Yiyun Cheng

Summary

Affiliation: University of Science and Technology of China
Country: China

Publications

  1. ncbi request reprint Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
    Cheng Yiyun
    School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    Eur J Med Chem 40:1188-92. 2005
  2. ncbi request reprint Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers
    Yiyun Cheng
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Pharm Sci 96:595-602. 2007
  3. ncbi request reprint Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug
    Minglu Ma
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 42:93-8. 2007
  4. ncbi request reprint Pharmaceutical applications of dendrimers: promising nanocarriers for drug delivery
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Front Biosci 13:1447-71. 2008
  5. pmc Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity
    Naimin Shao
    School of Life Sciences, East China Normal University, Shanghai, China
    Int J Nanomedicine 6:3361-72. 2011
  6. pmc Paramagnetic NMR investigation of dendrimer-based host-guest interactions
    Fei Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, People s Republic of China
    PLoS ONE 8:e64722. 2013
  7. ncbi request reprint Dendrimer-surfactant interactions
    Yiyun Cheng
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, People s Republic of China
    Soft Matter 10:2714-27. 2014
  8. doi request reprint External electrostatic interaction versus internal encapsulation between cationic dendrimers and negatively charged drugs: which contributes more to solubility enhancement of the drugs?
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    J Phys Chem B 112:8884-90. 2008
  9. doi request reprint Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
    Yiyun Cheng
    School of Life Sciences, East China Normal University, Shanghai, 200062, People s Republic of China
    Chem Soc Rev 40:2673-703. 2011
  10. doi request reprint The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P R China
    Eur J Med Chem 43:2291-7. 2008

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
    Cheng Yiyun
    School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    Eur J Med Chem 40:1188-92. 2005
    ..Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs...
  2. ncbi request reprint Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers
    Yiyun Cheng
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Pharm Sci 96:595-602. 2007
    ..These results demonstrated that PAMAM dendrimers can effectively facilitate skin penetration of NSAIDs and may have the potential applications for the development of new transdermal formulations...
  3. ncbi request reprint Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug
    Minglu Ma
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 42:93-8. 2007
    ..The in vitro release behavior and anti-bacterial activity studies indicated that PAMAM dendrimers might be considered as potential drug carriers of sulfonamides with a sustained release behavior under suitable conditions...
  4. ncbi request reprint Pharmaceutical applications of dendrimers: promising nanocarriers for drug delivery
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Front Biosci 13:1447-71. 2008
    ..In addition, the pharmacodynamic and pharmacokinetic properties of both dendrimer/drug complex and dendrimer-drug conjugation after their administration to animals are evaluated...
  5. pmc Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity
    Naimin Shao
    School of Life Sciences, East China Normal University, Shanghai, China
    Int J Nanomedicine 6:3361-72. 2011
    ..In the present study, the loading and release behaviors of generation 3 PAMAM and generation 4 PPI dendrimers with the same amount of surface amine groups (32 per dendrimer) were compared using phenylbutazone as a model drug...
  6. pmc Paramagnetic NMR investigation of dendrimer-based host-guest interactions
    Fei Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, People s Republic of China
    PLoS ONE 8:e64722. 2013
    ..The combination of paramagnetic probes and ¹H NMR linewidth analysis can be used as a powerful tool in the analysis of dendrimer-based host-guest systems...
  7. ncbi request reprint Dendrimer-surfactant interactions
    Yiyun Cheng
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, People s Republic of China
    Soft Matter 10:2714-27. 2014
    ..Applications of the dendrimer-surfactant aggregates as templates to guide the synthesis of nanoparticles and in drug or gene delivery were also mentioned. ..
  8. doi request reprint External electrostatic interaction versus internal encapsulation between cationic dendrimers and negatively charged drugs: which contributes more to solubility enhancement of the drugs?
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    J Phys Chem B 112:8884-90. 2008
    ..These results suggest that external electrostatic interaction contributes more to the solubility enhancement of drugs than internal encapsulation...
  9. doi request reprint Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
    Yiyun Cheng
    School of Life Sciences, East China Normal University, Shanghai, 200062, People s Republic of China
    Chem Soc Rev 40:2673-703. 2011
    ..Also, exciting opportunities and challenges on the development of dendrimer-based nanoplatforms for targeted cancer diagnosis and therapy are reviewed (404 references)...
  10. doi request reprint The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P R China
    Eur J Med Chem 43:2291-7. 2008
    ..In this mini-review, we will mainly discuss the influence of dendrimers on the PD and PK behaviors of drugs complexed or conjugated to them...
  11. doi request reprint Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies
    Yiyun Cheng
    Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China
    Eur J Med Chem 43:1791-5. 2008
    ..The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT...
  12. ncbi request reprint Dendrimer-based prodrugs: design, synthesis, screening and biological evaluation
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Comb Chem High Throughput Screen 10:336-49. 2007
    ..The design and synthesis of dendrimer-based prodrugs as well as screening their intrinsic properties in biological systems were fully discussed...
  13. doi request reprint New insights into the interactions between dendrimers and surfactants: 2. Design of new drug formulations based on dendrimer-surfactant aggregates
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    J Phys Chem B 113:8339-46. 2009
    ..The dendrimer-surfactant aggregates are promising carriers for hydrophobic drugs in transdermal administration routes...
  14. ncbi request reprint Solubility of nicotinic acid in polyamidoamine dendrimer solutions
    Cheng Yiyun
    Laboratory of Structural Biology, Department of Polymer Science and Engineering, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 40:1384-9. 2005
    ..Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of nicotinic acid...
  15. ncbi request reprint Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
    Cheng Yiyun
    Laboratory of Structural Biology, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 40:1390-3. 2005
    ..Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen...
  16. ncbi request reprint Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Eur J Med Chem 42:1032-8. 2007
    ..These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions...
  17. ncbi request reprint Dendrimers as drug carriers: applications in different routes of drug administration
    Yiyun Cheng
    Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    J Pharm Sci 97:123-43. 2008
    ..Furthermore, the interaction mechanisms between dendrimers and drug molecules, including simple encapsulation, electrostatic interaction, and covalent conjugation, were elaborated...
  18. doi request reprint Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles
    Xinyu Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200062, P R China
    J Am Chem Soc 135:9805-10. 2013
    ..In addition, DEGNPs showed excellent biocompatibility on several cell lines. This study provides a new insight into biomedical applications of dendrimers and dendrimer-encapsulated nanoparticles. ..
  19. doi request reprint Evaluation of phenylbutazone and poly(amidoamine) dendrimers interactions by a combination of solubility, 2D-NOESY NMR, and isothermal titration calorimetry studies
    Wenjun Yang
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Pharm Sci 98:1075-85. 2009
    ..The new techniques such as 2D-NOESY and ITC used in this study are useful tools in investigating the interactions between dendrimers and guest molecules...
  20. doi request reprint Reducing cytotoxicity while improving anti-cancer drug loading capacity of polypropylenimine dendrimers by surface acetylation
    Fei Wang
    Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China
    Acta Biomater 8:4304-13. 2012
    ....
  21. doi request reprint Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery
    Jingjing Hu
    Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China
    Biomaterials 32:9950-9. 2011
    ..The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications...
  22. doi request reprint Host-guest chemistry of dendrimer-drug complexes. 3. Competitive binding of multiple drugs by a single dendrimer for combination therapy
    Libo Zhao
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China
    J Phys Chem B 113:14172-9. 2009
    ..These results provide new insight into host-guest chemistry of dendrimer-drug complexes and the design/optimization of dendrimer-based drug delivery systems...
  23. doi request reprint Host-guest chemistry of dendrimer-drug complexes. 2. Effects of molecular properties of guests and surface functionalities of dendrimers
    Jingjing Hu
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P R China
    J Phys Chem B 113:10650-9. 2009
    ..The host-guest chemistry of dendrimer-drug complexes is promising for the development of new drug delivery systems...
  24. doi request reprint Insights into the interactions between dendrimers and bioactive surfactants: 3. Size-dependent and hydrophobic property-dependent encapsulation of bile salts
    Qinglin Wu
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    J Phys Chem B 113:12934-43. 2009
    ..These results suggest a new interaction model of dendrimer-surfactant aggregates and provide new insight into the interactions between dendrimers and bioactive surfactants...
  25. doi request reprint Host-guest chemistry of dendrimer-drug complexes. 5. Insights into the design of formulations for noninvasive delivery of heparin revealed by isothermal titration calorimetry and NMR studies
    Xueyan Feng
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    J Phys Chem B 114:11017-26. 2010
    ..The combination of ITC and NMR in this study provides new insight into the interactions between globular and linear polymers and the delivery of macromolecular therapeutics such as heparin by dendrimers...
  26. doi request reprint Host-guest chemistry of dendrimer-drug complexes. 6. Fully acetylated dendrimers as biocompatible drug vehicles using dexamethasone 21-phosphate as a model drug
    Kun Yang
    CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    J Phys Chem B 115:2185-95. 2011
    ..The dendrimer-drug binding and release mechanisms provide a new insight for the design and optimization of biocompatible dendrimer-based drug delivery systems...
  27. doi request reprint Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: Evidence from 2D-NOESY investigations
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Eur J Med Chem 44:2219-23. 2009
    ....
  28. doi request reprint Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities
    Chen Zhao
    School of Life Sciences, East China Normal University, Shanghai 200241, PR China
    Int J Pharm 421:301-9. 2011
    ..This research provides new insights into dendrimer-based drug delivery systems and will be helpful for the design of novel dendrimer/drug formulations...
  29. doi request reprint Fast screening of dendrimer-binding compounds by diffusion NMR techniques
    Naimin Shao
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China
    J Phys Chem B 116:5398-405. 2012
    ..The PGSE NMR-based screening method provides new insights into high-throughput screening of dendrimer-binding compounds and should facilitate the study of dendrimer-based host-guest systems...
  30. doi request reprint Host-guest chemistry of dendrimer-drug complexes: 7. Formation of stable inclusions between acetylated dendrimers and drugs bearing multiple charges
    Min Fang
    CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    J Phys Chem B 116:3075-82. 2012
    ..The present study provides a new insight into dendrimer-based host-guest systems, especially for those guest molecules bearing multiple charges...
  31. ncbi request reprint Targeting cancer cells with biotin-dendrimer conjugates
    Wenjun Yang
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 44:862-8. 2009
    ..Our results indicated that the biocompatible biotin-dendrimer conjugate might be a promising nano-platform for cancer therapy and cancer diagnosis...
  32. ncbi request reprint Catalytic water dissociation using hyperbranched aliphatic polyester (Boltorn series) as the interface of a bipolar membrane
    Yanhong Xue
    Laboratory of Functional Membranes, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, PR China
    J Colloid Interface Sci 316:604-11. 2007
    ..These effects were explained on the basis of the water dissociation theory and the characteristics of hyperbranched aliphatic polyester...
  33. doi request reprint Organic-inorganic hybrid anion exchange hollow fiber membranes: a novel device for drug delivery
    Na Wang
    CAS Key Laboratory of Soft Matter Chemistry, Lab of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei 230026, PR China
    Int J Pharm 408:39-49. 2011
    ..Meanwhile, the membrane is biocompatible and can support the adherence, growth, and survival of human cells. Overall, the prepared AEHFM is a promising scaffolding material for drug delivery and tissue engineering...
  34. doi request reprint Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost
    Hongmei Liu
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China
    J Am Chem Soc 134:17680-7. 2012
    ..Our study demonstrated that disulfide cross-linked low generation PAMAM dendrimers with high transfection efficacy, low cytotoxicity, and low cost are efficient alternatives to high generation PAMAM dendrimers in gene delivery...
  35. ncbi request reprint Host-guest chemistry of dendrimer-drug complexes. 4. An in-depth look into the binding/encapsulation of guanosine monophosphate by dendrimers
    Jingjing Hu
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    J Phys Chem B 114:7148-57. 2010
    ..All these findings provide a new insight into the host-guest chemistry of dendrimer/guest complexes and may play important roles in the study of dendrimer/DNA aggregates by a "bottom-up" strategy...
  36. ncbi request reprint New insights into interactions between dendrimers and surfactants. 4. Fast-exchange/slow-exchange transitions in the structure of dendrimer-surfactant aggregates
    Min Fang
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    J Phys Chem B 114:6048-55. 2010
    ..In comparison with previous investigations, the present study provides a new insight into interactions between dendrimers and surfactants, which may be helpful for the design of dendrimer-based microreactors or nanovehicles...
  37. doi request reprint Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies
    Xueyan Feng
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    J Phys Chem B 115:3777-83. 2011
    ..The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes...
  38. doi request reprint High-throughput screening of dendrimer-binding drugs
    Libo Zhao
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    J Am Chem Soc 132:13182-4. 2010
    ..The screening of dendrimer-binding insoluble or soluble compounds can be finished within an hour...
  39. doi request reprint Understanding the binding interactions between dendrimer and 18 common amino acids by NMR techniques
    Mingming Wang
    School of Life Sciences, East China Normal University, Shanghai, PR China
    J Phys Chem B 115:12728-35. 2011
    ....
  40. doi request reprint Dendrimer and cancer: a patent review (2006-present)
    Xiaopan Cai
    East China Normal University, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, Shanghai, PR China
    Expert Opin Ther Pat 23:515-29. 2013
    ..In addition, the interior pockets as well as the charged surface of dendrimer can be encapsulated/bound with anti-cancer drugs or therapeutic DNAs/siRNAs...
  41. doi request reprint Polyamidoamine dendronized hollow fiber membranes in the recovery of heavy metal ions
    Qian Zhang
    CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    ACS Appl Mater Interfaces 5:1907-12. 2013
    ..The results provide new insights into the applications of membrane-supported dendrimers in the recovery of heavy metal ions...
  42. doi request reprint Interactions between dendrimers and ionic liquids revealed by pulsed field gradient and nuclear Overhauser effect NMR studies
    Libo Zhao
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    J Phys Chem B 116:7203-12. 2012
    ..The results obtained from PFG and NOE studies provide new insights into dendrimer-based host-guest systems...
  43. doi request reprint Poly(amidoamine) dendronized hollow fiber membranes: synthesis, characterization, and preliminary applications as drug delivery devices
    Qian Zhang
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei 230026, Anhui, People s Republic of China
    Acta Biomater 8:1316-22. 2012
    ..The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering...
  44. doi request reprint Generation 9 polyamidoamine dendrimer encapsulated platinum nanoparticle mimics catalase size, shape, and catalytic activity
    Xinyu Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200062, People s Republic of China
    Langmuir 29:5262-70. 2013
    ..These results suggest that dendrimers are promising mimics of proteins with different sizes and Ac-G9/Pt NP can be used as an alternative candidate of catalase to decrease oxidation stress in cells...
  45. doi request reprint Surface-engineered dendrimers with a diaminododecane core achieve efficient gene transfection and low cytotoxicity
    Hong Chang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P R China
    Bioconjug Chem 25:342-50. 2014
    ..These results suggest that diaminododecane-cored dendrimers can be developed as a versatile scaffold in the design of efficient gene vectors. ..
  46. doi request reprint Host-guest chemistry of dendrimer-cyclodextrin conjugates: selective encapsulations of guests within dendrimer or cyclodextrin cavities revealed by NOE NMR techniques
    Hui Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China
    J Phys Chem B 116:11217-24. 2012
    ..The host behavior of G5-CD conjugates depends on CD cavity size, guest size, and hydrophobicity. The results obtained in this study are helpful in the optimization of dendrimer-CD conjugate-based drug delivery systems...
  47. ncbi request reprint Fluorinated poly(propylenimine) dendrimers as gene vectors
    Hongmei Liu
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China
    Biomaterials 35:5407-13. 2014
    ..These results demonstrate that fluorination is a promising strategy to improve the transfection efficacy of PPI dendrimers while reducing the cytotoxicity of these cationic polymers. ..
  48. ncbi request reprint Design, synthesis and potent pharmaceutical applications of glycodendrimers: a mini review
    Yiwen Li
    Laboratory of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, China
    Curr Drug Discov Technol 4:246-54. 2007
    ..In this mini-review, different approaches to construct glycodendrimers as well as their promising applications in biological systems are fully discussed...
  49. ncbi request reprint Insights into the Interactions between Dendrimers and Multiple Surfactants: 5. Formation of Miscellaneous Mixed Micelles Revealed by a Combination of (1)H NMR, Diffusion, and NOE Analysis
    Kun Yang
    CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China, School of Life Sciences, East China Normal University, Shanghai, 200062, People s Republic of China, and Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People s Republic of China
    J Phys Chem B 114:7265-73. 2010
    ..The competitive binding/encapsulation of the two surfactants at different stages was evaluated. The results provide a new insight into the interactions of dendrimers with mixed surfactant systems...
  50. doi request reprint A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios
    Mingming Wang
    1 Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China 2
    Nat Commun 5:3053. 2014
    ..The results suggest that fluorinated dendrimers are a new class of highly efficient gene vectors and fluorination is a promising strategy to design gene vectors without involving sophisticated syntheses. ..
  51. ncbi request reprint The effect of fluorination on the transfection efficacy of surface-engineered dendrimers
    Mingming Wang
    Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China
    Biomaterials 35:6603-13. 2014
    ..These results provide a new fluorination strategy to generate a library of highly efficient and non-cytotoxic polymeric gene vectors. ..
  52. ncbi request reprint Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies
    Man Na
    Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230027, China
    Eur J Med Chem 41:670-4. 2006
    ..Also, the blood level studies were investigated. We concluded that PAMAM dendrimers might be considered as a potential drug carrier of ketoprofen with a sustained release behavior under suitable conditions...