MCW Chan

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation
    Renee W Y Chan
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    PLoS ONE 5:e8713. 2010
  2. pmc Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses
    Renee W Y Chan
    Centre of Influenza Research and School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 7:e51057. 2012
  3. ncbi request reprint Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium
    M C W Chan
    Centre of Influenza Research, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Hong Kong Med J 19:24-8. 2013
  4. pmc Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
    Suki M Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
    Respir Res 11:147. 2010
  5. pmc Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
    Michael C W Chan
    Departments of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Respir Res 10:102. 2009
  6. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005

Collaborators

  • J M Nicholls
  • S W Tsao
  • Renee W Y Chan
  • J S Malik Peiris
  • Suki M Y Lee
  • Connie Y H Leung
  • Timothy K W Cheung
  • Malik J S Peiris
  • Carol C C Ho
  • Kit M Yuen
  • Y I Guan
  • Robert E W Hancock
  • Wendy C L Yu
  • Jennifer L Gardy
  • Sara S R Kang
  • Cheuk Kin Lo
  • Alan D L Sihoe

Detail Information

Publications6

  1. pmc Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation
    Renee W Y Chan
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    PLoS ONE 5:e8713. 2010
    ..Since influenza infection in the bronchial epithelium will lead to tissue damage and associate with the epithelium regeneration, the data generated from the undifferentiated NHBE cultures may also be relevant to disease pathogenesis...
  2. pmc Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses
    Renee W Y Chan
    Centre of Influenza Research and School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 7:e51057. 2012
    ....
  3. ncbi request reprint Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium
    M C W Chan
    Centre of Influenza Research, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Hong Kong Med J 19:24-8. 2013
    ..These viruses were potent inducers of cytokines and chemokines in primary human alveolar epithelial cells...
  4. pmc Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
    Suki M Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
    Respir Res 11:147. 2010
    ..However a comprehensive gene expression profile of pdmH1N1 in relevant primary human cells in vitro has not been reported. Type I alveolar epithelial cells are a key target cell in pdmH1N1 pneumonia...
  5. pmc Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
    Michael C W Chan
    Departments of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Respir Res 10:102. 2009
    ..These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease...
  6. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
    ..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...