Haitao Li


Affiliation: Tsinghua University
Country: China


  1. Zhao S, Yang M, Zhou W, Zhang B, Cheng Z, Huang J, et al. Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology. Proc Natl Acad Sci U S A. 2017;114:E7245-E7254 pubmed publisher
    ..Notably, a discovery on H3K4me3 recognition by the DNA mismatch repair protein MSH6 in Capsella rubella suggests a mechanism of H3K4me3-mediated DNA damage repair in plant. ..
  2. Zhao S, Zhang X, Li H. Beyond histone acetylation-writing and erasing histone acylations. Curr Opin Struct Biol. 2018;53:169-177 pubmed publisher
    ..Histone acylation readout, non-histone acylations and metabolic regulation are also discussed in this review. ..
  3. Zhao S, Cheng L, Gao Y, Zhang B, Zheng X, Wang L, et al. Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Res. 2018;: pubmed publisher
    ..Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. ..
  4. Cao R, Zhang X, Liu X, Li Y, Li H. Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res. 2018;28:494-496 pubmed publisher
  5. Guo J, Zhao F, Yin W, Zhu M, Hao C, Pang Y, et al. Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors. Eur J Med Chem. 2018;155:197-209 pubmed publisher
    ..Further profiling of compound 10a revealed it showed weak inhibitory activity against various isoforms of human cytochrome P450. ..
  6. Zhao S, Zhang B, Yang M, Zhu J, Li H. Systematic Profiling of Histone Readers in Arabidopsis thaliana. Cell Rep. 2018;22:1090-1102 pubmed publisher
    ..The differences in particular histone mark recognition by transcription regulator EML1 and DNA damage repair factor MSH6 indicate plant-specific histone PTMs function in Arabidopsis thaliana acquired during evolution. ..
  7. Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, et al. AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell. 2014;159:558-71 pubmed publisher
    ..Together, our studies identified the evolutionarily conserved YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L-mediated H3K79 methylation in transcription control. ..
  8. Zhao D, Zhang X, Guan H, Xiong X, Shi X, Deng H, et al. The BAH domain of BAHD1 is a histone H3K27me3 reader. Protein Cell. 2016;7:222-6 pubmed publisher
  9. Li Y, Sabari B, Panchenko T, Wen H, Zhao D, Guan H, et al. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Mol Cell. 2016;62:181-193 pubmed publisher
    ..Our studies define the evolutionarily conserved YEATS domain as a family of crotonyllysine readers and specifically demonstrate that the YEATS domain of AF9 directly links histone crotonylation to active transcription. ..

More Information


  1. Zhang X, Zhao D, Xiong X, He Z, Li H. Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C. J Biol Chem. 2016;291:12786-98 pubmed publisher
  2. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, et al. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell. 2016;63:470-84 pubmed publisher
  3. Zhao D, Li Y, Xiong X, Chen Z, Li H. YEATS Domain-A Histone Acylation Reader in Health and Disease. J Mol Biol. 2017;429:1994-2002 pubmed publisher
    ..In the review, we discuss the recognition of histone acylations by the YEATS domain and the biological significance of this readout from multiple perspectives. ..
  4. Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, et al. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun. 2017;8:1088 pubmed publisher
    ..Taken together, our study identifies YEATS2 as a histone H3K27ac reader that regulates a transcriptional program essential for NSCLC tumorigenesis. ..