Siu Tim Cheung

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint GEP associates with wild-type p53 in hepatocellular carcinoma
    Siu Tim Cheung
    Department of Surgery, University of Hong Kong, L9 55, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, P R China
    Oncol Rep 15:1507-11. 2006
  2. ncbi request reprint Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    Siu Tim Cheung
    Centre for the Study of Liver Disease and Departments of Surgery and Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 10:7629-36. 2004
  3. pmc Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy
    Siu Tim Cheung
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neoplasia 7:91-8. 2005
  4. pmc Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy
    Siu Tim Cheung
    Center for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neoplasia 8:696-701. 2006
  5. ncbi request reprint Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor
    Siu Tim Cheung
    Department of Surgery, Centre for the Study of Liver Disease, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 62:4711-21. 2002
  6. ncbi request reprint Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transfer
    Siu Tim Cheung
    Department of Surgery and Center for the Study of Liver Disease, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1008-14. 2002
  7. ncbi request reprint Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma
    Siu Tim Cheung
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Clin Cancer Res 11:551-6. 2005
  8. ncbi request reprint Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 63:3121-6. 2003
  9. ncbi request reprint Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells
    Ying Chi Ip
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Cancer Ther 6:2858-67. 2007
  10. pmc Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma
    Ching Yan Lam
    Department of Surgery, The University of Hong Kong, Hong Kong
    PLoS ONE 7:e40324. 2012

Collaborators

Detail Information

Publications26

  1. ncbi request reprint GEP associates with wild-type p53 in hepatocellular carcinoma
    Siu Tim Cheung
    Department of Surgery, University of Hong Kong, L9 55, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, P R China
    Oncol Rep 15:1507-11. 2006
    ..In summary, we demonstrated that p53 wild-type protein nuclei accumulation is associated with GEP protein expression in human HCC specimens, and GEP modulates p53 wild-type protein levels in vitro...
  2. ncbi request reprint Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    Siu Tim Cheung
    Centre for the Study of Liver Disease and Departments of Surgery and Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 10:7629-36. 2004
    ..The aim of this study was to investigate the clinical significance of GEP expression and its potential as a therapeutic target in HCC...
  3. pmc Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy
    Siu Tim Cheung
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neoplasia 7:91-8. 2005
    ..Our aim is to validate the prognostic significance of transcript AA454543 by alternative research methods and in a separate group of HCC patients...
  4. pmc Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy
    Siu Tim Cheung
    Center for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neoplasia 8:696-701. 2006
    ..We aim to examine whether quantitative measurement of preoperative plasma transcript AA454543 can provide similar prognostic information...
  5. ncbi request reprint Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor
    Siu Tim Cheung
    Department of Surgery, Centre for the Study of Liver Disease, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 62:4711-21. 2002
    ..These metastasis-associated genes may provide clues to reveal patients with increased risk of developing metastasis, and to identify novel therapeutic targets for the treatment of metastasis...
  6. ncbi request reprint Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transfer
    Siu Tim Cheung
    Department of Surgery and Center for the Study of Liver Disease, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1008-14. 2002
    ..In this study, we investigated the efficacy of hepatocyte transduction via introduction of the exogenous CTLA4Ig gene to the rat liver graft by retrovirus vector, and examined the presence of target serum protein after gene transfers...
  7. ncbi request reprint Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma
    Siu Tim Cheung
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Clin Cancer Res 11:551-6. 2005
    ..The aim of the current study is to validate the microarray data by an alternative research method applicable for routine practice...
  8. ncbi request reprint Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 63:3121-6. 2003
    ..This study provides strong evidence that supports the use of serum VEGF level as an indirect estimate of tumor VEGF expression...
  9. ncbi request reprint Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells
    Ying Chi Ip
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Cancer Ther 6:2858-67. 2007
    ..These findings showed that CLDN-10 is functionally involved in hepatocellular carcinoma invasion and is a potential target for hepatocellular carcinoma therapy...
  10. pmc Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma
    Ching Yan Lam
    Department of Surgery, The University of Hong Kong, Hong Kong
    PLoS ONE 7:e40324. 2012
    ..However, the nature and characteristics of GEP interacting partner remain unclear. The present study aims to identify and characterize the novel predominant interacting partner of GEP using co-immunoprecipitation and mass spectrometry...
  11. ncbi request reprint Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma
    Jenny C Y Ho
    Department of Surgery, The University of Hong Kong, L9 55, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road Pokfulam, Hong Kong, China
    J Cancer Res Clin Oncol 133:929-36. 2007
    ..The effects of retinoid are mediated by retinol-binding proteins (RBPs) through regulating cell proliferation and differentiation...
  12. ncbi request reprint Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma
    Ying Chi Ip
    Center for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, China
    World J Gastroenterol 11:6269-76. 2005
    ..To investigate the precise role of membrane type 1-matrix metalloproteinase (MT1-MMP) in hepatocellular carcinoma (HCC) metastasis...
  13. doi request reprint Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma
    Jenny C Ho
    Department of Surgery, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Hepatology 47:1524-32. 2008
    ..CONCLUSION: We have shown that anti-GEP antibody can inhibit HCC growth, providing evidence that GEP is a therapeutic target for HCC treatment...
  14. doi request reprint Albumin mRNA in plasma predicts post-transplant recurrence of patients with hepatocellular carcinoma
    Siu Tim Cheung
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Transplantation 85:81-7. 2008
    ..The former criteria have limited power on prognosis, whereas the latter do not provide complete information until explant is available...
  15. ncbi request reprint Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma
    Jenny C Ho
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Cancer 111:494-500. 2004
    ..It suggested that the differential expression of CYP2E1 may play an important role in HCC tumorigenesis...
  16. pmc Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study
    Chi Leung Liu
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 244:194-203. 2006
    ..To evaluate whether major right hepatectomy using the anterior approach technique for large hepatocellular carcinoma (HCC) results in better operative and long-term survival outcomes when compared with the conventional approach technique...
  17. ncbi request reprint Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma
    Ying Chi Ip
    Department of Surgery, Centre for the Study of Liver Disease, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Carcinog 46:225-30. 2007
    ..In summary, the association of nuclear MT1-MMP with aggressive tumor features including poor prognosis and large tumor expands its functional repertoire and further indicates a new functional role of MMPs within nuclei of tumor cells...
  18. ncbi request reprint Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma
    Jenny C Ho
    Centre for the Study of Liver Disease, The University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Cancer 119:1330-7. 2006
    ..037). Our data revealed GPAA1 gene amplification with overexpression of RNA and protein in HCC. GPAA1 is a potential amplification target of chromosome 8q and responsible to regulate tumor cells behavior...
  19. pmc Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells
    Phyllis Fung Yi Cheung
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e28246. 2011
    ..Here, we characterized its expression pattern and stem cell properties in fetal and cancerous livers...
  20. ncbi request reprint Development of antibody to hepatitis B surface antigen after liver transplantation for chronic hepatitis B
    Chung Mau Lo
    Department of Surgery, Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, China
    Hepatology 37:36-43. 2003
    ..The antibody is likely to be of donor origin, suggesting the possibility of adoptive immunity transfer through a liver graft...
  21. ncbi request reprint Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin
    Chung Mau Lo
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:557-63. 2004
    ..With combination of adefovir and high-dose HBIG, however, long-term survival can be achieved after retransplantation...
  22. doi request reprint Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance
    Siu Tim Cheung
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Gastroenterology 140:344-55. 2011
    ..Gene expression profiling studies have shown that hepatic cancer cells express granulin-epithelin precursor (GEP); we investigated its role in hepatic cancer stem cell functions and chemoresistance...
  23. ncbi request reprint Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Clin Cancer Res 10:4150-7. 2004
    ..The possible role of THBS 1 in the angiogenesis of HCC was also studied by correlating its expression with vascular endothelial growth factor (VEGF) expression...
  24. ncbi request reprint Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma
    Xiao Qi Wang
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Clin Cancer Res 12:5248-52. 2006
    ..Consequently, it is highly relevant to assess whether the presence of these single nucleotide polymorphisms in the general population represents a risk to the development of HCC...
  25. pmc Distinct pathways of genomic progression to benign and malignant tumors of the liver
    Aaron D Tward
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:14771-6. 2007
    ....
  26. pmc Gene expression patterns in human liver cancers
    Xin Chen
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 13:1929-39. 2002
    ..Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 overexpression...