Daniel Tt Chua

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi Patterns of failure after induction chemotherapy and radiotherapy for locoregionally advanced nasopharyngeal carcinoma: the Queen Mary Hospital experience
    D T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 49:1219-28. 2001
  2. ncbi Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 59:11-20. 2004
  3. ncbi Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Head Neck 30:863-7. 2008
  4. ncbi Prognostic impact of hemoglobin levels on treatment outcome in patients with nasopharyngeal carcinoma treated with sequential chemoradiotherapy or radiotherapy alone
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong Queen Mary Hospital, Hong Kong SAR, China
    Cancer 101:307-16. 2004
  5. ncbi Late oral complications following radiotherapy for head and neck cancers
    Daniel T T Chua
    The University of Hong Kong, PB 115, Department of Clinical Oncology, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Expert Rev Anticancer Ther 7:1215-24. 2007
  6. ncbi Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Int J Radiat Oncol Biol Phys 69:469-74. 2007
  7. ncbi Predictive factors of tumor control and survival after radiosurgery for local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 66:1415-21. 2006
  8. ncbi Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 65:1300-6. 2006
  9. ncbi A phase II study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, PB 115, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Oral Oncol 41:589-95. 2005
  10. ncbi Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Radiother Oncol 77:290-4. 2005

Collaborators

Detail Information

Publications38

  1. ncbi Patterns of failure after induction chemotherapy and radiotherapy for locoregionally advanced nasopharyngeal carcinoma: the Queen Mary Hospital experience
    D T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 49:1219-28. 2001
    ..To study the long-term outcome and patterns of failure after CT for NPC, we analyzed our own center data for which a uniform radiation treatment protocol was adopted and a longer follow-up time was available...
  2. ncbi Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 59:11-20. 2004
    ..A retrospective study was performed to correlate the expression of epidermal growth factor receptor (EGFR) with treatment outcome in advanced stage nasopharyngeal carcinoma (NPC)...
  3. ncbi Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Head Neck 30:863-7. 2008
    ..This single-center, phase II study assessed the safety/tolerability and initial efficacy of gefitinib in patients with nasopharyngeal carcinoma (NPC) pretreated with platinum-based chemotherapy...
  4. ncbi Prognostic impact of hemoglobin levels on treatment outcome in patients with nasopharyngeal carcinoma treated with sequential chemoradiotherapy or radiotherapy alone
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong Queen Mary Hospital, Hong Kong SAR, China
    Cancer 101:307-16. 2004
    ....
  5. ncbi Late oral complications following radiotherapy for head and neck cancers
    Daniel T T Chua
    The University of Hong Kong, PB 115, Department of Clinical Oncology, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Expert Rev Anticancer Ther 7:1215-24. 2007
    ..This article examines the current issue of late oral complications after radiotherapy, with an emphasis on the impact of recent advances in cancer treatment...
  6. ncbi Stereotactic radiosurgery versus gold grain implantation in salvaging local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Int J Radiat Oncol Biol Phys 69:469-74. 2007
    ..Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known...
  7. ncbi Predictive factors of tumor control and survival after radiosurgery for local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 66:1415-21. 2006
    ..To identify patients that would benefit from radiosurgery, we reviewed our data with emphasis on factors that predicted treatment outcome...
  8. ncbi Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 65:1300-6. 2006
    ..To evaluate the effect of induction chemotherapy in NPC further, we performed subgroup analysis of two Phase III trials according to the T and N stage...
  9. ncbi A phase II study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, PB 115, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Oral Oncol 41:589-95. 2005
    ..The dose of 60 mg/m2 for both drugs without colony-stimulating factor support should be further evaluated as a high incidence of febrile neutropenia was observed with 75 mg/m2 dose...
  10. ncbi Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Radiother Oncol 77:290-4. 2005
    ..To evaluate the treatment outcome in patients with locally recurrent nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT)...
  11. ncbi Tumor volume is not an independent prognostic factor in early-stage nasopharyngeal carcinoma treated by radiotherapy alone
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 58:1437-44. 2004
    ..To determine whether the tumor volume can predict the treatment outcome in early-stage nasopharyngeal carcinoma (NPC) treated by radiotherapy alone...
  12. ncbi A concurrent chemoirradiation with cisplatin followed by adjuvant chemotherapy with ifosfamide, 5-fluorouracil, and leucovorin for stage IV nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, PB 115, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Head Neck 26:118-26. 2004
    ..Radiotherapy was given using standard fractionation at 2 Gy/day to a total of 68 Gy to the nasopharynx and 66 Gy to the neck...
  13. doi Capecitabine monotherapy for recurrent and metastatic nasopharyngeal cancer
    Daniel Chua
    Department of Clinical Oncology, PB 115, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Jpn J Clin Oncol 38:244-9. 2008
    ..We conducted a retrospective review of patients who received capecitabine for recurrent and metastatic NPC to further evaluate its clinical benefits...
  14. ncbi Salvage treatment for persistent and recurrent T1-2 nasopharyngeal carcinoma by stereotactic radiosurgery
    D T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Head Neck 23:791-8. 2001
    ..To study the efficacy of stereotactic radiosurgery in salvaging early-stage persistent and recurrent nasopharyngeal carcinoma (NPC) after primary radiotherapy...
  15. ncbi The predictive value of the 1997 American Joint Committee on Cancer stage classification in determining failure patterns in nasopharyngeal carcinoma
    D T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Cancer 92:2845-55. 2001
    ....
  16. ncbi Control of regional metastasis after induction chemotherapy and radiotherapy for nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, PB 115, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong
    Head Neck 24:350-60. 2002
    ..To study the impact of adding induction chemotherapy to radiotherapy on the long-term control of regional metastasis and survival in patients with nasopharyngeal carcinoma (NPC)...
  17. pmc Comparison of single versus fractionated dose of stereotactic radiotherapy for salvaging local failures of nasopharyngeal carcinoma: a matched-cohort analysis
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Head Neck Oncol 1:13. 2009
    ..Stereotactic radiation using single or multiple fractions have been employed in re-irradiation of NPC, but the optimal fractionation scheme and dose are not clear...
  18. ncbi Concomitant chemoirradiation for stage III-IV nasopharyngeal carcinoma in Chinese patients: results of a matched cohort analysis
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 53:334-43. 2002
    ..To evaluate the toxicity and efficacy of concomitant chemoirradiation (CRT) followed by adjuvant chemotherapy compared with radiotherapy (RT) alone in Chinese patients with locoregionally advanced nasopharyngeal carcinoma (NPC)...
  19. pmc Validation of a prognostic scoring system for locally recurrent nasopharyngeal carcinoma treated by stereotactic radiosurgery
    Daniel T T Chua
    Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    BMC Cancer 9:131. 2009
    ..The purpose of the present study was to validate a previously published prognostic scoring system for local failures of NPC treated by radiosurgery based on reported results in the literature...
  20. ncbi A phase II study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam PB 115, Hong Kong SAR, China
    Oral Oncol 39:361-6. 2003
    ..Capecitabine is an effective salvage regimen in patients with recurrent and metastatic NPC. Capecitabine as a single agent or in combination with other chemotherapeutic agents or treatment modalities should be further studied in NPC...
  21. ncbi Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications
    Daniel T T Chua
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 56:177-83. 2003
    ..To evaluate the efficacy and complication of linear accelerator-based stereotactic radiosurgery (SRS) when used as salvage treatment for early-stage persistent and recurrent nasopharyngeal carcinoma (NPC) after primary radiotherapy (RT)...
  22. ncbi Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, PB 115, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong
    Head Neck 25:585-94. 2003
    ..To review the outcome and evaluate the prognostic factors in the treatment of synchronous locoregional failures of nasopharyngeal carcinoma (NPC)...
  23. ncbi Induction chemotherapy with cisplatin and gemcitabine followed by reirradiation for locally recurrent nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Clin Oncol 28:464-71. 2005
    ..This study was conducted to evaluate the benefits of adding induction chemotherapy with cisplatin and gemcitabine before reirradiation for locally recurrent NPC...
  24. ncbi Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study
    Dora L W Kwong
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    J Clin Oncol 22:2643-53. 2004
    ..To study the efficacy of concurrent chemoradiotherapy (CRT) and adjuvant chemotherapy (AC) for nasopharyngeal carcinoma (NPC)...
  25. doi Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, China
    J Natl Cancer Inst 102:1188-98. 2010
    ..Verification of the long-term therapeutic index of this regimen is needed...
  26. ncbi Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    Int J Radiat Oncol Biol Phys 66:142-51. 2006
    ..To compare the benefit achieved by concurrent chemoradiotherapy (CRT) and/or accelerated fractionation (AF) vs. radiotherapy (RT) alone with conventional fractionation (CF) for patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC)...
  27. ncbi Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    J Clin Oncol 23:1118-24. 2005
    ..To evaluate the long-term outcome in patients with nasopharyngeal carcinoma (NPC) treated with induction chemotherapy and radiotherapy (CRT) versus radiotherapy alone (RT)...
  28. ncbi Survival outcome of patients with nasopharyngeal carcinoma with first local failure: a study by the Hong Kong Nasopharyngeal Carcinoma Study Group
    Kwok Hung Yu
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Head Neck 27:397-405. 2005
    ..The purpose of this article is to report the overall survival (OS) outcome of patients with nasopharyngeal carcinoma (NPC) with local failure who received salvage treatment and to identify prognostic factors for OS...
  29. ncbi Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    J Clin Oncol 23:6966-75. 2005
    ..This randomized study compared the results achieved by concurrent chemoradiotherapy (CRT) versus radiotherapy (RT) alone for nasopharyngeal carcinoma (NPC) with advanced nodal disease...
  30. ncbi Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: a prospective study on disease control and preservation of salivary function
    Dora L W Kwong
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, SAR, People s Republic of China
    Cancer 101:1584-93. 2004
    ..Dosimetric studies suggested that intensity-modulated RT (IMRT) can spare part of the parotid glands from high-dose radiation. Disease control and salivary function after IMRT for early-stage NPC was studied prospectively...
  31. ncbi Treatment outcome after radiotherapy alone for patients with Stage I-II nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Cancer 98:74-80. 2003
    ..The objective of this study was to review the long-term treatment outcome of patients with American Joint Committee on Cancer (AJCC) 1997 Stage I-II nasopharyngeal carcinoma (NPC) who were treated with radiotherapy alone...
  32. ncbi Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong, China
    Int J Radiat Oncol Biol Phys 61:1107-16. 2005
    ..To analyze the treatment results achievable for nasopharyngeal carcinoma in the modern era to identify the key failures for future improvement and to provide an updated baseline for future trials...
  33. ncbi Randomized evaluation of the audiologic outcome of ventilation tube insertion for middle ear effusion in patients with nasopharyngeal carcinoma
    Wai Kuen Ho
    Department of Surgery, Division of Otorhinolaryngology Head and Neck Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, PR China
    J Otolaryngol 31:287-93. 2002
    ..This study evaluates the hearing improvement after tube insertion compared with observation alone to see if the benefits of the procedure outweigh its potential complications...
  34. ncbi Complementary activation of peripheral natural killer cell immunity in nasopharyngeal carcinoma
    Ying Zheng
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Cancer Sci 97:912-9. 2006
    ..Together, these data suggest complementary roles of innate and adaptive immune response in tumor immunity where NK cells, gammadelta- and alphabeta-CTL compensate for the deficits of one another at different stages of tumor invasion...
  35. ncbi Peripheral gamma delta T-cell deficit in nasopharyngeal carcinoma
    Bo Jian Zheng
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, People s Republic of China
    Int J Cancer 99:213-7. 2002
    ..It was noted that these immune cells comprise less than 5% of peripheral blood monocytic cells and hence it was not surprising that this component of host defense was breached early in the development of the cancer...
  36. ncbi Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients
    Bertrand Baujat
    Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 64:47-56. 2006
    ..To study the effect of adding chemotherapy to radiotherapy (RT) on overall survival and event-free survival for patients with nasopharyngeal carcinoma...
  37. ncbi [Concomitant chemo-radiotherapy for locoregionally advanced nasopharygeal carcinoma]
    Ye Tian
    Department of Radiotherapy and Oncology, Second Hospital, Suzhou University, Suzhou 215004, China
    Zhonghua Zhong Liu Za Zhi 27:429-31. 2005
    ..To evaluate the efficacy and toxicity of concomitant chemo-radiotherapy (CCRT) followed by adjuvant chemotherapy (ACT) in Chinese patients with locoregionally advanced nasopharygeal carcinoma (NPC)...
  38. ncbi Outcome of fractionated stereotactic radiotherapy for 90 patients with locally persistent and recurrent nasopharyngeal carcinoma
    Shao Xiong Wu
    Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Int J Radiat Oncol Biol Phys 69:761-9. 2007
    ..Stereotactic radiosurgery and fractionated stereotactic radiation therapy (FSRT) have recently evolved as a salvage option of NPC. This study was conducted to review the treatment outcome after FSRT for NPC...