Annie Ny Cheung

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. doi request reprint Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis
    Xiaoyun Liao
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Int J Cancer 123:296-302. 2008
  2. pmc Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers
    Lili Jiang
    Department of Pathology and, The University of Hong Kong, HKSAR, China
    Mol Cancer 9:318. 2010
  3. pmc p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression
    A N Cheung
    Department of Pathology, Queen Mary Hospital, University of Hong Kong
    J Clin Pathol 51:159-62. 1998
  4. ncbi request reprint Molecular targets in gynaecological cancers
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pathology 39:26-45. 2007
  5. doi request reprint Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Future Oncol 5:217-31. 2009
  6. pmc Chromosome in situ hybridisation, Ki-67, and telomerase immunocytochemistry in liquid based cervical cytology
    A N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Pathol 57:721-7. 2004
  7. ncbi request reprint Atypical squamous cells of undetermined significance on cervical smears: follow-up study of an Asian screening population
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 102:74-80. 2004
  8. ncbi request reprint Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population
    Annie N Y Cheung
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 99:331-5. 2003
  9. ncbi request reprint Pathology of gestational trophoblastic diseases
    Annie Nga Yin Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People s Republic of China
    Best Pract Res Clin Obstet Gynaecol 17:849-68. 2003
  10. ncbi request reprint Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 100:1411-7. 2004

Collaborators

Detail Information

Publications56

  1. doi request reprint Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis
    Xiaoyun Liao
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Int J Cancer 123:296-302. 2008
    ..DNMT1 protein overexpression might contribute to such aberrant DNA hypermethylation of specific tumor suppressor genes in endometrial cancers...
  2. pmc Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers
    Lili Jiang
    Department of Pathology and, The University of Hong Kong, HKSAR, China
    Mol Cancer 9:318. 2010
    ..Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive...
  3. pmc p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression
    A N Cheung
    Department of Pathology, Queen Mary Hospital, University of Hong Kong
    J Clin Pathol 51:159-62. 1998
    ..The p21WAF1/CIP1 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream effector of the tumour suppressor gene p53...
  4. ncbi request reprint Molecular targets in gynaecological cancers
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Pathology 39:26-45. 2007
    ..Interpretation must be integrated with clinical and histopathological context to avoid misleading judgement. The importance of quality assurance of all such molecular techniques and their ethical implications cannot be over-emphasised...
  5. doi request reprint Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Future Oncol 5:217-31. 2009
    ....
  6. pmc Chromosome in situ hybridisation, Ki-67, and telomerase immunocytochemistry in liquid based cervical cytology
    A N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Pathol 57:721-7. 2004
    ..To assess the potential value of chromosome in situ hybridisation (CISH), Ki-67, and telomerase immunocytochemistry in liquid based cervical cytology to help detect carcinoma cells and precursors...
  7. ncbi request reprint Atypical squamous cells of undetermined significance on cervical smears: follow-up study of an Asian screening population
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 102:74-80. 2004
    ..The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date...
  8. ncbi request reprint Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population
    Annie N Y Cheung
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 99:331-5. 2003
    ....
  9. ncbi request reprint Pathology of gestational trophoblastic diseases
    Annie Nga Yin Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People s Republic of China
    Best Pract Res Clin Obstet Gynaecol 17:849-68. 2003
    ..Alternative biological markers may be explored for better patient management...
  10. ncbi request reprint Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 100:1411-7. 2004
    ..Traditionally, it is believed that PHM carries a better prognosis and rarely develops metastasis. However, making a distinction between PHM and CHM using histologic criteria alone may be difficult...
  11. doi request reprint P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Mod Pathol 23:559-66. 2010
    ..In summary, p63 and p73 immunocytochemistry are potential good markers for detection of carcinoma and high-grade lesions in cervical cytology samples and for triage management of women with atypical squamous cells and low-grade lesions...
  12. ncbi request reprint Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome: a differential expression study
    Pui yee Fong
    Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 103:268-76. 2005
    ..In previous studies, the authors demonstrated that low apoptotic activity was correlated with the progression of HM to GTN, and they hypothesized that some apoptosis-related genes may determine this progression...
  13. ncbi request reprint Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis
    John M Luk
    Department of Surgery, The University of Hong Kong, Jockey Club Clinical Research Center, 21 Sassoon Road, Pokfulam, Hong Kong
    J Cell Physiol 209:755-66. 2006
    ..In short, AEP1 is an evolutionary-conserved acrosome-specific gene and likely functions in acrosome-cap formation...
  14. ncbi request reprint Cervical and peritoneal fluid cytology of uterine sarcomas
    Xiao Wang
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Acta Cytol 46:465-9. 2002
    ..To study the cytologic features of uterine sarcoma...
  15. ncbi request reprint Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization
    Caroline Y L Lai
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Mod Pathol 17:40-8. 2004
    ..As a partial mole still carries a risk of developing gestational trophoblastic neoplasia, follow-up is considered necessary for both complete and partial moles...
  16. pmc Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma
    Wei Cheng Xue
    Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Mol Diagn 6:326-34. 2004
    ..001, 0.0005, respectively). Hypermethylation of multiple genes, especially p16, might be related to the subsequent development of gestational trophoblastic neoplasia...
  17. ncbi request reprint Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening
    Hextan Y S Ngan
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Tumour Biol 23:87-92. 2002
    ..This study aims at exploring the potential use of telomerase activity assay and typing of human papillomaviruses (HPV) 16 and 18 in improving the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  18. doi request reprint Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis
    Kai Fai Lee
    Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    Mol Hum Reprod 14:465-74. 2008
    ..2 in the acrosome of spermatids and the binding of VAD1.2 protein with vesicle forming (syntaxin 1) and structural (beta-actin and MHC) proteins suggest that VAD1.2 maybe involved in acrosome formation during spermiogenesis...
  19. doi request reprint Distribution of six oncogenic types of human papillomavirus and type 16 integration analysis in Chinese women with cervical precancerous lesions and carcinomas
    Stephanie S Liu
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR China
    Tumour Biol 29:105-13. 2008
    ..The prevalent genotypes of human papillomavirus (HPV) infection and the significance of HPV16 integration in cervical precancerous lesions and cancer of Chinese women were investigated...
  20. ncbi request reprint Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer
    Fung Yu Huang
    Department of Obstetrics and Gynaecology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Gynecol Oncol 103:219-25. 2006
    ..Therefore, we pursued to identify potential candidate gene related to cervical cancer development...
  21. ncbi request reprint Human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy Chinese women from Hong Kong
    Hextan Y S Ngan
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Hong Kong Med J 16:171-9. 2010
    ..To assess the immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine in Chinese women aged 18 to 35 years enrolled from Hong Kong...
  22. ncbi request reprint Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix
    Tsin Wah Leung
    Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gynecol Oncol 92:866-72. 2004
    ....
  23. doi request reprint p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells
    Yuen L Pon
    School of Biological Sciences, University of Hong Kong, Hong Kong
    Cancer Res 68:6524-32. 2008
    ..These results indicate that p70(S6K) may play a critical role in tumor progression in ovarian cancer through the induction of EMT. Targeting p70(S6K) may thus be a useful strategy to impede cancer cell invasion and metastasis...
  24. ncbi request reprint The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissues
    Yue Wang
    Departments of Obstetrics and Gynaecology, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Gynecol Oncol 98:104-10. 2005
    ..We therefore investigated the relationship between mtMSI and mtDNA content in endometrial cancer...
  25. doi request reprint Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis
    Queeny K Y Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Carcinogenesis 30:114-21. 2009
    ..Our findings suggested that a tumor suppressor role of FSTL1 may be important in ovarian and endometrial carcinogenesis...
  26. pmc Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer
    N A Wei
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, PR China
    Mol Cancer 8:70. 2009
    ..The aim of this study was to investigate the expression, prognostic significance and potential function of Pdcd4 in ovarian cancer...
  27. doi request reprint Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    Christy W H Au
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Lett 281:151-61. 2009
    ..Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer...
  28. doi request reprint Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cancer Res 68:7200-9. 2008
    ..These results together suggest an important role of TGF-beta1 in the early process of cervical carcinogenesis...
  29. pmc Evaluation of a newly developed GenoArray human papillomavirus (HPV) genotyping assay and comparison with the Roche Linear Array HPV genotyping assay
    Stephanie S Liu
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Clin Microbiol 48:758-64. 2010
    ..It has the advantage that it specifically detects HPV-52, which overcomes a limitation of the LA assay, and hence, it has potential value for use for genotyping, especially in regions where HPV-52 has a high prevalence...
  30. doi request reprint Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin
    Xiaoyun Liao
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Mod Pathol 22:839-47. 2009
    ..In summary, overexpression of Gli1 was an early event in endometrial carcinogenesis. Aberrant activation of hedgehog pathway may play important roles in endometrial cancer through beta-catenin nuclear accumulation...
  31. doi request reprint Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion
    Michelle K Y Siu
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Int J Cancer 127:21-31. 2010
    ..Our findings suggest that Pak1, p-Pak1 and p-Pak2 play important roles in ovarian carcinogenesis. Pak1 and p-Pak1 may be potential prognostic markers and therapeutic molecular targets in ovarian cancer...
  32. pmc Age-period-cohort analysis of cervical cancer incidence in Hong Kong from 1972 to 2001 using maximum likelihood and Bayesian methods
    Gabriel M Leung
    Department of Community Medicine and School of Public Health, University of Hong Kong, China
    J Epidemiol Community Health 60:712-20. 2006
    ..To examine the secular effects of opportunistic screening for cervical cancer in a rich, developed community where most other such populations have long adopted organised screening. Design, setting, and..
  33. ncbi request reprint Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole
    Dan Hua Shen
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Arch Pathol Lab Med 127:e291-3. 2003
    ..The patient responded well to surgery. The presence of an epithelioid trophoblastic tumor should be considered in chemoresistant gestational trophoblast tumor...
  34. ncbi request reprint Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development
    Hui Juan Yang
    Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong SAR, China
    Tumour Biol 24:310-6. 2003
    ..The lower HPV 16 infection rates and lower copy numbers when compared with cervical cancer tend to suggest that HPV plays a less essential role in the development of endometrial cancer and ovarian cancer...
  35. ncbi request reprint Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells
    Lydia W T Cheung
    Department of Zoology, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Endocrinology 147:4179-91. 2006
    ..This study is the first to demonstrate a role of PEDF in OSE biology and ovarian cancer and suggests that the loss of PEDF may e of relevance in carcinogenesis...
  36. ncbi request reprint Differential expression of insulin-like growth factor binding protein 1 and ferritin light polypeptide in gestational trophoblastic neoplasia: combined cDNA suppression subtractive hybridization and microarray study
    Hui Chen Feng
    Department of Anatomy, The University of Hong Kong, Pokfulam, Queen Mary Hospital, Hong Kong, China
    Cancer 104:2409-16. 2005
    ..Few biologic markers can predict subsequent development of persistent gestational trophoblastic neoplasia (GTN) requiring chemotherapy...
  37. pmc Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome
    Michelle K Y Siu
    Department of Pathology, The University of Hong Kong Special Administrative Region, China
    Am J Pathol 173:1165-72. 2008
    ..These findings suggest that NANOG is involved in the pathogenesis and clinical progress of gestational trophoblastic disease, likely through its effect on apoptosis, cell migration, and invasion...
  38. pmc p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
    Michelle K Y Siu
    Department of Pathology, University of Hong Kong, Pokfulam, Hong Kong
    Proc Natl Acad Sci U S A 107:18622-7. 2010
    ..The implied possible cross-talk between Pak4 and EGFR suggests the potential of dual targeting of EGFR and Pak4 as a unique therapeutic approach for cancer therapy...
  39. ncbi request reprint Detection of mitochondrial DNA mutations in gestational trophoblastic disease
    Pui Man Chiu
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Hum Mutat 22:177. 2003
    ..Occurrence of multiple somatic mtDNA mutations in choriocarcinoma suggests that mtDNA mutations might play an important role in the molecular pathogenesis of invasive gestational trophoblastic disease...
  40. doi request reprint Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases
    Philip P C Ip
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Am J Surg Pathol 33:992-1005. 2009
    ..More recently, it has been suggested that immunohistochemical staining may be helpful in the diagnosis of STUMPs...
  41. ncbi request reprint Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma
    Huichen Feng
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Gynecol Oncol 94:375-82. 2004
    ..To assess the differential gene expression in neoplastic and normal trophoblastic cells and evaluate the effect of methylation on tissue inhibitor of metalloproteinase 3 (TIMP3) expression in choriocarcinoma (CCA) cells...
  42. doi request reprint Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
    Xiaoyun Liao
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Carcinogenesis 30:131-40. 2009
    ..Gli1 expression is an independent prognostic marker. Inhibition of the HH pathway molecules might be a valid therapeutic strategy for ovarian cancers...
  43. ncbi request reprint Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization
    Wei Cheng Xue
    Department of Pathology, People s Hospital, Peking University, Beijing, China
    Cancer 94:2288-94. 2002
    ..Most showed benign behavior whereas 10-15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty...
  44. doi request reprint Who receives, benefits from and is harmed by cervical and breast cancer screening among Hong Kong Chinese?
    Gabriel M Leung
    School of Public Health, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    J Public Health (Oxf) 30:282-92. 2008
    ..To estimate the proportion of and characterize women who had received cervical and breast screening and to quantify the associated preventable burden of disease and potential iatrogenic harm...
  45. ncbi request reprint Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1)
    Hui Chen Feng
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    J Soc Gynecol Investig 12:e21-32. 2005
    ..Research into the biology of human trophoblast invasion has been hampered by a lack of in vitro models. The aim of this study was to establish and characterize a human extravillous trophoblast cell line from the first-trimester placenta...
  46. ncbi request reprint Beliefs about cervical cancer and human papillomavirus (HPV) and acceptability of HPV vaccination among Chinese women in Hong Kong
    Peter W H Lee
    Division of Clinical Health Psychology, Department of Psychiatry, The University of Hong Kong, Hong Kong
    Prev Med 45:130-4. 2007
    ..To assess the knowledge and beliefs on cervical cancer and HPV infection and to evaluate the acceptability of HPV vaccination among Chinese women...
  47. ncbi request reprint Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas
    Philip P C Ip
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Am J Surg Pathol 31:1215-24. 2007
    ..Four hundred ninety patients with uterine leiomyomas in 2004 and 2005 were reviewed. Their ages ranged from 22 to 86 (mean 47.2). One hundred forty-seven (30%) were treated with tranexamic acid...
  48. ncbi request reprint The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study
    Carina C W Chan
    Departments of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Clin Endocrinol Metab 88:5846-50. 2003
    ..In conclusion, the suppressed GR expression after mifepristone administration may be part of the mechanism of mifepristone in causing abortion...
  49. pmc Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong
    J Mol Diagn 7:8-16. 2005
    ....
  50. ncbi request reprint Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
    Vera S F Chan
    Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    Nat Genet 38:38-46. 2006
    ..Thus, homozygosity for L-SIGN plays a protective role during SARS infection...
  51. ncbi request reprint Apoptotic and proliferative activity in ovarian benign, borderline and malignant tumors
    Aijun Liu
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Chin Med Sci J 17:106-11. 2002
    ..To determine the apoptotic and proliferative activities in various ovarian epithelial tumors...
  52. ncbi request reprint Single nucleotide polymorphism of pi-class glutathione s-transferase and susceptibility to endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 11:2981-5. 2005
    ..In this study, we aimed at determining the association between the GSTP1 polymorphism and the risk of endometrial carcinoma in a Chinese population...
  53. ncbi request reprint Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer
    Kelvin Y K Chan
    Department of Pathology, Queen Mary Hospital and The University of Hong Kong, Hong Kong
    Cancer Res 62:4151-6. 2002
    ..Our findings suggest that both genes may be involved in the development of sporadic ovarian cancer...
  54. doi request reprint TrkB as a therapeutic target for ovarian cancer
    Michelle K Y Siu
    The University of Hong Kong, Queen Mary Hospital, Department of Pathology, Hong Kong, China
    Expert Opin Ther Targets 13:1169-78. 2009
    ..Overexpression of Tropomyosin-related kinase B (TrkB), a tyrosine kinase receptor, has been documented in ovarian cancer and is found to be correlated with poor prognosis...
  55. ncbi request reprint Epigenetic and genetic alterations of p33ING1b in ovarian cancer
    Dan Hua Shen
    Department of Pathology, People s Hospital, Peking University, Beijing, Republic of China
    Carcinogenesis 26:855-63. 2005
    ..This is the first study reporting epigenetic mechanism regulating the p33ING1b expression. Our findings support that genetic and epigenetic alteration of p33ING1b are likely to contribute towards the pathogenesis of ovarian cancers...
  56. ncbi request reprint Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma
    Stephanie Si Liu
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 12:3922-7. 2006
    ....