronic Hypoxia
    Man Lung Fung
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong
    Open Cardiovasc Med J 1:1-7. 2007
    ..This may be an additional pathway enhancing the Ang II action for the activation of chemoreflex in the hypoxic response during chronic hypoxia...
  2. pmc Increased endogenous nitric oxide release by iron chelation and purinergic activation in the rat carotid body
    Man Lung Fung
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong, China
    Open Biochem J 1:1-6. 2007
    ..Collectively, results suggest that iron chelation and purinoceptor stimulation play a role in the hypoxic chemotransduction for an increase in the endogenous NO production in the rat carotid body...
  3. ncbi request reprint Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia?
    Man Lung Fung
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 3:254-9. 2003
    ..In addition, HIF-1-targeted genes are expressed in the carotid body and the expression is modulated by chronic hypoxemia, suggesting an active role for HIF-1 in moderate levels of hypoxic stress...
  4. ncbi request reprint Forskolin fails to activate L-type calcium current in hypertrophied cardiomyocytes of chronically hypoxic rats
    Man Lung Fung
    Department of Physiology, Institute of Cardiovascular Science and Medicine, University of Hong Kong, Pokfulam, People s Republic of China
    Life Sci 70:1801-9. 2002
    ..The failure of activation of the Ca2+ current is consistent with the idea that adenylyl cyclase function is down-regulated in CH hypertrophied myocytes...
  5. ncbi request reprint Pontine cholinergic respiratory depression in neonatal and young rats
    M L Fung
    Department of Physiology, The University of Hong Kong
    Life Sci 62:2249-56. 1998
    ..The site of injection in the pontine reticular formation was confirmed by histology. Results suggest that cholinergic mechanisms in the medial pons depress respiratory activity in the neonate...
  6. ncbi request reprint Absence of MK801-induced inspiratory prolongation in chronically hypoxic rats
    M L Fung
    Department of Physiology, University of Hong Kong, Pokfulam
    Life Sci 69:2319-26. 2001
    ..Results suggest that brainstem mechanisms underlying inspiratory termination mediated by NMDA receptors are modulated by early chronic hypoxia...
  7. ncbi request reprint Functional expression of angiotensin II receptors in type-I cells of the rat carotid body
    M L Fung
    Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, University of Hong Kong, Pokfulam, SAR
    Pflugers Arch 441:474-80. 2001
    ..It is concluded that angiotensin II modulates carotid body chemoreceptor function directly via AT1 receptors in the type-I cell...
  8. ncbi request reprint Role of voltage-gated Na+ channels in hypoxia-induced neuronal injuries
    M L Fung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Pokfulam
    Clin Exp Pharmacol Physiol 27:569-74. 2000
    ..These improve the ionic homeostasis and cellular energy levels and, thus, prevent hypoxia-induced neuronal injury and neuronal damage mediated by Ca2+ overload...
  9. ncbi request reprint Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Endocrinol 167:517-24. 2000
    ..This might be important in the modulation of cardiorespiratory functions as well as fluid and electrolyte homeostasis during chronic hypoxia...
  10. doi request reprint Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats
    H M Yeung
    Department of Physiology, University of Hong Kong, Hong Kong SAR, China
    J Pineal Res 45:373-82. 2008
    ..The results suggest that melatonin is cardioprotective against CH-induced myocardial injury by improving calcium handling in the SR of cardiomyocytes via an antioxidant mechanism...
  11. ncbi request reprint Role of HIF-1 in physiological adaptation of the carotid body during chronic hypoxia
    Man Lung Fung
    Department of Physiology, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 536:593-601. 2003
  12. ncbi request reprint Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis
    P S Leung
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    Regul Pept 96:143-9. 2001
    ..It was concluded that chronic hypoxia decreases the transcriptional and translational expression of angiotensinogen, and thus local formation of angiotensin II, in the rat epididymis...
  13. doi request reprint Upregulation of erythropoietin and its receptor expression in the rat carotid body during chronic and intermittent hypoxia
    S Y Lam
    Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 648:207-14. 2009
    ..The increased EPO binding to its receptor might play a role in the enhancement of CB excitability during the early pathogenesis in patients with sleep-disordered breathing...
  14. ncbi request reprint Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD)
    G L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Histol Histopathol 24:1161-9. 2009
    ..We propose that female rats fed with a diet containing highly unsaturated fatty acids are an extremely useful model for the study of NAFLD...
  15. ncbi request reprint Expression and functions of vasoactive substances regulated by hypoxia-inducible factor-1 in chronic hypoxemia
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cardiovasc Hematol Agents Med Chem 4:199-218. 2006
    ..In conclusion, the adaptive response to long-term hypoxemia involves compensatory mechanisms mediated by expressing significant levels of HIF-1alpha and vasoactive substances regulated by HIF-1...
  16. ncbi request reprint Acute hypoxia elevates nitric oxide generation in rat carotid body in vitro
    M L Fung
    Department of Medicine, University of Hong Kong, Pokfulam
    Pflugers Arch 442:903-9. 2001
    ..Hence, NO may play an active inhibitory role in the control of carotid chemoreceptor activity during hypoxia...
  17. ncbi request reprint Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia
    Siu Yin Lam
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong, China
    Histol Histopathol 23:271-80. 2008
    ..This differential regulation of the HIF-alpha subtypes and pathways could account for the morphological and neurochemical discrepancy in the CB responses to IH and CH...
  18. ncbi request reprint Expression of HIF-1alpha, VEGF and VEGF receptors in the carotid body of chronically hypoxic rat
    George L Tipoe
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong
    Respir Physiol Neurobiol 138:143-54. 2003
    ..Hence, HIF-1 may activate the expression of VEGF and VEGFR-1 in the CB and the expression of VEGF in the chemoreceptors may play a paracrine role in the vascular remodeling during chronic hypoxia...
  19. ncbi request reprint Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: an involvement of constitutive and inducible nitric oxide synthases
    Jian Shan Ye
    Department of Medicine, Faculty of Medicine, University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong
    Pflugers Arch 444:178-85. 2002
    ..The enhancement of NO generation may play a physiological role in blunting the hypoxic chemosensitivity during chronic hypoxia...
  20. ncbi request reprint Attenuated "cross talk" between kappa-opioid receptors and beta-adrenoceptors in the heart of chronically hypoxic rats
    Jian Shan
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, SAR, China
    Pflugers Arch 444:126-32. 2002
    ..The attenuation may be due to decreased responses of Gs-protein and adenylyl cyclase to kappa-opioid receptor activation in addition to desensitization of the receptor itself...
  21. ncbi request reprint Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression
    Yueping Chen
    Department of Physiology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong
    Pflugers Arch 443:565-73. 2002
    ..The enhancement of the paracrine/autocrine effect of ET-1 on the chemoreceptors is consistent with an excitatory and mitogenic role of the ET-1 and ETA receptor in the CB during chronic hypoxia...
  22. ncbi request reprint Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Cardiovasc Hematol Disord Drug Targets 7:135-44. 2007
    ..Green tea is proposed to be a dietary supplement in the prevention of cardiovascular diseases in which oxidative stress and proinflammation are the principal causes...
  23. doi request reprint Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia
    Y W Tjong
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Pineal Res 44:234-43. 2008
    ..Collectively, these results suggest that melatonin ameliorates the constitutive NO production and BK channel activity via an antioxidant mechanism against an IH-induced down-regulation of nNOS expression in hippocampal neurons...
  24. ncbi request reprint Nitric oxide deficit in chronic intermittent hypoxia impairs large conductance calcium-activated potassium channel activity in rat hippocampal neurons
    Yung Wui Tjong
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Free Radic Biol Med 44:547-57. 2008
    ....
  25. ncbi request reprint Hypoxia-inducible factor (HIF)-1alpha and endothelin-1 expression in the rat carotid body during intermittent hypoxia
    Siu Yin Lam
    Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 580:21-7; discussion 351-9. 2006
  26. ncbi request reprint Expression of HIF-2alpha and HIF-3alpha in the rat carotid body in chronic hypoxia
    Siu Yin Lam
    Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 580:29-36; discussion 351-9. 2006
  27. ncbi request reprint Elevated endogenous nitric oxide increases Ca2+ flux via L-type Ca2+ channels by S-nitrosylation in rat hippocampal neurons during severe hypoxia and in vitro ischemia
    Yung Wui Tjong
    Department of Physiology, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
    Free Radic Biol Med 42:52-63. 2007
    ..Taken together, the results suggest that an elevated endogenous NO production enhances the influx of Ca(2+) via the hippocampal L-type Ca(2+) channel by S-nitrosylation during an initial phase of energy deprivation...
  28. ncbi request reprint Chronic hypoxia modulates the function and expression of melatonin receptors in the rat carotid body
    Yung Wui Tjong
    Department of Physiology, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Pineal Res 40:125-34. 2006
    ..Taken together, our results suggest an upregulation of the carotid expression of melatonin receptors by chronic hypoxia, which modulates the carotid response to melatonin for the circadian influence on breathing...
  29. ncbi request reprint Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury
    G L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR
    Histol Histopathol 21:1157-65. 2006
    ....
  30. ncbi request reprint Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body
    Siu Yin Lam
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Appl Physiol (1985) 96:809-13. 2004
    ..This may be important in the modulation of cardiopulmonary adaptation in the hypoxic ventilatory response as well as for electrolyte and water homeostasis during chronic hypoxia...
  31. ncbi request reprint Melatonin enhances the hypoxic response of rat carotid body chemoreceptor
    Yueping Chen
    Department of Physiology, University of Hong Kong, Hong Kong, China
    J Pineal Res 38:157-63. 2005
    ..Hence, the circadian rhythm of melatonin in arterial blood can modulate the carotid chemoreceptor response to hypoxia. This modulation may be a physiological mechanism involved in the day-light differences in ventilatory activities...
  32. doi request reprint Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia
    Ming Wai Hung
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Pineal Res 44:214-21. 2008
    ....
  33. pmc Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis
    Tung Ming Leung
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Int J Exp Pathol 89:241-50. 2008
    ..Our results showed that the reduced eNOS expression in CCl(4)-treated mice was reversed by L-arginine. Furthermore, L-arginine also reversed the reduced AP-1 activity, an eNOS promoter...
  34. ncbi request reprint Nitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons
    Kuihuan Jian
    Department of Anatomy and Neurobiology, Southern Medical University, Guangzhou 510515, China
    Biochem Biophys Res Commun 359:481-5. 2007
    ..Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current...