Xiuping Chen

Summary

Affiliation: University of Macau
Country: China

Publications

  1. doi request reprint Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner
    Jiajie Guo
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    PLoS ONE 9:e88140. 2014
  2. pmc Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    PLoS ONE 8:e57414. 2013
  3. doi request reprint Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Electronic address
    Complement Ther Med 21:272-5. 2013
  4. doi request reprint Target network analysis of adiponectin, a multifaceted adipokine
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Cell Biochem 114:1145-52. 2013
  5. ncbi request reprint [Inspirations from natural products based drug research and development for Chinese medicine research--analysis of natural products recoded in TTD]
    Xiu ping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
    Yao Xue Xue Bao 47:1423-7. 2012
  6. ncbi request reprint Adiponectin: a biomarker for rheumatoid arthritis?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Cytokine Growth Factor Rev 24:83-9. 2013
  7. ncbi request reprint Quinones derived from plant secondary metabolites as anti-cancer agents
    Jin Jian Lu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Anticancer Agents Med Chem 13:456-63. 2013
  8. doi request reprint Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Anticancer Drugs 23:777-87. 2012
  9. ncbi request reprint No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau 999078, China
    Pharmacol Rep 63:724-32. 2011
  10. doi request reprint Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    Phytomedicine 18:1238-43. 2011

Collaborators

  • Yitao Wang
  • Jin Zheng
  • Mingqing Huang
  • Ji Li
  • Feng Chen
  • Wei Guo
  • Meiwan Chen
  • Lixia Pei
  • Zhangfeng Zhong
  • Zengtao Xu
  • Guosheng Wu
  • Wen Tan
  • Jiajie Guo
  • Jinjian Lu
  • Sheng Liu
  • Yuanwu Bao
  • Jin Jian Lu
  • Jiaolin Bao
  • Lidian Chen
  • Yuanye Dang
  • Yingbo Li
  • Wenhui Hao
  • Wen Shan Xu
  • Jiao Lin Bao
  • Xu Wei
  • Guo Sheng Wu
  • Jing Xie
  • Jingrong Cui
  • Lei Ma
  • Dejun Hu
  • Dongmei Dai
  • Qingwen Zhang
  • Yiyi Ye
  • Wenshan Xu
  • Xianghui Han
  • Xia Yuan
  • Zhengming Qian
  • Qiqi Wang
  • Tie Wu
  • Jian Gong
  • Liao Cui
  • Keyuan Zhou

Detail Information

Publications25

  1. doi request reprint Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner
    Jiajie Guo
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    PLoS ONE 9:e88140. 2014
    ..These observations provide novel mechanisms and potential targets for better understanding of the anti-cancer mechanisms of cucurbitacins. ..
  2. pmc Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    PLoS ONE 8:e57414. 2013
    ..The combination of PK with network pharmacology might be a potent method for exploring the material basis of TCM formulas...
  3. doi request reprint Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Electronic address
    Complement Ther Med 21:272-5. 2013
    ..However, are we heading to the right direction?..
  4. doi request reprint Target network analysis of adiponectin, a multifaceted adipokine
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Cell Biochem 114:1145-52. 2013
    ....
  5. ncbi request reprint [Inspirations from natural products based drug research and development for Chinese medicine research--analysis of natural products recoded in TTD]
    Xiu ping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
    Yao Xue Xue Bao 47:1423-7. 2012
    ..This paper briefly introduces the TTD, analyzes the natural products derived drugs/compounds recorded in TTD, which we think might provide some inspiration for the innovation of TCM...
  6. ncbi request reprint Adiponectin: a biomarker for rheumatoid arthritis?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Cytokine Growth Factor Rev 24:83-9. 2013
    ....
  7. ncbi request reprint Quinones derived from plant secondary metabolites as anti-cancer agents
    Jin Jian Lu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Anticancer Agents Med Chem 13:456-63. 2013
    ..We intend to summarize their anti-cancer effects and investigate the mechanism of actions to promote the research and development of anti-cancer agents from quinones...
  8. doi request reprint Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Anticancer Drugs 23:777-87. 2012
    ..The aim was to systematically analyze their bioactivities with an emphasis on their anticancer effects. Research and development has shed new insight into the beneficial properties of these compounds...
  9. ncbi request reprint No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau 999078, China
    Pharmacol Rep 63:724-32. 2011
    ..These results suggest that short pretreatment and subsequent longer co-treatment of low concentrations of curcumin showed no obvious protective effect on H₂O₂-induced HepG₂ cell injury...
  10. doi request reprint Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    Phytomedicine 18:1238-43. 2011
    ..Cpv treatment also modulated several signaling transduction pathways. These results might provide some molecular basis for the anti-tumor activity of Curcuma phaeocaulis Valeton...
  11. pmc Anti-cancer natural products isolated from chinese medicinal herbs
    Wen Tan
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av, Padre Toma s Pereira S, J, Taipa, Macao SAR, China
    Chin Med 6:27. 2011
    ..In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed...
  12. doi request reprint Adiponectin and breast cancer
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Tomás Pereira S J, Taipa, Macau, China
    Med Oncol 28:1288-95. 2011
    ..However, more convincing evidence is needed to fully elucidate the exact role of adiponectin in breast cancer, since both its beneficial effects and possible mechanisms remain controversial...
  13. doi request reprint Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo
    Zhangfeng Zhong
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China
    Cell Physiol Biochem 30:778-90. 2012
    ..H. Chen et C. Ling extract, which has a high furanodiene content, showed anti-cancer effects in breast cancer cells in vitro. The present study was designed to evaluate the in vitro and in vivo anti-cancer activity of furanodiene...
  14. ncbi request reprint Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells
    Guosheng Wu
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Am J Chin Med 40:631-42. 2012
    ..In conclusion, ESAC exerts anti-proliferation effects by inducing DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells...
  15. doi request reprint Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
    Zhangfeng Zhong
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Toma s Pereira S J, Taipa, Macau, 999078, China
    Eur J Pharmacol 667:50-5. 2011
    ..These results might provide some molecular basis for the anti-tumor activity of Rhizoma curcuma...
  16. ncbi request reprint Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities
    Zengtao Xu
    Institute of Chinese Medical Sciences, University of Macau, Macau, P R China
    Am J Chin Med 39:15-27. 2011
    ..However, many questions still need to be answered before both G. lucidum and GLPS can be widely accepted and used as anti-tumor agents...
  17. doi request reprint Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China
    J Mass Spectrom 47:962-8. 2012
    ..8 ± 0.7 h. Based on the results, the oral bioavailability of BA in rats at 20 mg/kg is 15.7%...
  18. doi request reprint A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Planta Med 78:244-51. 2012
    ..57 ± 0.70 h. Based on the results, the oral bioavailability of PD in rats at 10 mg/kg is 0.079 %...
  19. ncbi request reprint The anticancer properties of salvia miltiorrhiza bunge (danshen): a systematic review
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Med Res Rev 34:768-94. 2014
    ....
  20. doi request reprint Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells
    Zengtao Xu
    Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China
    Am J Chin Med 41:615-28. 2013
    ..Collectively, we concluded that celastrol inhibits RA-FLS proliferation by inducing DNA damage, cell cycle arrest, and apoptosis in vitro, which might provide data for its application in RA treatment...
  21. doi request reprint Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats
    Mingqing Huang
    College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350108, China
    Phytother Res 26:944-8. 2012
    ..These results suggested that PAF has antidiabetic potential in vivo...
  22. doi request reprint 2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Macau, PR China
    Free Radic Res 44:587-604. 2010
    ....
  23. doi request reprint A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Biomed Chromatogr 26:826-32. 2012
    ..1 h⋅ng/mL, and the elimination half-life was 2.40 ± 1.18 h. Based on this result, the oral bioavailability of furanodiene in rats at 10 mg/kg is 49.0%...
  24. ncbi request reprint Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro
    Zhangfeng Zhong
    University of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, Avenue Padre Tomas Pereira Taipa, Macau 999078, China
    Eur J Pharmacol 737:1-10. 2014
    ..Our results suggested that furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer. ..
  25. ncbi request reprint Recent advances in breast cancer metastasis suppressor 1
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Macau, China
    Int J Biol Markers 26:1-8. 2011
    ..In this review, the authors provide an overview of its biology, function, action mechanism and pathological significance...