Naihan Xu

Summary

Affiliation: Tsinghua University
Country: China

Publications

  1. pmc Akt: a double-edged sword in cell proliferation and genome stability
    Naihan Xu
    Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    J Oncol 2012:951724. 2012
  2. doi request reprint Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage
    N Xu
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Oncogene 31:1086-94. 2012
  3. doi request reprint Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency
    Naihan Xu
    Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China
    Biochem Biophys Res Commun 413:465-70. 2011
  4. pmc MiR-181a regulates inflammation responses in monocytes and macrophages
    Weidong Xie
    Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences and Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
    PLoS ONE 8:e58639. 2013
  5. pmc MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes
    Jie He
    School of Life Sciences, Tsinghua University, Beijing 100084, PR China
    Nucleic Acids Res 41:498-508. 2013
  6. doi request reprint The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
  7. doi request reprint miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo
    Weidong Xie
    Shenzhen Key Lab of Health Science and Technology, Division of Life Science and Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    Biochem Biophys Res Commun 430:647-52. 2013
  8. ncbi request reprint Chk1 is required for the metaphase-anaphase transition via regulating the expression and localization of Cdc20 and Mad2
    Xiaoyun Yang
    School of Life Sciences, Tsinghua University, Beijing 100084, PR China Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong Province, PR China
    Life Sci 106:12-8. 2014
  9. doi request reprint MiR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin
    Can Yi
    School of Life Sciences, Tsinghua University, Beijing, PR China
    FEBS Lett 585:3303-9. 2011

Collaborators

  • Wei Xu
  • Burton B Yang
  • Wei Dong Xie
  • Yaou Zhang
  • Jie He
  • Xiaoyun Yang
  • Jiangbin Wu
  • Can Yi
  • Joanne Smith
  • Zuowei Hu
  • Yuyang Jiang
  • Mengnan Li
  • Jianna Li
  • Fu Li
  • Dayong Gu
  • Qing Lv
  • Lye Mun Tho
  • David A Gillespie

Detail Information

Publications9

  1. pmc Akt: a double-edged sword in cell proliferation and genome stability
    Naihan Xu
    Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    J Oncol 2012:951724. 2012
    ..Akt therefore modifies both the response to and repair of genotoxic damage in complex ways that are likely to have important consequences for the therapy of tumors with deregulation of the PI3K-Akt-PTEN pathway...
  2. doi request reprint Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage
    N Xu
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Oncogene 31:1086-94. 2012
    ..Taken together, these data indicate that Cdk activity regulates multiple steps in the DNA damage response pathway including full activation of Chk1 and checkpoint proficiency...
  3. doi request reprint Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency
    Naihan Xu
    Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China
    Biochem Biophys Res Commun 413:465-70. 2011
    ..These data indicate that Cdk-mediated phosphorytion is required for efficient Chk1 activation and multiple checkpoint proficiency...
  4. pmc MiR-181a regulates inflammation responses in monocytes and macrophages
    Weidong Xie
    Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences and Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
    PLoS ONE 8:e58639. 2013
    ..Thus, we provide the first evidence for anti-inflammatory effects of miR-181a mediated at least in part by down-regulating IL1a...
  5. pmc MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes
    Jie He
    School of Life Sciences, Tsinghua University, Beijing 100084, PR China
    Nucleic Acids Res 41:498-508. 2013
    ..Taken together, these results implicate that miR-210 disturbs mitosis through targeting multi-genes involved in mitotic progression, which may contribute to its inhibitory role on tumor formation...
  6. doi request reprint The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
    ..Here, we review current understanding of the organization and functions of the ATM-Chk2 and ATR-Chk1 pathways and the prospects for targeting DNA damage signaling processes for therapeutic purposes...
  7. doi request reprint miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo
    Weidong Xie
    Shenzhen Key Lab of Health Science and Technology, Division of Life Science and Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    Biochem Biophys Res Commun 430:647-52. 2013
    ..These data indicate that the up-regulation of miR-181a may be associated with homeostatic response to inflammatory stimuli by TLR-4 pathway activation. Therefore, miR-181a may serve as a novel marker for inflammatory response...
  8. ncbi request reprint Chk1 is required for the metaphase-anaphase transition via regulating the expression and localization of Cdc20 and Mad2
    Xiaoyun Yang
    School of Life Sciences, Tsinghua University, Beijing 100084, PR China Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong Province, PR China
    Life Sci 106:12-8. 2014
    ..In this study, we investigated the role of Chk1 in regulating the metaphase-anaphase transition in mammalian cells...
  9. doi request reprint MiR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin
    Can Yi
    School of Life Sciences, Tsinghua University, Beijing, PR China
    FEBS Lett 585:3303-9. 2011
    ..The rare codons upstream of the target site regulate miR143-induced translational knockdown of PTN, which provides more insight into the mechanism of adipogenic differentiation...