Anming Meng


Affiliation: Tsinghua University
Country: China


  1. Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, et al. Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science. 2018;362: pubmed publisher
    ..Mechanistically, Huluwa binds to and promotes the tankyrase-mediated degradation of Axin. Therefore, maternal Huluwa is an essential determinant of the dorsal organizer and body axis in vertebrate embryos. ..
  2. Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A, et al. TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. J Mol Cell Biol. 2015;7:48-61 pubmed publisher
    ..Therefore, TGFβ/Smad5 signaling plays an important role in the zebrafish lateral line formation. ..
  3. Qiu J, Fan X, Wang Y, Jin H, Song Y, Han Y, et al. Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. J Mol Cell Biol. 2016;8:288-301 pubmed publisher
    ..Therefore, the embryonic origin of dHSCs in adults is not restricted to the AGM. ..
  4. Gong B, Li Z, Xiao W, Li G, Ding S, Meng A, et al. Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis. Nat Commun. 2019;10:1606 pubmed publisher
    ..Thus, we conclude that Sec14l3 controls vasculogenesis in zebrafish via the regulation of VEGFR2 activation. ..
  5. Zhang B, Wu X, Zhang W, Shen W, Sun Q, Liu K, et al. Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Mol Cell. 2018;72:673-686.e6 pubmed publisher
    ..These data reveal widespread enhancer dememorization and promoter priming during parental-to-zygotic transition. ..
  6. Sun J, Yan L, Shen W, Meng A. Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development. 2018;145: pubmed publisher
    ..Collectively, our results identify maternal Ybx1 as a global translational repressor required for oocyte maturation and early embryogenesis. ..
  7. Wu D, Chen L, Sun Q, Wu X, Jia S, Meng A. Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo. J Biol Chem. 2014;289:15463-73 pubmed publisher
    ..These results together suggest that Unga is implicated in postfertilization genomic DNA demethylation, zygotic gene transcription, and normal embryonic development in zebrafish. ..
  8. Liu X, Wang Q, Meng A. Detection of Smad Signaling in Zebrafish Embryos. Methods Mol Biol. 2016;1344:275-86 pubmed publisher
  9. Zhang J, Jiang Z, Liu X, Meng A. Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development. 2016;143:2603-15 pubmed publisher
    ..Therefore, our data uncover an important role of Eph/ephrin signaling in maintaining DFC cluster boundary and KV boundary for normal left-right asymmetrical development. ..

More Information


  1. Chen J, Wu X, Yao L, Yan L, Zhang L, Qiu J, et al. Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos. J Biol Chem. 2017;292:2315-2327 pubmed publisher
  2. Xu P, Zhu G, Wang Y, Sun J, Liu X, Chen Y, et al. Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos. J Mol Cell Biol. 2014;6:272-85 pubmed publisher
    ..Taken together, our findings reveal a conserved role of maternal T-box transcription factors in regulating nodal gene expression and mesendoderm induction in vertebrate embryos. ..
  3. Xiong C, Liu X, Meng A. The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo. J Biol Chem. 2015;290:25512-21 pubmed publisher
    ..Therefore, different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways. ..
  4. Ma A, Lin R, Chan P, Leung J, Chan L, Meng A, et al. The role of survivin in angiogenesis during zebrafish embryonic development. BMC Dev Biol. 2007;7:50 pubmed
    ..Survivin is involved in angiogenesis during zebrafish development and may be under VEGF regulation. ..