Zhongjun Dong

Summary

Affiliation: Tsinghua University
Country: China

Publications

  1. doi request reprint The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunity 36:974-85. 2012
  2. doi request reprint Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
    Mario Ernesto Cruz-Munoz
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Nat Immunol 10:297-305. 2009
  3. doi request reprint Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Nat Immunol 10:973-80. 2009
  4. doi request reprint Importance and mechanism of 'switch' function of SAP family adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 232:229-39. 2009
  5. pmc SAP expression in T cells, not in B cells, is required for humoral immunity
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:1273-8. 2008
  6. doi request reprint How do SAP family deficiencies compromise immunity?
    Zhongjun Dong
    Clinical Research Institute of Montreal, Quebec, Canada
    Trends Immunol 31:295-302. 2010
  7. ncbi request reprint Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Immunity 27:698-710. 2007

Collaborators

Detail Information

Publications7

  1. doi request reprint The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunity 36:974-85. 2012
    ..These data showed that SAP secures NK cell activation by a dichotomous molecular mechanism, which is required for conjugate formation. These findings may have implications for the role of SAP in other immune cell types...
  2. doi request reprint Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
    Mario Ernesto Cruz-Munoz
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Nat Immunol 10:297-305. 2009
    ..CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins...
  3. doi request reprint Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Nat Immunol 10:973-80. 2009
    ..Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells...
  4. doi request reprint Importance and mechanism of 'switch' function of SAP family adapters
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Immunol Rev 232:229-39. 2009
    ..Thus, SAP family adapters are molecular switches that regulate immunity as a result of their capacity to control the type of signals and functions emanating from SLAM family receptors...
  5. pmc SAP expression in T cells, not in B cells, is required for humoral immunity
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:1273-8. 2008
    ..These data provide a critical insight into the mechanism by which SAP regulates humoral immunity. They also help elucidate the basis of a severe human immunodeficiency...
  6. doi request reprint How do SAP family deficiencies compromise immunity?
    Zhongjun Dong
    Clinical Research Institute of Montreal, Quebec, Canada
    Trends Immunol 31:295-302. 2010
    ....
  7. ncbi request reprint Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Immunity 27:698-710. 2007
    ..The importance of the SLAM-SAP pathway in normal immunity is highlighted by the finding that SAP is mutated in humans suffering from the immunodeficiency X-linked lymphoproliferative disease...