Jian Zhi Wang

Summary

Affiliation: Tongji Medical College
Country: China

Publications

  1. doi request reprint Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3
    Yue Wang
    Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Committee, Tongji Medical College, Huazhong University of Science and Technical, Wuhan, China
    J Neurochem 106:2364-74. 2008
  2. ncbi request reprint Role of melatonin in Alzheimer-like neurodegeneration
    Jian Zhi Wang
    Pathophysiology Department, Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 27:41-9. 2006
  3. doi request reprint Microtubule-associated protein tau in development, degeneration and protection of neurons
    Jian Zhi Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Prog Neurobiol 85:148-75. 2008
  4. doi request reprint 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner
    Hai Rong Shi
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Ministry of Education and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    J Neural Transm 115:879-88. 2008
  5. ncbi request reprint Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture
    Ze Fen Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 98:1167-75. 2006
  6. ncbi request reprint Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats
    Jun Hua Peng
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neuropharmacology 52:1521-7. 2007
  7. doi request reprint Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2
    Xin an Liu
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 19:953-62. 2010
  8. doi request reprint Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors
    Hai Hong Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 21:167-79. 2010
  9. doi request reprint Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro
    Zan Chao Liu
    Department of Pathology and Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 29:727-40. 2012
  10. doi request reprint Biphasic effects of forskolin on tau phosphorylation and spatial memory in rats
    Qing Tian
    Department of Pathophysiology, Key Laboratory of Neurological Disease Education Ministry of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Chin a
    J Alzheimers Dis 17:631-42. 2009

Collaborators

Detail Information

Publications100

  1. doi request reprint Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3
    Yue Wang
    Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Committee, Tongji Medical College, Huazhong University of Science and Technical, Wuhan, China
    J Neurochem 106:2364-74. 2008
    ..Our data provide direct evidence demonstrating that activation of GSK-3 by WT/GFX may cause memory deficit through tau hyperphosphorylation and suppression of ACh in hippocampus...
  2. ncbi request reprint Role of melatonin in Alzheimer-like neurodegeneration
    Jian Zhi Wang
    Pathophysiology Department, Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 27:41-9. 2006
    ..The capacity of melatonin to prevent or ameliorate tau and Abeta pathology further enhances its potential in the prevention or treatment of AD...
  3. doi request reprint Microtubule-associated protein tau in development, degeneration and protection of neurons
    Jian Zhi Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Prog Neurobiol 85:148-75. 2008
    ..The primary aim of this review is to summarize the latest developments and perspectives in our understanding about the roles of tau, especially hyperphosphorylation, in the development, degeneration and protection of neurons...
  4. doi request reprint 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner
    Hai Rong Shi
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Ministry of Education and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    J Neural Transm 115:879-88. 2008
    ..We found that betaE2 could attenuate Wort/GFX-induced GSK-3beta activation and tau hyperphosphorylation with Akt-independent manner. It suggests that betaE2 may arrest AD-like tau hyperphosphorylation by directly targeting GSK-3beta...
  5. ncbi request reprint Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture
    Ze Fen Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 98:1167-75. 2006
    ..These results suggest that endogenously overproduced Abeta induces increased tau phosphorylation through activation of GSK-3, and that inactivation of PKC is at least one of the mechanisms involved in GSK-3 activation...
  6. ncbi request reprint Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats
    Jun Hua Peng
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neuropharmacology 52:1521-7. 2007
    ....
  7. doi request reprint Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2
    Xin an Liu
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 19:953-62. 2010
    ..These data suggest that tau dephosphorylation by PP2Ac facilitates cell apoptosis with the mechanisms involving a failed dephosphorylation/activation of Bcl-2...
  8. doi request reprint Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors
    Hai Hong Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 21:167-79. 2010
    ....
  9. doi request reprint Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro
    Zan Chao Liu
    Department of Pathology and Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 29:727-40. 2012
    ..All these data suggest an essential role of Bip in GSK-3β dependent tau hyperphosphorylation in ER stress by promoting the binding of GSK-3β to tau...
  10. doi request reprint Biphasic effects of forskolin on tau phosphorylation and spatial memory in rats
    Qing Tian
    Department of Pathophysiology, Key Laboratory of Neurological Disease Education Ministry of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Chin a
    J Alzheimers Dis 17:631-42. 2009
    ..These data suggest that the upregulation of PKA by forskolin to a certain level may activate PP-2A but that the latter can ameliorate the PKA-induced tau phosphorylation and memory impairment in the rats...
  11. doi request reprint Proteasome inhibition increases tau accumulation independent of phosphorylation
    Ying Hua Liu
    Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurobiol Aging 30:1949-61. 2009
    ....
  12. pmc Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms
    Ya Fei Xu
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Cell Stress Chaperones 9:304-12. 2004
    ....
  13. ncbi request reprint Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells
    Guo Gang Xu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Biochim Biophys Sin (Shanghai) 37:349-54. 2005
    ....
  14. ncbi request reprint Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms
    Yong Jie Zhang
    Pathophysiology Department, Key Laboratory of Neurological Disease of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    FASEB J 20:1431-42. 2006
    ..Our findings reveal a common upstream stimulator and a potential therapeutic target for Alzheimer-like neurodegeneration...
  15. doi request reprint Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C
    Xia Jiang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 118:864-78. 2011
    ..These results suggest that ALCAR could ameliorate WT/GFX-induced spatial memory deficits through inhibition tau hyperphosphorylation and modulation of memory-associated proteins...
  16. doi request reprint Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone
    Xiao ping Hong
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Neurochem Res 36:288-96. 2011
    ..The SVZ neurogenesis was also unaffected in tau knockout and human tau transgenic mice. These results suggest that tau phosphorylation and GSK-3 activation may not be essential for adult SVZ neurogenesis...
  17. ncbi request reprint Effect of melatonin on calyculin A-induced tau hyperphosphorylation
    Xia Chun Li
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Eur J Pharmacol 510:25-30. 2005
    ....
  18. doi request reprint Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
    Yan Xiong
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neurobiol Aging 34:745-56. 2013
    ..We concluded that zinc induces PP2A inactivation and tau hyperphosphorylation through Src-dependent pathway, regulation of zinc homeostasis may be a promising therapeutic for AD and the related tauopathies...
  19. doi request reprint Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells
    Ze Fen Wang
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Educational Ministry of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 20:145-57. 2010
    ..These findings provide an explanation of the chronic nature of neurodegeneration of neurons with neurofibrillary pathology of abnormal hyperphosphorylated tau in AD and related tauopathies...
  20. pmc Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration
    Hong Lian Li
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Proc Natl Acad Sci U S A 104:3591-6. 2007
    ..Our findings suggest that tau phosphorylation may lead the neurons to escape from an acute apoptotic death, implying the essence of neurodegeneration seen in the AD brains and related tauopathies...
  21. ncbi request reprint Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
    Jun Yin
    Department of Pathophysiology, Hua Zhong University of Science and Technology, Wuhan, China
    J Pineal Res 41:124-9. 2006
    ..We conclude that MEL can efficiently arrest peroxynitrite-induced tau hyperphosphorylation, and the underlying mechanism may involve scavenging the reactive species and suppressing the activated GSK-3beta and p38 MAPK family...
  22. ncbi request reprint Effects of melatonin on wortmannin-induced tau hyperphosphorylation
    Yan Qiu Deng
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 26:519-26. 2005
    ..To explore the underlying mechanism of tau hyperphosphorylation in an Alzheimeros-affected brain and the possible arresting strategies...
  23. ncbi request reprint Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat
    Ling Qiang Zhu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Pineal Res 37:71-7. 2004
    ..These results strongly support the involvement of decreased melatonin in Alzheimer-like spatial memory impairment and tau hyperphosphorylation, and PP-2A may play a role in mediating aberrant melatonin-induced lesions...
  24. doi request reprint Essential role of tau phosphorylation in adult hippocampal neurogenesis
    Xiao ping Hong
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Hippocampus 20:1339-49. 2010
    ..It suggests that spatial/temporal manipulation of tau phosphorylation may be compensatory for the neuron loss in neurological disorders, including AD...
  25. ncbi request reprint Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions
    Yi Peng Wang
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 25:276-80. 2004
    ..To explore the protective effects of melatonin (Mel) on the abnormal phosphorylation of neuronal cytoskeletal proteins...
  26. ncbi request reprint Inhibition of melatonin biosynthesis activates protein kinase a and induces Alzheimer-like tau hyperphosphorylation in rats
    Ling Qiang Zhu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
    Chin Med Sci J 20:83-7. 2005
    ....
  27. ncbi request reprint Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity
    Shu Peng Li
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    J Pineal Res 36:186-91. 2004
    ..It is concluded that inhibition of PP-2A/PP-1 by CA induces abnormalities in NF metabolism and cell survival, and melatonin efficiently arrests the lesions...
  28. ncbi request reprint [Alteration of beta-amyloid and glutamate transporter in the brain of diabetes rats and the underlying mechanism]
    Zhong sen Qu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:708-11. 2005
    ..To investigate the alteration of beta-amyloid (Abeta) and glutamate transporter in the brain cortex of diabetes mellitus (DM) rats and the underlying mechanism...
  29. doi request reprint Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation
    Xiao Hong Li
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Neuromolecular Med 14:338-48. 2012
    ..Thus, targeting MG may be a promising therapeutic strategy to prevent AD-like tau hyperphosphorylation...
  30. doi request reprint Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats
    Yang Yang Yin
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    J Alzheimers Dis 19:735-46. 2010
    ..Our study provides the first in vivo evidence that ALCAR can attenuate AD-like PP2A inhibition, tau hyperphosphorylation, and spatial memory deficit of the rats. It suggests that ALCAR may hold potential in AD treatment...
  31. ncbi request reprint Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5
    Shaohui Wang
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Neurochem Res 32:1329-35. 2007
    ..These results suggest that inhibition of melatonin biosynthesis may activate cdk-5 and thus induces Alzheimer-like hyperphosphorylation of neurofilament proteins...
  32. ncbi request reprint Inhibition of protein phosphatases induces transport deficits and axonopathy
    Ying Yang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 102:878-86. 2007
    ....
  33. ncbi request reprint Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms
    Rong Liu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 94:1225-34. 2005
    ..These data suggest that acute anoxia induces tau dephosphorylation, and that PP-2A may play a key role in tau dephosphorylation induced by acute anoxia...
  34. doi request reprint Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1
    Xiu Qing Yao
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    FEBS Lett 586:2522-8. 2012
    ..GSK-3 could negatively regulate PP2A regulatory subunit protein level. We conclude that GSK-3β can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1...
  35. doi request reprint Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats
    Wei Wei
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 27:639-50. 2011
    ..These data demonstrate that folate/vit-B12 supplementation is also effective in a chronic hyperhomocysteinemia model in reversing the AD-like tau pathologies and memory deficits...
  36. doi request reprint Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin
    Zhi Qun Ling
    Department of Pathology and Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 16:287-300. 2009
    ..It is suggested that melatonin deficiency may be an upstream effector responsible for the AD-like behavioral and molecular pathologies with ER stress-involved mechanisms...
  37. pmc Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
    Jian Zhi Wang
    Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan P R China
    Eur J Neurosci 25:59-68. 2007
    ..These findings suggest that activation of PP-2A or inhibition of either both GSK-3beta and cdk5 or one of these two kinases plus PKA or CaMKII might be required to inhibit Alzheimer neurofibrillary degeneration...
  38. doi request reprint PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B
    Yu Luo
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Biochim Biophys Acta 1833:1235-43. 2013
    ..Our data indicate that PTPA may activate PP2A through activating PTP1B and thus reducing the level of P-PP2AC, therefore upregulation of PTPA may represent a potential strategy in rescuing PP2A and arresting tau pathology in AD...
  39. ncbi request reprint Alzheimer-like phosphorylation of tau and neurofilament induced by cocaine in vivo
    Shi Jie Liu
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 24:512-8. 2003
    ..To explore the relationship between cocaine-induced cyclin-dependent kinase-5 (CDK5) overexpression or overactivation and Alzheimer-like hyperphosphorylation of cytoskeletal protein...
  40. ncbi request reprint Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain
    Dan Ling Wang
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Pineal Res 37:11-6. 2004
    ....
  41. ncbi request reprint The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation
    Qing Guo Ren
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    FEBS Lett 580:2503-11. 2006
    ..These results suggest that inhibition of proteasome by lactacystin induces tau accumulation and activation of GSK-3 and inhibition of PP-2A are involved...
  42. ncbi request reprint Melatonin attenuates beta-amyloid-induced inhibition of neurofilament expression
    Ying Chun Zhang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 25:447-51. 2004
    ..To explore the effect of beta-amyloid (A beta) on metabolism of cytoskeletal protein neurofilament, and search for effective cure to the lesion...
  43. ncbi request reprint Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell
    Hai Hong Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 26:679-84. 2005
    ..To investigate the effect of dishevelled-1 (DVL-1) on wortmannin-induced Alzheimer-like hyperphosphorylation of cytoskeletal proteins in mouse neuroblastoma 2a (N2a) cells...
  44. doi request reprint Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats
    Ning Ning Chen
    Department of Pathophysiology, Key Laboratory of Chinese Ministry of Education for Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    J Alzheimers Dis 30:585-94. 2012
    ..Additionally, neuron loss in the hippocampus and cortex was observed upon administration of the pesticides. These results indicate that the pesticides exposure could induce AD-like pathology and cognitive abnormality in rats...
  45. doi request reprint I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis
    Gong Ping Liu
    Pathophysiology Department, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurobiol Aging 33:254-64. 2012
    ..This finding contributes to the understanding of why most neurons in AD brain do not undergo apoptosis...
  46. doi request reprint Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities
    Peng Zhou
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Rejuvenation Res 14:669-79. 2011
    ..Our data suggest that ALC could be a promising candidate for arresting Hcy-induced AD-like pathological and behavioral impairments...
  47. doi request reprint Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling
    Li Ming Chen
    Pathophysiology Department, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 120:157-64. 2012
    ..Our data indicate that Ngb may attenuate tau hyperphosphorylation through activating Akt signaling pathway, implying a therapeutic target for AD...
  48. doi request reprint Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells
    Guang Yu
    Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 24:525-35. 2011
    ..Our findings suggest that berberine may be a potential therapeutic drug for AD...
  49. ncbi request reprint Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity
    Yong Jie Zhang
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    FEBS Lett 579:2421-7. 2005
    ....
  50. ncbi request reprint LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro
    Zheng Qi Fu
    Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 21:1107-17. 2010
    ..Our data provide further evidence supporting the role of ER stress in tau hyperphosphorylation and the protective role of lithium...
  51. ncbi request reprint [Duration of tau hyperphosphorylation and spatial memory deficit induced by single injection of Forskolin into lateral ventricle of rat]
    Jun Xia Zhang
    Department of Pathophysiology, Tongji Medical College, Huazhong Science and Technical University, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:355-9. 2006
    ....
  52. ncbi request reprint [Mechanism of tau hyperphosphorylation in brain cortex of diabetic rats and effect of LiCl]
    Zhong sen Qu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:244-8. 2006
    ..To explore the mechanism of tau hyperphosphorylation and the effect of LiCl on tau phosphorylation and the memory retention deficits in streptozotocin-induced diabetes mellitus (DM) rats...
  53. doi request reprint Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway
    Xiong Wang
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People s Republic of China
    Mol Neurobiol 47:373-81. 2013
    ..Our studies provide a novel underlying epigenetic mechanism for melatonin to attenuate the synaptic disorder and could benefit drug discovery in neurodegenerative diseases...
  54. doi request reprint Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice
    Xiu Ping Liu
    Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Glia 60:1279-88. 2012
    ....
  55. doi request reprint Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine
    Gao Shang Chai
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 124:388-96. 2013
    ..Our data suggest that betaine could be a promising candidate for arresting Hcy-induced AD-like pathological changes and memory deficits...
  56. doi request reprint NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1
    Shao Hui Wang
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Education Ministry of China, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    Neuropharmacology 63:1085-92. 2012
    ..Our data provide the first evidence that NGF supplement facilitates synaptic plasticity and the memory ability through PARP-1-mediated protein polyADP-ribosylation and activation of PKA-CREB pathway...
  57. doi request reprint Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
    Xiu Qing Yao
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Biochem J 437:335-44. 2011
    ..The results of the present study suggest that GSK-3β inhibits PP2A by increasing the inhibitory Tyr307 phosphorylation and decreasing the expression of PP2A, and the mechanism involves inhibition of PTP1B and CREB...
  58. doi request reprint Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A
    Xin an Liu
    Pathophysiology Department, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan, 430030, PR China
    Neurochem Res 33:1811-20. 2008
    ..These data provide the first evidence that 17beta-estradiol can inhibit PKA overactivation and the PKA-induced tau hyperphosphorylation, implying a preventive role of 17beta-estradiol in AD-like tau pathology...
  59. ncbi request reprint Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
    Chang E Zhang
    Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neurobiol Aging 29:1654-65. 2008
    ..These results suggest that homocysteine may be an upstream effector to induce AD-like tau hyperphosphorylation through inactivating PP2A...
  60. ncbi request reprint Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
    Ling Qiang Zhu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Neurosci 27:12211-20. 2007
    ..We conclude that upregulation of GSK-3 impairs the synaptic plasticity both functionally and structurally, which may underlie the GSK-3-involved memory deficits...
  61. doi request reprint Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2
    Ling Qiang Zhu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Neurosci 30:3839-48. 2010
    ..Our results reveal a mechanistic link between PP2A and axonogenesis/axonopathy, suggesting that upregulation of PP2A may be a promising therapeutic for some neurodegenerative disorders...
  62. doi request reprint AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation
    Xiao Hong Li
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neurobiol Aging 33:1400-10. 2012
    ....
  63. pmc Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A)
    Xu Ying Sun
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Biol Chem 287:11174-82. 2012
    ..Together, these results suggest that synaptically released zinc promotes tau hyperphosphorylation through PP2A inhibition...
  64. pmc EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
    Ying Yang
    Key Laboratory of Neurological Disease, Ministry of Education, China, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Neuron 73:774-88. 2012
    ..Thus, EPAC proteins control miR-124 transcription in the brain for processing spatial learning and social interactions...
  65. doi request reprint Upregulation of AKT attenuates amyloid-β-induced cell apoptosis
    Gang Yin
    Department of Pathophysiology, the Key Laboratory of Neurological Diseases of the Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 25:337-45. 2011
    ..Our data suggest that upregulation of AKT could be a promising therapeutic strategy for arresting Aβ toxicity in AD patients...
  66. ncbi request reprint Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
    Shi Jie Liu
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Biol Chem 279:50078-88. 2004
    ..These data provide a novel mechanism of the hyperphosphorylation of tau and identify both PKA and GSK-3 as promising therapeutic targets for AD and other tauopathies...
  67. ncbi request reprint Effects of tau phosphorylation on proteasome activity
    Qing Guo Ren
    Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    FEBS Lett 581:1521-8. 2007
    ..Furthermore, tau hyperphosphorylation could partially reverse lactacystin-induced inhibition of proteasome. These results suggest that phosphorylation of tau plays a dual role in modulating the activity of proteasome...
  68. doi request reprint Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells
    Xiao Chuan Wang
    Department of Pathophysiology, Hubei Provincial Key Laboratory in Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurochem Res 33:1138-44. 2008
    ..These results suggest that Mtv may be a better candidate in arresting the intracellular accumulation of Abeta and protecting the cells from Abeta-related toxicity...
  69. doi request reprint GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation
    Ling Qiang Zhu
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Neurosci 30:3624-33. 2010
    ..These results indicate that GSK-3beta negatively regulates synaptic vesicle fusion events via interfering with Ca(2+)-dependent SNARE complex formation...
  70. ncbi request reprint Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration
    Jian Zhi Wang
    Pathophysiology Department, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    J Alzheimers Dis 33:S123-39. 2013
    ..In this article we briefly review the progress made in these areas of research...
  71. ncbi request reprint Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms
    Gong Ping Liu
    Pathophysiology Department, Key Laboratory of Neurological Disease of Hubei Province, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430030, PR China
    Neurobiol Aging 29:1348-58. 2008
    ..The activation of GSK-3 increased the expression and the activity of proteasome system. It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP A18-involved mechanism...
  72. ncbi request reprint Correlation between choline signal intensity and acetylcholine level in different brain regions of rat
    Xiao Chuan Wang
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurochem Res 33:814-9. 2008
    ..127 (S1BF cortex), respectively (y means acetylcholine, and x means Cho). These data suggest that the Cho signal intensity observed by (1)H MRS may be used as an indicator of acetylcholine level in different brain regions of the rats...
  73. pmc Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
    Chang E Zhang
    Department of Pathophysiology, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Am J Pathol 174:1481-91. 2009
    ..It is suggested that hyperhomocysteinemia may serve as an upstream factor for increased Abeta production as seen in patients with Alzheimer disease...
  74. doi request reprint Nmnat2 attenuates Tau phosphorylation through activation of PP2A
    Xiang Shu Cheng
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Ministry of China, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 36:185-95. 2013
    ..Our data provide the first evidence that Nmnat2 affects tau phosphorylation by regulating PP2A activity, suggesting that Nmnat2 may serve as a potential target in arresting AD-like tau pathologies...
  75. ncbi request reprint Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by pin1 down-regulation
    Yan Si Xiong
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    CNS Neurol Disord Drug Targets 12:436-43. 2013
    ..Our data suggest that GSK-3β activation plays an important role in tau hyperphosphorylation induced by the down-regulation of Pin1, and the inhibition of GSK-3β might be a potential therapeutic approach for AD pathology...
  76. doi request reprint Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model
    Cai Xia Peng
    Pathophysiology Department, Key Laboratory of Education Ministry for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Neurobiol Aging 34:1555-63. 2013
    ..Our finding suggests that melatonin treatment only at proper timing could arrest AD by targeting the activated GSK-3β, which provides primary evidence for the importance and strategy in developing disease-modifying interventions of AD...
  77. doi request reprint The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats
    Xu Chen
    Department of Neurosurgery, Tongji Hospital, Huazhong University of Science and Technology, Jiefang Ave 1095, 430030 Wuhan, China
    Brain Res 1357:104-14. 2010
    ..The JNK inhibitor SP600125 can show a protective effect on hippocampal neurons in TLE by inhibiting JNK activation...
  78. doi request reprint Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response
    Xin an Liu
    Pathophysiology Department, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China
    Apoptosis 17:1039-49. 2012
    ..Our data suggest that tau hyperphosphorylation could attenuate the ER stress-induced apoptosis with the mechanism involving upregulation of UPR system...
  79. ncbi request reprint Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress
    Dan Li
    Department of Pathophysiology and Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neurochem Res 32:1375-80. 2007
    ..The Cygb-siRNA could exacerbate cell death upon H(2)O(2)-treatment, as demonstrated by MTT cell viability assay. Thus, Cygb in neuronal cells might be specifically induced under oxidative stress to protect them from death...
  80. doi request reprint Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain
    Jia Yu Zhang
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    J Alzheimers Dis 16:39-47. 2009
    ..Our data suggest that the lysosomal autophagic system may not degrade tau in the normal adult rat brain and inhibition of autophagy may induce tau proteolysis through activating calpain...
  81. ncbi request reprint Effect of amyloid peptides on serum withdrawal-induced cell differentiation and cell viability
    Yi Peng Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Cell Res 14:467-72. 2004
    ..These results suggest that the overproduction of A beta could not arrest cell differentiation induced by serum deprivation and that, at least to a certain degree and in a limited time period, is not toxic to cell viability...
  82. ncbi request reprint Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices
    Jiang Fang
    Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 28:1717-23. 2007
    ....
  83. doi request reprint Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease
    Wen zhen Zhu
    Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Radiology 253:497-504. 2009
    ..The aim of this study was to investigate the correlation of brain iron accumulation with the severity of cognitive impairment in patients with Alzheimer disease (AD)...
  84. doi request reprint Protective effect of granulocyte colony-stimulating factor on intracerebral hemorrhage in rat
    Lei Zhang
    Hubei Provincial Key Laboratory of Neurological Disease, Pathophysiology Department, Tongji Medical College, Hua Zhong University of Science and Technology, 430030, Wuhan, People s Republic of China
    Neurochem Res 34:1317-23. 2009
    ..Our results reveal that G-CSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells, the migration of HSCs and the activation of astrocytes...
  85. ncbi request reprint Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection
    Yao Zhang
    Li Yuan Hospital, Key Laboratory of Neurological Disorders of Education Ministry of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Pathophysiology 16:311-6. 2009
    ..The primary aim of this review is to summarize the latest developments and perspectives in our understanding about the roles of tau hyperphosphorylation in neurodegeneration and neuroprotection...
  86. ncbi request reprint Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
    Shi Jie Liu
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 87:1333-44. 2003
    ....
  87. ncbi request reprint Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314 6399, USA
    J Mol Neurosci 19:95-9. 2002
    ....
  88. ncbi request reprint Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin
    Shi Jie Liu
    Department of Pathophysiology, Tongji Medical College, Huazhong Science and Technical University, Wuhan 430030, China
    Acta Pharmacol Sin 23:183-7. 2002
    ..To investigate the in vivo induction of Alzheimer-like tau phosphorylation by wortmannin and the attenuation by melatonin...
  89. ncbi request reprint Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Mol Neurosci 20:425-9. 2003
    ..Development of high-throughput screening assays for potential drugs aimed at these therapeutic targets is currently under way...
  90. ncbi request reprint Correlation of behavior changes and BOLD signal in Alzheimer-like rat model
    Zheng Hui Hu
    Department of Physics and Bio X disciplinary Laboratory, Zhejiang University, Hangzhou, China
    Acta Biochim Biophys Sin (Shanghai) 36:803-10. 2004
    ..62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation...
  91. ncbi request reprint Overexpression of amyloid precursor protein inhibits neurite outgrowth and disrupts cytoskeleton in N2a cells
    Ze Fen Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 117:775-8. 2004
  92. ncbi request reprint Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients
    Yuan Yuan Hu
    Tongji Medical College, HUST, Wuhan 430030, PR China
    Neurosci Lett 320:156-60. 2002
    ....
  93. ncbi request reprint Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation
    George C Ruben
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Microsc Res Tech 67:175-95. 2005
    ..5-0.6 nm and 0.7-1.0 nm, respectively, and the right-hand helicity of the PHF was lost after deglycosylation. Dephosphorylation with PP-2A reduced the PHF wide regions by 6.0 nm and the thin regions by 2.6 nm...
  94. ncbi request reprint Nitric oxide induces tau hyperphosphorylation via glycogen synthase kinase-3beta activation
    Yong Jie Zhang
    Pathophysiology Department, Key Laboratory of Neurological Disease of Hubei Province, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430030, PR China
    FEBS Lett 579:6230-6. 2005
    ..It is suggested that nitric oxide may be an upstream element of tau abnormal hyperphosphorylation in AD...
  95. ncbi request reprint [Effect of different culture media on viability and tau protein expression in rat hippocampal slices]
    Ying Chun Zhang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:513-7. 2005
    ..To explore the effect of different culture media on viability and expression of tau protein in organotypic hippocampal slice...
  96. ncbi request reprint [Effect of calpain on the degradation of tau protein in rat brain cortex extracts]
    Zheng Yu Fang
    Neuroscience Institute Pathophysiology Department Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:629-34. 2003
    ..These data suggest that both mu-calpain and m-calpain in brain cortex extracts are activated by Ca(2+) and both of them degraded tau protein, although, m-calpain plays a more important role in proteolysis of the tau protein...
  97. ncbi request reprint Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices
    Cheng Xin Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Neurosci Lett 340:107-10. 2003
    ..These findings suggest that the hyperphosphorylation and accumulation of NF found in AD brain could have been caused by the down-regulation of PP2A...
  98. ncbi request reprint Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
    Xu Li
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P R China
    Eur J Neurosci 23:2078-86. 2006
    ....
  99. ncbi request reprint Effects of EGF and bFGF on expression of microtubule-associated protein tau and MAP-2 mRNA in human umbilical cord mononuclear cells
    Wen Hai Yan
    Department of Pathophysiology, Medical College of Zhengzhou University, Zhengzhou 450052, PR China
    Cell Biol Int 29:153-7. 2005
    ..The same upregulatory tendency was noted for tau mRNA expression. It is concluded that MNCs derived from human UCB cells may express some neural specific molecules that can be upregulated by cytokines, especially EGF and bFGF together...