Annie L M Cheung

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi Detection of human papillomavirus in cervical carcinoma: comparison of peroxidase, Nanogold, and catalyzed reporter deposition (CARD)-Nanogold in situ hybridization
    A L Cheung
    Department of Anatomy, University of Hong Kong, China
    Mod Pathol 12:689-96. 1999
  2. ncbi Telomere dysfunction, genome instability and cancer
    Annie L M Cheung
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Front Biosci 13:2075-90. 2008
  3. ncbi Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 125:2576-85. 2009
  4. ncbi Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis
    Pak Yan Cheung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cancer Lett 293:41-51. 2010
  5. ncbi MAD2 interacts with DNA repair proteins and negatively regulates DNA damage repair
    Maggie K L Fung
    Department of Anatomy, Cancer Biology Group, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    J Mol Biol 381:24-34. 2008
  6. ncbi MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour
    Maggie K L Fung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:821-32. 2007
  7. ncbi Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines
    Wen Deng
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Oncogene 23:9090-101. 2004
  8. ncbi Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cancer Res 68:7200-9. 2008
  9. ncbi Id-1 promotes proliferation of p53-deficient esophageal cancer cells
    Cheuk Man Hui
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Cancer 119:508-14. 2006
  10. ncbi Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Carcinogenesis 28:2313-20. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Detection of human papillomavirus in cervical carcinoma: comparison of peroxidase, Nanogold, and catalyzed reporter deposition (CARD)-Nanogold in situ hybridization
    A L Cheung
    Department of Anatomy, University of Hong Kong, China
    Mod Pathol 12:689-96. 1999
    ..Our findings precisely demonstrated the need for improved sensitivity in the in situ detection of HPV. The CARD-Nanogold-gold technology looks promising as a highly sensitive method for routine ISH in molecular pathology...
  2. ncbi Telomere dysfunction, genome instability and cancer
    Annie L M Cheung
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Front Biosci 13:2075-90. 2008
    ..In this review, we summarize our knowledge on the association between telomere dysfunction, genomic instability and cancer development...
  3. ncbi Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 125:2576-85. 2009
    ..In conclusion, our results provide the first evidence that Id-1 promotes tumorigenicity and metastasis of human esophageal cancer in vivo and that the PI3K inhibitor LY294002 can attenuate these effects...
  4. ncbi Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis
    Pak Yan Cheung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cancer Lett 293:41-51. 2010
    ..Our data also revealed a novel positive regulation of p16(INK4a) on cyclin D1. These findings probably represent early crucial events and mechanisms in esophageal carcinogenesis...
  5. ncbi MAD2 interacts with DNA repair proteins and negatively regulates DNA damage repair
    Maggie K L Fung
    Department of Anatomy, Cancer Biology Group, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    J Mol Biol 381:24-34. 2008
    ..Our results suggest a novel function of MAD2 by interfering with DNA repair proteins...
  6. ncbi MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour
    Maggie K L Fung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:821-32. 2007
    ..06) than normal samples. Our results suggest that aberrant MAD2 expression may play an essential role in a defective mitotic checkpoint in TGCT cells, which may contribute to CIN commonly observed in TGCT tumours...
  7. ncbi Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines
    Wen Deng
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Oncogene 23:9090-101. 2004
    ....
  8. ncbi Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cancer Res 68:7200-9. 2008
    ..These results together suggest an important role of TGF-beta1 in the early process of cervical carcinogenesis...
  9. ncbi Id-1 promotes proliferation of p53-deficient esophageal cancer cells
    Cheuk Man Hui
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Cancer 119:508-14. 2006
    ....
  10. ncbi Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Carcinogenesis 28:2313-20. 2007
    ..Inactivation of Id-1 may provide us with a novel strategy to improve the treatment and survival of patients with esophageal cancer...
  11. ncbi Targeting NF-kappaB signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer
    Bin Li
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Mol Cancer Ther 8:2635-44. 2009
    ..In summary, our data suggest that NF-kappaB inhibitors may be potentially useful as therapeutic agents for patients with esophageal cancer...
  12. ncbi Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
    Amy L S Tai
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Cancer 106:146-55. 2006
    ..CONCLUSION: These results suggest that co-overexpression of FGF3 and EGFR may play an important role in the pathogenesis of lung carcinoma...
  13. ncbi Role of short telomeres in inducing preferential chromosomal aberrations in human ovarian surface epithelial cells: A combined telomere quantitative fluorescence in situ hybridization and whole-chromosome painting study
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Genes Chromosomes Cancer 37:92-7. 2003
    ..Our findings suggest that nonrandom chromosome aberrations in HOSE cells occurring before cellular immortalization could be caused by the telomere length heterogeneity...
  14. ncbi Induction of senescent-like growth arrest as a new target in anticancer treatment
    Xianghong Wang
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Curr Cancer Drug Targets 3:153-9. 2003
    ..In addition, the possible factors and mechanisms involved in this process are also discussed. Finally, the implications on how senescent-like growth arrest might be exploited as a possible new target for anti-cancer drugs are addressed...
  15. ncbi Viral load of HPV in esophageal squamous cell carcinoma
    Hua Xin Si
    Department of Anatomy, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong SAR, People's Republic of China
    Int J Cancer 103:496-500. 2003
    ..However, with the consistent detection of oncogenic HPVs in ESCC from some regions of China, the possibility of HPV infection being one of the multiple risk factors of ESCC in some geographic areas cannot be excluded...
  16. ncbi A new method for improving metaphase chromosome spreading
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cytometry A 51:46-51. 2003
    ..CONCLUSIONS: A new and simple method for improving metaphase chromosome spreading was developed based on our study on the characteristics of chromosome spreading...
  17. ncbi Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells
    Xiaomeng Zhang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, Pokfulam, University of Hong Kong, Hong Kong, Special Administrative Region, China
    J Biol Chem 282:33284-94. 2007
    ....
  18. ncbi Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region, China
    PLoS ONE 7:e48576. 2012
    ....
  19. ncbi Epstein-Barr virus-encoded latent membrane protein 1 impairs G2 checkpoint in human nasopharyngeal epithelial cells through defective Chk1 activation
    Wen Deng
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e39095. 2012
    ..Elucidation of the mechanisms involved in LMP1-induced genomic instability in nasopharyngeal epithelial cells will shed lights on the understanding of role of EBV infection in NPC development...
  20. ncbi Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Cancer Res 62:1662-8. 2002
    ..This provides a novel insight into the molecular basis of CIN in ovarian carcinoma and has implications for effective use of checkpoint-targeting drugs...
  21. ncbi Male genital tract antioxidant enzymes: their source, function in the female, and ability to preserve sperm DNA integrity in the golden hamster
    Hong Chen
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China
    J Androl 24:704-11. 2003
    ..The GPx activity came from both epididymis and ASGs. We conclude that ASG secretions play a significant role in protecting sperm against oxidative stress...
  22. ncbi Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells
    Yu Liu
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China
    J Med Virol 66:63-9. 2002
    ..Alternatively, LMP1 alone may not be sufficient to facilitate nasopharyngeal carcinoma cell growth and additional oncogenic factors may be needed along with LMP1 in modulating the malignant property of nasopharyngeal carcinoma...