Leung Wing Chu

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Increased alpha 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients
    L W Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Dement Geriatr Cogn Disord 19:106-12. 2005
  2. ncbi request reprint Incidence and predictors of falls in the chinese elderly
    L W Chu
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    Ann Acad Med Singapore 34:60-72. 2005
  3. ncbi request reprint Alzheimer's disease: early diagnosis and treatment
    L W Chu
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Hong Kong Med J 18:228-37. 2012
  4. ncbi request reprint Impact of falls on the balance, gait, and activities of daily living functioning in community-dwelling Chinese older adults
    Leung Wing Chu
    FRCP, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong SAR
    J Gerontol A Biol Sci Med Sci 61:399-404. 2006
  5. ncbi request reprint Falls and subsequent health service utilization in community-dwelling Chinese older adults
    Leung Wing Chu
    Division of Geriatric Medicine, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong SAR, China
    Arch Gerontol Geriatr 46:125-35. 2008
  6. ncbi request reprint Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
    Clin Endocrinol (Oxf) 68:589-98. 2008
  7. doi request reprint Nursing homes in China
    Leung Wing Chu
    Sau Po Centre on Aging, The University of Hong Kong, Hong Kong
    J Am Med Dir Assoc 9:237-43. 2008
  8. doi request reprint Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men
    Leung Wing Chu
    Division of Geriatric Medicine, Faculty of Medicine, Research Center of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong SAR
    J Am Geriatr Soc 56:1286-91. 2008
  9. doi request reprint Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong
    Leung Wing Chu
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Am Med Dir Assoc 12:143-52. 2011
  10. doi request reprint Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer's disease
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR
    J Alzheimers Dis 17:223-32. 2009

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Increased alpha 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients
    L W Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Dement Geriatr Cogn Disord 19:106-12. 2005
    ..These findings showed that the alpha7nAChR protein levels would be a potentially useful diagnostic marker for AD...
  2. ncbi request reprint Incidence and predictors of falls in the chinese elderly
    L W Chu
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    Ann Acad Med Singapore 34:60-72. 2005
    ..This is the first prospective longitudinal study carried out in a Chinese elderly population with the objective of identifying the incidence and predictors of falls...
  3. ncbi request reprint Alzheimer's disease: early diagnosis and treatment
    L W Chu
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Hong Kong Med J 18:228-37. 2012
    ..Disease-modifying therapies are still under development, whilst immunotherapy may be a viable option in the near future...
  4. ncbi request reprint Impact of falls on the balance, gait, and activities of daily living functioning in community-dwelling Chinese older adults
    Leung Wing Chu
    FRCP, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong SAR
    J Gerontol A Biol Sci Med Sci 61:399-404. 2006
    ..The objective of the present study was to investigate the impact of incident falls on the balance, gait, and Activities of Daily Living functioning in community-dwelling older adults...
  5. ncbi request reprint Falls and subsequent health service utilization in community-dwelling Chinese older adults
    Leung Wing Chu
    Division of Geriatric Medicine, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong SAR, China
    Arch Gerontol Geriatr 46:125-35. 2008
    ..A population-based falls prevention program is recommended to reduce falls, fall-related health care service utilizations and health care expenditure...
  6. ncbi request reprint Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
    Clin Endocrinol (Oxf) 68:589-98. 2008
    ..We investigated the risk of amnestic mild cognitive impairment (aMCI) in relation to serum bioavailable (BT) and total testosterone (TT) levels in older men...
  7. doi request reprint Nursing homes in China
    Leung Wing Chu
    Sau Po Centre on Aging, The University of Hong Kong, Hong Kong
    J Am Med Dir Assoc 9:237-43. 2008
    ..The current policy is to encourage private and foreign investors to participate in the nursing home business in China...
  8. doi request reprint Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men
    Leung Wing Chu
    Division of Geriatric Medicine, Faculty of Medicine, Research Center of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong SAR
    J Am Geriatr Soc 56:1286-91. 2008
    ..To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men...
  9. doi request reprint Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong
    Leung Wing Chu
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Am Med Dir Assoc 12:143-52. 2011
    ....
  10. doi request reprint Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer's disease
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR
    J Alzheimers Dis 17:223-32. 2009
    ..002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD...
  11. ncbi request reprint Bioavailable testosterone predicts a lower risk of Alzheimer's disease in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong
    J Alzheimers Dis 21:1335-45. 2010
    ..04 and 5.04 respectively. In conclusion, the serum level of bioavailable testosterone in late life predicts a lower risk of future AD development in older men...
  12. ncbi request reprint Risk factors for falls in hospitalized older medical patients
    L W Chu
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    J Gerontol A Biol Sci Med Sci 54:M38-43. 1999
    ..Prevention is important, but factors associated with these falls are less well studied than falls occurring in the community or nursing homes...
  13. ncbi request reprint The reliability and validity of the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) among the elderly Chinese in Hong Kong
    L W Chu
    Division of Geriatrics, University Department of Medicine, Queen Mary Hospital, Hong Kong SAR
    Ann Acad Med Singapore 29:474-85. 2000
    ..The English, Greek, Spanish but not Chinese versions had been validated previously...
  14. ncbi request reprint A randomized controlled trial of low-dose recombinant human growth hormone in the treatment of malnourished elderly medical patients
    L W Chu
    Divisions of Geriatric Medicine, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Clin Endocrinol Metab 86:1913-20. 2001
    ..It led to a faster gain in total lean body mass, which was associated with greater improvement in walking speed when compared with dietary intervention alone. There were no apparent side effects...
  15. ncbi request reprint Risk factors for early emergency hospital readmission in elderly medical patients
    L W Chu
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Gerontology 45:220-6. 1999
    ..Early emergency readmissions is a common and important problem in the elderly patient. Identification of the risk factors for early emergency readmissions is needed to prevent this occurring...
  16. ncbi request reprint A short version of the ADAM Questionnaire for androgen deficiency in Chinese men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR
    J Gerontol A Biol Sci Med Sci 63:426-31. 2008
    ..We therefore investigated the validity of a Chinese version of the Saint Louis University ADAM questionnaire to screen for androgen deficiency in Chinese men...
  17. ncbi request reprint A study on the association of the chromosome 12p13 locus with sporadic late-onset Alzheimer's disease in Chinese
    Yan Li
    Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 27:508-12. 2009
    ..0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese...
  18. doi request reprint Functional status of older nursing home residents can affect the efficacy of influenza vaccination
    Tuen Ching Chan
    Division of Geriatrics, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Gerontol A Biol Sci Med Sci 68:324-30. 2013
    ..The efficacy of influenza vaccination in older nursing home residents is frequently overestimated due to frailty selection bias. Limited data exist to examine this issue...
  19. doi request reprint CYP46A1 functional promoter haplotypes decipher genetic susceptibility to Alzheimer's disease
    Yan Li
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Alzheimers Dis 21:1311-23. 2010
    ..In general, our results show that promoter haplotypes could significantly affect CYP46A1 gene transcription level possibly through interacting with certain transcription factors...
  20. doi request reprint Prevalence of anemia in Chinese nursing home older adults: implication of age and renal impairment
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong, China
    Geriatr Gerontol Int 13:591-6. 2013
    ..The objective of this study was to investigate the prevalence and associated comorbidities of anemia in Chinese nursing home older adults...
  21. doi request reprint Quantitative assessment of cerebral hemodynamic parameters by QUASAR arterial spin labeling in Alzheimer's disease and cognitively normal Elderly adults at 3-tesla
    Henry K F Mak
    Department of Diagnostic Radiology, The University of Hong Kong, HKSAR, Pokfulam, Hong Kong
    J Alzheimers Dis 31:33-44. 2012
    ..As potential biomarkers, these hemodynamic parameters could differentiate patients from volunteers, and possibly indicate the conversion from healthy aging to mild cognitive impairment to AD...
  22. doi request reprint Relationship between admission albumin levels and rehabilitation outcomes in older patients
    James Ka Hay Luk
    The University of Hong Kong, Division of Geriatrics, Department of Medicine, Queen Mary Hospital, Room 801 Administrative Block, Pokfulam Road, Hong Kong, SAR, China
    Arch Gerontol Geriatr 53:84-9. 2011
    ..Admission albumin levels were related to functional and motor efficiency, but not with absolute functional and motor gain. Albumin was not an independent predictor for satisfactory motor and functional outcome...
  23. doi request reprint Gender differences in rehabilitation outcomes among older Chinese patients
    James Ka Hay Luk
    The University of Hong Kong Division of Geriatrics, Department of Medicine, Queen Mary Hospital, Room 801 Administrative Block, Pokfulam Road, Hong Kong SAR, China
    Arch Gerontol Geriatr 52:28-32. 2011
    ..0004); admission EMS (p=0.005); BI (p<0.001). Women achieved a better functional outcome but a poorer motor outcome on discharge. Female gender was a positive predictor for functional outcome but a negative factor for motor outcome...
  24. doi request reprint Chronic kidney disease and its association with mortality and hospitalization in Chinese nursing home older residents: a 3-year prospective cohort study
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong SAR, China
    J Am Med Dir Assoc 13:782-7. 2012
    ..To investigate chronic kidney disease (CKD) as a predictor of mortality and hospitalization in Chinese nursing homes older residents...
  25. doi request reprint Continuous use of antipsychotics and its association with mortality and hospitalization in institutionalized Chinese older adults: an 18-month prospective cohort study
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong SAR, China
    Int Psychogeriatr 23:1640-8. 2011
    ....
  26. doi request reprint Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population
    Lu Hua Chen
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People s Republic of China
    Neurobiol Aging 33:210.e1-7. 2012
    ....
  27. doi request reprint Rehabilitation of older Chinese patients with different cognitive functions: how do they differ in outcome?
    James K Luk
    Division of Geriatrics, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Arch Phys Med Rehabil 89:1714-9. 2008
    ..To examine the effect of cognition on functional and motor gain in older Chinese patients undergoing geriatric inpatient rehabilitation...
  28. doi request reprint Factors affecting institutionalization in older Hong Kong Chinese patients after recovery from acute medical illnesses
    James Ka Hay Luk
    The University of Hong Kong Division of Geriatrics, Department of Medicine, Queen Mary Hospital, Room 801 Administrative Block, Pokfulam Road, Hong Kong, China
    Arch Gerontol Geriatr 49:e110-4. 2009
    ..02) were independent protecting factors against nursing home admission. Knowledge of these factors can allow us to predict accommodation outcome and develop intervention strategy to reduce institutionalization in the older patients...
  29. doi request reprint Effects of cognitive function and depressive mood on the quality of life in Chinese Alzheimer's disease patients in Hong Kong
    Ivy Wai Ping Chan
    Department of Occupational Therapy, Castle Peak Hospital, LKS Faculty of Medicine, University of Hong Kong, Hong Kong
    Geriatr Gerontol Int 11:69-76. 2011
    ....
  30. ncbi request reprint Community end-of-life care among Chinese older adults living in nursing homes
    Leung Wing Chu
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong Acute Geriatric Unit, Grantham Hospital, Hong Kong
    Geriatr Gerontol Int 14:273-84. 2014
    ..The aim of the present study was to investigate the preference and willingness-to-pay (WTP) of older Chinese adults for community end-of-life care in a nursing home rather than a hospital...
  31. doi request reprint Prevention of mortality and pneumonia among nursing home older adults by dual pneumococcal and seasonal influenza vaccination during a pandemic caused by novel pandemic influenza A (H1N1)
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Pokfulam, Hong Kong SAR, China
    J Am Med Dir Assoc 13:698-703. 2012
    ..To evaluate the efficacy of dual vaccination of seasonal influenza and pneumococcus in nursing home older adults during a novel pandemic of influenza A (H1N1)...
  32. doi request reprint Development and validation of a prognostic index for 2-year mortality in Chinese older residents living in nursing homes
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong, China
    Geriatr Gerontol Int 12:555-62. 2012
    ..There is no mortality prediction index for Chinese nursing home older residents. The objective of this study was to derive and validate a 2-year mortality prognostic index for them...
  33. doi request reprint Possible retrogenesis observed with fiber tracking: an anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer's disease
    Junling Gao
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
    J Alzheimers Dis 26:47-58. 2011
    ..Consistent with a proposal of retrogenesis, our results demonstrate an anteroposterior pattern of white matter disintegrity in both normal aging and AD, with the pattern being more salient in the latter than in the former...
  34. doi request reprint Rehabilitation outcomes of older Chinese patients with different cognitive function in a geriatric day hospital
    James Ka Hay Luk
    The University of Hong Kong Division of Geriatrics, Department of Medicine, Queen Mary Hospital, Room 801 Administrative Block, Pokfulam Road, Hong Kong, SAR, China
    Arch Gerontol Geriatr 53:e144-8. 2011
    ..Cognitive function was not associated with FIM gain and efficiency. This suggested that selected patients with impaired cognition could still benefit from GDH rehabilitation...
  35. ncbi request reprint A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese
    Leung Wing Chu
    Department of Medicine, The University of Hong Kong, Hong Kong
    Am J Med Genet B Neuropsychiatr Genet 144:1007-13. 2007
    ..Further functional analysis of this polymorphism should be a high priority...
  36. ncbi request reprint A 2-year open-label study of galantamine therapy in Chinese Alzheimer's disease patients in Hong Kong
    L W Chu
    Division of Geriatrics, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China
    Int J Clin Pract 61:403-10. 2007
    ..control groups. Adverse effects were commonly mild. In Chinese mild-moderate AD patients, galantamine showed beneficial effects mainly on the cognitive function...
  37. pmc The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia
    Junling Gao
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, P R China Alzheimer s Disease Research Network, Strategic Research Theme of Healthy Aging, The University of Hong Kong, Hong Kong, P R China
    PLoS ONE 9:e90307. 2014
    ..This study suggests that the disintegrity of short-range fibers may contribute more to the lower cognitive efficiency and higher compensatory brain activation in healthy older adults and more in AD patients. ..
  38. doi request reprint Effectiveness of influenza vaccination in institutionalized older adults: a systematic review
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong SAR, China Division of Geriatrics, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China Electronic address
    J Am Med Dir Assoc 15:226.e1-6. 2014
    ..Criticism regarding the effectiveness of influenza vaccine estimated by nonrandomized observational studies include the frailty selection bias and use of nonspecific outcome, such as all-cause mortality...
  39. ncbi request reprint Translation and validation of the standard Chinese version of PDQ-39: a quality-of-life measure for patients with Parkinson's disease
    Kin Lun Tsang
    Division of Neurology, Department of Medicine, The University of Hong Kong, Hong Kong, China
    Mov Disord 17:1036-40. 2002
    ..54-0.90) and was comparable to versions in other languages. Further analysis showed good construct validity and test-retest reliability. Implications and limitations of the study are discussed...
  40. ncbi request reprint Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong
    Moira Chan-Yeung
    Respiratory Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Geriatr Soc 54:1334-40. 2006
    ..To assess the prevalence of tuberculous infection and active tuberculosis (TB) in old age homes in Hong Kong and to determine whether there is institutional transmission in these homes...
  41. ncbi request reprint The relationship between non-cognitive symptoms and functional impairment in Alzheimer's disease
    W Y W Mok
    Division of Geriatrics, Department of Medicine, Queen Mary Hospital, Hong Kong, SAR, China
    Int J Geriatr Psychiatry 19:1040-6. 2004
    ..The role of non-cognitive symptom is uncertain. The objective of this study was to investigate the role of non-cognitive symptoms as predictive factors for functional outcome in A.D...
  42. doi request reprint Relationship between symptoms of androgen deficiency and psychological factors and quality of life among Chinese men
    A M Lee
    Department of Psychiatry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Int J Androl 33:755-63. 2010
    ..Further research and clinical attention to the psychological needs of this population is warranted...
  43. ncbi request reprint Age-related osteoporosis in Chinese: an evaluation of the response of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivation
    A W Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Am J Clin Nutr 68:1291-7. 1998
    ..Age-related osteoporosis may be associated with inefficient intestinal calcium absorption and bone remodeling...
  44. ncbi request reprint Validation study of Charlson Comorbidity Index in predicting mortality in Chinese older adults
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital, Hong Kong SAR, China Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Geriatr Gerontol Int 14:452-7. 2014
    ..The objective of the present study was to validate the use of CCI in Chinese older adults for predicting mortality...
  45. pmc Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T
    Pui Wai Chiu
    Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Age (Dordr) 36:251-64. 2014
    ..Such findings highlight the metabolic changes of ACC and PCC with age, which could be compensatory to an increased energy demand coupled with a lower cerebral blood flow. ..
  46. doi request reprint Neural activities during affective processing in people with Alzheimer's disease
    Tatia M C Lee
    Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong, China
    Neurobiol Aging 34:706-15. 2013
    ..Findings of our study indicate that neural changes in regions associated with the motor and emotional simulation systems might play an important role in the development of Alzheimer's disease...
  47. doi request reprint Efficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in Alzheimer's disease patients and cognitively normal older adults at 3.0 Tesla MR imaging
    Henry Ka Fung Mak
    Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Alzheimers Dis 23:655-64. 2011
    ..6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. As imaging biomarkers, VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults...
  48. doi request reprint Association between alcohol consumption and cognitive impairment in Southern Chinese older adults
    Ka Kin King Chan
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Int J Geriatr Psychiatry 25:1272-9. 2010
    ..There is limited data on the effects of alcohol consumption on cognitive impairment in Chinese populations...
  49. doi request reprint Amyloid beta 1-42 and tau in the cerebrospinal fluid of renal failure patients for the diagnosis of Alzheimer's disease
    Yat Fung Shea
    Queen Mary Hospital, Hong Kong, Hong Kong, Guangdong, Hong Kong
    J Nephrol 27:217-20. 2014
    ..We found that the diagnosis of AD with CSF biomarkers appears to be useful in renal failure patients. But our results need to be confirmed in a larger study, comparing these CSF biomarkers in AD vs. non-AD patients with concomitant CKD. ..
  50. doi request reprint Delayed recovery from ertapenem induced encephalopathy: case-report and a possible mechanism
    Yat Fung Shea
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China
    Int J Clin Pharm 35:535-7. 2013
    ..There are increasing reports of encephalopathy being related to ertapenem and most commonly subsides within days and extended recovery of up to 2 weeks have only been reported in patients with end-stage renal failure...
  51. doi request reprint Association between functional status of Chinese nursing home older adults and long term mortality
    Tuen Ching Chan
    Department of Medicine and Geriatrics, Fung Yiu King Hospital
    J Am Med Dir Assoc 14:147.e1-5. 2013
    ..To investigate the strength of association between impaired functional status and long-term (3-year) mortality in Chinese nursing home older adults...
  52. ncbi request reprint Differential age-related change of prose memory in older Hong Kong Chinese of higher and lower education
    T M C Lee
    Neuropsychology Laboratory, Department of Psychology, The University of Hong Kong, Hong Kong
    Int J Geriatr Psychiatry 19:216-22. 2004
    ....
  53. doi request reprint Cerebrospinal fluid biomarkers of Alzheimer's disease in Chinese patients: a pilot study
    Yat Fung Shea
    1Division of Geriatrics, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Am J Alzheimers Dis Other Demen 28:769-75. 2013
    ..Only the Aβ42-p-tau ratio showed satisfactory sensitivity and specificity in the diagnosis of AD versus other dementia. ..
  54. doi request reprint Efficacy of trivalent seasonal influenza vaccination in reducing mortality and hospitalization in Chinese nursing home older adults
    Tuen Ching Chan
    Department of Medicine and Geriatrics, The University of Hong Kong, Fung Yiu King Hospital, Hong Kong SAR, China Division of Geriatrics, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China Electronic address
    J Am Med Dir Assoc 14:889-94. 2013
    ..To examine the clinical efficacy of the trivalent seasonal influenza vaccination among Chinese older adults residing in a nursing home...
  55. ncbi request reprint Delayed diagnosis of 22q11.2 deletion syndrome in an adult Chinese lady
    Yat Fung Shea
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Chin Med J (Engl) 125:2945-7. 2012
    ..Clinicians should consider the diagnosis of DiGeorge syndrome in adult patient with past medical history of congenital heart disease, facial dysmorphism, intellectual disability and primary hypoparathyroidism...
  56. doi request reprint Final Declaration of the Asian Metaforum on the Role of Vitamin D and the Management of Osteoporosis
    Siew Pheng Chan
    c o Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    Public Health Nutr 12:578-80. 2009
    ..Vitamin D is essential for Ca absorption, prevention of falls and fracture, and maintenance of muscle strength and balance. Lack of awareness of the importance of vitamin D in bone health is common in Asia...
  57. ncbi request reprint Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients
    Y Li
    Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:399-404. 2006
    ..Genetic association of CYP46A1 polymorphisms with AD had been under extensive investigations; however, observations on intron 2 T-->C (rs754203) generated inconclusive results...
  58. ncbi request reprint Immune response to influenza vaccination in community-dwelling Chinese elderly persons
    S L Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    Vaccine 24:5371-80. 2006
    ....
  59. ncbi request reprint Financial abuse in a mentally incapacitated old man
    T C Chan
    Division of Geriatrics, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Hong Kong Med J 15:213-6. 2009
    ..The Guardianship Board appointed the Director of Social Welfare as his public guardian. This case illustrates that hospital staff should be alert to potential elder abuse to ensure timely protection of potential victims...
  60. ncbi request reprint Age-related differences in response regulation as revealed by functional MRI
    Tatia M C Lee
    Neuropsychology Laboratory, Department of Psychology, The University of Hong Kong, Hong Kong
    Brain Res 1076:171-6. 2006
    ..The findings suggested a higher level of neural activity in the right prefrontal and left inferior parietal regions during response regulation for the older adults than for the younger adults...
  61. ncbi request reprint The economics of Alzheimer disease
    G M Leung
    Department of Community Medicine, University of Hong Kong, Pokfulam, PR China
    Dement Geriatr Cogn Disord 15:34-43. 2003
    ..We conclude that there are significant opportunities to strengthen research on standardised cost-of-illness analyses and new cost-effectiveness studies on a broader range of AD interventions...