Ye-Guang Chen

Summary

Affiliation: Tsinghua University
Country: China

Publications

  1. ncbi request reprint Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:9688-95. 2007
  2. pmc Regulation of TGF-β receptor activity
    Fei Huang
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, THU PKU Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China
    Cell Biosci 2:9. 2012
  3. pmc Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Cell Stem Cell 10:231-2. 2012
  4. doi request reprint Dishevelled: The hub of Wnt signaling
    Chan Gao
    Tsinghua University, Beijing, China
    Cell Signal 22:717-27. 2010
  5. doi request reprint Finale: the last minutes of Smads
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Tsinghua University, Beijing 100084, China
    Cell 139:658-60. 2009
  6. doi request reprint Endocytic regulation of TGF-beta signaling
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Cell Res 19:58-70. 2009
  7. ncbi request reprint Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo
    Zhihui Sun
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 345:694-703. 2006
  8. pmc Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    Suping Zhang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Mol Cell Biol 27:4488-99. 2007
  9. ncbi request reprint The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling
    Ying Su
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    FASEB J 21:682-90. 2007
  10. ncbi request reprint Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
    Long Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 281:8607-12. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:9688-95. 2007
    ..Together, our findings suggest that endofin facilitates TGF-beta signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing Smad4 to the proximity of the receptor complex...
  2. pmc Regulation of TGF-β receptor activity
    Fei Huang
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, THU PKU Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China
    Cell Biosci 2:9. 2012
    ..This review focuses on our recent understanding of regulation of TGF-β receptor activity...
  3. pmc Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Cell Stem Cell 10:231-2. 2012
    ..In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3β/β-catenin signaling...
  4. doi request reprint Dishevelled: The hub of Wnt signaling
    Chan Gao
    Tsinghua University, Beijing, China
    Cell Signal 22:717-27. 2010
    ..In this review, we summarize the current understanding of Dvl functions in Wnt signal transduction and its biological functions in mouse development, and also discuss the molecular mechanisms of its actions...
  5. doi request reprint Finale: the last minutes of Smads
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Tsinghua University, Beijing 100084, China
    Cell 139:658-60. 2009
    ..Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009) reveal a dual role for this linker phosphorylation, which is required for activation of Smads and for their degradation...
  6. doi request reprint Endocytic regulation of TGF-beta signaling
    Ye Guang Chen
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Cell Res 19:58-70. 2009
    ..This review summarizes current understanding of TGF-beta receptor endocytosis, the possible mechanisms underlying this process, and the role of endocytosis in modulation of TGF-beta signaling...
  7. ncbi request reprint Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo
    Zhihui Sun
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 345:694-703. 2006
    ....
  8. pmc Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    Suping Zhang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Mol Cell Biol 27:4488-99. 2007
    ..Finally, we provide evidence that Smad7 disrupts the formation of the TGF-beta-induced functional Smad-DNA complex. Our findings suggest that Smad7 inhibits TGF-beta signaling in the nucleus by a novel mechanism...
  9. ncbi request reprint The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling
    Ying Su
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    FASEB J 21:682-90. 2007
    ..Our data indicate that the function of Dpr2 as a negative regulator of the TGF-beta/Nodal signal pathway is evolutionally conserved, at least in part, in fish and mammals...
  10. ncbi request reprint Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
    Long Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 281:8607-12. 2006
    ..Taken together, our data indicate that the inhibitory activity of Dpr on Wnt signaling is conserved from Xenopus to human and that Dpr1 antagonizes Wnt signaling by inducing Dvl degradation...
  11. ncbi request reprint MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4
    Qiang Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 111:588-95. 2008
    ..Thus, our findings define a regulation mode of miR-24 on erythropoiesis by impeding ALK4 expression...
  12. ncbi request reprint Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors
    Xiaoping Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Microvasc Res 71:12-9. 2006
    ..Our results suggest that ALK1 appears to have important functions in regulating proliferation of ECs, whereas ALK5 tends to modulate cell-cell interaction and cell adhesion and extracellular matrix remodeling...
  13. ncbi request reprint Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling
    Xingang Zhao
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 283:3272-80. 2008
    ..Our results reveal a novel mode of Smad3 action in a Smad4-independent manner and may lead to successful strategies for SARS treatment by targeting the TGF-beta signaling molecules...
  14. ncbi request reprint Functional analysis of mutations in the kinase domain of the TGF-beta receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia
    Yi Gu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Blood 107:1951-4. 2006
    ..These data indicate that loss-of-function mutations in a single allele of the ALK1 locus are sufficient to contribute to defects in maintaining endothelial integrity...
  15. ncbi request reprint MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration
    Jing Ma
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Blood 109:987-94. 2007
    ..Taken together, our findings suggest that MCP-1 mediates TGF-beta-stimulated angiogenesis by enhancing migration of mural cells toward ECs and thus promoting the maturation of new blood vessels...
  16. ncbi request reprint Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity
    Bo Xiong
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Protein Sciences Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Cell 11:225-38. 2006
    ..We further demonstrate that Tob family members across species share similar biochemical properties and biological activities...
  17. ncbi request reprint Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors
    Lixia Zhang
    Laboratory of Developmental Biology, Ministry of Education MOE, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Science 306:114-7. 2004
    ..Dpr2 is localized in late endosomes, binds to the TGFbeta receptors ALK5 and ALK4, and accelerates lysosomal degradation of these receptors...
  18. ncbi request reprint PTEN, a general negative regulator of cyclin D expression
    Lirong Diao
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Cell Res 17:291-2. 2007
  19. pmc TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity
    Xiaohua Yan
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Mol Cell Biol 31:3700-9. 2011
    ..Taken together with the notion that TGF-β induces TSC-22 expression, our findings suggest that TSC-22 regulates TGF-β signaling via a positive-feedback mechanism and may contribute to myocardial fibrosis...
  20. ncbi request reprint Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells
    Junping Yu
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    J Phys Chem B 111:13619-25. 2007
    ..The results suggested a more stable binding of TGF-beta1 with the receptor after TbetaRI is recruited and the important contribution of TbetaRI to the signaling complex formation during TGF-beta1 signaling...
  21. pmc Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation
    Chen Wang
    Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences and Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Biol Cell 17:3075-84. 2006
    ..Blocking the bone morphogenetic protein (BMP) pathway by overexpressing Smad6 in P19 cells, we also show that FGF signaling plays a BMP inhibition-independent role in P19 cell neural differentiation...
  22. ncbi request reprint Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging
    Xinyong Ma
    Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    Biochem Biophys Res Commun 356:67-71. 2007
    ..Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of TbetaRI and TbetaRII for cell signaling...
  23. pmc Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
    Wei Liu
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
    EMBO J 25:1646-58. 2006
    ..However, coexpression of Wnt-1 reduced Smad7 ubiquitination by downregulating Axin levels, underscoring the importance of Axin as an intrinsic regulator in TGF-beta signaling...
  24. ncbi request reprint PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 125:915-28. 2006
    ..This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling...
  25. ncbi request reprint Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis
    Zhongxian Lu
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 277:29363-8. 2002
    ..Thus, our findings suggest that receptor endocytosis is dispersible for TGF-beta-mediated activation of Smad2 and that this activation can be mediated by both SARA-dependent and -independent mechanisms...