Chor Sang Chim

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Mucosa-associated lymphoid tissue (MALT) lymphoma of the jejunum: an elusive cause of recurrent upper gastrointestinal bleeding
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 45:405-7. 2004
  2. ncbi request reprint Primary extramedullary plasmacytoma of the lacrimal gland
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Leuk Lymphoma 42:831-4. 2001
  3. ncbi request reprint Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Hum Pathol 38:1849-57. 2007
  4. ncbi request reprint Acute biphenotypic leukaemia
    C S Chim
    Honorary Clinical Associate Professor, Department of Medicine, Queen Mary Hospital, Hong Kong, ROC
    Haematologica 87:EIM03. 2002
  5. ncbi request reprint Gut perforation in MALT lymphoma of colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 87:EIM15. 2002
  6. ncbi request reprint Magnetic resonance imaging of leptomeningeal lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Haematol 124:566. 2004
  7. ncbi request reprint Eosinophilic leukemic transformation in polycythemia rubra vera (PRV)
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 46:447-50. 2005
  8. ncbi request reprint Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 23:57-60. 2005
  9. ncbi request reprint Primary follicular lymphoma of the small intestine
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 45:1463-6. 2004
  10. ncbi request reprint Concurrent hyperreactive malarial splenomegaly and quartan malarial nephropathy - Plasmodium malariae revisited
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 89:ECR21. 2004

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Mucosa-associated lymphoid tissue (MALT) lymphoma of the jejunum: an elusive cause of recurrent upper gastrointestinal bleeding
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 45:405-7. 2004
    ..The diagnosis was based on the small B cell morphology, demonstration of lympho-epithelial lesions, and immunophenotypic profile...
  2. ncbi request reprint Primary extramedullary plasmacytoma of the lacrimal gland
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Leuk Lymphoma 42:831-4. 2001
    ..The usefulness of CD79a in the diagnosis of plasmacytoma and the good response of the tumor to combined surgery and radiotherapy are illustrated. Plamacytoma should be included in the differential diagnosis of lacrimal tumors...
  3. ncbi request reprint Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Hum Pathol 38:1849-57. 2007
    ..There is more frequent p16 hypermethylation in mantle cell lymphoma and p15 or Rb1 hypermethylation in follicular lymphoma. The role of Rb methylation in disease or histologic transformation in follicular lymphoma warrants further study...
  4. ncbi request reprint Acute biphenotypic leukaemia
    C S Chim
    Honorary Clinical Associate Professor, Department of Medicine, Queen Mary Hospital, Hong Kong, ROC
    Haematologica 87:EIM03. 2002
  5. ncbi request reprint Gut perforation in MALT lymphoma of colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 87:EIM15. 2002
  6. ncbi request reprint Magnetic resonance imaging of leptomeningeal lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Haematol 124:566. 2004
  7. ncbi request reprint Eosinophilic leukemic transformation in polycythemia rubra vera (PRV)
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 46:447-50. 2005
    ..The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies...
  8. ncbi request reprint Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 23:57-60. 2005
    ..We hypothesized that AML in this case resulted from a complex pre-disposition by the natural progression of ET, prolonged use of HU, and the prior evolution into MF. The leukemogenic risk of HU is critically appraised...
  9. ncbi request reprint Primary follicular lymphoma of the small intestine
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 45:1463-6. 2004
    ..This is followed by the discussion on the frequency and staging systems for primary gastrointestinal lymphomas, and the relevance of monoclonal anti-CD20 antibody therapy...
  10. ncbi request reprint Concurrent hyperreactive malarial splenomegaly and quartan malarial nephropathy - Plasmodium malariae revisited
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 89:ECR21. 2004
  11. doi request reprint Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: a multivariate analysis by Cox regression in 141 patients
    C S Chim
    Department of Medicine and Cancer Research Centre, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematology 15:187-92. 2010
    ..To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET)...
  12. doi request reprint Epigenetic inactivation of the miR-34a in hematological malignancies
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Carcinogenesis 31:745-50. 2010
    ....
  13. ncbi request reprint Bull's neck in Hodgkin's disease: a CT imaging appraisal
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 89:EIM11. 2004
  14. ncbi request reprint Cast nephropathy in multiple myeloma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 89:EIM08. 2004
  15. ncbi request reprint Methylation profiling in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, PR China
    Leuk Res 28:379-85. 2004
    ..We analysed the methylation status of a panel of 10 genes including p15, p16, DAPK, p73, VHL, E-CAD, MGMT, RARbeta, RIZ1, and ER...
  16. ncbi request reprint Primary gastrointestinal lymphoma of the colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 90:EIM01. 2005
  17. ncbi request reprint Primary hepatic lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Leuk Lymphoma 40:667-70. 2001
    ..She presented with a massive, painless abdominal mass. The tumor responded to chemotherapy but the patient died of neutropenic sepsis...
  18. ncbi request reprint Primary CD30-positive anaplastic large cell lymphoma of the lip
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Oral Oncol 34:313-5. 1998
    ..The clinical features and clinical outcome in Ki-1 anaplastic large cell lymphoma are discussed...
  19. ncbi request reprint Mantle cell lymphoma in the Chinese: clinicopathological features and treatment outcome
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 59:295-301. 1998
    ..Clinicopathologic features and treatment outcome were similar to Caucasian patients, in that the disease combined the aggressive nature of DLC lymphoma and the incurability of low-grade lymphoma...
  20. ncbi request reprint Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong
    Leuk Lymphoma 33:385-8. 1999
    ..We describe a patient with chronic myeloid leukemia on interferon treatment, who developed BMN with symptoms and signs masquerading as interferon toxicity. This is followed by a literature review of BMN in CML...
  21. ncbi request reprint Primary anaplastic large cell lymphoma of skeletal muscle presenting with compartment syndrome
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 33:601-5. 1999
    ..Urgent decompression fasciotomy and combination chemotherapy resulted in durable remission status. This is followed by a review of primary skeletal muscle lymphoma in the English literature...
  22. ncbi request reprint Isolated uterine relapse of nasal T/Nk cell lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 34:629-32. 1999
    ....
  23. ncbi request reprint Treatment of de novo acute myeloid leukaemia in Hong Kong: a twenty-year experience (1975 to 1996)
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Aust N Z J Med 29:726-30. 1999
    ..Small patient numbers and short follow-up are common in some acute myeloid leukaemia (AML) studies and data on secondary malignancies after treatment of AML are rare...
  24. ncbi request reprint Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Cancer 91:2222-9. 2001
    ..Gene-promoter methylation is an epigenetic mechanism of transcription inactivation. In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia...
  25. ncbi request reprint CD-30 positive peripheral T-cell lymphoma of the Waldeyer's ring
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 38:199-202. 2000
    ..This is followed by a discussion on the differential diagnoses of nasal T/NK cell lymphoma and Ki-1 ALCL, based on clinical and pathological features...
  26. ncbi request reprint Primary anaplastic large cell lymphoma of the pancreas
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 46:457-9. 2005
    ..The proper diagnosis was only derived later with CD30 immunohistochemical study. This carries important implications on the management, as radical surgery is indicated in resectable carcinoma but not for a chemosensitive lymphoma...
  27. ncbi request reprint Long-term outcome of 231 patients with essential thrombocythemia: prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, ROC
    Arch Intern Med 165:2651-8. 2005
    ..Essential thrombocythemia (ET) is a clonal myeloproliferative disease associated with thrombohemorrhagic complications and myeloid transformation to diseases such as myelofibrosis and acute myeloid leukemia...
  28. ncbi request reprint Primary CD56 positive lymphomas of the gastrointestinal tract
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Cancer 91:525-33. 2001
    ..However, they have a considerable degree of morphologic and immunophenotypic overlap, making a definitive diagnosis difficult...
  29. ncbi request reprint Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia
    Wing Yan Au
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Leuk Res 29:1213-5. 2005
    ..There were no significant side effects, and normalization of erythropoiesis was durable. Alemtuzumab is active in PRCA that is idiopathic or secondary to T-cell lymphoproliferative diseases...
  30. pmc Epigenetic inactivation of the MIR129-2 in hematological malignancies
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 6:16. 2013
    ..MIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers...
  31. pmc Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 5:28. 2012
    ..Here we compared the outcomes of the staged approach with frontline PAD (bortezomib/doxorubicin/dexamethasone) or VTD (bortezomib/thalidomide/dexamethasone) induction, and analysed prognostic factors for outcome...
  32. doi request reprint Epigenetic inactivation of the MIR34B/C in multiple myeloma
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, University of Hong King, Pokfulam, Hong Kong
    Blood 118:5901-4. 2011
    ..Hypermethylation of MIR34B/C is tumor-specific. Frequent MIR34B/C hypermethylation during relapse/progression but not at diagnosis implicated a role of MIR34B/C hypermethylation in myeloma relapse/progression...
  33. doi request reprint Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor
    Anskar Y H Leung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 88:485-91. 2013
    ..011) on CR/CRi. RIC-HSCT as primary treatment for acute leukemic relapses post-HSCT induced a high CR rate with low TRM. Optimal postremission treatment remains to be defined...
  34. ncbi request reprint Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Hong Kong
    Br J Haematol 131:632-5. 2005
    ..At first or subsequent relapses, owing to highly effective salvage by arsenic trioxide, CDKN2B methylation did not impact on event-free survival or overall survival...
  35. doi request reprint Epigenetic silencing of MIR203 in multiple myeloma
    Kwan Yeung Wong
    Departments of Medicine Pathology Biochemistry, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Haematol 154:569-78. 2011
    ..Comparable occurrence of MIR203 methylation in MGUS and MM at diagnosis or relapse suggested that MIR203 methylation may be an early event in myelomagenesis instead of being acquired during disease progression...
  36. pmc Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma
    Chor Sang Chim
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong
    J Clin Pathol 60:664-9. 2007
    ..To study the role of gene promoter hypermethylation of the putative tumour suppressor genes involved in the death-associated protein (DAP) kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma (MM)...
  37. doi request reprint Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment
    Thomas S Y Chan
    Department of Medicine, Queen Mary Hospital Department of Pathology, Queen Mary Hospital, Hong Kong, China
    Clin Transplant 26:679-83. 2012
    ..EBV-positive PTLD occurred much later in Asian patients. Treatment results of PTLD were favorable...
  38. pmc Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
    ..MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis...
  39. doi request reprint Epigenetic inactivation of the hsa-miR-203 in haematological malignancies
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Cell Mol Med 15:2760-7. 2011
    ..In NHL, hsa-miR-203 methylation was associated with concomitant methylation of other tumour suppressor miRNAs. The frequent hsa-miR-203 methylation in lymphoid malignancies suggested a pathogenetic role of hsa-miR-203 methylation...
  40. doi request reprint Multiple myeloma with testicular involvement
    Yu Yan Hwang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Clin Oncol 26:1558-9. 2008
  41. ncbi request reprint Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 103:216-21. 2004
    ..4% versus 27.6%, P = 0.012), as well as for patients treated with chemotherapy/radiotherapy (IPI <or= 1 superior to IPI >or= 2 for CR: 76.7% versus 35.7%, P =.017; and 10-year OS: 63.8% versus 26.8%, P =.003)...
  42. ncbi request reprint SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Blood 103:4630-5. 2004
    ..SHP1 methylation leading to epigenetic activation of the Jak/STAT pathway might have a tentative role in the pathogenesis of myeloma, which should be further confirmed by functional studies in primary myeloma samples...
  43. pmc Epigenetic inactivation of the miR-124-1 in haematological malignancies
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e19027. 2011
    ..Amongst haematological cancers, miR-124-1 was more frequently hypermethylated in NHL, and hence warrants further study...
  44. pmc Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Pathol 60:104-6. 2007
    ..Methylation of DAP kinase and oestrogen receptor genes was comparable in multiple myeloma and MGUS. In conclusion, methylation of p16, SHP1 and E-cadherin genes might be involved in the progression of MGUS to multiple myeloma...
  45. ncbi request reprint Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Blood 104:243-9. 2004
    ..During treatment, patients with EBV DNA that showed further increases or failed to become undetectable had significantly inferior OS. In EBV-positive lymphomas, plasma EBV DNA is valuable as a tumor biomarker and for prognostication...
  46. doi request reprint SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Blood 120:2973-80. 2012
    ..Multivariate analysis showed that international prognostic index was the most significant factor impacting on outcome and survivals...
  47. pmc Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidomide/dexamethasone in transplant eligible patients
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Transl Med 8:124. 2010
    ....
  48. ncbi request reprint Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leukemia 19:2241-6. 2005
    ..RARA is the first myeloid-specific transcription factor shown to be dysregulated by both translocation and aberrant methylation...
  49. pmc A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Ann Hematol 89:1019-27. 2010
    ..Our approach reduced the use of bortezomib without compromising the ultimate CR rate and is of financial significance for less affluent communities...
  50. ncbi request reprint Bulbar palsy in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 90:ECR42. 2005
  51. doi request reprint Methylation of tumor suppressor microRNAs: lessons from lymphoid malignancies
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Expert Rev Mol Diagn 12:755-65. 2012
    ..In this review, the authors will focus on the aberrant methylation of miRNAs in the pathogenesis of lymphoid malignancies including chronic lymphocytic leukemia, multiple myeloma and acute lymphoblastic leukemia...
  52. doi request reprint DNA methylation of microRNA genes in multiple myeloma
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong, China
    Carcinogenesis 33:1629-38. 2012
    ....
  53. pmc Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Pathol 59:921-6. 2006
    ..INK4 (p15, p16, p18 and p19) and CIP/KIP (p21, p27 and p57) are two families of cyclin-dependent kinase inhibitors (CKI) targeting CDK4/6 and CDK2, respectively...
  54. ncbi request reprint Plasma cell problems: Case 2. Extramedullary cardiac plasmacytoma presenting with cardiac tamponade
    C S Chim
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 23:3140-3. 2005
  55. ncbi request reprint Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias
    C S Chim
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Ann Hematol 82:738-42. 2003
    ..In AML, p15 gene methylation was associated with the M2 subtype, but was not prognostic for CR, OS, or DFS...
  56. pmc Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFκB pathway
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Mol Cancer 12:173. 2013
    ..The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. We postulated that miR-9-1, miR-9-2 and miR-9-3 might be inactivated by DNA hypermethylation in chronic lymphocytic leukemia (CLL)...
  57. doi request reprint DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Epigenomics 3:83-92. 2011
    ..Finally, the potential role of miRNA methylation as a biomarker for diagnosis, prognosis (and hence the potential of developing a risk-stratified approach) and a therapeutic target is discussed...
  58. doi request reprint Use of fludarabine-containing chemotherapeutic regimen results in durable complete remission of subcutaneous panniculitis-like T-cell lymphoma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Clin Dermatol 9:396-8. 2008
    ..The patient achieved complete remission after one course of treatment. After completion of six courses of FND, the patient has remained in remission for more than 3 years. FND may be an effective treatment for aggressive SPTCL...
  59. doi request reprint CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
    Xiao Tong Hu
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 115:2458-61. 2010
    ..The ectopic expression of CD44DeltaEx1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation...
  60. ncbi request reprint Clinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura in adult Chinese patients: an analysis of 220 cases
    A Y Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Ann Hematol 80:384-6. 2001
    ..In addition, primary steroid refractoriness and positive ANA were bad prognostic factors of the subsequent response to splenectomy...
  61. ncbi request reprint Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study
    Y L Kwong
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 66:274-9. 2001
    ..This regimen avoids the possible long-term toxicities of As2O3 and mutagenicity of combination chemotherapy, a strategy that might be suitable for this potentially curable leukaemia...
  62. ncbi request reprint Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide
    W Y Au
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Haematol 117:130-2. 2002
    ..Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse...
  63. ncbi request reprint Candida tropicalis fungaemia in adult patients with haematological malignancies: clinical features and risk factors
    A Y H Leung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Hosp Infect 50:316-9. 2002
    ..The clinicopathologic features and risk factors identified in this study may help design better treatment strategies for this often-lethal complication...
  64. ncbi request reprint Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 80:282-7. 2005
    ..A review of the literature showed a marked variation in the frequencies of methylation of these genes, which might be attributable to difference in methodologies used to detect gene methylation...
  65. ncbi request reprint Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 19:2033-40. 2001
    ..To investigate the frequency of p15 and p16 gene promoter methylation in acute promyelocytic leukemia (APL), and to define its value in the detection of minimal residual disease (MRD) and treatment prognostication...
  66. ncbi request reprint Can defects in transferrin receptor 2 and hereditary hemochromatosis genes account for iron overload in HbH disease?
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, SAR China
    Blood Cells Mol Dis 30:107-11. 2003
    ....
  67. ncbi request reprint Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leukemia 21:2527-36. 2007
    ..Methylation study of a panel of genes, regulating a cellular pathway instead of isolated genes, is important...
  68. ncbi request reprint Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Haematol 119:988-90. 2002
    ..Aberrant CEBPA methylation is infrequent in AML, but may occur preferentially in the M2 phenotype...
  69. ncbi request reprint Pathological bone fracture in non-Hodgkin's lymphoma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 25:3175-6. 2007
  70. ncbi request reprint Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors
    Chee Kin Hui
    Division of Gastroenterology and Hepatology, The University of Hong Kong, China
    Am J Transplant 5:1437-45. 2005
    ..01, adjusted hazards ratio 7.27, 95%CI 1.62-32.58). Our data support the use of prophylactic therapy in preventing HBV-related hepatitis after allogeneic HSCT from HBsAg-positive donor...
  71. doi request reprint Pulmonary interstitial amyloidosis complicating multiple myeloma
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Hong Kong
    J Clin Oncol 26:504-6. 2008
  72. pmc DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas
    Rita Lok Hay Yim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong, China
    Front Genet 3:233. 2012
    ..Herein, we review the recent literature of methylation of tumor suppressive miRNAs in different histopathologic subtypes of lymphomas, and discuss its potential diagnostic, prognostic, and therapeutic significance...
  73. doi request reprint Restoration of chemosensitivity by bortezomib: implications for refractory myeloma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Nat Rev Clin Oncol 6:237-40. 2009
    ..The patient underwent autologous bone-marrow transplantation, and 14 months later she developed obstructive jaundice...
  74. pmc Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results
    Harinder Gill
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 90:1399-407. 2011
    ..Early stage, good performance status, and low international prognostic index risk scores significantly impacted on CR rate and survivals. Rituximab and fludarabine were safe for non-gastric MZL and resulted in more durable remissions...
  75. ncbi request reprint Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    Leuk Res 30:1135-9. 2006
    ..In conclusion, Wif-1 is infrequently methylated in CLL. Other factors leading to activation of the Wnt pathway warrant further study...
  76. ncbi request reprint Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias
    C S Chim
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Ann Hematol 83:527-32. 2004
    ..Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias...
  77. ncbi request reprint Common malignancies with uncommon sites of presentation: case 2. Mantle-cell lymphoma of the prostate
    C S Chim
    University Departments of Medicine, Pathology, and Radiology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 21:4456-8. 2003
  78. ncbi request reprint Arsenic trioxide in comparison with chemotherapy and bone marrow transplantation for the treatment of relapsed acute promyelocytic leukaemia
    W Y Au
    Departments of Medicine and Pathology, Queen Mary Hospital, Hong Kong
    Ann Oncol 14:752-7. 2003
    ..The best overall treatment strategy for patients with acute promyelocytic leukaemia (APL) in relapse with chemotherapy, bone marrow transplantation (BMT) or arsenic trioxide (As(2)O(3)) based therapy remains undefined...
  79. ncbi request reprint Side effects and good effects from new chemotherapeutic agents. Case 3. Bortezomib in primary refractory plasmacytoma
    C S Chim
    University Departments of Medicine, Radiology and Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 23:2426-8. 2005
  80. ncbi request reprint Absence of p300 gene promoter methylation in acute leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Cancer Genet Cytogenet 150:164-7. 2004
    ..None of the cell lines and patient samples showed p300 gene methylation. Therefore, hypermethylation of p300 is not an important mechanism in leukemogenesis...
  81. ncbi request reprint Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with BMT at first remission and HLA-matched unrelated donor
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Bone Marrow Transplant 40:339-47. 2007
    ..In summary, the adverse impact of Ph chromosome, B-cell phenotype and high leukocyte count was overcome by allogeneic BMT. Matched unrelated donor transplantation appears promising...
  82. ncbi request reprint Radiologic manifestations of granulocytic sarcoma in adult leukemia
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, Rm. 405, Block K, Pokfulam Rd, Pokfulam, Hong Kong
    AJR Am J Roentgenol 176:1427-31. 2001
    ..The presence of peripheral rim enhancement with hypodense or hypointense centers on T1-weighted images may, however, mimic an abscess...
  83. ncbi request reprint Fine needle aspiration cytology in follicular dendritic cell sarcoma: a report of two cases
    Yuen Shan Fan
    Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Hong Kong SAR, China
    Acta Cytol 51:642-7. 2007
    ..However, difficulties persist in making cytologic diagnosis...
  84. ncbi request reprint Adverse prognostic impact of CDKN2B hyper-methylation in acute promyelocytic leukemia
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Hong Kong, PR China
    Leuk Lymphoma 47:815-25. 2006
    ..Therefore, CDKN2B methylation is a potential prognostic factor that may be incorporated into a risk-stratified therapeutic strategy, which aims at achieving a cure with optimal amounts of treatment...
  85. ncbi request reprint Extramedullary sites of involvement in hematologic malignancies: case 3. Hemorrhagic gastric plasmacytoma as the primary presentation in multiple myeloma
    C S Chim
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 20:344-7. 2002
  86. ncbi request reprint Unusual abdominal tumors: case 3. Multiple lymphomatous polyposis in lymphoma of colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People s Republic of China
    J Clin Oncol 21:953-5. 2003
  87. ncbi request reprint Unusual hematologic malignancies. Case 3. CNS involvement in CD56-positive intestinal gamma/delta T-cell lymphoma
    C S Chim
    Queen Mary Hospital, Hong Kong
    J Clin Oncol 20:3742-4. 2002
  88. ncbi request reprint Hypermethylation of gene promoters in hematological neoplasia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 20:167-76. 2002
    ..Emerging evidence suggests a possible prognostic value of gene promoter hypermethylation. Moreover, gene hypermethylation may also serve as a target for therapeutic invention by hypomethylating agents...
  89. ncbi request reprint Outcome of Chinese patients with chronic myeloid leukaemia (CML) underwent allogeneic bone-marrow transplantation (BMT)
    C K Lee
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Am J Hematol 61:85-9. 1999
    ..Therefore, we followed a cohort of 81 Chinese patients who received allogeneic BMT...
  90. ncbi request reprint Two cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease
    W Y Au
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Ann Hematol 81:659-61. 2002
    ..For patients with a history of active malignancy and heavy previous chemotherapy exposure, the use of nontoxic arsenic therapy appeared to be effective and prudent...
  91. ncbi request reprint Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease
    Joyce C W Chan
    Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    Br J Haematol 133:198-205. 2006
    ..All systolic function parameters were normal. A longer treatment period is desirable to demonstrate improvement in cardiac function...
  92. ncbi request reprint GI manifestations of mantle cell lymphoma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Gastrointest Endosc 58:931-3. 2003
  93. ncbi request reprint Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma
    S Y Ma
    Division of Haematology and Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Hong Kong Med J 10:77-83. 2004
    ..To present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among Chinese patients...
  94. ncbi request reprint Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China
    AJR Am J Roentgenol 174:1141-5. 2000
    ..Presence of bone erosion is suggestive but not diagnostic of the disease...
  95. ncbi request reprint Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Hum Genet 51:832-8. 2006
    ..Moreover Chinese patients with CLL share a similarly indolent clinical course, and this is the first comprehensive study on p14, DAP kinase and Apaf-1 hypermethylation in CLL...
  96. ncbi request reprint Analysis of Clonality in Kimura's Disease
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Surg Pathol 26:1083-6. 2002
    ..Furthermore, the presence of identical T cell clones in different sites and at different times suggested that a clonal T cell population might have contributed to the pathogenesis in this case of Kimura's disease...
  97. ncbi request reprint Hemophilia B in a female carrier due to skewed inactivation of the normal X-chromosome
    V Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 58:72-6. 1998
    ..Analysis of the methyl-sensitive Hpa II sites at the 5' end of the hypoxanthine phosphoribosyltransferase gene showed that skewed inactivation of the X chromosome carrying her normal FIX gene accounted for the hemophilia phenotype...
  98. ncbi request reprint Primary granulocytic sarcoma of the mediastinum
    W S Wong
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Leuk Lymphoma 45:1931-3. 2004
    ..We presented the clinico-pathological and radiological features of a patient with primary mediastinal GS, and discussed the differential diagnoses and clinical management...
  99. ncbi request reprint Deafness associated with the use of Bortezomib in multiple myeloma
    C S Chim
    Acta Oncol 47:323-4. 2008
  100. ncbi request reprint Infrequent epigenetic dysregulation of CIP/KIP family of cyclin-dependent kinase inhibitors in multiple myeloma
    C S Chim
    Leukemia 19:2352-5. 2005
  101. ncbi request reprint SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway
    C S Chim
    Leukemia 18:356-8. 2004