K-C Chang

Summary

Affiliation: Tuberculosis and Chest Service
Country: China

Publications

  1. pmc WHO group 5 drugs and difficult multidrug-resistant tuberculosis: a systematic review with cohort analysis and meta-analysis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Heath, Hong Kong SAR, China
    Antimicrob Agents Chemother 57:4097-104. 2013
  2. pmc Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Heath, Hong Kong SAR, China
    Antimicrob Agents Chemother 56:5465-75. 2012
  3. doi request reprint A systematic review of rapid drug susceptibility tests for multidrug-resistant tuberculosis using rifampin resistance as a surrogate
    Kwok Chiu Chang
    Senior Medical and Health Officer Tuberculosis and Chest Service, Wanchai Chest Clinic, Department of Health, 1st Floor, Wanchai Polyclinic, 99, Kennedy Road, Wanchai, Hong Kong, China 852 25911147 852 28346627
    Expert Opin Med Diagn 3:99-122. 2009
  4. doi request reprint Management of difficult multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis: update 2012
    Kwok Chiu Chang
    Department of Health, Tuberculosis and Chest Service, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 18:8-21. 2013
  5. doi request reprint Hepatotoxicity of pyrazinamide: cohort and case-control analyses
    Kwok C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 177:1391-6. 2008
  6. doi request reprint Supervised and induced sputum among patients with smear-negative pulmonary tuberculosis
    K C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Departrment of Health, Hong Kong, China
    Eur Respir J 31:1085-90. 2008
  7. ncbi request reprint Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
    K C Chang
    Department of Health, Tuberculosis and Chest Service, Centre for Health Protection, Hong Kong, China
    Int J Tuberc Lung Dis 13:341-6. 2009
  8. doi request reprint Newer fluoroquinolones for treating respiratory infection: do they mask tuberculosis?
    K C Chang
    Centre for Health Protection, Dept of Health, Hong Kong SAR, China
    Eur Respir J 35:606-13. 2010
  9. doi request reprint Systematic review of interferon-gamma release assays in tuberculosis: focus on likelihood ratios
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China
    Thorax 65:271-6. 2010
  10. doi request reprint Rapid assays for fluoroquinolone resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong, China
    J Antimicrob Chemother 65:1551-61. 2010

Detail Information

Publications27

  1. pmc WHO group 5 drugs and difficult multidrug-resistant tuberculosis: a systematic review with cohort analysis and meta-analysis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Heath, Hong Kong SAR, China
    Antimicrob Agents Chemother 57:4097-104. 2013
    ..Our findings substantiated the use of linezolid in the treatment of XDR-TB or fluoroquinolone-resistant MDR-TB and call for further studies to evaluate the roles of other group 5 drugs. ..
  2. pmc Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Heath, Hong Kong SAR, China
    Antimicrob Agents Chemother 56:5465-75. 2012
    ..Pyrazinamide is likely important in fluoroquinolone-based treatment of MDR-TB...
  3. doi request reprint A systematic review of rapid drug susceptibility tests for multidrug-resistant tuberculosis using rifampin resistance as a surrogate
    Kwok Chiu Chang
    Senior Medical and Health Officer Tuberculosis and Chest Service, Wanchai Chest Clinic, Department of Health, 1st Floor, Wanchai Polyclinic, 99, Kennedy Road, Wanchai, Hong Kong, China 852 25911147 852 28346627
    Expert Opin Med Diagn 3:99-122. 2009
    ..Although rapid assays are fairly reliable for ruling out MDR-TB, careful consideration of clinical risk factors is required before using these assays to rule in MDR-TB under different epidemiological settings...
  4. doi request reprint Management of difficult multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis: update 2012
    Kwok Chiu Chang
    Department of Health, Tuberculosis and Chest Service, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 18:8-21. 2013
    ..Difficult MDR-TB/XDR-TB cannot be tackled without achieving high cure rates with quality DOTS and beyond, and concurrently addressing poverty and HIV...
  5. doi request reprint Hepatotoxicity of pyrazinamide: cohort and case-control analyses
    Kwok C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 177:1391-6. 2008
    ..Relatively little is known about the hepatotoxicity of pyrazinamide...
  6. doi request reprint Supervised and induced sputum among patients with smear-negative pulmonary tuberculosis
    K C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Departrment of Health, Hong Kong, China
    Eur Respir J 31:1085-90. 2008
    ..In summary, it may be practical to collect a sample of unsupervised, supervised and induced sputum for smear-negative patients with extent of disease less than the right upper lobe, especially when respiratory symptoms are absent...
  7. ncbi request reprint Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
    K C Chang
    Department of Health, Tuberculosis and Chest Service, Centre for Health Protection, Hong Kong, China
    Int J Tuberc Lung Dis 13:341-6. 2009
    ..Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used...
  8. doi request reprint Newer fluoroquinolones for treating respiratory infection: do they mask tuberculosis?
    K C Chang
    Centre for Health Protection, Dept of Health, Hong Kong SAR, China
    Eur Respir J 35:606-13. 2010
    ..3 (0.1-0.9). Newer fluoroquinolones appear to mask active pulmonary TB...
  9. doi request reprint Systematic review of interferon-gamma release assays in tuberculosis: focus on likelihood ratios
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China
    Thorax 65:271-6. 2010
    ..Clinical roles of QuantiFERON-TB Gold (QFT-G)/Gold in-Tube (QFT-G-IT) and T-SPOT.TB in tuberculosis require clarification...
  10. doi request reprint Rapid assays for fluoroquinolone resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong, China
    J Antimicrob Chemother 65:1551-61. 2010
    ..This review aims at evaluating these rapid assays...
  11. doi request reprint Treatment of tuberculosis and optimal dosing schedules
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Wanchai Chest Clinic, 1st Floor, Wanchai Polyclinic, 99 Kennedy Road, Wanchai, Hong Kong
    Thorax 66:997-1007. 2011
    ....
  12. pmc Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: a systematic review with meta-analyses
    Kwok Chiu Chang
    Wanchai Chest Clinic, 1st Floor, Wanchai Polyclinic, 99 Kennedy Road, Wanchai, Hong Kong SAR, China
    Antimicrob Agents Chemother 55:4499-505. 2011
    ..Molecular assays are probably the way forward for detecting pyrazinamide resistance...
  13. doi request reprint Peak plasma rifampicin level in tuberculosis patients with slow culture conversion
    K C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Wanchai Chest Clinic, 1 F Wanchai Polyclinic, 99 Kennedy Road, Wanchai, Hong Kong, China
    Eur J Clin Microbiol Infect Dis 27:467-72. 2008
    ..Thus, there is probably no association between Cmax-rfm and slow culture conversion...
  14. ncbi request reprint Standard anti-tuberculosis treatment and hepatotoxicity: do dosing schedules matter?
    K C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Eur Respir J 29:347-51. 2007
    ..6% (1.9-3.5%) to 4.1% (3.2-5.3%) as age exceeded 49 yrs. Dosing schedules in the first 9 weeks have little impact on hepatotoxicity. If patients at risk of both hepatitis and relapse receive standard treatment, daily dosing is preferable...
  15. ncbi request reprint Dosing schedules of 6-month regimens and relapse for pulmonary tuberculosis
    Kwok C Chang
    Tuberculosis and Chest Service, Center for Health Protection, Department of Health Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Am J Respir Crit Care Med 174:1153-8. 2006
    ..The optimal approach for reducing tuberculosis relapse is open...
  16. ncbi request reprint Efficacy of the BCG revaccination programme in a cohort given BCG vaccination at birth in Hong Kong
    C C Leung
    Department of Health, The University of Hong Kong, Hong Kong SAR, China
    Int J Tuberc Lung Dis 5:717-23. 2001
    ..Revaccination of tuberculin-negative school-children is a regular practice in Hong Kong...
  17. ncbi request reprint Tuberculosis risk factors in a silicotic cohort in Hong Kong
    K C Chang
    TB and Chest Service, Department of Health, Hong Kong SAR, China
    Int J Tuberc Lung Dis 5:177-84. 2001
    ..Hong Kong silicotic patients are followed regularly at the Pneumoconiosis Clinic...
  18. ncbi request reprint Socio-economic factors and tuberculosis: a district-based ecological analysis in Hong Kong
    C C Leung
    TB and Chest Service, Department of Health, Hong Kong, China
    Int J Tuberc Lung Dis 8:958-64. 2004
    ..Relatively little is known about the impact of socio-economic factors on tuberculosis in a metropolitan city with high disease incidence...
  19. ncbi request reprint Risk factors for defaulting from anti-tuberculosis treatment under directly observed treatment in Hong Kong
    K C Chang
    TB and Chest Service, Department of Health, Hong Kong
    Int J Tuberc Lung Dis 8:1492-8. 2004
    ..To identify risk factors for defaulting from anti-tuberculosis treatment...
  20. pmc Tuberculin response in BCG vaccinated schoolchildren and the estimation of annual risk of infection in Hong Kong
    C C Leung
    Tuberculosis Service and Chest Service, Department of Health, Hong Kong, China
    Thorax 60:124-9. 2005
    ..In Hong Kong there has been nearly universal neonatal BCG vaccination coverage since 1980...
  21. ncbi request reprint Smoking and tuberculosis in Hong Kong
    C C Leung
    TB and Chest Service, Department of Health, Shaukiwan Jockey Club Clinic, Hong Kong, SAR China
    Int J Tuberc Lung Dis 7:980-6. 2003
    ..To study the relationship between smoking and tuberculosis in Hong Kong...
  22. ncbi request reprint Malignant mesothelioma in Hong Kong
    Kwok C Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong Pneumoconiosis Medical Board, Hong Kong
    Respir Med 100:75-82. 2006
    ..Asbestos consumption in Hong Kong rose in the 1970s and peaked in early 1980s and late 1990s. Hong Kong may encounter an epidemic of mesothelioma in the 2010s if effective occupational asbestos control measures are not in place...
  23. ncbi request reprint A nested case-control study on treatment-related risk factors for early relapse of tuberculosis
    Kwok C Chang
    Tuberculosis and Chest Service, Department of Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 170:1124-30. 2004
    ..9-5.5%) for standard daily regimen; 0.5% (95% CI 0.1-2.6%) for extended thrice-weekly regimen; and 0.4% (95% CI 0.1-0.9%) for extended daily regimen. Further studies are required to reduce the risk of relapse under program settings...
  24. ncbi request reprint Determinants of spirometric abnormalities among silicotic patients in Hong Kong
    Chi C Leung
    Department of Health Pneumoconiosis Clinic 4 F, Shaukiwan Jockey Club Clinic 8, Hong Kong
    Occup Med (Lond) 55:490-3. 2005
    ..Silicosis is the second commonest notified occupational disease in Hong Kong...
  25. ncbi request reprint Smoking and tuberculosis among the elderly in Hong Kong
    Chi C Leung
    TB and Chest Service, Department of Community Medicine, The University of Hong Kong, China
    Am J Respir Crit Care Med 170:1027-33. 2004
    ..9-48.0%), 8.6% (95% CI, 3.3-15.1%), and 18.7% (95% CI, 7.7-30.4%) of the TB risk among males, females, and the entire cohort, respectively. Approximately 44.9% (95% CI, 20.7-64.6%) of the sex difference was attributable to smoking...
  26. doi request reprint Diabetic control and risk of tuberculosis: a cohort study
    Chi C Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong, People s Republic of China
    Am J Epidemiol 167:1486-94. 2008
    ..lt;7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively...
  27. ncbi request reprint Lower risk of tuberculosis in obesity
    Chi C Leung
    Tuberculosis and Chest Service, Department of Health, The University of Hong Kong, and Tuberculosis and Chest Unit, Grantham Hospital, Wanchai Chest Clinic, 99 Kennedy Rd, Wanchai, Hong Kong, China
    Arch Intern Med 167:1297-304. 2007
    ..The association with body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), as categorized by the Asian standards, was assessed with the control of other baseline characteristics...